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Research Article

Methyl tertiary-Butyl Ether: Studies for Potential Human Health Hazards

Pages 319-358 | Published online: 10 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Emine Kaya Ekinci. (2022) Mesoporous magnesia sorbent for removal of organic contaminant methyl tert -butyl ether (MTBE) from water. Separation Science and Technology 57:6, pages 843-853.
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Kenneth T. Bogen & Jacqueline M. Heilman. (2015) Reassessment of MTBE cancer potency considering modes of action for MTBE and its metabolites. Critical Reviews in Toxicology 45:sup1, pages 1-56.
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James S. Bus, Marcy I. Banton, Willem D. Faber, Christopher R. Kirman, Douglas B. McGregor & Daniel B. Pourreau. (2015) Human health screening level risk assessments of tertiary-butyl acetate (TBAC): Calculated acute and chronic reference concentration (RfC) and Hazard Quotient (HQ) values based on toxicity and exposure scenario evaluations. Critical Reviews in Toxicology 45:2, pages 142-171.
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Williams Estève, Francine Lhuillier, Christel Ravera, Michel Grzebyck & Eddy Langlois. (2013) Developing a New Simplified Method to Determine Diffusive Uptake Rates of Volatile Organic Compounds in Workplaces Based on a Fractional Factorial Designs Approach. Journal of Occupational and Environmental Hygiene 10:9, pages 505-518.
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Douglas McGregor. (2010) Tertiary-Butanol: A toxicological review. Critical Reviews in Toxicology 40:8, pages 697-727.
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Douglas McGregor. (2007) Ethyl tertiary-Butyl Ether: A Toxicological Review. Critical Reviews in Toxicology 37:4, pages 287-312.
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George Cruzan & Daniel Kirkpatrick. (2006) Tertiary-butyl acetate metabolism, toxicity, and human health considerations. Toxicological & Environmental Chemistry 88:3, pages 405-421.
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Articles from other publishers (46)

Mingxiao Guo, Mengdi Li, Li Chen, Hanyun Wang, Jiajia Wang, Piye Niu & Junxiang Ma. (2023) Glutaminase 1 isoform up-regulation associated with lipid metabolism disorder induced by methyl tertiary-butyl ether in male rats. Ecotoxicology and Environmental Safety 255, pages 114763.
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Uchenna Estella Odoh & Chukwuma Onyegbulam Micheal. 2023. Management and Mitigation of Emerging Pollutants. Management and Mitigation of Emerging Pollutants 201 220 .
Chunrong Jia, Xianqiang Fu, Bhavin Chauhan, Zhuqing Xue, Reeva Joyce Kedia & Chaitanya S. Mishra. (2021) Exposure to volatile organic compounds (VOCs) at gas stations: a probabilistic analysis. Air Quality, Atmosphere & Health 15:3, pages 465-477.
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Z He, H Xian, M Tang, Y Chen, Z Lian, D Fang, X Peng & D Hu. (2021) DNA polymerase β may be involved in protecting human bronchial epithelial cells from the toxic effects induced by methyl tert-butyl ether exposure. Human & Experimental Toxicology 40:12, pages 2135-2144.
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Qidong Ren, Xinni Xie, Yue Tang, Qing Hu & Yuguo Du. (2021) Methyl tertiary-butyl ether inhibits THP-1 macrophage cholesterol efflux in vitro and accelerates atherosclerosis in ApoE-deficient mice in vivo. Journal of Environmental Sciences 101, pages 236-247.
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Aino Pelto-Huikko, Merja Ahonen, Mia Ruismäki, Tuija Kaunisto & Martti Latva. (2021) Migration of Volatile Organic Compounds (VOCs) from PEX-a Pipes into the Drinking Water during the First Five Years of Use. Materials 14:4, pages 746.
