Citations (81)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (5)
Tordis J. Dahle, Anne Marit Rykkelid, Camilla H. Stokkevåg, Andrea Mairani, Andreas Görgen, Nina J. Edin, Eivind Rørvik, Lars Fredrik Fjæra, Eirik Malinen & Kristian S. Ytre-Hauge. (2017) Monte Carlo simulations of a low energy proton beamline for radiobiological experiments. Acta Oncologica 56:6, pages 779-786.
Read now
Read now
Brita Singers Sørensen, Jens Overgaard & Niels Bassler. (2011) In vitro RBE-LET dependence for multiple particle types. Acta Oncologica 50:6, pages 757-762.
Read now
Read now
Ariungerel Gerelchuluun, Zhengshan Hong, Lue Sun, Kenshi Suzuki, Toshiyuki Terunuma, Kiyoshi Yasuoka, Takeji Sakae, Takashi Moritake & Koji Tsuboi. (2011) Induction of in situ DNA double-strand breaks and apoptosis by 200 MeV protons and 10 MV X-rays in human tumour cell lines. International Journal of Radiation Biology 87:1, pages 57-70.
Read now
Read now
M. Belli, F. Cera, R. Cherubini, F. Ianzini, G. Moschini, O. Sapora, G. Simone, M.A. Tabocchini & P. Tiveron. (1994) DNA Double-strand Breaks Induced by Low Energy Protons in V79 Cells. International Journal of Radiation Biology 65:5, pages 529-536.
Read now
Read now
R. Verrijk, R. Huiskamp, A.C. Begg, F.J. Wheeler & P.R.D. Watkins. (1994) A Comprehensive PC-based Computer Model for Microdosimetry of BNCT. International Journal of Radiation Biology 65:2, pages 241-253.
Read now
Read now
Articles from other publishers (76)
Farshid Tabbakh & Narayan S. Hosmane. (2023) Enhanced biological effectiveness with carbon nanoparticles in proton therapy: a simulation study. The European Physical Journal Plus 138:6.
Crossref
Crossref
Valentina Dini, Giuseppe Esposito, Andrea Sacconi, Marco D’Andrea, Maria Antonella Tabocchini, Pasquale Anello, Lucia Ricci-Vitiani, Mariachiara Buccarelli, Roberto Pallini & Lidia Strigari. (2023) Effectiveness of Flattening-Filter-Free versus Flattened Beams in V79 and Glioblastoma Patient-Derived Stem-like Cells. International Journal of Molecular Sciences 24:2, pages 1107.
Crossref
Crossref
Floriane Poignant, Ianik Plante, Zarana S. Patel, Janice L. Huff & Tony C. Slaba. (2022) Geometrical Properties of the Nucleus and Chromosome Intermingling Are Possible Major Parameters of Chromosome Aberration Formation. International Journal of Molecular Sciences 23:15, pages 8638.
Crossref
Crossref
Hossein Taghipour & Payvand Taherparvar. (2022) Development of modified microdosimetric kinetic model for relative biological effectiveness in proton therapy. Radiation and Environmental Biophysics 61:3, pages 375-390.
Crossref
Crossref
Luis G. Crespo, Tony C. Slaba, Floriane A. Poignant & Sean P. Kenny. 2022. Information Processing and Management of Uncertainty in Knowledge-Based Systems. Information Processing and Management of Uncertainty in Knowledge-Based Systems
99
114
.
Fredrik Kalholm, Leszek Grzanka, Erik Traneus & Niels Bassler. (2021) A systematic review on the usage of averaged LET in radiation biology for particle therapy. Radiotherapy and Oncology 161, pages 211-221.
Crossref
Crossref
Yoshitaka Matsumoto. 2020. Proton Beam Radiotherapy. Proton Beam Radiotherapy
209
222
.
Eivind Rørvik, Sara Thörnqvist & Kristian S Ytre-Hauge. (2019)
The experimental dose ranges influence the LET
d
dependency of the proton minimum RBE (RBE
min
)
. Physics in Medicine & Biology 64:19, pages 195001.
Crossref
Crossref
Lei Zhao, Xinye He, Xinpeng Chen, Yuxuan Shang, Dong Mi & Yeqing Sun. (2019) Fitting the Generalized Target Model to Cell Survival Data of Proton Radiation Reveals Dose-Dependent RBE and Inspires an Alternative Method to Estimate RBE in High-Dose Regions. Radiation Research 192:5, pages 507.
Crossref
Crossref
Mehrdad Shahmohammadi Beni, Dragana Krstic, Dragoslav Nikezic & Kwan Ngok Yu. (2019) Medium-thickness-dependent proton dosimetry for radiobiological experiments. Scientific Reports 9:1.
