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Research Article

Three A's of repopulation during fractionated irradiation of squamous epithelia: Asymmetry loss, Acceleration of stem-cell divisions and Abortive divisions

Pages 635-643 | Published online: 03 Jul 2009

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Martín Parga-Pazos, Óscar López Pouso, John D. Fenwick & Juan Pardo-Montero. (2020) A mathematical model of dynamics of cell populations in squamous epithelium after irradiation. International Journal of Radiation Biology 96:9, pages 1165-1172.
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Michael Baumann, Mechthild Krause, Howard Thames, Klaus Trott & Daniel Zips. (2009) Cancer stem cells and radiotherapy. International Journal of Radiation Biology 85:5, pages 391-402.
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Wolfgang Dörr, Katrin Heider & Kathrin Spekl. (2005) Reduction of oral mucositis by palifermin (rHuKGF): Dose-effect of rHuKGF. International Journal of Radiation Biology 81:8, pages 557-565.
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J. W. Denham. (2003) Clinical implications of mucosal regeneration. International Journal of Radiation Biology 79:7, pages 511-512.
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W. Dörr. (2003) Modulation of repopulation processes in oral mucosa: experimental results. International Journal of Radiation Biology 79:7, pages 531-537.
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J. W. Hopewell, J. Nyman & I. Turesson. (2003) Time factor for acute tissue reactions following fractionated irradiation: a balance between repopulation and enhanced radiosensitivity. International Journal of Radiation Biology 79:7, pages 513-524.
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K.‐R. Trott. (2003) Perspectives of experimental research on repopulation during radiotherapy. International Journal of Radiation Biology 79:7, pages 577-580.
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Heidi Heidi Lyng, Gunnar Tanum, Jan F. Evensen, Einar K. Rofstad. (1999) Changes in Oxygen Tension During Radiotherapy of Head and Neck Tumours. Acta Oncologica 38:8, pages 1037-1042.
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Loredana G. Marcu, Mikaela Dell’Oro & Eva Bezak. (2023) Opportunities in Cancer Therapies: Deciphering the Role of Cancer Stem Cells in Tumour Repopulation. International Journal of Molecular Sciences 24:24, pages 17258.
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Isabel González-Crespo, Antonio Gómez-Caamaño, Óscar López Pouso, John D. FenwickJuan Pardo-Montero. (2023) A Biomathematical Model of Tumor Response to Radioimmunotherapy With αPDL1 and αCTLA4. IEEE/ACM Transactions on Computational Biology and Bioinformatics 20:2, pages 808-821.
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Loredana G. Marcu, Leyla Moghaddasi & Eva Bezak. (2023) Cannot Target What Cannot Be Seen: Molecular Imaging of Cancer Stem Cells. International Journal of Molecular Sciences 24:2, pages 1524.
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Guoqi Lv, Xiuling Wu, Zhengying Wang, Kanglong Wu, Geer Ang, Shulin Cui, Yuqi Shi, Yu Wang & Delong Liu. (2022) Higher radiation doses after partial laryngectomy may raise the incidence of pneumonia: A retrospective cohort study. Frontiers in Oncology 12.
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Sonja Dragojevic, Jianxiong Ji, Pankaj K. Singh, Margaret A. Connors, Robert W. Mutter, Scott C. Lester, Surabhi M. Talele, Wenjuan Zhang, Brett L. Carlson, Nicholas B. Remmes, Sean S. Park, William F. Elmquist, Sunil Krishnan, Erik J. Tryggestad & Jann N. Sarkaria. (2021) Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers. International Journal of Radiation Oncology*Biology*Physics 111:5, pages e54-e62.
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Juan Pardo‐Montero, Martín Parga‐Pazos & John D. Fenwick. (2021) Classification of tolerable/intolerable mucosal toxicity of head‐and‐neck radiotherapy schedules with a biomathematical model of cell dynamics. Medical Physics 48:7, pages 4075-4084.
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Sara Neira, Araceli Gago-Arias, Jacobo Guiu-Souto & Juan Pardo-Montero. (2020) A kinetic model of continuous radiation damage to populations of cells: comparison to the LQ model and application to molecular radiotherapy. Physics in Medicine & Biology 65:24, pages 245015.
