Advanced search
Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 23, 2020 - Issue 2
Submit an article Journal homepage
1,082
Views
25
CrossRef citations to date
0
Altmetric
Reviews

Improvement of cognitive function in schizophrenia with N-acetylcysteine: A theoretical review

Caitlin O. B. YollandCentre for Mental Health, Swinburne University of Technology, Hawthorn, AustraliaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1942-1492View further author information
ORCID Icon,
Andrea PhillipouCentre for Mental Health, Swinburne University of Technology, Hawthorn, Australia;Department of Psychiatry, St Vincent’s Hospital, Melbourne, Australia;Psychiatry, Faculty of Medicine, University of Melbourne, Melbourne, AustraliaView further author information
,
David J. CastleCentre for Mental Health, Swinburne University of Technology, Hawthorn, Australia;Department of Psychiatry, St Vincent’s Hospital, Melbourne, Australia;Psychiatry, Faculty of Medicine, University of Melbourne, Melbourne, AustraliaView further author information
,
Erica NeillCentre for Mental Health, Swinburne University of Technology, Hawthorn, Australia;Department of Psychiatry, St Vincent’s Hospital, Melbourne, Australia;Psychiatry, Faculty of Medicine, University of Melbourne, Melbourne, AustraliaView further author information
,
Matthew E. HughesCentre for Mental Health, Swinburne University of Technology, Hawthorn, AustraliaView further author information
,
Cherrie GalletlyDiscipline of Psychiatry, University of Adelaide, Adelaide, Australia;Ramsay Health Care (SA) Mental Health, Adelaide, Australia;Northern Adelaide Local Health Network, Adelaide, AustraliaView further author information
,
Zoe M. SmithSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, AustraliaORCID Iconhttps://orcid.org/0000-0002-0694-3590View further author information
ORCID Icon,
Paul S. FrancisSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds, AustraliaORCID Iconhttps://orcid.org/0000-0003-4165-6922View further author information
ORCID Icon,
Olivia M. DeanPsychiatry, Faculty of Medicine, University of Melbourne, Melbourne, Australia;IMPACT Strategic Research Centre, Barwon Health, Deakin University, Geelong, Australia;Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, AustraliaORCID Iconhttps://orcid.org/0000-0002-2776-3935View further author information
ORCID Icon,
Jerome SarrisNICM Health Research Institute, School of Science and Health, Western Sydney University, Campbelltown, Australia;Department of Psychiatry, Professorial Unit, The Melbourne Clinic, University of Melbourne, Melbourne, AustraliaView further author information
,
Dan SiskindMetro South Addiction and Mental Health Service, Brisbane, Australia;Faculty of Medicine, University of Queensland, Brisbane, AustraliaORCID Iconhttps://orcid.org/0000-0002-2072-9216View further author information
ORCID Icon,
Anthony W. F. HarrisDiscipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, Australia;Brain Dynamics Centre, The Westmead Institute for Medical Research, University of Sydney, Sydney, AustraliaView further author information
&
Susan L. RossellCentre for Mental Health, Swinburne University of Technology, Hawthorn, Australia;Department of Psychiatry, St Vincent’s Hospital, Melbourne, Australia;Monash Alfred Psychiatry Research Centre (MAPrc), The Alfred Hospital and Monash University Central Clinical School, Melbourne, AustraliaCorrespondence[email protected]
View further author information
 show all
Pages 139-148 | Published online: 30 May 2018

Citations (25)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Yunhong Li, Ying Liu, Yaling Xu, Hanqing Chen, Zhiqiang Yan & Xijin Wang. (2021) Aggravated behavioral and neurochemical deficits and redox imbalance in mice with enhanced neonatal iron intake: improvement by biochanin A and role of microglial p38 activation. Nutritional Neuroscience 24:3, pages 161-172.
Read now

Articles from other publishers (24)

