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Leukemia & Lymphoma Volume 43, 2002 - Issue 2
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Research Article

Induction of Apoptosis by Cladribine (2-CdA), Gemcitabine and Other Chemotherapeutic Drugs on CD34 + /CD38 + and CD34 + /CD38 - Hematopoietic Progenitor Cells: Selective Effects of Doxorubicin and 2-CdA with Protection of Immature Cells

Kai U. Chow Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
,
Simone Boehrer Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
,
Joerg Bojunga Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
,
Manuela Stieler Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
,
Mathias J. Rummel Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
,
Florian Fauth Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
,
Bernd Schneider Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
,
Hans Martin Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
,
Dieter Hoelzer Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
,
Eckhart Weidmann Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
&
Paris S. Mitrou Departments of Internal Medicine III, Hematology/Oncology, and Internal Medicine I, Endocrinology, Johann Wolfgang Goethe-UniversityHospital, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
 show all
Pages 377-384 | Published online: 04 Apr 2011

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Pradeep Pant, Amita Pathak & B. Jayaram. (2023) Bicyclo-DNA mimics with enhanced protein binding affinities: insights from molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 41:9, pages 4040-4047.
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Federico Carlini, Federico Ivaldi, Francesca Gualandi, Ursula Boschert, Diego Centonze, Giuseppe Matarese, Marco Salvetti, Nicole Kerlero de Rosbo & Antonio Uccelli. (2021) Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kinase Activity Linked to Activation Status. Journal of Neuroimmune Pharmacology 17:1-2, pages 195-205.
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Pradeep Pant, Amita Pathak & B. Jayaram. (2021) Symmetric Nucleosides as Potent Purine Nucleoside Phosphorylase Inhibitors. The Journal of Physical Chemistry B 125:11, pages 2856-2862.
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Pradeep Pant & Maria Fisher. (2021) Marshall's nucleic acid: From double-helical structure to a potent intercalator. Biophysical Chemistry 269, pages 106525.
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Marcus J.C. Long, Yi Zhao & Yimon Aye. (2020) Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis. Cell Chemical Biology 27:1, pages 122-133.e5.
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Pradeep Pant & B. Jayaram. (2019) C5′ omitted DNA enhances bendability and protein binding. Biochemical and Biophysical Research Communications 514:3, pages 979-984.
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Dustin CarrollDaret K. St. Clair. (2018) Hematopoietic Stem Cells: Normal Versus Malignant . Antioxidants & Redox Signaling 29:16, pages 1612-1632.
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Marian Jędrych, Ewelina Wawryk-Gawda, Barbara Jodłowska-Jędrych, Patrycja Chylińska-Wrzos & Ludwik Jasiński. (2013) Immunohistochemical evaluation of cell proliferation and apoptosis markers in ovarian surface epithelial cells of cladribine-treated rats. Protoplasma 250:5, pages 1025-1034.
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Thomas P. Leist & Robert Weissert. (2011) Cladribine. Clinical Neuropharmacology 34:1, pages 28-35.
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Armen A. Galoyan, Josef Krieglstein, Susanne Klumpp, Kristina E. Danielian, Karine A. Galoian, Wolfram Kremers, Kristina B. Bezirganyan & Tigran K. Davtyan. (2007) Effect of Hypothalamic Proline-Rich Peptide (PRP-1) on Neuronal and Bone Marrow Cell Apoptosis. Neurochemical Research 32:11, pages 1898-1905.
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C. Nickenig, M. Dreyling, E. Hoster, W.-D. Ludwig, B. Dörken, M. Freund, C. Huber, A. Ganser, L. Trümper, R. Forstpointner, M. Unterhalt & W. Hiddemann. (2007) Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas—results of a randomized comparison by the German Low-Grade Lymphoma Study Group. Annals of Oncology 18:1, pages 136-142.
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Tasha Gray, Erin L. Morrey, Bagirath Gangadharan, Takita F. Sumter, Jozef Spychala, David R. Archer & H. Trent Spencer. (2005) Enforced expression of cytosolic 5′-nucleotidase I confers resistance to nucleoside analogues in vitro but systemic chemotherapy toxicity precludes in vivo selection. Cancer Chemotherapy and Pharmacology 58:1, pages 117-128.
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Alvin Y. Liu, Martine P. Roudier & Lawrence D. True. (2004) Heterogeneity in Primary and Metastatic Prostate Cancer as Defined by Cell Surface CD Profile. The American Journal of Pathology 165:5, pages 1543-1556.
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A. Marczak, D. Łubgan, T. Robak & Z. Jóźwiak. (2004) Influence of 2-chlorodeoxyadenosine (cladribine) on human erythrocytes. The International Journal of Biochemistry & Cell Biology 36:8, pages 1645-1654.
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