3,369
Views
13
CrossRef citations to date
0
Altmetric
Review Articles

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

ORCID Icon, ORCID Icon &
Pages 373-394 | Received 15 Mar 2021, Accepted 01 Jun 2021, Published online: 15 Jul 2021

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Tomoya Yamada, Brian G. Lake & Samuel M. Cohen. (2022) Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action. Critical Reviews in Toxicology 52:1, pages 1-31.
Read now

Articles from other publishers (10)

Ivonne M.C.M. Rietjens, Samuel M. Cohen, Gerhard Eisenbrand, Shoji Fukushima, Nigel J. Gooderham, F. Peter Guengerich, Stephen S. Hecht, Thomas J. Rosol, Jeanne M. Davidsen, Christie L. Harman & Sean V. Taylor. (2023) FEMA GRAS assessment of natural flavor complexes: Allspice, anise, fennel-derived and related flavoring ingredients. Food and Chemical Toxicology 174, pages 113643.
Crossref
Kenta Minami, Hidenori Suto, Akira Sato, Keiko Ogata, Tadashi Kosaka, Hitoshi Hojo, Naofumi Takahashi, Naruto Tomiyama, Takako Fukuda, Katsumasa Iwashita, Hiroaki Aoyama & Tomoya Yamada. (2023) Feasibility study for a downsized comparative thyroid assay with measurement of brain thyroid hormones and histopathology in rats: Case study with 6-propylthiouracil and sodium phenobarbital at high dose. Regulatory Toxicology and Pharmacology 137, pages 105283.
Crossref
Satoki Fukunaga, Keiko Ogata, Ayumi Eguchi, Kohei Matsunaga, Kengo Sakurai, Jun Abe, Samuel M. Cohen & Hiroyuki Asano. (2022) Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil. Regulatory Toxicology and Pharmacology 136, pages 105268.
Crossref
Takumi Sato, Ryota Shizu, Yoshie Miura, Takuomi Hosaka, Yuichiro Kanno, Takamitsu Sasaki & Kouichi Yoshinari. (2022) Development of a strategy to identify and evaluate direct and indirect activators of constitutive androstane receptor in rats. Food and Chemical Toxicology 170, pages 113510.
Crossref
Heike Sprenger, Josef Daniel Rasinger, Helen Hammer, Wael Naboulsi, Elke Zabinsky, Hannes Planatscher, Michael Schwarz, Oliver Poetz & Albert Braeuning. (2022) Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Archives of Toxicology 96:10, pages 2739-2754.
Crossref
Kouichi Yoshinari & Ryota Shizu. (2022) Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development. Drug Metabolism and Disposition 50:7, pages 1019-1026.
Crossref
Antonio Guzmán, Araceli Tortajada, Ana-Paz Marín, Cristina Vila & Gregorio Encina. (2022) Results from two-year rodent oral carcinogenicity studies of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator. Regulatory Toxicology and Pharmacology 132, pages 105182.
Crossref
Pengfei Zhao, Shicheng Fan, Yue Gao, Min Huang & Huichang Bi. (2022) Nuclear Receptor-Mediated Hepatomegaly and Liver Regeneration: An Update. Drug Metabolism and Disposition 50:5, pages 636-645.
Crossref
Keiko Ogata, Yang Liu, Ayako Ohara, Kensuke Kawamoto, Miwa Kondo, Kumiko Kobayashi, Takako Fukuda, Hiroyuki Asano, Sachiko Kitamoto, Brian G Lake, Samuel M Cohen & Tomoya Yamada. (2021) Club Cells Are the Primary Target for Permethrin-Induced Mouse Lung Tumor Formation. Toxicological Sciences 184:1, pages 15-32.
Crossref
Tomoya Yamada. (2021) Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Journal of Toxicologic Pathology 34:4, pages 283-297.
Crossref