Crossref
Crossref
Hong Qi Tan, Wei Yang Calvin Koh, Lloyd Kuan Rui Tan, Jun Hao Phua, Khong Wei Ang, Sung Yong Park, Wen Siang Lew & James Cheow Lei Lee. (2019) Dependence of LET on material and its impact on current RBE model. Physics in Medicine & Biology 64:13, pages 135022.
Crossref
Crossref
Harald Paganetti. (2018) Proton Relative Biological Effectiveness – Uncertainties and Opportunities. International Journal of Particle Therapy 5:1, pages 2-14.
Crossref
Crossref
N. T. Henthorn, J. W. Warmenhoven, M. Sotiropoulos, R. I. Mackay, N. F. Kirkby, K. J. Kirkby & M. J. Merchant. (2018) In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density. Scientific Reports 8:1.
Crossref
Crossref
Eivind Rørvik, Sara Thörnqvist, Camilla H. Stokkevåg, Tordis J. Dahle, Lars Fredrik Fjaera & Kristian S. Ytre-Hauge. (2017) A phenomenological biological dose model for proton therapy based on linear energy transfer spectra. Medical Physics 44:6, pages 2586-2594.
Crossref
Crossref
Mario P. Carante & Francesca Ballarini. (2017) Modelling cell death for cancer hadrontherapy. AIMS Biophysics 4:3, pages 465-490.
Crossref
Crossref
Eliedonna Cacao, Megumi Hada, Premkumar B. Saganti, Kerry A. George & Francis A. Cucinotta. (2016) Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints. PLOS ONE 11:4, pages e0153998.
Crossref
Crossref
Aimee L McNamara, Jan Schuemann & Harald Paganetti. (2015)
A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published
in vitro
cell survival data
. Physics in Medicine and Biology 60:21, pages 8399-8416.
Crossref
Crossref
Kerry A. George, Megumi Hada & Francis A. Cucinotta. (2015) Biological Effectiveness of Accelerated Protons for Chromosome Exchanges. Frontiers in Oncology 5.
Crossref
Crossref
Ariungerel Gerelchuluun, Eri Manabe, Takaaki Ishikawa, Lue Sun, Kazuya Itoh, Takeji Sakae, Kenshi Suzuki, Ryoichi Hirayama, Aroumougame Asaithamby, David J. Chen & Koji Tsuboi. (2015) The Major DNA Repair Pathway after Both Proton and Carbon-Ion Radiation is NHEJ, but the HR Pathway is More Relevant in Carbon Ions. Radiation Research 183:3, pages 345-356.
Crossref
Crossref
Harald Paganetti. (2014) Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer. Physics in Medicine and Biology 59:22, pages R419-R472.
Crossref
Crossref
F. Tommasino, T. Friedrich, U. Scholz, G. Taucher-Scholz, M. Durante & M. Scholz. (2013) A DNA Double-Strand Break Kinetic Rejoining Model Based on the Local Effect Model. Radiation Research 180:5, pages 524-538.
Crossref
Crossref
Kerry A. George, Megumi Hada, Lori Chappell & Francis A. Cucinotta. (2013) Biological Effectiveness of Accelerated Particles for the Induction of Chromosome Damage: Track Structure Effects. Radiation Research 180:1, pages 25-33.
Crossref
Crossref
T. Friedrich, U. Scholz, T. ElsaSser, M. Durante & M. Scholz. (2012) Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation. Journal of Radiation Research 54:3, pages 494-514.
Crossref
Crossref
Alejandro Carabe, Samuel España, Clemens Grassberger & Harald Paganetti. (2013) Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Physics in Medicine and Biology 58:7, pages 2103-2117.
Crossref
Crossref
Maria Antonella Tabocchini, Alessandro Campa & Valentina Dini. (2012) DNA and Cellular Effects of Charged Particles. Health Physics 103:5, pages 547-555.
Crossref
Crossref
Y. Chen & S. Ahmad. (2011) Empirical model estimation of relative biological effectiveness for proton beam therapy. Radiation Protection Dosimetry 149:2, pages 116-123.
Crossref
Crossref
Alejandro Carabe, Maryam Moteabbed, Nicolas Depauw, Jan Schuemann & Harald Paganetti. (2012) Range uncertainty in proton therapy due to variable biological effectiveness. Physics in Medicine and Biology 57:5, pages 1159-1172.