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Jinwen Wang, Yibing Mo, Brian T. McVerry, Shaily Mahendra, Richard B. Kaner & Eric M.V. Hoek. (2020) How permeable could a reverse osmosis membrane be if it was specifically developed for uncharged organic solute rejection?. AWWA Water Science 2:5.
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Harshada Sowani, Mohan Kulkarni & Smita Zinjarde. (2019) Harnessing the catabolic versatility of Gordonia species for detoxifying pollutants. Biotechnology Advances 37:3, pages 382-402.
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Guangshan Xie, Wen-Xu Hong, Li Zhou, Xifei Yang, Haiyan Huang, Desheng Wu, Xinfeng Huang, Weiguo Zhu & Jianjun Liu. (2017) An investigation of methyl tert-butyl ether-induced cytotoxicity and protein profile in Chinese hamster ovary cells. Molecular Medicine Reports 16:6, pages 8595-8604.
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Wolfgang Dekant, James Bridges & Anthony R. Scialli. (2017) A quantitative weight of evidence assessment of confidence in modes-of-action and their human relevance. Regulatory Toxicology and Pharmacology 90, pages 51-71.
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Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Lutz Edler, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Nebbia, Isabelle Oswald, Annette Petersen, Martin Rose, Alain‐Claude Roudot, Tanja Schwerdtle, Günter Vollmer, Heather Wallace, Bettina Grasl‐Kraupp, Konrad Grob, André Penninks, Marco Binaglia, Ruth Roldán Torres & Christiane Vleminckx. (2017) Scientific opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils. EFSA Journal 15:1.
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Dalin Hu, Jianping Yang, Yungang Liu, Wenjuan Zhang, Xiaowu Peng, Qinzhi Wei, Jianhui Yuan & Zhiliang Zhu. (2016) Health Risk Assessment for Inhalation Exposure to Methyl Tertiary Butyl Ether at Petrol Stations in Southern China. International Journal of Environmental Research and Public Health 13:2, pages 204.
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Li'e Zhang, Jian Qin, Zhiyong Zhang, Qin Li, Jiongli Huang, Xiaowu Peng, Li Qing, Guiqiang Liang, Linhan Liang, Yuman Huang, Xiaobo Yang & Yunfeng Zou. (2016) Concentrations and potential health risks of methyl tertiary-butyl ether (MTBE) in air and drinking water from Nanning, South China. Science of The Total Environment 541, pages 1348-1354.
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Jeffrey M. Bergthorson & Murray J. Thomson. (2015) A review of the combustion and emissions properties of advanced transportation biofuels and their impact on existing and future engines. Renewable and Sustainable Energy Reviews 42, pages 1393-1417.
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Akihiro Hagiwara, Yuko Doi, Norio Imai, Mayuko Suguro, Mayumi Kawabe, Fumio Furukawa, Seiko Tamano, Kasuke Nagano & Shoji Fukushima. (2015) Promotion of liver and kidney carcinogenesis by ethyl <i>tertiary</i>-butyl ether (ETBE) in male Wistar rats. Journal of Toxicologic Pathology 28:4, pages 189-195.
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Meng Lei, Lun Zhang, Jianjun Lei, Liang Zong, Jiahui Li, Zheng Wu & Zheng Wang. (2015) Overview of Emerging Contaminants and Associated Human Health Effects. BioMed Research International 2015, pages 1-12.
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Ann de Peyster & Ellen Mihaich. (2014) Hypothesis-driven weight of evidence analysis to determine potential endocrine activity of MTBE. Regulatory Toxicology and Pharmacology 69:3, pages 348-370.
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Ann de Peyster, Ellen Mihaich, Do Hyung Kim, William A. Elyea, Matthew J. Nemec, Brad P. Hirakawa & Shannon E. Leggieri. (2014) Responses of the steroidogenic pathway from exposure to methyl-tert-butyl ether and tert-butanol. Toxicology 319, pages 23-37.