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Nuradh Joseph, Norman F. Kirkby, Peter J Hoskin, Catharine M L West, Ananya Choudhury & Roger G. Dale. (2020) Radiobiologically derived biphasic fractionation schemes to overcome the effects of tumour hypoxia. The British Journal of Radiology 93:1112, pages 20190250.
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Sylvia Gruber, Nilsu Cini, Lisa-Marie Kowald, Julia Mayer, Andreas Rohorzka, Peter Kuess & Wolfgang Dörr. (2018) Upregulated epithelial junction expression represents a novel parameter of the epithelial radiation response to fractionated irradiation in oral mucosaHochregulierung von Zellverbindungen repräsentiert einen neuen Parameter der Strahlenreaktion der Mundschleimhaut auf fraktionierte Bestrahlung. Strahlentherapie und Onkologie 194:8, pages 771-779.
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Sylvia Gruber, Katharina Frings, Peter Kuess & Wolfgang Dörr. (2018) Protective effects of systemic dermatan sulfate treatment in a preclinical model of radiation-induced oral mucositisSchützende Wirkung einer systemischen Behandlung mit Dermatansulfat in einem präklinischen Modell strahleninduzierter oraler Mukositis. Strahlentherapie und Onkologie 194:7, pages 675-685.
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Jake C. Forster, Michael J. J. Douglass, Wendy M. Harriss-Phillips & Eva Bezak. (2017) Simulation of head and neck cancer oxygenation and doubling time in a 4D cellular model with angiogenesis. Scientific Reports 7:1.
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Sylvia Gruber, Eva Bozsaky, Eva Roitinger, Karoline Schwarz, Margret Schmidt & Wolfgang Dörr. (2017) Early inflammatory changes in radiation-induced oral mucositisFrühe entzündliche Veränderungen bei strahleninduzierter oraler Mukositis. Strahlentherapie und Onkologie 193:6, pages 499-507.
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Jake C. Forster, Michael J.J. Douglass, Wendy M. Harriss-Phillips & Eva Bezak. (2017) Development of an in silico stochastic 4D model of tumor growth with angiogenesis . Medical Physics 44:4, pages 1563-1576.
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Michèle T. Martin, Adeline Vulin & Jolyon H. Hendry. (2016) Human epidermal stem cells: Role in adverse skin reactions and carcinogenesis from radiation. Mutation Research/Reviews in Mutation Research 770, pages 349-368.
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Sylvia Gruber & Wolfgang Dörr. (2016) Tissue reactions to ionizing radiation—Oral mucosa. Mutation Research/Reviews in Mutation Research 770, pages 292-298.
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Katharina Frings, Sylvia Gruber, Peter Kuess, Miriam Kleiter & Wolfgang Dörr. (2016) Modulation of radiation-induced oral mucositis by thalidomideModulation der strahleninduzierten oralen Mukositis durch Thalidomid. Strahlentherapie und Onkologie 192:8, pages 561-568.
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Crossref
Jolinta Y. Lin, Isabel L. Jackson & Zeljko Vujaskovic. 2016. Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment. Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment 1 28 .
Loredana G. Marcu. (2015) The first Rs of radiotherapy: or standing on the shoulders of giants. Australasian Physical & Engineering Sciences in Medicine 38:4, pages 531-541.
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Sylvia Gruber, Margret Schmidt, Eva Bozsaky, Kathrin Wolfram, Julia Haagen, Bettina Habelt, Martin Puttrich & Wolfgang Dörr. (2014) Modulation of radiation-induced oral mucositis by pentoxifylline: Preclinical studiesModulation der strahleninduzierten oralen Mukositis durch Pentoxifyllin: Präklinische Studien. Strahlentherapie und Onkologie 191:3, pages 242-247.
