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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 21, 2018 - Issue 5
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Neurophysiological symptoms and aspartame: What is the connection?

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Kyung-Shin Lee, Yoon-Jung Choi, Youn-Hee Lim, Ji Young Lee, Moon-Kyung Shin, Bung-Nyun Kim, Choong Ho Shin, Young Ah Lee, Johanna Inhyang Kim & Yun-Chul Hong. (2022) Dietary patterns are associated with attention-deficit hyperactivity disorder (ADHD) symptoms among preschoolers in South Korea: a prospective cohort study. Nutritional Neuroscience 25:3, pages 603-611.
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Vicko Suswidiantoro, Nuriza Ulul Azmi, Donny Lukmanto, Fadlina Chany Saputri, Abdul Mun'im & Ahmad Aulia Jusuf. (2023) The neuroprotective potential of turmeric rhizome and bitter melon on aspartame-induced spatial memory impairment in rats. Heliyon 9:11, pages e21693.
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Chang Wang, Xiangyu Wang, Zhemin Zhou & Zhongmei Liu. (2023) Developing a green and efficient biosynthesis system for l -aspartic acid by addressing enzyme imbalance and catalysis-extraction circulation processes . Green Chemistry 25:21, pages 8615-8624.
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Alan C. Logan & Stephen J. Schoenthaler. (2023) Nutrition, Behavior, and the Criminal Justice System: What Took so Long? An Interview with Dr. Stephen J. Schoenthaler. Challenges 14:3, pages 37.
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Junning Zhang, Zixing Tang, Zhenyu Liu, Guangyu Wang, Xueli Yang & Xianliang Hou. (2023) Metabolomic and proteomic analyses of primary Sjogren’s syndrome. Immunobiology 228:5, pages 152722.
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Sharon Parten Fowler, David Gimeno Ruiz de Porras, Michael D. Swartz, Paula Stigler Granados, Lynne Parsons Heilbrun & Raymond F. Palmer. (2023) Daily Early-Life Exposures to Diet Soda and Aspartame Are Associated with Autism in Males: A Case-Control Study. Nutrients 15:17, pages 3772.
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Shurooq Asaad Abdulameer Shaher, Dan Florin Mihailescu & Bogdan Amuzescu. (2023) Aspartame Safety as a Food Sweetener and Related Health Hazards. Nutrients 15:16, pages 3627.
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Melissa M. Lane, Mojtaba Lotfaliany, Allison M. Hodge, Adrienne O'Neil, Nikolaj Travica, Felice N. Jacka, Tetyana Rocks, Priscila Machado, Malcolm Forbes, Deborah N. Ashtree & Wolfgang Marx. (2023) High ultra-processed food consumption is associated with elevated psychological distress as an indicator of depression in adults from the Melbourne Collaborative Cohort Study. Journal of Affective Disorders 335, pages 57-66.
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Xiaoyi He, Qianyi Zhong, Kai Yan, Guoying Li & Junhua Yang. (2023) Oral exposure to an acceptable daily intake dose of aspartame induced a delayed proinflammatory cytokine response in the cerebrospinal fluid of rats. Food and Chemical Toxicology 178, pages 113931.
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Zheyi Song, Renyi Song, Yanan Liu, Zufang Wu & Xin Zhang. (2023) Effects of ultra-processed foods on the microbiota-gut-brain axis: The bread-and-butter issue. Food Research International 167, pages 112730.
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Benjamin Miller & Paul Branscum. (2021) Evaluating the Association Between Artificial Sweetener Intake and Indicators of Stress and Anxiety. Community Health Equity Research & Policy 43:3, pages 339-342.
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Naieli Schiefelbein Souto, Micheli Dassi, Ana Cláudia Monteiro Braga, Érica Vanessa Furlan Rosa, Michele Rechia Fighera, Luiz Fernando Freire Royes, Mauro Schneider Oliveira, Marcel Henrique Marcondes Sari & Ana Flávia Furian. (2023) Repeated co‐exposure to aflatoxin B 1 and aspartame disrupts the central nervous system homeostasis: Behavioral, biochemical, and molecular insights . Journal of Food Science 88:4, pages 1731-1742.
