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International Journal of Radiation Biology Volume 64, 1993 - Issue 5
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Original Article

Two-stage Cell Shrinkage and the OER for Radiation-induced Apoptosis of Rat Thymocytes

N.V. Klassen Institute for National Measurement Standards, Ionizing Radiation Standards Group, National Research Council of Canada, Ottawa, Ontario, K1A 0R6, Canada
,
P.R. Walker Molecular Cell Biology Group, National Research Council of Canada, Institute for Biological Sciences, Ottawa, Ontario, K1A 0R6, Canada
,
C.K. Ross Civic Division, Ontario Regional Cancer Centre, Ottawa, Ontario, Canada
,
J. Cygler Department of Laboratory Medicine, University of Ottawa and Ottawa Civic Hospital, Ottawa, Ontario, Canada
&
B. Lach Institute for National Measurement Standards, Ionizing Radiation Standards Group, National Research Council of Canada, Ottawa, Ontario, K1A 0R6, Canada
Pages 571-581 | Received 02 Apr 1993, Accepted 09 Aug 1993, Published online: 03 Jul 2009

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K. R. BLANK, M. S. RUDOLTZ, G. D. KAO, R. J. MUSCHEL and W. GILLIES McKENNA. (1997) Review: The molecular regulation of apoptosis and implications for radiation oncology. International Journal of Radiation Biology 71:5, pages 455-466.
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A. Chukhlovin, J. Dahm-Daphi, G. Gercken, A. Rolf Zander & E. Dikomey. (1995) Comparative Studies of Induction and Repair of DNA Double-strand Breaks in X-irradiated Alveolar Macrophages and Resting Peripheral Blood Lymphocytes Using Constant-field Gel Electrophoresis. International Journal of Radiation Biology 68:2, pages 163-168.
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Articles from other publishers (43)

Carl D. Bortner & John A. Cidlowski. (2020) Ions, the Movement of Water and the Apoptotic Volume Decrease. Frontiers in Cell and Developmental Biology 8.
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Yasunobu Okada, Tomohiro Numata, Kaori Sato-Numata, Ravshan Z. Sabirov, Hongtao Liu, Shin-ichiro Mori & Shigeru Morishima. 2019. Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders. Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders 205 283 .
Ivan A. Vorobjev & Natasha S. Barteneva. (2017) Multi-parametric imaging of cell heterogeneity in apoptosis analysis. Methods 112, pages 105-123.
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Nicolas J. PillonKenny L. ChanShitian Zhang, Marios MejdaniMaya R. JacobsonAlexandre DucosPhilip J. BilanWenyan Niu & Amira Klip. (2016) Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release. American Journal of Physiology-Endocrinology and Metabolism 311:5, pages E825-E835.
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Syaefudin .W.T. Wahyuni, I.M. Artika & Sulistiyani .. (2014) Antioxidant Activity of Flavonoid from Guazuma ulmifolia Lamk. Leaves and Apoptosis Induction in Yeast Cells. Journal of Biological Sciences 14:4, pages 305-310.
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Alexander Khmaladze, Rebecca L. Matz, Tamir Epstein, Joshua Jasensky, Mark M. Banaszak Holl & Zhan Chen. (2012) Cell volume changes during apoptosis monitored in real time using digital holographic microscopy. Journal of Structural Biology 178:3, pages 270-278.
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Kazuki Koizumi, Takuya Kawanai, Erika Hashimoto, Yasuhiro Kanbara, Toshiya Masuda, Kaori Kanemaru, Yoshiro Okano & Yasuo Oyama. (2011) Cytometric analysis on cytotoxicity of curcumin on rat thymocytes: Proapoptotic and antiapoptotic actions of curcumin. Toxicology in Vitro 25:4, pages 985-990.
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Carl D. Bortner & John A. Cidlowski. (2011) Life and Death of Lymphocytes: A Volume Regulation Affair. Cellular Physiology and Biochemistry 28:6, pages 1079-1088.
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Zhi-zhen Wang, Hai-li Yu, Zhi-yong Yuan & Ping Wang. (2011) Initial approach to the cellular irradiation injury of human pancreatic carcinoma cell line MIA PaCa-2 by high dose per fraction. Clinical Oncology and Cancer Research 7:6, pages 352-358.
