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Articles

Health-promoting effects of the citrus flavanone hesperidin

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Sukanya Bhoumik, Rashmi Kesherwani, Raushan Kumar & Syed Ibrahim Rizvi. (2023) Hesperidin augments the health beneficial effects of alternate day fasting in male rats. Egyptian Journal of Basic and Applied Sciences 10:1, pages 1-11.
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Ayomide Victor Atoki, Patrick Maduabuchi Aja, Tijjani Salihu Shinkafi, Erick Nyakundi Ondari & Chinaza Godswill Awuchi. (2023) Hesperidin plays beneficial roles in disorders associated with the central nervous system: a review. International Journal of Food Properties 26:1, pages 1867-1884.
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Masaudat A. Adebayo, Adejoke N. Kolawole, Babatunde A. Falese & Ayodele O. Kolawole. (2023) Spectroscopic and in silico evaluation of hesperetin, aglycone flavanone, as a prospective regulatory ligand for human salivary α-amylase. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-16.
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Xingmiao Lu, Chengying Zhao, Huan Shi, Yongcheng Liao, Fei Xu, Hengjun Du, Hang Xiao & Jinkai Zheng. (2023) Nutrients and bioactives in citrus fruits: Different citrus varieties, fruit parts, and growth stages. Critical Reviews in Food Science and Nutrition 63:14, pages 2018-2041.
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Jingwen Liu, Jiaoxian Cao, Yiming Li & Fujiang Guo. (2023) Beneficial Flavonoid in Foods and Anti-obesity Effect. Food Reviews International 39:1, pages 560-600.
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Weilong Zheng, Fang Wu, Xi Luo, Caimiao Bian, Yingying Zhang, Fengwei Yin, Haiyu Liu & Yongqian Fu. (2022) Separation of Citrus Essential Oil and Hesperidin from Citrus Peel Through Combined Mixed-Solvent and Multi-Phase Salting Out Extraction. Journal of Essential Oil Bearing Plants 25:4, pages 899-909.
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Mohammed N. A. Khalil, Hebatullah H. Farghal & Mohamed A. Farag. (2022) Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit Citrus Χ paradisi: A comprehensive review for maximizing its value. Critical Reviews in Food Science and Nutrition 62:4, pages 935-956.
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Mehmet Berköz, Serap Yalın, Ferbal Özkan-Yılmaz, Arzu Özlüer-Hunt, Mirosław Krośniak, Renata Francik, Oruç Yunusoğlu, Abdullah Adıyaman, Hava Gezici, Ayhan Yiğit, Seda Ünal, Davut Volkan & Metin Yıldırım. (2021) Protective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression. Immunopharmacology and Immunotoxicology 43:3, pages 353-369.
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Amr A. Fouad, Seham A. Abdel-Gaber & Manal I. Abdelghany. (2021) Hesperidin opposes the negative impact of cyclophosphamide on mice kidneys. Drug and Chemical Toxicology 44:3, pages 223-228.
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Ebenezer Tunde Olayinka & Kayode Ezekiel Adewole. (2021) In vivo and in silico evaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats. Toxicology Mechanisms and Methods 31:2, pages 81-89.
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Shailesh S. Chalikwar, Sanjay J. Surana, Sameer N. Goyal, Kaushalendra K. Chaturvedi & Pankaj V. Dangre. (2021) Solid self-microemulsifying nutraceutical delivery system for hesperidin using quality by design: assessment of biopharmaceutical attributes and shelf-life. Journal of Microencapsulation 38:1, pages 61-79.
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Sukhvinder Singh Purewal & Kawaljit Singh Sandhu. (2020) Nutritional Profile and Health Benefits of Kinnow: An Updated Review. International Journal of Fruit Science 20:sup3, pages S1385-S1405.
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Wei Hong & Wenjie Zhang. (2020) Hesperidin promotes differentiation of alveolar osteoblasts via Wnt/β-Catenin signaling pathway. Journal of Receptors and Signal Transduction 40:5, pages 442-448.
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Shuyun Wang, Ning He, Haiyan Xing, Yuemei Sun, Juan Ding & Liping Liu. (2020) Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis. Journal of Receptors and Signal Transduction 40:4, pages 388-394.
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Minwoo Hwang, Jeong Nam Kim & Byung Joo Kim. (2020) Hesperidin depolarizes the pacemaker potentials through 5-HT4 receptor in murine small intestinal interstitial cells of Cajal. Animal Cells and Systems 24:2, pages 84-90.
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Chengying Zhao, Feng Wang, Yunhe Lian, Hang Xiao & Jinkai Zheng. (2020) Biosynthesis of citrus flavonoids and their health effects. Critical Reviews in Food Science and Nutrition 60:4, pages 566-583.
