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Research Article

Mode of Action: Inhibition of Androgen Receptor Function—Vinclozolin-Induced Malformations in Reproductive Development

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Pages 721-726 | Published online: 10 Oct 2008

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Haroon Habib, Md Rafi Haider, Shikha Sharma, Shahzad Ahmad, Sadaf Dabeer, Mohammad Shahar Yar & Sheikh Raisuddin. (2020) Molecular interactions of vinclozolin metabolites with human estrogen receptors 1GWR-α and 1QKM and androgen receptor 2AM9-β: Implication for endocrine disruption. Toxicology Mechanisms and Methods 30:5, pages 370-377.
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Marycarmen Cruz-Hurtado, Ma de Lourdes López-González, Victor Mondragón & Adolfo Sierra-Santoyo. (2019) In vitro phase I metabolism of vinclozolin by human liver microsomes. Xenobiotica 49:8, pages 895-904.
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KathrynZ. Guyton, Stanley Barone$suffix/text()$suffix/text(), RebeccaC. Brown, SusanY. Euling, Jennifer Jinot & Susan Makris. (2008) Mode of Action Frameworks: A Critical Analysis. Journal of Toxicology and Environmental Health, Part B 11:1, pages 16-31.
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Alan R. Boobis, John E. Doe, Barbara Heinrich-Hirsch, M. E. (Bette) Meek, Sharon Munn, Mathuros Ruchirawat, Josef Schlatter, Jennifer Seed & Carolyn Vickers. (2008) IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans. Critical Reviews in Toxicology 38:2, pages 87-96.
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Daniele Marcoccia, Antonella Smeriglio, Alberto Mantovani, Domenico Trombetta & Stefano Lorenzetti. (2022) Intracellular distribution of vinclozolin and its metabolites differently affects 5α-dihydrotestosterone (DHT)-induced PSA secretion in LNCaP cells. Reproductive Toxicology 111, pages 83-91.
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Haiming Yu, Jinru Yang, Yujing Zhang, Hu Fu, Zhengli Yan & Yongfei Zhu. (2021) Vinclozolin-induced mouse penile malformation and “small testis” via miR132, miR195a together with the Hippo signaling pathway. Toxicology 460, pages 152842.
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