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Molecular Membrane Biology Volume 22, 2005 - Issue 6
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Original

Fluorescence and molecular dynamics studies of the acetylcholine receptor γM4 transmembrane peptide in reconstituted systems

Silvia S. Antollini Instituto de Investigaciones Bioquímicas de Bahía Blanca and UNESCO Chair of Biophysics & Molecular Neurobiology, Argentina
,
Yechun Xu Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Shanghai, China
,
Hualiang Jiang Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Shanghai, China; School of Pharmacy, East China University of Science and Technology, Shanghai, China
&
Dr Francisco J. Barrantes Instituto de Investigaciones Bioquímicas de Bahía Blanca and UNESCO Chair of Biophysics & Molecular Neurobiology, ArgentinaCorrespondence[email protected]
Pages 471-483 | Received 09 Jun 2005, Published online: 09 Jul 2009

Citations (32)

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Xuebin Chen, Timothy I. Webb & Joseph W. Lynch. (2009) The M4 transmembrane segment contributes to agonist efficacy differences between α1 and α3 glycine receptors. Molecular Membrane Biology 26:5-7, pages 321-332.
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Rodrigo F. M. de Almeida, Luís M. S. Loura, Manuel Prieto, Anthony Watts, Aleksandre Fedorov & Francisco J. Barrantes. (2006) Structure and dynamics of the γM4 transmembrane domain of the acetylcholine receptor in lipid bilayers: insights into receptor assembly and function. Molecular Membrane Biology 23:4, pages 305-315.
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Articles from other publishers (30)