Crossref
Markus Hartenbach, Andreas Delker, Sabrina Hartenbach, Juli Schlichtiger, Sabrina Niedermoser, Carmen Wängler, Björn Wängler, Guido Böning, Franz Josef Gildehaus, Klement Neumaier, Kirsten Lauber, Klaus Kraft, Claus Belka, Marcus Hacker, Viktor Meineke & Peter Bartenstein. (2014) Dose-Dependent Uptake of 3′-deoxy-3′-[18 F]Fluorothymidine by the Bowel after Total-Body Irradiation. Molecular Imaging and Biology 16:6, pages 846-853.
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Margret Schmidt, Aline Piro-Hussong, Annett Siegemund, Peggy Gabriel & Wolfgang Dörr. (2014) Modification of radiation-induced oral mucositis (mouse) by adult stem cell therapy: single-dose irradiation. Radiation and Environmental Biophysics 53:4, pages 629-634.
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Xuefeng Gao, J. Tyson McDonald, Mamta Naidu, Philip Hahnfeldt & Lynn Hlatky. (2014) A Proposed Quantitative Index for Assessing the Potential Contribution of Reprogramming to Cancer Stem Cell Kinetics. Stem Cells International 2014, pages 1-8.
Crossref
. (2014) References. Journal of the International Commission on Radiation Units and Measurements 14:2, pages 123-145.
Crossref
W. Dörr & M. Schmidt. 2014. Comprehensive Biomedical Physics. Comprehensive Biomedical Physics 75 95 .
J.H. Hendry. 2014. Comprehensive Biomedical Physics. Comprehensive Biomedical Physics 63 74 .
Loredana G. Marcu. (2013) Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments. BioMed Research International 2013, pages 1-9.
Crossref
W. Dörr. 2013. Strahlentherapie. Strahlentherapie 87 98 .
W. Dörr & C. Herskind. (2012) Strahlenbiologie der NormalgewebeRadiation biology of normal tissues. Strahlentherapie und Onkologie 188:S3, pages 295-298.
Crossref
L. G. Marcu & E. Bezak. (2012) Influence of stem-cell cycle time on accelerated re-population during radiotherapy in head and neck cancer. Cell Proliferation 45:5, pages 404-412.
Crossref
Loredana G. Marcu, Eva Bezak & Sanda M. Filip. (2012) The role of PET imaging in overcoming radiobiological challenges in the treatment of advanced head and neck cancer. Cancer Treatment Reviews 38:3, pages 185-193.
Crossref
Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou & Eva Forssell-Aronsson. (2012) Transcriptional response of BALB/c mouse thyroids following in vivo astatine-211 exposure reveals distinct gene expression profiles. EJNMMI Research 2:1, pages 32.
Crossref
W. M. Harriss-Phillips, E. Bezak & E. Yeoh. (2012) The HYP-RT Hypoxic Tumour Radiotherapy Algorithm and Accelerated Repopulation Dose per Fraction Study. Computational and Mathematical Methods in Medicine 2012, pages 1-13.
Crossref
Loredana Marcu, Eva Bezak & Barry AllenLoredana Marcu, Eva Bezak & Barry Allen. 2012. Biomedical Physics in Radiotherapy for Cancer. Biomedical Physics in Radiotherapy for Cancer 89 105 .
Mechthild Krause, Ala Yaromina, Wolfgang Eicheler, Ulrike Koch & Michael Baumann. (2011) Cancer Stem Cells: Targets and Potential Biomarkers for Radiotherapy. Clinical Cancer Research 17:23, pages 7224-7229.
Crossref
W M Harriss-Phillips, E Bezak & E K Yeoh. (2011) Monte Carlo radiotherapy simulations of accelerated repopulation and reoxygenation for hypoxic head and neck cancer. The British Journal of Radiology 84:1006, pages 903-918.
Crossref
Jean-François Morère, Françoise Mornex & Denis SoulièresN. Girard, E. Lartigau, D. Azria & F. Mornex. 2011. Thérapeutique du cancer. Thérapeutique du cancer 91 98 .
Søren M. Bentzen. 2010. Leibel and Phillips Textbook of Radiation Oncology. Leibel and Phillips Textbook of Radiation Oncology 40 54 .
Daniel Zips. 2009. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies 291 298 .