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Lea Victoria Griebsch, Elena Leoni Theiss, Daniel Janitschke, Vincent Konrad Johannes Erhardt, Tobias Erhardt, Elodie Christiane Haas, Konstantin Nicolas Kuppler, Juliane Radermacher, Oliver Walzer, Anna Andrea Lauer, Veronika Matschke, Tobias Hartmann, Marcus Otto Walter Grimm & Heike Sabine Grimm. (2023) Aspartame and Its Metabolites Cause Oxidative Stress and Mitochondrial and Lipid Alterations in SH-SY5Y Cells. Nutrients 15:6, pages 1467.
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Adriana Monserrath Orellana-Paucar. (2023) Steviol Glycosides from Stevia rebaudiana: An Updated Overview of Their Sweetening Activity, Pharmacological Properties, and Safety Aspects. Molecules 28:3, pages 1258.
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Mary M. Mwale. 2023. Health Risks of Food Additives - Recent Developments and Trends in Food Sector [Working Title]. Health Risks of Food Additives - Recent Developments and Trends in Food Sector [Working Title].
Emmanuel Iván Morales-RíosJazmín García-MachorroAlfredo Briones-ArandaRaquel Gómez-PliegoJudith Espinosa-Raya. (2022) Effect of Long-Term Intake of Nutritive and Non-Nutritive Sweeteners on Metabolic Health and Cognition in Adult Male Rats. Journal of Medicinal Food 25:11, pages 1059-1065.
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Melissa M. Lane, Elizabeth Gamage, Nikolaj Travica, Thusharika Dissanayaka, Deborah N. Ashtree, Sarah Gauci, Mojtaba Lotfaliany, Adrienne O’Neil, Felice N. Jacka & Wolfgang Marx. (2022) Ultra-Processed Food Consumption and Mental Health: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients 14:13, pages 2568.
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Zhen Li, Yue Mu, Chunlan Guo, Xin You, Xiaoyan Liu, Qian Li & Wei Sun. (2022) Analysis of the saliva metabolic signature in patients with primary Sjögren’s syndrome. PLOS ONE 17:6, pages e0269275.
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Xiang Li, Gaopan Dong, Guangxi Han, Lupei Du & Minyong Li. (2021) Zebrafish Behavioral Phenomics Links Artificial Sweetener Aspartame to Behavioral Toxicity and Neurotransmitter Homeostasis. Journal of Agricultural and Food Chemistry 69:50, pages 15393-15402.
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Florence Couillard, Chloé Ayroulet, Céline Roussin, Christophe Vanhecke, Julia Goossens, Hélène Combres, Kim Ly & Claire François. (2021) Une hypokaliémie symptomatique induite par une consommation excessive de Coca-Cola zéro®. Nutrition Clinique et Métabolisme 35:4, pages 317-320.
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Sourav Nandi, Souvik Layek, Pratyush Kiran Nandi, Nanigopal Bera, Ritwik Hazra & Nilmoni Sarkar. (2021) Self-assembly of artificial sweetener aspartame adversely affects phospholipid membranes: plausible reason for its deleterious effects. Chemical Communications 57:81, pages 10532-10535.
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Maria Novozhilova, Tatiana Mishchenko, Elena Kondakova, Tatiana Lavrova, Maria Gavrish, Svetlana Aferova, Claudio Franceschi & Maria Vedunova. (2021) Features of age-related response to sleep deprivation: in vivo experimental studies. Aging 13:15, pages 19108-19126.
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Laura Papetti, Romina Moavero, Michela A. N. Ferilli, Giorgia Sforza, Samuela Tarantino, Fabiana Ursitti, Claudia Ruscitto, Federico Vigevano & Massimiliano Valeriani. (2021) Truths and Myths in Pediatric Migraine and Nutrition. Nutrients 13:8, pages 2714.
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Nicholas G. Norwitz & Uma Naidoo. (2021) Nutrition as Metabolic Treatment for Anxiety. Frontiers in Psychiatry 12.
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Dominic O'Connor, Michelle Pang, Gabriele Castelnuovo, Graham Finlayson, Ellen Blaak, Catherine Gibbons, Santiago Navas-Carretero, Eva Almiron-Roig, Jo Harrold, Anne Raben & J. Alfredo Martinez. (2021) A rational review on the effects of sweeteners and sweetness enhancers on appetite, food reward and metabolic/adiposity outcomes in adults. Food & Function 12:2, pages 442-465.
