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Research Article

Propylene Oxide: Genotoxicity Profile of a Rodent Nasal Carcinogen

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Pages 489-520 | Published online: 10 Oct 2008

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Annie M. Jarabek, Lynn H. Pottenger, Larry S. Andrews, Daniel Casciano, Michelle R. Embry, James H. Kim, R. Julian Preston, M. Vijayaraj Reddy, Rita Schoeny, David Shuker, Julie Skare, James Swenberg, Gary M. Williams & Errol Zeiger. (2009) Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization. Critical Reviews in Toxicology 39:8, pages 659-678.
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Lisa M. Sweeney, Christopher R. Kirman, Richard J. Albertini, Yu-Mei Tan, Harvey J. Clewell$suffix/text()$suffix/text(), Johannes G. Filser, György Csanády, Lynn H. Pottenger, Marcy I. Banton, Cynthia J. Graham, Larry S. Andrews, Raymond J. Papciak & Michael L. Gargas. (2009) Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: Example of a threshold carcinogen. Critical Reviews in Toxicology 39:6, pages 462-486.
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Articles from other publishers (24)

Timothy J. Wiegand. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 987 991 .
Joanna Klapacz & Claire Doskey. 2003. Patty's Toxicology. Patty's Toxicology 1 59 .
Seulgi Ji, Chanwon Park, Young Bum Lee, Seong K. Kim, Ki-Seok An & Sun Sook Lee. (2023) Sorption of hazardous industrial organic liquids with environmentally friendly functionalized cellulosic sorbents. Journal of Polymer Engineering 43:3, pages 243-253.
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Qi Liu, Yanjian Wan, Bing Zhu, Xinyan Xie, Kaiheng Zhu, Qi Jiang, Yanan Feng, Pei Xiao, Zhen Xiang, Xiaoqian Wu, Jiajia Zhang, Heng Meng & Ranran Song. (2022) Association between urinary propylene oxide metabolite and the risk of dyslexia. Environmental Pollution 292, pages 118469.
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Joanna Klapacz & B. Bhaskar Gollapudi. (2019) Considerations for the Use of Mutation as a Regulatory Endpoint in Risk Assessment. Environmental and Molecular Mutagenesis 61:1, pages 84-93.
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V. Sharma, P.B. Upton, J.A. Swenberg & D. La. 2018. Comprehensive Toxicology. Comprehensive Toxicology 68 86 .
Mugimane G. Manjanatha, Sharon D. Shelton, Ying Chen, Barbara L. Parsons, Meagan B. Myers, Karen L. McKim, B. Bhaskar Gollapudi, Nigel P. Moore, Lynne T. Haber, Bruce Allen & Martha M. Moore. (2017) Dose and temporal evaluation of ethylene oxide-induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations. Environmental and Molecular Mutagenesis 58:3, pages 122-134.
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M. Bader, P. Lämmlein & K. Klotz. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 11 .
Joanna Klapacz, Lynn H. Pottenger, Bevin P. Engelward, Christopher D. Heinen, George E. Johnson, Rebecca A. Clewell, Paul L. Carmichael, Yeyejide Adeleye & Melvin E. Andersen. (2016) Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents. Mutation Research/Reviews in Mutation Research 767, pages 77-91.
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Hermann M. Bolt. 2016. Thresholds of Genotoxic Carcinogens. Thresholds of Genotoxic Carcinogens 117 128 .
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H.A. Shojaei Saadi. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 1117 1119 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 19 .
M. Bader, P. Lämmlein & K. Klotz. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 10 .
Holger Baer, Massimo Bergamo, Anna Forlin, Lynn H. Pottenger & Joerg Lindner. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Lynn H. Pottenger, Darrell R. Boverhof & John M. WaechterJr.Jr.. 2003. Patty's Toxicology. Patty's Toxicology 425 490 .
Romualdo Benigni & Cecilia Bossa. (2011) Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology. Chemical Reviews 111:4, pages 2507-2536.
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David J. Snodin. (2010) Genotoxic Impurities: From Structural Alerts to Qualification. Organic Process Research & Development 14:4, pages 960-976.
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Charles L. Gaworski, Michael J. Oldham & Christopher R.E. Coggins. (2010) Toxicological considerations on the use of propylene glycol as a humectant in cigarettes. Toxicology 269:1, pages 54-66.
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Bo Hang. (2010) Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts. Journal of Nucleic Acids 2010, pages 1-29.
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D.K. La, P.B. Upton & J.A. Swenberg. 2010. Comprehensive Toxicology. Comprehensive Toxicology 63 83 .
Lynn H. Pottenger, Melissa R. Schisler, Fagen Zhang, Michael J. Bartels, Donald D. Fontaine, Lisa G. McFadden & B. Bhaskar Gollapudi. (2009) Dose–response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 678:2, pages 138-147.
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Mohammad D.H. Khan, Dominik Klein, Ilona Mossbrugger, Doris Oesterle, György A. Csanády, Letitia Quintanilla-Martinez & Johannes G. Filser. (2009) Is propylene oxide induced cell proliferation in rat nasal respiratory epithelium mediated by a severe depletion of water-soluble non-protein thiol?. Toxicology Letters 185:3, pages 203-210.
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Johannes G. Filser, Christoph Hutzler, Florian Rampf, Winfried Kessler, Thomas H. Faller, Edgar Leibold, Christian Pütz, Stefan Halbach & György A. Csanády. (2008) Concentrations of the Propylene Metabolite Propylene Oxide in Blood of Propylene-Exposed Rats and Humans—a Basis for Risk Assessment. Toxicological Sciences 102:2, pages 219-231.
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