Ann S.J. Yeoh, Rachel J. Gibson, Eric E.K. Yeoh, Joanne M. Bowen, Andrea M. Stringer, Kar A. Giam & Dorothy M.K. Keefe. (2007) A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-κB, COX-1, and COX-2. Molecular Cancer Therapeutics 6:8, pages 2319-2327.
Crossref
Yasemin Kiliç, Katja Rajewski & Wolfgang Dörr. (2006) Effect of post-exposure administration of keratinocyte growth factor (Palifermin) on radiation effects in oral mucosa in mice. Radiation and Environmental Biophysics 46:1, pages 13-19.
Crossref
Yang Fan, Zhengyan Liu, Philip R. Weinstein, John R. Fike & Jialing Liu. (2007) Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation. European Journal of Neuroscience 25:1, pages 38-46.
Crossref
John R. Fike, Radoslaw Rola & Charles L. Limoli. (2007) Radiation Response of Neural Precursor Cells. Neurosurgery Clinics of North America 18:1, pages 115-127.
Crossref
Hinne A. RakhorstWendy M.W. TraSandra T. Posthumus-Van SluijsSteven E.R. HoviusPeter C. LevendagRoland KanaarStefan O.P. Hofer. (2006) Quantitative Analysis of Radiation-Induced DNA Break Repair in a Cultured Oral Mucosal Model. Tissue Engineering 12:12, pages 3395-3403.
Crossref
Ann Yeoh, Rachel Gibson, Eric Yeoh, Joanne Bowen, Andrea Stringer, Kar Giam, Richard Logan & Dorothy Keefe. (2006) Radiation therapy-induced mucositis: Relationships between fractionated radiation, NF-κB, COX-1, and COX-2. Cancer Treatment Reviews 32:8, pages 645-651.
Crossref
Hinne A. Rakhorst, Wendy M.W. Tra, Sandra T. Posthumus-Van Sluijs, Steven E.R. Hovius, Peter C. Levendag, Roland Kanaar & Stefan O.P. Hofer. (2006) Quantitative Analysis of Radiation-Induced DNA Break Repair in a Cultured Oral Mucosal Model. Tissue Engineering 0:0, pages 061121120510001.
Crossref
Søren M. Bentzen. (2006) Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nature Reviews Cancer 6:9, pages 702-713.
Crossref
John D. Fenwick. (2006) Delay differential equations and the dose-time dependence of early radiotherapy reactions. Medical Physics 33:9, pages 3526-3540.
Crossref
W. Dörr. 2006. Strahlentherapie. Strahlentherapie 81 91 .
Wolfgang Dörr, Dorothea Riesenbeck & Carsten Nieder. 2006. Multimodal Concepts for Integration of Cytotoxic Drugs. Multimodal Concepts for Integration of Cytotoxic Drugs 317 332 .
Ami M. Karkar, Radoslaw Rola & John R. Fike. 2006. Mammalian Subventricular Zones. Mammalian Subventricular Zones 185 209 .
Aya Fukuda, Hirotsugu Fukuda, Marie Jonsson, Janos Swanpalmer, Sven Hertzman, Birgitta Lannering, Thomas Bjork-Eriksson, Ildiko Marky & Klas Blomgren. (2005) Progenitor cell injury after irradiation to the developing brain can be modulated by mild hypothermia or hyperthermia. Journal of Neurochemistry 94:6, pages 1604-1619.
Crossref
John J. Kim & Ian F. Tannock. (2005) Repopulation of cancer cells during therapy: an important cause of treatment failure. Nature Reviews Cancer 5:7, pages 516-525.
Crossref
Wolfgang Dörr, Stefan Bässler, Sandra Reichel & Kathrin Spekl. (2005) Reduction of radiochemotherapy-induced early oral mucositis by recombinant human keratinocyte growth factor (palifermin): Experimental studies in mice. International Journal of Radiation Oncology*Biology*Physics 62:3, pages 881-887.
Crossref
Wolfgang Dörr, Sandra Reichel & Kathrin Spekl. (2005) Effects of keratinocyte growth factor (palifermin) administration protocols on oral mucositis (mouse) induced by fractionated irradiation. Radiotherapy and Oncology 75:1, pages 99-105.