Ignasi Oliveras, Toni Cañete, Daniel Sampedro-Viana, Cristóbal Río-Álamos, Adolf Tobeña, Maria Giuseppa Corda, Osvaldo Giorgi & Alberto Fernández-Teruel. (2023) Neurobehavioral Profiles of Six Genetically-based Rat Models of Schizophrenia- related Symptoms. Current Neuropharmacology 21:9, pages 1934-1952.
Crossref
Jiaxin Li, Deyang Li, Junru Guo, Dongmei Wang & Xiangyang Zhang. (2023) Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia. Antioxidants 12:6, pages 1259.
Crossref
Priyanka N. Bushana, Michelle A. Schmidt, Kevin M. Chang, Trisha Vuong, Barbara A. Sorg & Jonathan P. Wisor. (2023) Effect of N-Acetylcysteine on Sleep: Impacts of Sex and Time of Day. Antioxidants 12:5, pages 1124.
Crossref
Ekram Mohammadi, Farnaz Nikbakht, Somayeh Vazifekhah, Javad Fahanik Babae & Mohamad Taghi Jogataei. (2023) Evaluation the cognition-improvement effects of N-acetyl cysteine in experimental temporal lobe epilepsy in rat. Behavioural Brain Research 440, pages 114263.
Crossref
Jerome Sarris, Patricia L. Gerbarg, Richard P. Brown & Philip R. Muskin. 2020. Tasman’s Psychiatry. Tasman’s Psychiatry 1 59 .
Erica Neill, Susan L Rossell, Caitlin Yolland, Denny Meyer, Cherrie Galletly, Anthony Harris, Dan Siskind, Michael Berk, Kiymet Bozaoglu, Frances Dark, Olivia M Dean, Paul S Francis, Dennis Liu, Andrea Phillipou, Jerome Sarris & David J Castle. (2022) N -Acetylcysteine (NAC) in Schizophrenia Resistant to Clozapine: A Double-Blind, Randomized, Placebo-Controlled Trial Targeting Negative Symptoms . Schizophrenia Bulletin 48:6, pages 1263-1272.
Crossref
Megan Maroney. (2022) Management of cognitive and negative symptoms in schizophrenia. Mental Health Clinician 12:5, pages 282-299.
Crossref
Paulina M. Getsy, Santhosh M. Baby, Walter J. May, Tristan H.J. Lewis, James N. Bates, Yee-Hsee Hsieh, Benjamin Gaston & Stephen J. Lewis. (2022) L-NAC reverses of the adverse effects of fentanyl infusion on ventilation and blood-gas chemistry. Biomedicine & Pharmacotherapy 153, pages 113277.
Crossref
Michel Cuenod, Pascal Steullet, Jan-Harry Cabungcal, Daniella Dwir, Ines Khadimallah, Paul Klauser, Philippe Conus & Kim Q. Do. (2021) Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia. Molecular Psychiatry 27:4, pages 1886-1897.
Crossref
Li Zhang, Zhenxing Li, Lei Mao & Handong Wang. (2022) Circular RNA in Acute Central Nervous System Injuries: A New Target for Therapeutic Intervention. Frontiers in Molecular Neuroscience 15.
Crossref
Zofia Rogóż, Kinga Kamińska, Marta Anna Lech & Elżbieta Lorenc-Koci. (2022) N-Acetylcysteine and Aripiprazole Improve Social Behavior and Cognition and Modulate Brain BDNF Levels in a Rat Model of Schizophrenia. International Journal of Molecular Sciences 23:4, pages 2125.
Crossref
Shen He, Yange Li, Tian Li, Feikang Xu, Duan Zeng, Yue Shi, Nan Zhao, Lei Zhang, Yin Zhu Ma, Qiang Wang, Wenjuan Yu, Yifeng Shen, Jingjing Huang & Huafang Li. (2021) Sex differences between serum total bilirubin levels and cognition in patients with schizophrenia. BMC Psychiatry 21:1.
Crossref
Antón L. Martínez, José Brea, Sara Rico, María Teresa de los Frailes & María Isabel Loza. (2021) Cognitive Deficit in Schizophrenia: From Etiology to Novel Treatments. International Journal of Molecular Sciences 22:18, pages 9905.
Crossref
Ventriglio Antonio, Bellomo Antonello, Favale Donato, Bonfitto Iris, Vitrani Giovanna, Di Sabatino Dario, Cuozzo Edwige, Di Gioia Ilaria, Mauro Pettorruso, Giampaolo Perna, Alessandro Valchera & De Berardis Domenico. (2021) Oxidative Stress in the Early Stage of Psychosis. Current Topics in Medicinal Chemistry 21.
Crossref
Micaely Cristina dos Santos Tenório, Nayara Gomes Graciliano, Fabiana Andréa Moura, Alane Cabral Menezes de Oliveira & Marília Oliveira Fonseca Goulart. (2021) N-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants 10:6, pages 967.
Crossref
Julie Deguil & Régis Bordet. (2021) Contributions of animal models of cognitive disorders to neuropsychopharmacology. Therapies 76:2, pages 87-99.
Crossref
Tonali Blanco Ayala, Daniela Ramírez Ortega, Paulina Ovalle Rodríguez, Benjamín Pineda, Gonzalo Pérez de la Cruz, Dinora González Esquivel, Robert Schwarcz, Korrapati V. Sathyasaikumar, Anabel Jiménez Anguiano & Verónica Pérez de la Cruz. (2021) Subchronic N-acetylcysteine Treatment Decreases Brain Kynurenic Acid Levels and Improves Cognitive Performance in Mice. Antioxidants 10:2, pages 147.
Crossref
Aurelia Magdalena Pisoschi, Aneta Pop, Florin Iordache, Loredana Stanca, Gabriel Predoi & Andreea Iren Serban. (2021) Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status. European Journal of Medicinal Chemistry 209, pages 112891.
Crossref
Mary V. Seeman. (2021) The gut microbiome and antipsychotic treatment response. Behavioural Brain Research 396, pages 112886.
Crossref
Haixia Wang, Ning Jiang, Jingwei Lv, Hong Huang & Xinmin Liu. (2020) Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice. Life Sciences 258, pages 118107.
Crossref
T. Blanco-Ayala, K.V. Sathyasaikumar, J.D. Uys, V. Pérez-de-la-Cruz, L.S. Pidugu & R. Schwarcz. (2020) N-Acetylcysteine Inhibits Kynurenine Aminotransferase II. Neuroscience 444, pages 160-169.
Crossref
Caitlin OB Yolland, Donal Hanratty, Erica Neill, Susan L Rossell, Michael Berk, Olivia M Dean, David J Castle, Eric J Tan, Andrea Phillipou, Anthony WF Harris, Ana Rita Barreiros, Abigail Hansen & Dan Siskind. (2019) Meta-analysis of randomised controlled trials with N -acetylcysteine in the treatment of schizophrenia . Australian & New Zealand Journal of Psychiatry 54:5, pages 453-466.
Crossref
Ehud Mekori-Domachevsky, Hadar Segal-Gavish & Raz Gross. 2020. Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease. Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease 101 122 .
Ruhi Turkmen, Murat Sirri Akosman & Hasan Huseyin Demirel. (2019) Protective effect of N-acetylcysteine on MK-801-induced testicular oxidative stress in mice. Biomedicine & Pharmacotherapy 109, pages 1988-1993.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.