Francisco J. Barrantes. (2023) Structure and function meet at the nicotinic acetylcholine receptor-lipid interface. Pharmacological Research 190, pages 106729.
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C. Fabiani, V.N. Georgiev, D.A. Peñalva, L. Sigaut, L. Pietrasanta, J. Corradi, R. Dimova & S.S. Antollini. (2022) Membrane lipid organization and nicotinic acetylcholine receptor function: A two-way physiological relationship. Archives of Biochemistry and Biophysics 730, pages 109413.
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Casey I. Gallagher, Damien A. Ha, Robert J. Harvey & Robert J. Vandenberg. (2022) Positive Allosteric Modulators of Glycine Receptors and Their Potential Use in Pain Therapies. Pharmacological Reviews 74:4, pages 933-961.
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Casey I. Gallagher, Diba Sheipouri, Susan Shimmon, Tristan Rawling & Robert J. Vandenberg. (2020) Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors. Biochemical Pharmacology 180, pages 114117.
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Mackenzie J. Thompson & John E. Baenziger. (2020) Structural basis for the modulation of pentameric ligand-gated ion channel function by lipids. Biochimica et Biophysica Acta (BBA) - Biomembranes 1862:9, pages 183304.
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Mackenzie J. Thompson, Jaimee A. Domville & John E. Baenziger. (2020) The functional role of the αM4 transmembrane helix in the muscle nicotinic acetylcholine receptor probed through mutagenesis and coevolutionary analyses. Journal of Biological Chemistry 295:32, pages 11056-11067.
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Camila Fabiani & Silvia S. Antollini. (2019) Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts. Frontiers in Cellular Neuroscience 13.
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Xiaolin Cheng & Jeremy C. Smith. (2019) Biological Membrane Organization and Cellular Signaling. Chemical Reviews 119:9, pages 5849-5880.
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Gregory A. Caputo & Erwin London. 2019. Lipid-Protein Interactions. Lipid-Protein Interactions 351 368 .
Wuyi Liu & Kunkai Su. (2018) A Review on the Receptor-ligand Molecular Interactions in the Nicotinic Receptor Signaling Systems. Pakistan Journal of Biological Sciences 21:2, pages 51-66.
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Sandip Basak, Nicolaus Schmandt, Yvonne Gicheru & Sudha Chakrapani. (2017) Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel. eLife 6.
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Jiayin Sun, J. Frederique Comeau & John E. Baenziger. (2017) Probing the structure of the uncoupled nicotinic acetylcholine receptor. Biochimica et Biophysica Acta (BBA) - Biomembranes 1859:2, pages 146-154.
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John E. Baenziger, Jaimee A. Domville & J.P. Daniel Therien. 2017. Sterol Regulation of Ion Channels. Sterol Regulation of Ion Channels 95 137 .
Francisco J. Barrantes & Jacques Fantini. (2016) From hopanoids to cholesterol: Molecular clocks of pentameric ligand-gated ion channels. Progress in Lipid Research 63, pages 1-13.
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Camille M. Hénault, Peter F. Juranka & John E. Baenziger. (2015) The M4 Transmembrane α-Helix Contributes Differently to Both the Maturation and Function of Two Prokaryotic Pentameric Ligand-gated Ion Channels. Journal of Biological Chemistry 290:41, pages 25118-25128.
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Casey L. Carswell, Camille M. Hénault, Sruthi Murlidaran, J.P. Daniel Therien, Peter F. Juranka, Julian A. Surujballi, Grace Brannigan & John E. Baenziger. (2015) Role of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels. Structure 23:9, pages 1655-1664.
Crossref
Camille M. Hénault, Jiayin Sun, J.P. Daniel Therien, Corrie J.B. daCosta, Casey L. Carswell, Jonathan M. Labriola, Peter F. Juranka & John E. Baenziger. (2015) The role of the M4 lipid-sensor in the folding, trafficking, and allosteric modulation of nicotinic acetylcholine receptors. Neuropharmacology 96, pages 157-168.
Crossref
Francisco J. Barrantes. (2015) Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:9, pages 1796-1805.
Crossref
John E. Baenziger, Camille M. Hénault, J.P. Daniel Therien & Jiayin Sun. (2015) Nicotinic acetylcholine receptor–lipid interactions: Mechanistic insight and biological function. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:9, pages 1806-1817.
Crossref
Casey L. Carswell, Jiayin Sun & John E. Baenziger. (2015) Intramembrane Aromatic Interactions Influence the Lipid Sensitivities of Pentameric Ligand-gated Ion Channels. Journal of Biological Chemistry 290:4, pages 2496-2507.
Crossref
John E. Baenziger & Corrie J. B. daCosta. (2012) Molecular mechanisms of acetylcholine receptor–lipid interactions: from model membranes to human biology. Biophysical Reviews 5:1, pages 1-9.
Crossref
Gregory A. Caputo & Erwin London. 2013. Lipid-Protein Interactions. Lipid-Protein Interactions 279 295 .
Satoko Aoki & Richard M. Epand. (2012) Caveolin-1 hydrophobic segment peptides insertion into membrane mimetic systems: Role of Proline residue. Biochimica et Biophysica Acta (BBA) - Biomembranes 1818:1, pages 12-18.
Crossref
John E. Baenziger & Pierre-Jean Corringer. (2011) 3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels. Neuropharmacology 60:1, pages 116-125.
Crossref
Vicente Bermúdez, Silvia S. Antollini, Gaspar A. Fernández Nievas, Marta I. Aveldaño & Francisco J. Barrantes. (2010) Partition profile of the nicotinic acetylcholine receptor in lipid domains upon reconstitution. Journal of Lipid Research 51:9, pages 2629-2641.
Crossref
Vasyl Bondarenko, Tommy Tillman, Yan Xu & Pei Tang. (2010) NMR structure of the transmembrane domain of the n-acetylcholine receptor ?2 subunit. Biochimica et Biophysica Acta (BBA) - Biomembranes 1798:8, pages 1608-1614.
Crossref
Natalie Bordag & Sandro Keller. (2010) α-Helical transmembrane peptides: A “Divide and Conquer” approach to membrane proteins. Chemistry and Physics of Lipids 163:1, pages 1-26.
Crossref
Barbara Orioni, Gianfranco Bocchinfuso, Jin Young Kim, Antonio Palleschi, Giacinto Grande, Sara Bobone, Yoonkyung Park, Jae Il Kim, Kyung-soo Hahm & Lorenzo Stella. (2009) Membrane perturbation by the antimicrobial peptide PMAP-23: A fluorescence and molecular dynamics study. Biochimica et Biophysica Acta (BBA) - Biomembranes 1788:7, pages 1523-1533.
Crossref
Xinli Liu, Yechun Xu, Honglin Li, Xicheng Wang, Hualiang Jiang & Francisco J Barrantes. (2008) Mechanics of Channel Gating of the Nicotinic Acetylcholine Receptor. PLoS Computational Biology 4:1, pages e19.
Crossref
Devaki A. Kelkar & Amitabha Chattopadhyay. (2006) Monitoring ion channel conformations in membranes utilizing a novel dual fluorescence quenching approach. Biochemical and Biophysical Research Communications 343:2, pages 483-488.
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