Crossref
Aya Fukuda, Hirotsugu Fukuda, Janos Swanpalmer, Sven Hertzman, Birgitta Lannering, Ildiko Marky, Thomas Bjork-Eriksson & Klas Blomgren. (2005) Age-dependent sensitivity of the developing brain to irradiation is correlated with the number and vulnerability of progenitor cells. Journal of Neurochemistry 92:3, pages 569-584.
Crossref
Carolyn I Sartor. (2004) Mechanisms of Disease: radiosensitization by epidermal growth factor receptor inhibitors. Nature Clinical Practice Oncology 1:2, pages 80-87.
Crossref
Liguang Chen, David M. Brizel, Zahid N. Rabbani, Thaddeus V. Samulski, Catherine L. Farrell, Nicole Larrier, Mitchell S. Anscher & Zeljko Vujaskovic. (2004) The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. International Journal of Radiation Oncology*Biology*Physics 60:5, pages 1520-1529.
Crossref
L Marcu, T van Doorn & I Olver. (2004) Modelling of post-irradiation accelerated repopulation in squamous cell carcinomas. Physics in Medicine and Biology 49:16, pages 3767-3779.
Crossref
Stefanie Pabst, Kathrin Spekl & Wolfgang Dörr. (2004) Changes in the effect of dose fractionation during daily fractionated irradiation: studies in mouse oral mucosa. International Journal of Radiation Oncology*Biology*Physics 58:2, pages 485-492.
Crossref
Jesper Grau Eriksen, Torben Steiniche, Jon Askaa, Jan Alsner & Jens Overgaard. (2004) The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck. International Journal of Radiation Oncology*Biology*Physics 58:2, pages 561-566.
Crossref
W. Dörr. 2003. Modification of Radiation Response. Modification of Radiation Response 113 122 .
K.-R. Trott. 2003. Modification of Radiation Response. Modification of Radiation Response 3 13 .
Wolfgang Dörr, Kathrin Spekl & Catherine L Farrell. (2002) Amelioration of acute oral mucositis by Keratinocyte growth factor: fractionated irradiation. International Journal of Radiation Oncology*Biology*Physics 54:1, pages 245-251.
Crossref
W. Dörr, K. Spekl & M. Martin. (2002) Radiation-induced oral mucositis in mice: strain differences. Cell Proliferation 35, pages 60-67.
Crossref
Wolfgang Dörr, Christopher S Hamilton, Teresa Boyd, Barry Reed & James W Denham. (2002) Radiation-induced changes in cellularity and proliferation in human oral mucosa. International Journal of Radiation Oncology*Biology*Physics 52:4, pages 911-917.
Crossref
Michael Baumann, Steffen Appold, Cordula Petersen, Daniel Zips & Thomas Herrmann. (2001) Dose and fractionation concepts in the primary radiotherapy of non-small cell lung cancer. Lung Cancer 33, pages S35-S45.
Crossref
Søren M Bentzen, Michele I Saunders, Stanley Dische & Simon J Bond. (2001) Radiotherapy-related early morbidity in head and neck cancer: quantitative clinical radiobiology as deduced from the CHART trial. Radiotherapy and Oncology 60:2, pages 123-135.
Crossref
E Tada, J.M Parent, D.H Lowenstein & J.R Fike. (2000) X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 99:1, pages 33-41.
Crossref
Eiji Tada, Cindy Yang, Glenn T. Gobbel, Kathleen R. Lamborn & John R. Fike. (1999) Long-Term Impairment of Subependymal Repopulation Following Damage by Ionizing Irradiation. Experimental Neurology 160:1, pages 66-77.
Crossref
Klaus-Rüdiger Trott, Ali Shirazi & Frazer Heasman. (1999) Modulation of accelerated repopulation in mouse skin during daily irradiation. Radiotherapy and Oncology 50:3, pages 261-266.
Crossref
Jorge A. Lazareff, Rafal Suwinski, Roberto De Rosa & Charles E. Olmstead. (1999) Tumor Volume and Growth Kinetics in Hypothalamic-Chiasmatic Pediatric Low Grade Gliomas. Pediatric Neurosurgery 30:6, pages 312-319.
Crossref

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