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Laura Musumeci, Alessandro Maugeri, Santa Cirmi, Giovanni Enrico Lombardo, Caterina Russo, Sebastiano Gangemi, Gioacchino Calapai & Michele Navarra. (2020) Citrus fruits and their flavonoids in inflammatory bowel disease: an overview. Natural Product Research 34:1, pages 122-136.
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Saja H. Ali, Ghassan M. Sulaiman, Mohammad M. F. Al-Halbosiy, Majid S. Jabir & Anaheed H. Hameed. (2019) Fabrication of hesperidin nanoparticles loaded by poly lactic co-Glycolic acid for improved therapeutic efficiency and cytotoxicity. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 378-394.
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Articles from other publishers (183)

Dalia Zaafar, Heba M.A. Khalil, Reham Elnaggar, Diana Z. Saad & Rabab Ahmed Rasheed. (2024) Protective role of hesperetin in sorafenib-induced hepato- and neurotoxicity in mice via modulating apoptotic pathways and mitochondrial reprogramming. Life Sciences 336, pages 122295.
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Yuqing Zhong, Yu Liang, Mengwei Jia, Bo Si & Lishuang Lv. (2024) Synephrine, as a scavenger and promoter, cooperates with hesperidin to reduce acrolein levels. Food Chemistry 431, pages 136896.
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Mahnaz Zarein, Asghar Zarban, Hamed Shoorei, Mehdi Gharekhani & Mohammadmehdi Hassanzadeh-Taheri. (2023) The amelioration of ovarian dysfunction by hesperidin in malathion-treated mice through the overexpression of PCNA and FSHR proteins. Heliyon 9:12, pages e22484.
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Haohai Huang, Dan Liao, Bin He, Guanghui Zhou & Yejia Cui. (2023) Effects of citrus flavanone hesperidin extracts or purified hesperidin consumption on risk factors for cardiovascular disease: evidence from an updated meta-analysis of randomized controlled trials. Current Developments in Nutrition, pages 102055.
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Sanaz Akbari, Reza Assaran Darban, Hossein Javid, Ali Esparham & Seyed Isaac Hashemy. (2023) The anti-tumoral role of Hesperidin and Aprepitant on prostate cancer cells through redox modifications. Naunyn-Schmiedeberg's Archives of Pharmacology 396:12, pages 3559-3567.
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Dina A. Moawad, Hoda A.S. El-Garhy, Mohamed H. Refaat & Mohamed S. Hassaan. (2023) Protecting deleterious effects of high stocking density of Nile tilapia, Oreochromis niloticus using dietary microalgae Golenkinia longispicula: Growth, immune-oxidative markers and associated gene expression. Aquaculture, pages 740430.
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Yuting Chen, Yujuan Xu, Jing Wen, Yuanshan Yu, Jijun Wu, Lina Cheng, Wai-San Cheang, Wenwen Liu & Manqin Fu. (2023) Analysis of Flavonoid Metabolites in Citrus reticulata ‘Chachi’ at Different Collection Stages Using UPLC-ESI-MS/MS. Foods 12:21, pages 3945.
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G. N. Turmanidze, V. V. Sorokin, K. S. Stepanov & M. A. Ignatenko. (2023) Improvement of Technologies for Isolation and Purification of Biologically Active Substances from Plant Raw Materials. Drug development & registration.
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Rohit Tayal, Kavita Munjal, Vinod Kumar Gauttam, Pankaj Popli, Loveleen Khurana & Neeraj Choudhary. (2023) Potential role of hesperidin in lifestyle disorders: A scoping review. South African Journal of Botany 161, pages 542-554.
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Xinyi Deng, Shiqiang He, Yuxin Han & Yingjuan Chen. (2023) Metabolites profiling reveals the dynamic changes of non-volatiles in Pu-erh during Ganpu tea processing. Food Chemistry: X 19, pages 100774.
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Sang Suk Kim, YoSup Park & Seung-Gab Han. (2023) Characterization of Flavonoid, Free Amino Acid, Volatiles Components of ‘Minihyang’ Fruit, a New Cultivar Citrus reticulata . Korean Journal of Breeding Science 55:3, pages 244-253.
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Yutong Yuan, Jingxuan Zhou, Nanhai Zhang, Xin Xing, Liang Zhao & Feng Zhou. (2023) In vivo study of orange peel fermentation and improvement of androgen overproduction causing acne. Food Bioscience, pages 103124.
