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Leukemia & Lymphoma Volume 43, 2002 - Issue 2
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Research Article

Expression of the Multidrug Transporter P-glycoprotein is Highly Correlated with Clinical Outcome in Childhood Acute Lymphoblastic Leukemia: Results of a Long-Term Prospective Study

Catharina Dhooge Department of Pediatrics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
,
Barbara De Moerloose Department of Pediatrics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
,
Geneviève Laureys Department of Pediatrics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
,
Alice Ferster Department of Pediatrics Reine Fabiola, Brussels, Belgium
,
Dirk De Bacquer Department of Public Health, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
,
Jan Philippe Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
,
Jules Leroy Department of Pediatrics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
&
Yves Benoit Department of Pediatrics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
 show all
Pages 309-314 | Published online: 01 Jul 2009

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Ana Carolina Rabello de Moraes, Marley Aparecida Licínio, Júlio Araújo Zampirolo, Susie Coutinho Liedke, Joanita Ângela Gonzaga Del Moral, Marcos José Machado, Maria Luiza Bazzo & Maria Cláudia Santos da Silva. (2012) Evaluation of multidrug resistance in 46 newly diagnosed patients with acute leukemia. Hematology 17:2, pages 59-65.
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Arcadi I. Svirnovski, Tatsiana V. Shman, Tatsiana F. Serhiyenka, Valery P. Savitski, Victoria V. Smolnikova & Uladzimir U. Fedasenka. (2009) ABCB1 and ABCG2 proteins, their functional activity and gene expression in concert with drug sensitivity of leukemia cells. Hematology 14:4, pages 204-212.
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Bahareh Samii, Abbas Jafarian, Mohamad Rabbani, Behzad Zolfaghari, Soheila Rahgozar & Elnaz Pouraboutaleb. (2023) The effects of Astragalus polysaccharides, tragacanthin, and bassorin on methotrexate-resistant acute lymphoblastic leukemia. Research in Pharmaceutical Sciences 18:4, pages 381-391.
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Nathália Moreno Cury, Tobias Mühlethaler, Angelo Brunelli Albertoni Laranjeira, Rafael Renatino Canevarolo, Priscila Pini Zenatti, Daniel Lucena-Agell, Isabel Barasoain, Chunhua Song, Dongxiao Sun, Sinisa Dovat, Rosendo Augusto Yunes, Andrea Enrico Prota, Michel Olivier Steinmetz, José Fernando Díaz & José Andrés Yunes. (2019) Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia. iScience 21, pages 95-109.
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Rosanna K. Jackson, Julie A. E. Irving & Gareth J. Veal. (2016) Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia. British Journal of Haematology 173:1, pages 13-24.
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Alexander V. LyubimovSteven J. Wolf & Caroline G. Lee. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 40 .
Hairong Huo, Pellegrino G. Magro, E. Christy Pietsch, Brijesh B. Patel & Kathleen W. Scotto. (2010) Histone Methyltransferase MLL1 Regulates MDR1 Transcription and Chemoresistance . Cancer Research 70:21, pages 8726-8735.
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Maureen M. O'Brien, Norman J. Lacayo, Bert L. Lum, Smita Kshirsagar, Steven Buck, Yaddanapudi Ravindranath, Mark Bernstein, Howard Weinstein, Myron N. Chang, Robert J. Arceci, Branimir I. Sikic & Gary V. Dahl. (2010) Phase I study of valspodar (PSC‐833) with mitoxantrone and etoposide in refractory and relapsed pediatric acute leukemia: A report from the Children's Oncology Group. Pediatric Blood & Cancer 54:5, pages 694-702.
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Maria A.A. Cortez, Carlos A. Scrideli, José A. Yunes, Elvis T. Valera, Sílvia R.C. Toledo, Patrícia C.B. Pavoni‐Ferreira, Maria L.M. Lee, Antônio S. Petrilli, Silvia R. Brandalise & Luiz G. Tone. (2009) mRNA expression profile of multidrug resistance genes in childhood acute lymphoblastic leukemia. Low expression levels associated with a higher risk of toxic death. Pediatric Blood & Cancer 53:6, pages 996-1004.
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S. Balamurugan, D. Sugapriya, P. Shanthi, V. Thilaka, S. Venkatadesilalu, V. Pushpa & M. Madhavan. (2008) Multidrug resistance 1 gene expression and AgNOR in childhood acute leukemias. Indian Journal of Hematology and Blood Transfusion 23:3-4, pages 73-78.
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David A. Estes, Debbie M. Lovato, Hadya M. Khawaja, Stuart S. Winter & Richard S. Larson. (2007) Genetic alterations determine chemotherapy resistance in childhood T-ALL: modelling in stage-specific cell lines and correlation with diagnostic patient samples. British Journal of Haematology 139:1, pages 20-30.
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M. Kourti, N. Vavatsi, N. Gombakis, V. Sidi, G. Tzimagiorgis, T. Papageorgiou, D. Koliouskas & F. Athanassiadou. (2007) Expression of Multidrug Resistance 1 (MDR1), Multidrug Resistance-Related Protein 1 (MRP1), Lung Resistance Protein (LRP), and Breast Cancer Resistance Protein (BCRP) Genes and Clinical Outcome in Childhood Acute Lymphoblastic Leukemia. International Journal of Hematology 86:2, pages 166-173.
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T. V. Shman, V. P. Savitskii, M. P. Potapnev & O. V. Aleinikova. (2006) Study of expression and functional activity of P-GP membrane glycoprotein in children with acute leukemia. Bulletin of Experimental Biology and Medicine 141:6, pages 727-730.
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Katrien Swerts, Barbara De Moerloose, Catharina Dhooge, Geneviève Laureys, Yves Benoit & Jan Philippé. (2006) Prognostic significance of multidrug resistance-related proteins in childhood acute lymphoblastic leukaemia. European Journal of Cancer 42:3, pages 295-309.
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George S. Sheppard & Jennifer J. Bouska. (2005) Why optimize cancer drugs for ADMET?. Drug Discovery Today: Therapeutic Strategies 2:4, pages 343-349.
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Geraldo Barroso Cavalcanti, Flavia da Cunha Vasconcelos, Giselle Pinto de Faria, Marcos Ant�nio Maur�cio Scheiner, Jane de Almeida Dobbin, Claudete Esteves Klumb & Raquel C. Maia. (2004) Coexpression of p53 protein and MDR functional phenotype in leukemias: The predominant association in chronic myeloid leukemia. Cytometry 61B:1, pages 1-8.
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Sabine L.A Plasschaert, Willem A Kamps, Edo Vellenga, Elisabeth G.E de Vries & Eveline S.J.M de Bont. (2004) Prognosis in childhood and adult acute lymphoblastic leukaemia: a question of maturation?. Cancer Treatment Reviews 30:1, pages 37-51.
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R W Stam, M M van den Heuvel-Eibrink, M L den Boer, M E G Ebus, G E Janka-Schaub, J D Allen & R Pieters. (2003) Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein. Leukemia 18:1, pages 78-83.
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William W. Johnson. 2004. Cellular Drug Delivery. Cellular Drug Delivery 129 162 .
C Martin, J Walker, A Rothnie & R Callaghan. (2003) The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models. British Journal of Cancer 89:8, pages 1581-1589.
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. (2002) Current Awareness in Hematological Oncology. Hematological Oncology 20:4, pages 189-196.
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