1,017
Views
57
CrossRef citations to date
0
Altmetric
Review Articles

Thiazolidinedione drugs in the treatment of type 2 diabetes mellitus: past, present and future

, , &
Pages 52-108 | Received 07 Jun 2016, Accepted 02 Jul 2017, Published online: 17 Aug 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Vijay Kumar Sharma, Anup Barde & Sunita Rattan. (2021) A short review on synthetic strategies toward glitazone drugs. Synthetic Communications 51:1, pages 57-80.
Read now
John M Dennis, Beverley M Shields, Angus G Jones, Ewan R Pearson, Andrew T Hattersley & William E Henley. (2018) Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: a joint modeling approach. Clinical Epidemiology 10, pages 1869-1877.
Read now
Weifeng Huang, Liangliang Yao, Xiao He, Lei Wang, Mingxi Li, Youxin Yang & Chunpeng Wan. (2018) Hypoglycemic activity and constituents analysis of blueberry (Vaccinium corymbosum) fruit extracts. Diabetes, Metabolic Syndrome and Obesity 11, pages 357-366.
Read now

Articles from other publishers (54)

Kaiyue DingChongbin LiuLi LiMing YangNa JiangShilu LuoLin Sun. (2023) Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism. Chinese Medical Journal 136:21, pages 2521-2537.
Crossref
Ajinath Kale, Anshima Sharma, Hans-Joachim Anders & Anil Bhanudas Gaikwad. (2023) Diabetes and Cardiorenal Complications: A Clinical Review of Existing Therapies and Novel Combinations, Focusing on SGLT2 Inhibitors. Current Diabetes Reviews 19:8.
Crossref
Xiao-Wei Liu, Tian-Yu Shi, Dong Gao, Cai-Yi Ma, Hao Lin, Dan Yan & Ke-Jun Deng. (2023) iPADD: A Computational Tool for Predicting Potential Antidiabetic Drugs Using Machine Learning Algorithms. Journal of Chemical Information and Modeling 63:15, pages 4960-4969.
Crossref
Tarang Patel & Vatsal Patel. (2023) Thiazolidinediones: Recent Development in Analytical Methodologies. Journal of Chromatographic Science.
Crossref
Jieying Liu, Dongmei Wang, Ziyan Xie, Lu Ding, Shunhua Li, Xuemei Ma, Jing Liu, Jing Ren, Cheng Xiao, Chunru Yang & Xinhua Xiao. (2023) Combination of Pioglitazone and Metformin Actions on Liver Lipid Metabolism in Obese Mice. Biomolecules 13:8, pages 1199.
Crossref
Jian Yu, Yepeng Hu, Maozheng Sheng, Mingyuan Gao, Wenxiu Guo, Zhe Zhang, Dongmei Wang, Xia Wu, Jin Li, Yantao Chen, Wenjun Zhao, Caizhi Liu, Xiangdi Cui, Xin Chen, Cheng Zhao, Huang Chen, Junjie Xiao, Shijie Chen, Cheng Luo, Lingyan Xu, Xuejiang Gu & Xinran Ma. (2023) Selective PPARγ modulator diosmin improves insulin sensitivity and promotes browning of white fat. Journal of Biological Chemistry 299:4, pages 103059.
Crossref
Aikaterini Saiti, Alexandros Giannopoulos-Dimitriou, Ioannis Kazakos, Eleftheria Galatou & Ioannis S. Vizirianakis. (2023) Systems Pharmacology and Network Analysis to Advance Pharmacogenomics and Precision Medicine Decisions in Type-2 Diabetes Therapy. Future Pharmacology 3:1, pages 329-363.
Crossref
Domenico Accili, Wen Du, Takumi Kitamoto, Taiyi Kuo, Wendy McKimpson, Yasutaka Miyachi, Maria Mukhanova, Jinsook Son, Liheng Wang & Hitoshi Watanabe. (2022) Reflections on the state of diabetes research and prospects for treatment. Diabetology International 14:1, pages 21-31.