Crossref
Crossref
D. Doria, K. F. Kakolee, S. Kar, S. K. Litt, F. Fiorini, H. Ahmed, S. Green, J. C. G. Jeynes, J. Kavanagh, D. Kirby, K. J. Kirkby, C. L. Lewis, M. J. Merchant, G. Nersisyan, R. Prasad, K. M. Prise, G. Schettino, M. Zepf & M. Borghesi. (2012) Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s. AIP Advances 2:1.
Crossref
Crossref
Harald PaganettiHarald Paganetti. 2011. Proton Therapy Physics. Proton Therapy Physics
593
626
.
Marco Durante & Francis A. Cucinotta. (2011) Physical basis of radiation protection in space travel. Reviews of Modern Physics 83:4, pages 1245-1281.
Crossref
Crossref
S. Rollet, P. Colautti, B. Grosswendt, J. Herault, M. Wind, E. Gargioni, P. Beck, M. Latocha & D. Moro. (2010) Microdosimetric assessment of the radiation quality of a therapeutic proton beam: comparison between numerical simulation and experimental measurements. Radiation Protection Dosimetry 143:2-4, pages 445-449.
Crossref
Crossref
I. K. Khvostunov, H. Nikjoo, S. Uehara & M. Hoshi. (2011) The consideration of biological effectiveness of low energy protons using biophysical modeling of the effects induced by exposure of V79 cells. Biophysics 55:6, pages 1067-1075.
Crossref
Crossref
Eleanor A. Blakely & Polly Y. Chang. (2009) Biology of Charged Particles. The Cancer Journal 15:4, pages 271-284.
Crossref
Crossref
Antonio ANTOCCIA, Antonella SGURA, Francesco BERARDINELLI, Maria CAVINATO, Roberto CHERUBINI, Silvia GERARDI & Caterina TANZARELLA. (2009) Cell Cycle Perturbations and Genotoxic Effects in Human Primary Fibroblasts Induced by Low-energy Protons and X/γ-rays. Journal of Radiation Research 50:5, pages 457-468.
Crossref
Crossref
Mauro BELLI, Daniela BETTEGA, Paola CALZOLARI, Roberto CHERUBINI, Giacomo CUTTONE, Marco DURANTE, Giuseppe ESPOSITO, Yoshiya FURUSAWA, Silvia GERARDI, Giancarlo GIALANELLA, Gianfranco GROSSI, Lorenzo MANTI, Renato MARCHESINI, Mariagabriella PUGLIESE, Paola SCAMPOLI, Giustina SIMONE, Eugenio SORRENTINO, Maria Antonella TABOCCHINI & Lucia TALLONE. (2008) Effectiveness of Monoenergetic and Spread-Out Bragg Peak Carbon-Ions for Inactivation of Various Normal and Tumour Human Cell Lines. Journal of Radiation Research 49:6, pages 597-607.
Crossref
Crossref
. (2008) REFERENCES. Journal of the ICRU 7:2, pages 189-210.
Crossref
Crossref
Francis A. Cucinotta, Myung-Hee Y. Kim & Lei Ren. (2006) Evaluating shielding effectiveness for reducing space radiation cancer risks. Radiation Measurements 41:9-10, pages 1173-1185.
Crossref
Crossref
M. Scholz. 2006. Microdosimetric Response of Physical and Biological Systems to Low- and High-LET Radiations. Microdosimetric Response of Physical and Biological Systems to Low- and High-LET Radiations
1
73
.
Qiang Li, Yoshiya Furusawa, Mitsutaka Kanazawa, Tatsuaki Kanai, Atsushi Kitagawa, Mizuho Aoki, Eriko Urakabe, Takehiro Tomitani, Shinji Sato, Mitsuo Yoshimoto & Zengquan Wei. (2005) Enhanced efficiency in cell killing at the penetration depths around the Bragg peak of a radioactive 9C-ion beam. International Journal of Radiation Oncology*Biology*Physics 63:4, pages 1237-1244.
Crossref
Crossref
H. Paganetti. (2005) Interpretation of proton relative biological effectiveness using lesion induction, lesion repair, and cellular dose distribution. Medical Physics 32:8, pages 2548-2556.
Crossref
Crossref
N Tilly, J Johansson, U Isacsson, J Medin, E Blomquist, E Grusell & B Glimelius. (2005) The influence of RBE variations in a clinical proton treatment plan for a hypopharynx cancer. Physics in Medicine and Biology 50:12, pages 2765-2777.
Crossref
Crossref
Chizuru Tsuruoka, Masao Suzuki, Tatsuaki Kanai & Kazunobu Fujitaka. (2005) LET and Ion Species Dependence for Cell Killing in Normal Human Skin Fibroblasts. Radiation Research 163:5, pages 494-500.