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R Núñez, S M Sancho-Martínez, J M L Novoa & F J López-Hernández. (2010) Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies. Cell Death & Differentiation 17:11, pages 1665-1671.
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Aya Fujimoto, Yoshimi Shingai, Toshihisa B. Oyama, Takuya Kawanai, Erika Hashimoto, Kazuki Koizumi, Kaori Kimura, Toshiya Masuda & Yasuo Oyama. (2010) Apoptosis-inducing action of two products from oxidation of sesamol, an antioxidative constituent of sesame oil: A possible cytotoxicity of oxidized antioxidant. Toxicology in Vitro 24:6, pages 1720-1726.
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Tomohiro M. Oyama, Keisuke Oyama, Toshihisa B. Oyama, Shiro Ishida, Yoshiro Okano & Yasuo Oyama. (2010) Zinc at clinically-relevant concentrations potentiates the cytotoxicity of polysorbate 80, a non-ionic surfactant. Toxicology in Vitro 24:3, pages 737-744.
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Toshihisa B. Oyama, Keisuke Oyama, Takuya Kawanai, Tomohiro M. Oyama, Erika Hashimoto, Masaya Satoh & Yasuo Oyama. (2009) Tri-n-butyltin increases intracellular Zn2+ concentration by decreasing cellular thiol content in rat thymocytes. Toxicology 262:3, pages 245-249.
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Rodrigo Franco, Wayne I. DeHaven, Maria I. Sifre, Carl D. Bortner & John A. Cidlowski. (2008) Glutathione Depletion and Disruption of Intracellular Ionic Homeostasis Regulate Lymphoid Cell Apoptosis. Journal of Biological Chemistry 283:52, pages 36071-36087.
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Yumiko Nishimura, Toshihisa B. Oyama, Yoko Sakanashi, Tomohiro M. Oyama, Hiroko Matsui, Yoshiro Okano & Yasuo Oyama. (2008) Some characteristics of quercetin-induced cytotoxicity on rat thymocytes under in vitro condition. Toxicology in Vitro 22:4, pages 1002-1007.
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Hiroko Matsui, Midori Morimoto, Kanna Horimoto & Yumiko Nishimura. (2007) Some characteristics of fluoride-induced cell death in rat thymocytes: Cytotoxicity of sodium fluoride. Toxicology in Vitro 21:6, pages 1113-1120.
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Carl D. Bortner & John A. Cidlowski. (2007) Cell shrinkage and monovalent cation fluxes: Role in apoptosis. Archives of Biochemistry and Biophysics 462:2, pages 176-188.
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Carl D. Bortner, Maria I. Sifre & John A. Cidlowski. 2007. Osmosensing and Osmosignaling. Osmosensing and Osmosignaling 161 181 .
Alistair Hunter, Andre Hendrikse, Michael Renan & Raymond Abratt. (2006) Does the tumor microenvironment influence radiation-induced apoptosis?. Apoptosis 11:10, pages 1727-1735.
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M. I. Panayiotidis, C. D. Bortner & J. A. Cidlowski. (2006) On the mechanism of ionic regulation of apoptosis: would the Na+/K+-ATPase please stand up?. Acta Physiologica 187:1-2, pages 205-215.
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Zoltán Varga & Rezsoő Gáspár. 2005. Biophysical Aspects of Transmembrane Signaling. Biophysical Aspects of Transmembrane Signaling 293 315 .
Alexandra d'Anglemont de Tassigny, Rachid Souktani, Bijan Ghaleh, Patrick Henry & Alain Berdeaux. (2003) Structure and pharmacology of swelling-sensitive chloride channels, ICl,swell. Fundamental and Clinical Pharmacology 17:5, pages 539-553.
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Mireia Gómez-Angelats & John A. Cidlowski. (2016) Invited Review: Cell Volume Control and Signal Transduction in Apoptosis. Toxicologic Pathology 30:5, pages 541-551.
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Mireia Gómez-Angelats & John A. Cidlowski. 2002. 175 201 .