Crossref
Noori Mohammed Aziz & Wisam Sbhan Khalf Mohamed. (2022) Article Review: Biochemical Aspect of Survivin Hormone. Journal for Research in Applied Sciences and Biotechnology 1:5, pages 1-15.
Crossref
David Seung U. Lee & Howard Lee. (2022) Adherence and persistence rates of major antidiabetic medications: a review. Diabetology & Metabolic Syndrome 14:1.
Crossref
Roy A Goode, Julia M Hum & Michael A Kalwat. (2023) Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement. Endocrinology 164:1.
Crossref
Sean Irwin, Craig Karr, Craig Furman, Jennifer Tsai, Patricia Gee, Deepti Banka, Ardian S. Wibowo, Alexey A. Dementiev, Morgan O’Shea, Joyce Yang, Jason Lowe, Lorna Mitchell, Sabine Ruppel, Peter Fekkes, Ping Zhu, Manav Korpal & Nicholas A. Larsen. (2022) Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists. Journal of Biological Chemistry 298:11, pages 102539.
Crossref
Li Zhang, Xinzhou Wang & Xin Zhang. (2022) Modulation of Intestinal Flora by Dietary Polysaccharides: A Novel Approach for the Treatment and Prevention of Metabolic Disorders. Foods 11:19, pages 2961.
Crossref
Soree Ryang, Sang Soo Kim, Ji Cheol Bae, Ji Min Han, Su Kyoung Kwon, Young Il Kim, Il Seong Nam‐Goong, Eun Sook Kim, Mi‐kyung Kim, Chang Won Lee, Soyeon Yoo, Gwanpyo Koh, Min Jeong Kwon, Jeong Hyun Park & In Joo Kim. (2022) A double‐blind, Randomized controlled trial on glucose‐lowering EFfects and safety of adding 0.25 or 0.5 mg lobeglitazone in type 2 diabetes patients with INadequate control on metformin and dipeptidyl peptidase‐4 inhibitor therapy: REFIND study . Diabetes, Obesity and Metabolism 24:9, pages 1800-1809.
Crossref
Ya-han Liu, Yan Liu, Xu Zhang, Li Fang, Bei-lei Zhao & Nan-ping Wang. (2022) Activation of the endocannabinoid system mediates cardiac hypertrophy induced by rosiglitazone. Acta Pharmacologica Sinica 43:9, pages 2302-2312.
Crossref
Tomohito Mizuno, Nobuhiko Satoh, Shoko Horita, Hiroyuki Tsukada, Mayuko Takagi, Yusuke Sato, Haruki Kume, Masaomi Nangaku & Motonobu Nakamura. (2022) Oxidized alkyl phospholipids stimulate sodium transport in proximal tubules via a nongenomic PPARγ-dependent pathway. Journal of Biological Chemistry 298:3, pages 101681.
Crossref
Zhipeng Zhang, Yanqiu Meng, Zhan Wang, Yu Mei, Shite Gao, Yuejiao Wu & Shuxian Du. (2022) Discovery of Potent Glucokinase and PPARγ Dual-Target Agonists through an Innovative Scheme for Regioselective Modification of Silybin. ACS Omega 7:4, pages 3812-3822.
Crossref
Marialuigia Fantacuzzi, Rosa Amoroso & Alessandra Ammazzalorso. (2022) PPAR Ligands Induce Antiviral Effects Targeting Perturbed Lipid Metabolism during SARS-CoV-2, HCV, and HCMV Infection. Biology 11:1, pages 114.
Crossref
Haiyang Yu, Tong Sun, Xin He, Zhen Wang, Kaidong Zhao, Jing An, Lulu Wen, Jia-Yi Li, Wen Li & Juan Feng. (2022) Association between Parkinson’s Disease and Diabetes Mellitus: From Epidemiology, Pathophysiology and Prevention to Treatment. Aging and disease 13:6, pages 1591.
Crossref
Armand A. Krikorian & Angela Pauline P. Calimag. 2022. Diabetes and Kidney Disease. Diabetes and Kidney Disease 443 467 .