Crossref
Crossref
Jan J. Wilkens & Uwe Oelfke. (2005) Optimization of radiobiological effects in intensity modulated proton therapy. Medical Physics 32:2, pages 455-465.
Crossref
Crossref
Heinrich Moertel, Jens-Christoph Georgi, Luitpold Distel, Wolfgang Eyrich, Miriam Fritsch, Gerhard Grabenbauer & Rolf Sauer. (2004) Effects of low energy protons on clonogenic survival, DSB repair and cell cycle in human glioblastoma cells and B14 fibroblasts. Radiotherapy and Oncology 73, pages S115-S118.
Crossref
Crossref
Q Li, M Komori, T Kanai, A Kitagawa, E Urakabe, M Kanazawa, T Tomitani & S Sato. (2004)
The LET spectra at different penetration depths along secondary
9
C and
11
C beams
. Physics in Medicine and Biology 49:22, pages 5119-5133.
Crossref
Crossref
J J Wilkens & U Oelfke. (2004) A phenomenological model for the relative biological effectiveness in therapeutic proton beams. Physics in Medicine and Biology 49:13, pages 2811-2825.
Crossref
Crossref
Q. Li, A. Kitagawa, T. Kanai, M. Kanazawa, E. Urakabe, T. Tomitani, S. Sato & Z. Wei. (2004) Therapeutic purpose 9C beams produced in the secondary beam line at HIMAC. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 222:1-2, pages 270-284.
Crossref
Crossref
Qiang Li, Tatsuaki Kanai & Atsushi Kitagawa. (2004)
The potential application of β-delayed particle decay beam
9
C in cancer therapy
. Physics in Medicine and Biology 49:9, pages 1817-1831.
Crossref
Crossref
M. Scholz & G. Kraft. (2004) The Physical and Radiobiological Basis of the Local Effect Model:A Response to the Commentary by R. Katz. Radiation Research 161:5, pages 612-620.
Crossref
Crossref
Jan J. Wilkens & Uwe Oelfke. (2004) Three-dimensional LET calculations for treatment planning of proton therapy. Zeitschrift für Medizinische Physik 14:1, pages 41-46.
Crossref
Crossref
F. Ballarini, M. Biaggi, L. De Biaggi, A. Ferrari, A. Ottolenghi, A. Panzarasa, H.G. Paretzke, M. Pelliccioni, P. Sala, D. Scannicchio & M. Zankl. (2004) Role of shielding in modulating the effects of solar particle events: Monte Carlo calculation of absorbed dose and DNA complex lesions in different organs. Advances in Space Research 34:6, pages 1338-1346.
Crossref
Crossref
H. Paganetti. (2016) Significance and Implementation of RBE Variations in Proton Beam Therapy. Technology in Cancer Research & Treatment 2:5, pages 413-426.
Crossref
Crossref
Qiang Li, Tatsuaki Kanai & Atsushi Kitagawa. (2003) A model to evaluate the biological effect induced by the emitted particles from a -delayed particle decay beam. Physics in Medicine and Biology 48:18, pages 2971-2986.
Crossref
Crossref
Roland B. Hawkins. (2003) A Microdosimetric-Kinetic Model for the Effect of Non-Poisson Distribution of Lethal Lesions on the Variation of RBE with LET. Radiation Research 160:1, pages 61-69.
Crossref
Crossref
Maddalena Mognato, Elisabetta Bortoletto, Paola Ferraro, Laura Baggio, Roberto Cherubini, Sabrina Canova, Antonella Russo & Lucia Celotti. (2003)
Genetic Damage Induced by
In Vitro
Irradiation of Human G
0
Lymphocytes with Low-Energy Protons (28 keV/μm):
HPRT
Mutations and Chromosome Aberrations
. Radiation Research 160:1, pages 52-60.
Crossref
Crossref
M. Scholz. 2003. Radiation Effects on Polymers for Biological Use. Radiation Effects on Polymers for Biological Use
95
155
.
Harald Paganetti, Andrzej Niemierko, Marek Ancukiewicz, Leo E Gerweck, Michael Goitein, Jay S Loeffler & Herman D Suit. (2002) Relative biological effectiveness (RBE) values for proton beam therapy. International Journal of Radiation Oncology*Biology*Physics 53:2, pages 407-421.
Crossref
Crossref
H Paganetti. (2002) Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles. Physics in Medicine and Biology 47:5, pages 747-764.