Alexei B Chukhlovin, Sergei V Tokalov, Alexei S Yagunov, Johannes Westendorf, Heinrich Reincke & Ludwig Karbe. (2001) In vitro suppression of thymocyte apoptosis by metal-rich complex environmental mixtures: potential role of zinc and cadmium excess. Science of The Total Environment 281:1-3, pages 153-163.
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Zeev Shiffer, Naomi Zurgil, Yana Shafran & Motti Deutsch. (2001) Analysis of Laser Scattering Pattern as an Early Measure of Apoptosis. Biochemical and Biophysical Research Communications 289:5, pages 1320-1327.
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Yasunobu Okada, Emi Maeno, Takahiro Shimizu, Katsuya Dezaki, Jun Wang & Shigeru Morishima. (2001) Receptor‐mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). The Journal of Physiology 532:1, pages 3-16.
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Carl D. Bortner & John A. Cidlowski. 2001. Apoptosis. Apoptosis 49 67 .
Shan Ping Yu & Dennis W. Choi. (2000) Ions, cell volume, and apoptosis. Proceedings of the National Academy of Sciences 97:17, pages 9360-9362.
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Denis deBlois, Sergei Orlov & Pavel Harnet. 2000. Apoptosis in Cardiac Biology. Apoptosis in Cardiac Biology 213 222 .
Sergei N. Orlov, Nathalie Thorin-Trescases, Sergei V. Kotelevtsev, Johanne Tremblay & Pavel Hamet. (1999) Inversion of the Intracellular Na+/K+Ratio Blocks Apoptosis in Vascular Smooth Muscle at a Site Upstream of Caspase-3. Journal of Biological Chemistry 274:23, pages 16545-16552.
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Carl D. Bortner & John A. Cidlowski. (1998) A necessary role for cell shrinkage in apoptosis. Biochemical Pharmacology 56:12, pages 1549-1559.
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T.M. Illidge. (1998) Radiation-induced apoptosis. Clinical Oncology 10:1, pages 3-13.
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Mark Raffray & Cohen Gerald M.. (1997) Apoptosis and necrosis in toxicology: A continuum or distinct modes of cell death?. Pharmacology & Therapeutics 75:3, pages 153-177.
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Carl D. Bortner, Francis M. HughesJr.Jr. & John A. Cidlowski. 1997. Programmed Cell Death. Programmed Cell Death 63 70 .
Carl D. Bortner & John A. Cidlowski. 1997. Cell Death in Reproductive Physiology. Cell Death in Reproductive Physiology 230 248 .
C. D. BortnerJ. A. Cidlowski. (1996) Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. American Journal of Physiology-Cell Physiology 271:3, pages C950-C961.
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P Hamet, D deBlois, T -V Dam, L Richard, E Teiger, B -S Tea, S N Orlov & J Tremblay. (1996) Apoptosis and vascular wall remodeling in hypertension. Canadian Journal of Physiology and Pharmacology 74:7, pages 850-861.
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Alexei B. Chukhlovin. 1996. Gene Technology. Gene Technology 399 404 .
William C. Dewey, Clifton C. Ling & Raymond E. Meyn. (1995) Radiation-induced apoptosis: Relevance to radiotherapy. International Journal of Radiation Oncology*Biology*Physics 33:4, pages 781-796.
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James A Wheeler, L.Clifton Stephens, Carmen Tornos, Patricia J Eifel, K.Kian Ang, Luka Milas, Pamela K Allen & Raymond E MeynJr.Jr.. (1995) Astro research fellowship: Apoptosis as a predictor of tumor response to radiation in Stage IB cervical carcinoma. International Journal of Radiation Oncology*Biology*Physics 32:5, pages 1487-1493.
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Nena Mirkovic, Raymond E. Meyn, Nancy R. Hunter & Luka Was. (1994) Radiation-induced apoptosis in a murine lymphoma in vivo. Radiotherapy and Oncology 33:1, pages 11-16.
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P. J. Smith, C. Rackstraw & F. Cotter. (1994) DNA fragmentation as a consequence of cell cycle traverse in doxorubicin- and idarubicin-treated human lymphoma cells. Annals of Hematology 69:1, pages S7-S11.
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