T. S. Panevin, M. S. Eliseev & E. L. Nasonov. (2021) Urate-lowering drugs in the treatment of gout: The unknown about the known. Rheumatology Science and Practice 59:6, pages 727-737.
Crossref
Manal Y. Sameeh, Manal M. Khowdiary, Hisham S. Nassar, Mahmoud M. Abdelall, Suliman A. Alderhami & Ahmed A. Elhenawy. (2021) Discovery Potent of Thiazolidinedione Derivatives as Antioxidant, α-Amylase Inhibitor, and Antidiabetic Agent. Biomedicines 10:1, pages 24.
Crossref
T. S. Panevin. (2021) Effect of oral antihyperglycemic drugs on purine metabolism. Diabetes mellitus 24:4, pages 342-349.
Crossref
Neng Xiong, Jin‐Rong Huang, Sheng Wei, Ji‐Wei Song, Zhong‐Ce Hu, Ya‐Ping Xue & Yu‐Guo Zheng. (2021) Hydrogenation involved in the chemical–biological synthesis of miglitol: effect of biological impurities on catalytic activity and catalyst reuse. Journal of Chemical Technology & Biotechnology 96:11, pages 3043-3051.
Crossref
Yiming Ma, Xinyi Du, Dandan Zhao, Kegong Tang, Xiaona Wang, Shaoting Guo, Xiaobei Li, Song Mei, Na Sun, Jiaqi Liu & Chengyu Jiang. (2021) 18:0 Lyso PC, a natural product with potential PPAR-γ agonistic activity, plays hypoglycemic effect with lower liver toxicity and cardiotoxicity in db/db mice. Biochemical and Biophysical Research Communications.
Crossref
Jana Blahova, Monika Martiniakova, Martina Babikova, Veronika Kovacova, Vladimira Mondockova & Radoslav Omelka. (2021) Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus. Pharmaceuticals 14:8, pages 806.
Crossref
Paulina Escandon, Brenda Vasini, Amy E. Whelchel, Sarah E. Nicholas, H. Greg Matlock, Jian-Xing Ma & Dimitrios Karamichos. (2021) The role of peroxisome proliferator-activated receptors in healthy and diseased eyes. Experimental Eye Research 208, pages 108617.
Crossref
Guido Gembillo, Ylenia Ingrasciotta, Salvatore Crisafulli, Nicoletta Luxi, Rossella Siligato, Domenico Santoro & Gianluca Trifirò. (2021) Kidney Disease in Diabetic Patients: From Pathophysiology to Pharmacological Aspects with a Focus on Therapeutic Inertia. International Journal of Molecular Sciences 22:9, pages 4824.
Crossref
W. David Strain, Su Down, Pam Brown, Amar Puttanna & Alan Sinclair. (2021) Diabetes and Frailty: An Expert Consensus Statement on the Management of Older Adults with Type 2 Diabetes. Diabetes Therapy 12:5, pages 1227-1247.
Crossref
Anna Veelen, Edmundo Erazo-Tapia, Jan Oscarsson & Patrick Schrauwen. (2021) Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?. Molecular Metabolism 46, pages 101158.
Crossref
Marcelo Borges Cavalcante, Candice Torres de Melo Bezerra Cavalcante, Ana Catherine Sampaio Braga, Dennyse Araújo Andrade, Mariana Albuquerque Montenegro, Paula Andrade Neiva Santos, Paula Vitória Pereira Motoyama, Marcelo Gondim Rocha, Luciana Azôr Dib & Edward Araujo Júnior. (2021) COVID-19 Treatment: Drug Safety Prior to Conception and During Pregnancy and Breastfeeding. Geburtshilfe und Frauenheilkunde 81:01, pages 46-60.
Crossref
Mette Simone Aae Madsen, Rikke Veggerby Grønlund, John Eid, Mikkel Christensen-Dalsgaard, Morten Sommer, Kristoffer Rigbolt, Martin Rønn Madsen, Jacob Jelsing, Niels Vrang, Henrik H. Hansen & Martin Mikkelsen. (2021) Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in diabetic db/db mice. Biomedicine & Pharmacotherapy 133, pages 110966.