Crossref
Crossref
Francis A. Cucinotta, Walter Schimmerling, John W. Wilson, Leif E. Peterson, Gautam D. Badhwar, Premkumar B. Saganti & John F. Dicello. (2001) Space Radiation Cancer Risks and Uncertainties for Mars Missions. Radiation Research 156:5, pages 682-688.
Crossref
Crossref
G. Schettino, M. Folkard, K. M. Prise, B. Vojnovic, A. G. Bowey & B. D. Michael. (2001) Low-Dose Hypersensitivity in Chinese Hamster V79 Cells Targeted with Counted Protons Using a Charged-Particle Microbeam. Radiation Research 156:5, pages 526-534.
Crossref
Crossref
A. Sgura, A. Antoccia, R. Cherubini & C. Tanzarella. (2001) Chromosome Nondisjunction and Loss Induced by Protons and X Rays in Primary Human Fibroblasts: Role of Centromeres in Aneuploidy. Radiation Research 156:3, pages 225-231.
Crossref
Crossref
L. JUDAS & M. LOKAJÍČEK. (2001) Cell Inactivation by Ionizing Particles and the Shapes of Survival Curves. Journal of Theoretical Biology 210:1, pages 15-21.
Crossref
Crossref
L. M. Green, D. K. Murray, D. T. Tran, A. M. Bant, G. Kazarians, M. F. Moyers & G. A. Nelson. (2001) Response of Thyroid Follicular Cells to Gamma Irradiation Compared to Proton Irradiation. I. Initial Characterization of DNA Damage, Micronucleus Formation, Apoptosis, Cell Survival, and Cell Cycle Phase Redistribution. Radiation Research 155:1, pages 32-42.
Crossref
Crossref
K Parodi & S Squarcia. (2001) Improvement of low-energy stopping power algorithms in the FLUKA simulation program. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 456:3, pages 352-368.
Crossref
Crossref
John W. Wilson. (2000) Overview Of Radiation Environments And Human Exposures. Health Physics 79:5, pages 470-494.
Crossref
Crossref
John Gueulette, Lothar Böhm, Jacobus P Slabbert, Blanche M De Coster, Gerald S Rutherfoord, Arnout Ruifrok, Michelle Octave-Prignot, Peter J Binns, A.Nicholaas Schreuder, Julian E Symons, Pierre Scalliet & Dan T.L Jones. (2000) Proton relative biological effectiveness (RBE) for survival in mice after thoracic irradiation with fractionated doses. International Journal of Radiation Oncology*Biology*Physics 47:4, pages 1051-1058.
Crossref
Crossref
F.A Cucinotta, J.W Wilson, J.R Williams & J.F Dicello. (2000) Analysis of MIR-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO. Radiation Measurements 32:3, pages 181-191.
Crossref
Crossref
B Dörschel, D Hermsdorf & H Kühne. (2000) Biological experiments in low-flux light-particle fields produced by accelerators. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 161-163, pages 872-876.
Crossref
Crossref
Leif E Peterson & Francis A Cucinotta. (1999) Monte Carlo mixture model of lifetime cancer incidence risk from radiation exposure on shuttle and international space station. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 430:2, pages 327-335.
Crossref
Crossref
Francis A. Cucinotta. (1999) Issues in risk assessment from solar particle events. Radiation Measurements 30:3, pages 261-268.
Crossref
Crossref
J. Besserer, J. de Boer, M. Dellert, C. Gahn, M. Moosburger, P. Pemler, P. Quicken, L. Distel & H. Schüßler. (1999) An irradiation facility with a vertical beam for radiobiological studies. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 430:1, pages 154-160.
Crossref
Crossref
Roland B. Hawkins. (1998) A microdosimetric-kinetic theory of the dependence of the RBE for cell death on LET. Medical Physics 25:7, pages 1157-1170.
Crossref
Crossref
Robert Katz, Francis A. Cucinotta & C.X. Zhang. (1996) The calculation of radial dose from heavy ions: predictions of biological action cross sections. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 107:1-4, pages 287-291.
Crossref
Crossref
M. Belli, F. Ianzini, O. Sapora, M.A. Tabocchini, F. Cera, R. Cherubini, A.M.I. Haque, G. Moschini, P. Tiveron & G. Simone. (1996) DNA double strand break production and rejoining in V79 cells irradiated with light ions. Advances in Space Research 18:1-2, pages 73-82.
Crossref
Crossref
M. Scholz & G. Kraft. (1996) Track structure and the calculation of biological effects of heavy charged particles. Advances in Space Research 18:1-2, pages 5-14.
Crossref
Crossref
G. Gademann, G. Kraft & M. Wannenmacher. 1996. Strahlentherapie. Strahlentherapie
161
180
.