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Anna Kakehashi, Akihiro Hagiwara, Norio Imai, Kasuke Nagano, Fukumi Nishimaki, Marcy Banton, Min Wei, Shoji Fukushima & Hideki Wanibuchi. (2013) Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: Evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways. Toxicology and Applied Pharmacology 273:2, pages 390-400.
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Ritva Karinen, Vigdis Vindenes, Inge Morild, Lene Johnsen, Ilah Le Nygaard & Asbjørg S. Christophersen. (2013) Methyl tert ‐Butyl Ether ( MTBE ) Detected in Abnormally High Concentrations in Postmortem Blood and Urine from Two Persons Found Dead Inside a Car Containing a Gasoline Spill . Journal of Forensic Sciences 58:5, pages 1393-1396.
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John Kozlosky, Josephine Bonventre & Keith Cooper. (2012) Methyl tert butyl ether is anti‐angiogenic in both in vitro and in vivo mammalian model systems . Journal of Applied Toxicology 33:8, pages 820-827.
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Darol Dodd, Gabrielle Willson, Horace Parkinson & Edilberto Bermudez. (2011) Two‐year drinking water carcinogenicity study of methyl tertiary‐butyl ether (MTBE) in Wistar rats. Journal of Applied Toxicology 33:7, pages 593-606.
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Arata Saito, Toshiaki Sasaki, Tatuya Kasai, Taku Katagiri, Tomoshi Nishizawa, Tadashi Noguchi, Shigetoshi Aiso, Kasuke Nagano & Shoji Fukushima. (2013) Hepatotumorigenicity of ethyl tertiary-butyl ether with 2-year inhalation exposure in F344 rats. Archives of Toxicology 87:5, pages 905-914.
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Tadashi Noguchi, Tomoyuki Kamigaito, Taku Katagiri, Hitomi Kondou, Kazunori Yamazaki, Shigetoshi Aiso, Tomoshi Nishizawa, Kasuke Nagano & Shoji Fukushima. (2013) Lack of micronucleus induction activity of ethyl <i>tertiary</i>-butyl ether in the bone marrow of F344 rats by sub-chronic drinking-water treatment, inhalation exposure, or acute intraperitoneal injection. The Journal of Toxicological Sciences 38:6, pages 913-924.
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Akihiro Hagiwara, Norio Imai, Yuko Doi, Mayuko Suguro, Mayumi Kawabe, Fumio Furukawa, Kasuke Nagano & Shoji Fukushima. (2013) No Promoting Effect of Ethyl <i>Tertiary</i>-butyl Ether (ETBE)on Rat Urinary Bladder Carcinogenesis Initiated with <i>N</i>-Butyl-<i>N</i>-(4-hydroxybutyl)nitrosamine. Journal of Toxicologic Pathology 26:4, pages 351-357.
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Edilberto Bermudez, Gabrielle Willson, Horace Parkinson & Darol Dodd. (2012) Toxicity of methyl tertiary-butyl ether (MTBE) following exposure of Wistar Rats for 13 weeks or one year via drinking water. Journal of Applied Toxicology 32:9, pages 687-706.
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Masaaki Suzuki, Kazunori Yamazaki, Hirokazu Kano, Shigetoshi Aiso, Kasuke Nagano & Shoji Fukushima. (2012) No carcinogenicity of ethyl <i>tertiary</i>-butyl ether by 2-year oral administration in rats. The Journal of Toxicological Sciences 37:6, pages 1239-1246.
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Kerstin Bluhm, Sebastian Heger, Thomas-Benjamin Seiler, Arnold V. Hallare, Andreas Schäffer & Henner Hollert. (2012) Toxicological and ecotoxicological potencies of biofuels used for the transport sector—a literature review. Energy & Environmental Science 5:6, pages 7381.