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Mahendra P. Kapoor, Masamitsu Moriwaki, Aya Abe, So Morishima, Makoto Ozeki & Norio Sato. (2023) Hesperetin-7-O-glucoside/β-cyclodextrin Inclusion Complex Induces Acute Vasodilator Effect to Inhibit the Cold Sensation Response during Localized Cold-Stimulate Stress in Healthy Human Subjects: A Randomized, Double-Blind, Crossover, and Placebo-Controlled Study. Nutrients 15:17, pages 3702.
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Chi Zhang, Yao Zhao, Han Tao, Linying Li, Yuqing He, Xueying Zhang, Ying Zhu & Gaojie Hong. (2023) Analysis of the Flavonoidome Reveals the Different Health-Promoting Flavonoid Characteristics in Fruit. Antioxidants 12:9, pages 1665.
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Lea Ling-Yu Kan, Ben Chung-Lap Chan, Ping-Chung Leung & Chun-Kwok Wong. (2023) Natural-Product-Derived Adjunctive Treatments to Conventional Therapy and Their Immunoregulatory Activities in Triple-Negative Breast Cancer. Molecules 28:15, pages 5804.
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Hui Cao, Dong Yang, Kechao Nie, Ruoheng Lin, Luqi Peng, Xuhui Zhou, Mei Zhang, Ying Zeng, Lini Liu & Wei Huang. (2023) Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model. European Journal of Pharmacology 952, pages 175670.
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Kanta Noguchi, Daisuke Imahori, Yusuke Kido, Poomraphie Nuntawong, Hiroyuki Tanaka, Satoshi Morimoto & Seiichi Sakamoto. (2023) Quality assessment method for Chinpi, dried Citrus spp. peel and its derived Kampo medicines using specific monoclonal antibody against hesperidin . Phytochemical Analysis 34:6, pages 652-660.
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Qin Li, Junfei Yao, Wei Zheng, Jialu Wang, Ling Liao, Guochao Sun, Xun Wang, Honghong Deng, Mingfei Zhang, Zhihui Wang & Bo Xiong. (2023) Hetero-grafting affects flavonoid biosynthesis in sweet orange 'Newhall' (Citrus sinensis) peels: a metabolomics and transcriptomics analysis. Frontiers in Plant Science 14.
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Arshad Husain Rahmani, Ali Yousif Babiker & Shehwaz Anwar. (2023) Hesperidin, a Bioflavonoid in Cancer Therapy: A Review for a Mechanism of Action through the Modulation of Cell Signaling Pathways. Molecules 28:13, pages 5152.
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Mariem Ben Abdallah, Morad Chadni, Nouha M’hiri, Fanny Brunissen, Nesrine Rokbeni, Irina Ioannou, Karim Allaf, Colette Besombes & Nourhene Boudhrioua. (2023) Optimization of DIC-Tripolium Ecofriendly Extraction Process: Recovery of Hesperidin from Orange Byproducts, Antioxidant and α-Amylase Inhibition of Extracts. Antioxidants 12:7, pages 1346.
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Patricia Milagros Maquera-Huacho, Denise Palomari Spolidorio, John Manthey & Daniel Grenier. (2023) Effect of Hesperidin on Barrier Function and Reactive Oxygen Species Production in an Oral Epithelial Cell Model, and on Secretion of Macrophage-Derived Inflammatory Mediators during Porphyromonas gingivalis Infection. International Journal of Molecular Sciences 24:12, pages 10389.
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Gözde Özge Önder, Özge Göktepe, Münevver Baran, Nazmiye Bitgen, Funda Aydın & Arzu Yay. (2023) Therapeutic potential of hesperidin: Apoptosis induction in breast cancer cell lines. Food and Chemical Toxicology 176, pages 113791.
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Abeer Ramzy Hussieny Mahmoud & Nashwa Mohamad Mohamad Shalaby. (2023) Effectiveness of hesperidin against toxic effect of silver nanoparticles on the brain via apoptotic/antiapoptotic pathway in adult albino rats. Toxicology and Environmental Health Sciences 15:2, pages 119-125.
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Yasmine A. Ali, Hanan A. Soliman, Mohamed Abdel-Gabbar, Noha A. Ahmed, Kandil A. A. Attia, Fatma M. Shalaby, El-Shaymaa El-Nahass & Osama M. Ahmed. (2023) Rutin and Hesperidin Revoke the Hepatotoxicity Induced by Paclitaxel in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities. Evidence-Based Complementary and Alternative Medicine 2023, pages 1-17.
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Hanchi Chen, Jiajun Wang, Yi Liu, Yongfan Chen, Chunfeng Wang, Linjiang Zhu, Yuele Lu & Xiaolong Chen. (2023) Rational Design of Cyclodextrin Glycosyltransferase with Improved Hesperidin Glycosylation Activity. Catalysts 13:5, pages 885.