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Uma Naidoo. (2020) Eat to Beat Stress. American Journal of Lifestyle Medicine 15:1, pages 39-42.
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Kim Hecht & Lilian Au. 2021. Migraine. Migraine 175 209 .
Hatem M. Eltahan, Linh T.N. Nguyen, Guofeng Han, Hui Yang, Mohamed N. Ali, Khairy A. Amber, Mitsuhiro Furuse & Vishwajit S. Chowdhury. (2020) Hypothermia induced by central injection of sucralose potentially occurs via monoaminergic pathways in the hypothalamus of chicks. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 248, pages 110752.
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Moufidath Adjibade, Chantal Julia, Benjamin Allès, Mathilde Touvier, Cédric Lemogne, Bernard Srour, Serge Hercberg, Pilar Galan, Karen E. Assmann & Emmanuelle Kesse-Guyot. (2019) Prospective association between ultra-processed food consumption and incident depressive symptoms in the French NutriNet-Santé cohort. BMC Medicine 17:1.
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Arbind K. Choudhary & Yeong Y. Lee. (2019) Mechanistic Insights into Aspartame-induced Immune Dysregulation. Current Nutrition & Food Science 15:7, pages 653-661.
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Bibin Gnanadhason Anand, Kailash Prasad Prajapati, Kriti Dubey, Naseem Ahamad, Dolat Singh Shekhawat, Pramod Chandra Rath, George Kodimattam Joseph & Karunakar Kar. (2019) Self-Assembly of Artificial Sweetener Aspartame Yields Amyloid-like Cytotoxic Nanostructures. ACS Nano 13:5, pages 6033-6049.
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Arbind Kumar Choudhary & Yeong Yeh Lee. (2018) The debate over neurotransmitter interaction in aspartame usage. Journal of Clinical Neuroscience 56, pages 7-15.
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Lluis Serra-Majem, António Raposo, Javier Aranceta-Bartrina, Gregorio Varela-Moreiras, Caomhan Logue, Hugo Laviada, Susana Socolovsky, Carmen Pérez-Rodrigo, Jorge Aldrete-Velasco, Eduardo Meneses Sierra, Rebeca López-García, Adriana Ortiz-Andrellucchi, Carmen Gómez-Candela, Rodrigo Abreu, Erick Alexanderson, Rolando Álvarez-Álvarez, Ana Álvarez Falcón, Arturo Anadón, France Bellisle, Ina Beristain-Navarrete, Raquel Blasco Redondo, Tommaso Bochicchio, José Camolas, Fernando Cardini, Márcio Carocho, Maria Costa, Adam Drewnowski, Samuel Durán, Víctor Faundes, Roxana Fernández-Condori, Pedro García-Luna, Juan Garnica, Marcela González-Gross, Carlo La Vecchia, Rosaura Leis, Ana López-Sobaler, Miguel Madero, Ascensión Marcos, Luis Mariscal Ramírez, Danika Martyn, Lorenza Mistura, Rafael Moreno Rojas, José Moreno Villares, José Niño-Cruz, María Oliveira, Nieves Palacios Gil-Antuñano, Lucía Pérez-Castells, Lourdes Ribas-Barba, Rodolfo Rincón Pedrero, Pilar Riobó, Juan Rivera Medina, Catarina Tinoco de Faria, Roxana Valdés-Ramos, Elsa Vasco, Sandra Wac, Guillermo Wakida, Carmina Wanden-Berghe, Luis Xóchihua Díaz, Sergio Zúñiga-Guajardo, Vasiliki Pyrogianni & Sérgio Cunha Velho de Sousa. (2018) Ibero–American Consensus on Low- and No-Calorie Sweeteners: Safety, Nutritional Aspects and Benefits in Food and Beverages. Nutrients 10:7, pages 818.
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Robert Winther, Martin Aasbrenn & Per G. Farup. (2017) Intake of non-nutritive sweeteners is associated with an unhealthy lifestyle: a cross-sectional study in subjects with morbid obesity. BMC Obesity 4:1.
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Szimonetta Lohner, Ingrid Toews & Joerg J. Meerpohl. (2017) Health outcomes of non-nutritive sweeteners: analysis of the research landscape. Nutrition Journal 16:1.
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Arbind Kumar Choudhary & Yeong Lee. (2017) Dysregulated microbiota-gut-brain axis. Nutrition & Food Science 47:5, pages 648-658.
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