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Biocatalysis and Biotransformation Volume 27, 2009 - Issue 3
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Original Article

Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative activity

Eleni Theodosiou Biotechnology Laboratory, Department of Chemical Engineering, National Technical University of Athens, Athens, Greece
,
Maria H. Katsoura Laboratory of Biotechnology, Department of Biological Applications and Technologies, University of Ioannina, Ioannina, Greece
,
Heleni Loutrari G. P. Livanos and M. Simou Laboratories, Department of Critical Care and Pulmonary Services, Evangelismos Hospital, University of Athens Medical School, Athens, Greece
,
Kateřina Purchartová Laboratory of Biotransformation, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
,
Vladimír Křen Laboratory of Biotransformation, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
,
Fragiskos N. Kolisis Biotechnology Laboratory, Department of Chemical Engineering, National Technical University of Athens, Athens, Greece
&
Haralambos Stamatis Laboratory of Biotechnology, Department of Biological Applications and Technologies, University of Ioannina, Ioannina, GreeceCorrespondence[email protected]
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Pages 161-169 | Published online: 13 Aug 2009

Citations (17)

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Douglas Chaves de Alcântara Pinto, Paulo Pitasse-Santos, Gabriela Alves de Souza, Rosane Nora Castro & Marco Edilson Freire de Lima. (2023) Peracetylation of polyphenols under rapid and mild reaction conditions. Natural Product Research 37:13, pages 2279-2284.
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Manuel Ferrer, Rafael Bargiela, Mónica Martínez-Martínez, Jaume Mir, Rainhard Koch, Olga V. Golyshina & Peter N. Golyshin. (2015) Biodiversity for biocatalysis: A review of the α/β-hydrolase fold superfamily of esterases-lipases discovered in metagenomes. Biocatalysis and Biotransformation 33:5-6, pages 235-249.
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Articles from other publishers (15)

Lisha Hao, Mengmeng Zhang, Xiaofeng Li, Xuan Xin, Faling Lei, Xueneng Lai, Guanglei Zhao & Hui Wu. (2021) Highly efficient whole-cell biosynthesis and cytotoxicity of esculin esters. Journal of Biotechnology 337, pages 46-56.
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Jie Tang, Hang Song, Xueting Feng, Alula Yohannes & Shun Yao. (2019) Ionic Liquid-Like Pharmaceutical Ingredients and Applications of Ionic Liquids in Medicinal Chemistry: Development, Status and Prospects. Current Medicinal Chemistry 26:32, pages 5947-5967.
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Yongmei Xiao, Ming Li, Pu Mao, Liangru Yang & Lingbo Qu. (2019) Enzymatic synthesis, antioxidant ability and oil-water distribution coefficient of troxerutin fatty acid esters. Grain & Oil Science and Technology 2:3, pages 78-84.
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Io Antonopoulou, Simona Varriale, Evangelos Topakas, Ulrika Rova, Paul Christakopoulos & Vincenza Faraco. (2016) Enzymatic synthesis of bioactive compounds with high potential for cosmeceutical application. Applied Microbiology and Biotechnology 100:15, pages 6519-6543.
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Eva Vavříková, Jan Vacek, Kateřina Valentová, Petr Marhol, Jitka Ulrichová, Marek Kuzma & Vladimír Křen. (2014) Chemo-Enzymatic Synthesis of Silybin and 2,3-Dehydrosilybin Dimers. Molecules 19:4, pages 4115-4134.
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Eleni Theodosiou, Kateřina Purchartová, Haralambos Stamatis, Fragiskos Kolisis & Vladimír Křen. (2013) Bioavailability of silymarin flavonolignans: drug formulations and biotransformation. Phytochemistry Reviews 13:1, pages 1-18.
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D. Biedermann, E. Vavříková, L. Cvak & V. Křen. (2014) Chemistry of silybin. Nat. Prod. Rep. 31:9, pages 1138-1157.
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Arlene A. Sy-Cordero, Tyler N. Graf, Scott P. Runyon, Mansukh C. Wani, David J. Kroll, Rajesh Agarwal, Scott J. Brantley, Mary F. Paine, Stephen J. Polyak & Nicholas H. Oberlies. (2013) Enhanced bioactivity of silybin B methylation products. Bioorganic & Medicinal Chemistry 21:3, pages 742-747.
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Efrosini Barbayianni & George Kokotos. (2012) Biocatalyzed Regio‐ and Chemoselective Ester Cleavage: Synthesis of Bioactive Molecules. ChemCatChem 4:5, pages 592-608.
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Radek Gažák, Kateřina Valentová, Kateřina Fuksová, Petr Marhol, Marek Kuzma, Miguel Ángel Medina, Ivana Oborná, Jitka Ulrichová & Vladimír Křen. (2011) Synthesis and Antiangiogenic Activity of New Silybin Galloyl Esters. Journal of Medicinal Chemistry 54:20, pages 7397-7407.
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Kateřina Purchartová, Petr Marhol, Radek Gažák, Daniela Monti, Sergio Riva, Marek Kuzma & Vladimír Křen. (2011) Regioselective alcoholysis of silybin A and B acetates with lipases. Journal of Molecular Catalysis B: Enzymatic 71:3-4, pages 119-123.
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Eleni Theodosiou, Heleni Loutrari, Haralambos Stamatis, Charis Roussos & Fragiskos N. Kolisis. (2011) Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids. New Biotechnology 28:4, pages 342-348.
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Radek Gažák, Petr Marhol, Kateřina Purchartová, Daniela Monti, David Biedermann, Sergio Riva, Ladislav Cvak & Vladimír Křen. (2010) Large-scale separation of silybin diastereoisomers using lipases. Process Biochemistry 45:10, pages 1657-1663.
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Daniela Monti, Radek Gažák, Petr Marhol, David Biedermann, Kateřina Purchartová, Mirko Fedrigo, Sergio Riva & Vladimír Křen. (2010) Enzymatic Kinetic Resolution of Silybin Diastereoisomers. Journal of Natural Products 73:4, pages 613-619.
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Radek Gažák, Kateřina Purchartová, Petr Marhol, Lucie Živná, Petr Sedmera, Kateřina Valentová, Nobuo Kato, Hiroyo Matsumura, Kunihiro Kaihatsu & Vladimír Křen. (2010) Antioxidant and antiviral activities of silybin fatty acid conjugates. European Journal of Medicinal Chemistry 45:3, pages 1059-1067.
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