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Yang Yang, Yanqun Li, Victor Amoroso, Florfe Acma, Maria Melanie Guiang & Hong Wu. (2023) Comparison of production of bioactive components in Zanthoxylum nitidum taproots from different regions in southern China . Biomedical Chromatography 37:5.
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Akash Rana, Amit & Navneeta Bharadvaja. (2023) Plant-based phytochemical mediated inhibition of breast cancer by targeting PLAT: An in-silico study. Plant-based phytochemical mediated inhibition of breast cancer by targeting PLAT: An in-silico study.
Zahra Nasehi, Nejat Kheiripour, Maryam Akhavan Taheri, Abolfazl Ardjmand, Faezeh Jozi & Mohammad Esmaeil Shahaboddin. (2023) Efficiency of Hesperidin against Liver Fibrosis Induced by Bile Duct Ligation in Rats. BioMed Research International 2023, pages 1-12.
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Sakshi Bajaj & Sumeet Gupta. (2023) Nutraceuticals: A Promising Approach Towards Diabetic Neuropathy. Endocrine, Metabolic & Immune Disorders - Drug Targets 23:5, pages 581-595.
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Xiaohua Yang, Shuangqi Wang, Lina Qi, Shujing Chen, Kunze Du, Ye Shang, Jiading Guo, Shiming Fang, Jin Li, Han Zhang & Yanxu Chang. (2023) An efficient method for qualitation and quantitation of multi-components of the herbal medicine Qingjin Yiqi Granules. Journal of Pharmaceutical and Biomedical Analysis 227, pages 115288.
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Cailan Li, Ying Tang, Yonghao Ye, Manhua Zuo & Qiang Lu. (2023) Potential of natural flavonols and flavanones in the treatment of ulcerative colitis. Frontiers in Pharmacology 14.
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Ashwani K. Dhingra, Bhawna Chopra, Vaibhav Rathi & Sameer Sapra. (2023) Hesperidin: A Potential Therapeutic Agent against COVID-19. Current Drug Discovery Technologies 20:2.
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Xinyu Li, Wei Huang, Rongrong Tan, Caijuan Xu, Xi Chen, Sixin Li, Ying Liu, Huiwen Qiu, Hui Cao & Quan Cheng. (2023) The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect. Biomedicine & Pharmacotherapy 159, pages 114222.
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Jingxuan Li, Shiqi Zou, Wanling Yang, Mengdie Peng, Baizhong Chen, Jinji Deng, Minyan Wei & Guodong Zheng. (2023) Identification of volatile and nonvolatile compounds in Citri Reticulatae Pericarpium Viride using GC–MS , UPLC‐Q‐Exactive Orbitrap‐MS, and HPLC‐PDA . Food Science & Nutrition 11:3, pages 1415-1425.
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Jie Wang, Yong-Mei Liu, Jun Hu & Cong Chen. (2023) Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease. Frontiers in Pharmacology 14.
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Mariem Ben Abdallah, Morad Chadni, Nouha M’hiri, Fanny Brunissen, Nesrine Rokbeni, Karim Allaf, Colette Besombes, Irina Ioannou & Nourhene Boudhrioua. (2023) Intensifying Effect of Instant Controlled Pressure Drop (DIC) Pre-Treatment on Hesperidin Recovery from Orange Byproducts: In Vitro Antioxidant and Antidiabetic Activities of the Extracts. Molecules 28:4, pages 1858.
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Yueyin Pang, Qianlong Wu, Ming Zhang, Jia Lai, Danyang Chen, Jingyao Su, Bing Zhu, Hongmei Zhou & Yinghua Li. (2023) Hesperidin Induced HePG-2 Cell Apoptosis through ROS-Mediated p53/Bcl-2/Bax and p-mTOR Signaling Pathways. Journal of Food Biochemistry 2023, pages 1-10.
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Paolo Bellavite. (2023) Neuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action. Antioxidants 12:2, pages 280.
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J C Pizano-Andrade, B Vargas-Guerrero, C M Gurrola-Díaz, J J Vargas-Radillo & M A Ruiz-López. (2022) Natural products and their mechanisms in potential photoprotection of the skin. Journal of Biosciences 47:4.
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Shiqi Li, Siyan Che, Sunni Chen, Zheng Ruan & Li Zhang. (2022) Hesperidin partly ameliorates the decabromodiphenyl ether-induced reproductive toxicity in pubertal mice. Environmental Science and Pollution Research 29:60, pages 90391-90403.