Crossref
Charles E. Leonard, Colleen M. Brensinger, Ghadeer K. Dawwas, Rajat Deo, Warren B. Bilker, Samantha E. Soprano, Neil Dhopeshwarkar, James H. Flory, Zachary T. Bloomgarden, Joshua J. Gagne, Christina L. Aquilante, Stephen E. Kimmel & Sean Hennessy. (2020) The risk of sudden cardiac arrest and ventricular arrhythmia with rosiglitazone versus pioglitazone: real-world evidence on thiazolidinedione safety. Cardiovascular Diabetology 19:1.
Crossref
Michela Novelli, Pellegrino Masiello, Pascale Beffy & Marta Menegazzi. (2020) Protective Role of St. John’s Wort and Its Components Hyperforin and Hypericin against Diabetes through Inhibition of Inflammatory Signaling: Evidence from In Vitro and In Vivo Studies. International Journal of Molecular Sciences 21:21, pages 8108.
Crossref
Sin Gon Kim, Kyoung Jin Kim, Kun Ho Yoon, Sung Wan Chun, Kyong Soo Park, Kyung Mook Choi, Soo Lim, Ji‐Oh Mok, Hyoung Woo Lee, Ji A. Seo, Bong‐Soo Cha, Mi Kyung Kim, Ho Sang Shon, Dong Seop Choi & Doo Man Kim. (2020) Efficacy and safety of lobeglitazone versus sitagliptin as an add‐on to metformin in patients with type 2 diabetes with two or more components of metabolic syndrome over 24 weeks. Diabetes, Obesity and Metabolism 22:10, pages 1869-1873.
Crossref
Sonia Marlen Escandón-Rivera, Rachel Mata & Adolfo Andrade-Cetto. (2020) Molecules Isolated from Mexican Hypoglycemic Plants: A Review. Molecules 25:18, pages 4145.
Crossref
Clemens Engler, Marco Leo, Bernhard Pfeifer, Martin Juchum, Di Chen-Koenig, Karin Poelzl, Hans Schoenherr, David Vill, Juliana Oberdanner, Egon Eisendle, Klaus Middeldorf, Bernhard Heindl, Hannes Gaenzer, Gerald Bode, Karl Kirchmeyr, Guenther Ladner, Lisa Rieger, Ursula Koellensperger, Andrea Schwaiger, Florian Stoeckl, Guenther Zangerl, Monika Lechleitner, Irmgard Delmarko, Wilhelm Oberaigner, Clemens Rissbacher, Herbert Tilg & Christoph Ebenbichler. (2020) Long-term trends in the prescription of antidiabetic drugs: real-world evidence from the Diabetes Registry Tyrol 2012–2018. BMJ Open Diabetes Research & Care 8:1, pages e001279.
Crossref
Michael A. Hendley, Christopher Isely, Kendall P. Murphy, Hayley E. Hall, Prakasam Annamalai & R. Michael Gower. (2020) Scaffold Implant Into the Epididymal Adipose Tissue Protects Mice From High Fat Diet Induced Ectopic Lipid Accumulation and Hyperinsulinemia. Frontiers in Bioengineering and Biotechnology 8.
Crossref
Rubiya Khursheed, Sachin Kumar Singh, Sheetu Wadhwa, Bhupinder Kapoor, Monica Gulati, Rajan Kumar, Arya Kadukkattil Ramanunny, Ankit Awasthi & Kamal Dua. (2019) Treatment strategies against diabetes: Success so far and challenges ahead. European Journal of Pharmacology 862, pages 172625.
Crossref
Yuxi Chen, Liqiang Liu, Gang Cui, Xiaoling Wu, Hua Kuang & Chuanlai Xu. (2019) Development of an immunochromatographic strip for the detection of rosiglitazone in functional foods based on monoclonal antibodies. Analytical Methods 11:38, pages 4910-4916.
