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Intestinal in vitro cell culture models and their potential to study the effect of food components on intestinal inflammation

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Abigail González, Eva Conceição, José António Teixeira & Clarisse Nobre. (2023) In vitro models as a tool to study the role of gut microbiota in obesity. Critical Reviews in Food Science and Nutrition 0:0, pages 1-12.
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Maria Helena Macedo, Mafalda Dias Neto, Lorenzo Pastrana, Catarina Gonçalves & Miguel Xavier. (2023) Recent Advances in Cell‐Based In Vitro Models to Recreate Human Intestinal Inflammation. Advanced Science 10:31.
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Manuela Machado, Eduardo M. Costa, Sara Silva, Luís M. Rodriguez-Alcalá, Ana Maria Gomes & Manuela Pintado. (2023) Understanding the Anti-Obesity Potential of an Avocado Oil-Rich Cheese through an In Vitro Co-Culture Intestine Cell Model. Molecules 28:15, pages 5923.
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Adele Cicio, Stefania Sut, Stefano Dall’Acqua, Maurizio Bruno, Claudio Luparello, Rosa Serio & Maria Grazia Zizzo. (2023) Chemical Characterization and Cytotoxic and Antioxidant Activity Evaluation of the Ethanol Extract from the Bulbs of Pancratium maritimun Collected in Sicily. Molecules 28:10, pages 3986.
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Maxi B. Paul, Marén Schlief, Hannes Daher, Albert Braeuning, Holger Sieg & Linda Böhmert. (2023) A human Caco-2-based co-culture model of the inflamed intestinal mucosa for particle toxicity studies. In vitro models.
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Michelle J. Haddad, Wendy Sztupecki, Carine Delayre-Orthez, Larbi Rhazi, Nicolas Barbezier, Flore Depeint & Pauline M. Anton. (2023) Complexification of In Vitro Models of Intestinal Barriers, A True Challenge for a More Accurate Alternative Approach. International Journal of Molecular Sciences 24:4, pages 3595.
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Dominik Wendner, Theresa Schott, Elisabeth Mayer & Klaus Teichmann. (2023) Beneficial Effects of Phytogenic Feed Additives on Epithelial Barrier Integrity in an In Vitro Co-Culture Model of the Piglet Gut. Molecules 28:3, pages 1026.
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Yue Li, Meng-Xin Hu, Ming Yan, Ya-Xin Guo, Xue-Ke Ma, Jian-Zhong Han & Yu-Mei Qin. (2023) Intestinal models based on biomimetic scaffolds with an ECM micro-architecture and intestinal macro-elasticity: close to intestinal tissue and immune response analysis. Biomaterials Science 11:2, pages 567-582.
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Lihua Xiao, Yong Sun & Rong Tsao. (2022) Paradigm Shift in Phytochemicals Research: Evolution from Antioxidant Capacity to Anti-Inflammatory Effect and to Roles in Gut Health and Metabolic Syndrome. Journal of Agricultural and Food Chemistry 70:28, pages 8551-8568.
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Fanghua Guo, Rong Tsao, Chuyao Li, Xiaoya Wang, Hua Zhang, Li Jiang, Yong Sun & Hua Xiong. (2022) Polyphenol Content of Green Pea ( Pisum sativum L.) Hull under In Vitro Digestion and Effects of Digestive Products on Anti-Inflammatory Activity and Intestinal Barrier in the Caco-2/Raw264.7 Coculture Model . Journal of Agricultural and Food Chemistry 70:11, pages 3477-3488.
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Crossref
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Crossref
Peng Chen, Fuchao Chen, Jiexin Lei & Benhong Zhou. (2021) Gut microbial metabolite urolithin B attenuates intestinal immunity function in vivo in aging mice and in vitro in HT29 cells by regulating oxidative stress and inflammatory signalling . Food & Function 12:23, pages 11938-11955.