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Fan Liu, Linkai Qu, Hua Li, Jiaxuan He, Lei Wang, Yimeng Fang, Xiaoqing Yan, Qinsi Yang, Bo Peng, Wei Wu, Libo Jin & Da Sun. (2022) Advances in Biomedical Functions of Natural Whitening Substances in the Treatment of Skin Pigmentation Diseases. Pharmaceutics 14:11, pages 2308.
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Ting Xu, Shanshan Hu, Yan Liu, Kang Sun, Liyong Luo & Liang Zeng. (2022) Hawk Tea Flavonoids as Natural Hepatoprotective Agents Alleviate Acute Liver Damage by Reshaping the Intestinal Microbiota and Modulating the Nrf2 and NF-κB Signaling Pathways. Nutrients 14:17, pages 3662.
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Seon Ae Jeong, Changwon Yang, Jisoo Song, Gwonhwa Song, Wooyoung Jeong & Whasun Lim. (2022) Hesperidin Suppresses the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress and Disrupting Ca2+ Homeostasis. Antioxidants 11:9, pages 1633.
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Sanne Ahles, I. Cuijpers, F. Hartgens & F. J. Troost. (2022) The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial. The journal of nutrition, health & aging 26:9, pages 839-846.
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Zheng Zha, Sisi Liu, Yijiang Liu, Chen Li & Lei Wang. (2022) Potential Utility of Natural Products against Oxidative Stress in Animal Models of Multiple Sclerosis. Antioxidants 11:8, pages 1495.
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Zhiheng Zhang, Xiaojing Li, Shangyuan Sang, David Julian McClements, Long Chen, Jie Long, Aiquan Jiao, Zhengyu Jin & Chao Qiu. (2022) Polyphenols as Plant-Based Nutraceuticals: Health Effects, Encapsulation, Nano-Delivery, and Application. Foods 11:15, pages 2189.
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Shuxun Liu, Ying Lou, Yixian Li, Jiaojiao Zhang, Ping Li, Baoru Yang & Qing Gu. (2022) Review of phytochemical and nutritional characteristics and food applications of Citrus L. fruits. Frontiers in Nutrition 9.
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Anna Crescenti, Antoni Caimari, Juan María Alcaide-Hidalgo, Roger Mariné-Casadó, Rosa M. Valls, Judit Companys, Patricia Salamanca, Lorena Calderón-Pérez, Laura Pla-Pagà, Anna Pedret, Antoni Delpino-Rius, Pol Herrero, Iris Samarra, Lluís Arola, Rosa Solà & Josep M. Del Bas. (2022) Hesperidin Bioavailability Is Increased by the Presence of 2S-Diastereoisomer and Micronization—A Randomized, Crossover and Double-Blind Clinical Trial. Nutrients 14:12, pages 2481.
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Krystyna Pyrzynska. (2022) Hesperidin: A Review on Extraction Methods, Stability and Biological Activities. Nutrients 14:12, pages 2387.
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Yuting Zhu, Hongwei Gao, Shanhao Han, Jianhui Li, Qiqin Wen & Bo Dong. (2022) Antidiabetic activity and metabolite profiles of ascidian Halocynthia roretzi. Journal of Functional Foods 93, pages 105095.
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Satoshi Nishino, Yoko Fujiki, Takanari Sato, Yukino Kato, Remina Shirai, Hiroaki Oizumi, Masahiro Yamamoto, Katsuya Ohbuchi, Yuki Miyamoto, Kazushige Mizoguchi & Junji Yamauchi. (2022) Hesperetin, a Citrus Flavonoid, Ameliorates Inflammatory Cytokine-Mediated Inhibition of Oligodendroglial Cell Morphological Differentiation. Neurology International 14:2, pages 471-487.
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Ademola C. Famurewa, Kaviyarasi Renu, Mohamed Ahmed Eladl, Rituraj Chakraborty, Haritha Myakala, Mohamed El-Sherbiny, Dalia Mahmoud Abdelmonem Elsherbini, Balachandar Vellingiri, Harishkumar Madhyastha, Uddesh Ramesh Wanjari, Anirban Goutam Mukherjee & Abilash Valsala Gopalakrishnan. (2022) Hesperidin and hesperetin against heavy metal toxicity: Insight on the molecular mechanism of mitigation. Biomedicine & Pharmacotherapy 149, pages 112914.
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Shênia Santos Monteiro, Verônica Macário de Oliveira & Matheus Augusto de Bittencourt Pasquali. (2022) Probiotics in Citrus Fruits Products: Health Benefits and Future Trends for the Production of Functional Foods—A Bibliometric Review. Foods 11:9, pages 1299.
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