Crossref
Khalil Eskandari, Yaghoub Pourshojaei, Fatemeh Haghani, Mahnaz Shabani & Ali Asadipour. (2019) Synthesis, and molecular modeling of bis(3-(piperazine-1-yl)propyl)tungstate (BPPT) nanoparticles, and its first catalytic application for one-pot synthesis of 4H-chromene derivatives. Heliyon 5:9, pages e02426.
Crossref
Pedro Silvino Pereira, Maria do Carmo Alves de Lima, Pedro Paulo Marcelino Neto, Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Irwin Rose de Alencar Menezes, Jamerson Ferreira de Oliveira, Pascal Marchand, Henrique Douglas Melo Coutinho, Maria do Desterro Rodrigues & Teresinha Gonçalves da Silva. (2019) Thiazolidinedione and thiazole derivatives potentiate norfloxacin activity against NorA efflux pump over expression in Staphylococcus aureus 1199B strains. Bioorganic & Medicinal Chemistry 27:17, pages 3797-3804.
Crossref
Francesca Fiory, Giuseppe Perruolo, Ilaria Cimmino, Serena Cabaro, Francesca Chiara Pignalosa, Claudia Miele, Francesco Beguinot, Pietro Formisano & Francesco Oriente. (2019) The Relevance of Insulin Action in the Dopaminergic System. Frontiers in Neuroscience 13.
Crossref
Safikur Rahman, Md Tabish Rehman, Gulam Rabbani, Parvez Khan, Mohamed F AlAjmi, Md. Imtaiyaz Hassan, Ghazala Muteeb & Jihoe Kim. (2019) Insight of the Interaction between 2,4-thiazolidinedione and Human Serum Albumin: A Spectroscopic, Thermodynamic and Molecular Docking Study. International Journal of Molecular Sciences 20:11, pages 2727.
Crossref
Helena C. KennyE. Dale Abel. (2019) Heart Failure in Type 2 Diabetes Mellitus. Circulation Research 124:1, pages 121-141.
Crossref
ThushanDhananja Gooneratne & Gnaneswar Atturu. (2019) Introduction to translational research in vascular surgery/medicine. Indian Journal of Vascular and Endovascular Surgery 6:3, pages 162.
Crossref
Juliette Raffort, Fabien Lareyre, Marc Clément, Réda Hassen-Khodja, Giulia Chinetti & Ziad Mallat. (2018) Diabetes and aortic aneurysm: current state of the art. Cardiovascular Research 114:13, pages 1702-1713.
Crossref
Jeny Laskar, Kasturi Bhattacharjee, Mahuya Sengupta & Yashmin Choudhury. (2018) Anti-Diabetic Drugs: Cure or Risk Factors for Cancer?. Pathology & Oncology Research 24:4, pages 745-755.
Crossref
Eleni Xourgia, Athanasia Papazafiropoulou & Andreas Melidonis. (2018) Effects of antidiabetic drugs on epicardial fat. World Journal of Diabetes 9:9, pages 141-148.
Crossref
Domenico Accili. (2018) Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture. Diabetes 67:9, pages 1701-1709.
Crossref
Tao Fang, Yanbo Di, Guangkuo Li, Xiaoxu Cui, Na Shen, Yonghui Li, Peiqi Xi, Yun Xie, Fengshi Tian & Guangwei Li. (2018) Effects of telmisartan on TNFα induced PPARγ phosphorylation and insulin resistance in adipocytes. Biochemical and Biophysical Research Communications 503:4, pages 3044-3049.
Crossref
Hessah Al‑Muzafar & Kamal Amin. (2018) Thiazolidinedione induces a therapeutic effect on hepatosteatosis by regulating stearoyl‑CoA desaturase‑1, lipase activity, leptin and resistin. Experimental and Therapeutic Medicine.
Crossref
Reinhard Brunmeir & Feng Xu. (2018) Functional Regulation of PPARs through Post-Translational Modifications. International Journal of Molecular Sciences 19:6, pages 1738.
Crossref
Xiaoda Yang. 2018. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.