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Akihiro Hagiwara, Yuko Doi, Norio Imai, Hironao Nakashima, Takahiro Ono, Mayumi Kawabe, Fumio Furukawa, Seiko Tamano, Kasuke Nagano & Shoji Fukushima. (2011) Medium-term multi-organ carcinogenesis bioassay of ethyl tertiary-butyl ether in rats. Toxicology 289:2-3, pages 160-166.
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Aaron K. Grant, Elena Vinogradov, Xiaoen Wang, Robert E. Lenkinski & David C. Alsop. (2011) Perfusion imaging with a freely diffusible hyperpolarized contrast agent. Magnetic Resonance in Medicine 66:3, pages 746-755.
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Dongmei Li & Xiaodong Han. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 617 621 .
Susan J. Borghoff, Horace Parkinson & Teresa L. Leavens. (2010) Physiologically based pharmacokinetic rat model for methyl tertiary-butyl ether; comparison of selected dose metrics following various MTBE exposure scenarios used for toxicity and carcinogenicity evaluation. Toxicology 275:1-3, pages 79-91.
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Edward A. Lock & Gordon C. Hard. 2010. Cancer Risk Assessment. Cancer Risk Assessment 482 500 .
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Ann de Peyster. (2010) Ethyl t-butyl ether: review of reproductive and developmental toxicity. Birth Defects Research Part B: Developmental and Reproductive Toxicology, pages n/a-n/a.
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Ann de Peyster, Bradley Stanard & Christian Westover. (2009) Effect of ETBE on reproductive steroids in male rats and rat Leydig cell cultures. Toxicology Letters 190:1, pages 74-80.
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Teresa L. Leavens & Susan J. Borghoff. (2009) Physiologically Based Pharmacokinetic Model of Methyl Tertiary Butyl Ether and Tertiary Butyl Alcohol Dosimetry in Male Rats Based on Binding to α2u-Globulin. Toxicological Sciences 109:2, pages 321-335.
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Noushin Rastkari, Reza Ahmadkhaniha & Masud Yunesian. (2009) Single-walled carbon nanotubes as an effective adsorbent in solid-phase microextraction of low level methyl tert-butyl ether, ethyl tert-butyl ether and methyl tert-amyl ether from human urine. Journal of Chromatography B 877:14-15, pages 1568-1574.
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Dongmei Li, Qin Liu, Yi Gong, Yufeng Huang & Xiaodong Han. (2009) Cytotoxicity and oxidative stress study in cultured rat Sertoli cells with Methyl tert-butyl ether (MTBE) exposure. Reproductive Toxicology 27:2, pages 170-176.
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Scott Phillips, Robert B. Palmer & Aaron Brody. (2008) Epidemiology, toxicokinetics, and health effects of methyltert-butyl ether (MTBE). Journal of Medical Toxicology 4:2, pages 115-126.
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Julie E. Goodman, David Gaylor, Leslie A. Beyer, Lorenz R. Rhomberg & Barbara D. Beck. (2008) Effects of MTBE on the reported incidence of Leydig cell tumors in Sprague–Dawley rats: Range of possible Poly-3 results. Regulatory Toxicology and Pharmacology 50:3, pages 273-284.
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Tomasz Kuder & Paul Philp. (2007) Modern geochemical and molecular tools for monitoring in-situ biodegradation of MTBE and TBA. Reviews in Environmental Science and Bio/Technology 7:1, pages 79-91.
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George Cruzan, Susan J. Borghoff, Ann de Peyster, Gordon C. Hard, Michael McClain, Douglas B. McGregor & Michael G. Thomas. (2007) Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents. Regulatory Toxicology and Pharmacology 47:2, pages 156-165.
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Licia Scibetta, Laura Campo, Rosa Mercadante, Vito Foà & Silvia Fustinoni. (2007) Determination of low level methyl tert-butyl ether, ethyl tert-butyl ether and methyl tert-amyl ether in human urine by HS-SPME gas chromatography/mass spectrometry. Analytica Chimica Acta 581:1, pages 53-62.
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