Crossref
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Crossref
Lei-Min Yu, Li-Qi Mao, Chun-Yan Wu, Wei Ye & Xi Wang. (2021) Chlorogenic acid improves intestinal barrier function by downregulating CD14 to inhibit the NF-κB signaling pathway. Journal of Functional Foods 85, pages 104640.
Crossref
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Crossref
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Crossref
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Crossref
Balaji Venkataraman, Saeeda Almarzooqi, Vishnu Raj, Abdullah T. Alhassani, Ahmad S. Alhassani, Khadijah J. Ahmed, Veedamali S. Subramanian, Shreesh K. Ojha, Samir Attoub, Thomas E. Adrian & Sandeep B. Subramanya. (2021) Thymoquinone, a Dietary Bioactive Compound, Exerts Anti-Inflammatory Effects in Colitis by Stimulating Expression of the Colonic Epithelial PPAR-γ Transcription Factor. Nutrients 13:4, pages 1343.
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Diego Marescotti, Giuseppe Lo Sasso, Diego Guerrera, Kasper Renggli, Pedro A. Ruiz Castro, Romain Piault, Vincent Jaquet, Fabian Moine, Karsta Luettich, Stefan Frentzel, Manuel C. Peitsch & Julia Hoeng. (2021) Development of an Advanced Multicellular Intestinal Model for Assessing Immunomodulatory Properties of Anti-Inflammatory Compounds. Frontiers in Pharmacology 12.
Crossref
María Jesús Rodríguez-Sojo, Antonio Jesús Ruiz-Malagón, María Elena Rodríguez-Cabezas, Julio Gálvez & Alba Rodríguez-Nogales. (2021) Limosilactobacillus fermentum CECT5716: Mechanisms and Therapeutic Insights. Nutrients 13:3, pages 1016.
Crossref
Kai-Hong Tu, Ling-Shan Yu, Zong-Han Sie, Han-Yi Hsu, Khuloud T. Al-Jamal, Julie Tzu-Wen Wang & Ya-Yu Chiang. (2020) Development of Real-Time Transendothelial Electrical Resistance Monitoring for an In Vitro Blood-Brain Barrier System. Micromachines 12:1, pages 37.
Crossref
Josep Rubert, Pawel J. Schweiger, Fulvio Mattivi, Kieran Tuohy, Kim B. Jensen & Andrea Lunardi. (2020) Intestinal Organoids: A Tool for Modelling Diet–Microbiome–Host Interactions. Trends in Endocrinology & Metabolism 31:11, pages 848-858.
Crossref
Albert P. Li. (2020) In Vitro Human Cell–Based Experimental Models for the Evaluation of Enteric Metabolism and Drug Interaction Potential of Drugs and Natural Products. Drug Metabolism and Disposition 48:10, pages 980-992.
Crossref
Vladana Domazetovic, Teresa Iantomasi, Andrea Giovanni Bonanomi & Maria Stio. (2020) Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling. International Journal of Colorectal Disease 35:7, pages 1231-1242.
Crossref
Natalya N. Besednova, Tatyana S. Zaporozhets, Tatyana A. Kuznetsova, Ilona D. Makarenkova, Sergey P. Kryzhanovsky, Lydmila N. Fedyanina & Svetlana P. Ermakova. (2020) Extracts and Marine Algae Polysaccharides in Therapy and Prevention of Inflammatory Diseases of the Intestine. Marine Drugs 18:6, pages 289.
Crossref
Sarah Lechner, Matthew Yee, Berkeley N. Limketkai & Edward A. Pham. (2020) Fecal Microbiota Transplantation for Chronic Liver Diseases: Current Understanding and Future Direction. Digestive Diseases and Sciences 65:3, pages 897-905.
Crossref
Ran Xu, Niel A. Karrow, Umesh K. Shandilya, Lv-hui Sun & Haruki Kitazawa. (2020) In-Vitro Cell Culture for Efficient Assessment of Mycotoxin Exposure, Toxicity and Risk Mitigation. Toxins 12:3, pages 146.
Crossref

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