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Research Article

Bone Morphogenetic Protein (BMP)-2 Induces Apoptosis in Human Myeloma Cells

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Pages 635-639 | Published online: 01 Jul 2009

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Read on this site (3)

Haralampos TH Dinopoulos & Peter V Giannoudis. (2006) Safety and efficacy of use of demineralised bone matrix in orthopaedic and trauma surgery. Expert Opinion on Drug Safety 5:6, pages 847-866.
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Paul J Harwood & Peter V Giannoudis. (2005) Application of bone morphogenetic proteins in orthopaedic practice: their efficacy and side effects. Expert Opinion on Drug Safety 4:1, pages 75-89.
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Quan Chen, Subrata Ray, Mohamad A. Hussein, Gordan Srkalovic & Alexandru Almasan. (2003) Role of Apo2L/TRAIL and Bcl-2-family Proteins in Apoptosis of Multiple Myeloma. Leukemia & Lymphoma 44:7, pages 1209-1214.
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Articles from other publishers (36)

Kyungsoo Kim, Mi Gyeom Kim & Gyun Min Lee. (2023) Improving bone morphogenetic protein (BMP) production in CHO cells through understanding of BMP synthesis, signaling and endocytosis. Biotechnology Advances 62, pages 108080.
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Jing Gao, Ryusuke Muroya, Fei Huang, Kengo Nagata, Masashi Shin, Ryoko Nagano, Yudai Tajiri, Shinsuke Fujii, Takayoshi Yamaza, Kazuhiro Aoki, Yukihiko Tamura, Mayuko Inoue, Sakura Chishaki, Toshio Kukita, Koji Okabe, Miho Matsuda, Yoshihide Mori, Tamotsu Kiyoshima & Eijiro Jimi. (2021) Bone morphogenetic protein induces bone invasion of melanoma by epithelial–mesenchymal transition via the Smad1/5 signaling pathway. Laboratory Investigation 101:11, pages 1475-1483.
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Rebecca E. Andrews, Janet E. Brown, Michelle A. Lawson & Andrew D. Chantry. (2021) Myeloma Bone Disease: The Osteoblast in the Spotlight. Journal of Clinical Medicine 10:17, pages 3973.
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Bum Sik Tae, Seok Cho, Hyun Cheol Kim, Cheol Hwan Kim, Seok Ho Kang, Jeong Gu Lee, Je Jong Kim, Hong Seok Park, Jun Cheon, Mi Mi Oh & Sung Gu Kang. (2018) Decreased expression of bone morphogenetic protein-2 is correlated with biochemical recurrence in prostate cancer: Immunohistochemical analysis. Scientific Reports 8:1.
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Charlotte Lagler, Mohamed El-Mesery, Alexander Christian Kübler, Urs Dietmar Achim Müller-Richter, Thorsten Stühmer, Joachim Nickel, Thomas Dieter Müller, Harald Wajant & Axel Seher. (2017) The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent. PLOS ONE 12:10, pages e0185720.
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Axel Seher, Charlotte Lagler, Thorsten Stühmer, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Walter Sebald, Thomas Dieter Müller & Joachim Nickel. (2017) Utilizing BMP-2 muteins for treatment of multiple myeloma. PLOS ONE 12:5, pages e0174884.
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Ximao Cui, Yili Yang, Deshui Jia, Ying Jing, Shouhua Zhang, Shan Zheng, Long Cui, Rui Dong & Kuiran Dong. (2017) Downregulation of bone morphogenetic protein receptor 2 promotes the development of neuroblastoma. Biochemical and Biophysical Research Communications 483:1, pages 609-616.
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Khaled Waleed Zaid, Mansour Chantiri & Ghassan Bassit. (2016) Recombinant Human Bone Morphogenetic Protein-2 in Development and Progression of Oral Squamous Cell Carcinoma. Asian Pacific Journal of Cancer Prevention 17:3, pages 927-932.
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Yozo Mitsui, Hiroshi Hirata, Naoko Arichi, Miho Hiraki, Hiroaki Yasumoto, Inik Chang, Shinichiro Fukuhara, Soichiro Yamamura, Varahram Shahryari, Guoren Deng, Sharanjot Saini, Shahana Majid, Rajvir Dahiya, Yuichiro Tanaka & Hiroaki Shiina. (2015) Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways. Oncotarget 6:11, pages 9577-9591.
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SEBASTIAN WOLF, BEATE HAGL & ROLAND KAPPLER. (2014) Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma. International Journal of Oncology 44:5, pages 1727-1735.
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Alexander P. Hughes, Fadi Taher, Mazda Farshad & Alexander Aichmair. (2014) Multiple myeloma exacerbation following utilization of bone morphogenetic protein-2 in lateral lumbar interbody fusion: a case report and review of the literature. The Spine Journal 14:4, pages e13-e19.
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Ashley M. Driver, Wen Huang, Jenna Kropp, Francisco Peñagaricano & Hasan Khatib. (2013) Knockdown of CDKN1C (p57kip2) and PHLDA2 Results in Developmental Changes in Bovine Pre-implantation Embryos. PLoS ONE 8:7, pages e69490.
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Laura C. Bridgewater, Jaime L. Mayo, Bradley G. Evanson, Megan E. Whitt, Spencer A. Dean, Joshua D. Yates, Devin N. Holden, Alina D. Schmidt, Christopher L. Fox, Saroj Dhunghel, Kevin S. Steed, Michael M. Adam, Caitlin A. Nichols, Sampath K. Loganathan, Jeffery R. Barrow & Chad R. Hancock. (2013) A Novel Bone Morphogenetic Protein 2 Mutant Mouse, , Displays Impaired Intracellular Handling in Skeletal Muscle. BioMed Research International 2013, pages 1-11.
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Sharon L. Hyzy, Rene Olivares-Navarrete, Zvi Schwartz & Barbara D. Boyan. (2012) BMP2 induces osteoblast apoptosis in a maturation state and noggin-dependent manner. Journal of Cellular Biochemistry 113:10, pages 3236-3245.
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Michelle J. Connolly & Philip I. Aaronson. (2011) Key role of the RhoA/Rho kinase system in pulmonary hypertension. Pulmonary Pharmacology & Therapeutics 24:1, pages 1-14.
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Jenny E Felin, Jaime L Mayo, Trina J Loos, J Daniel Jensen, Daniel K Sperry, Stephanie L Gaufin, Christopher A Meinhart, Jennie B Moss & Laura C Bridgewater. (2010) Nuclear variants of bone morphogenetic proteins. BMC Cell Biology 11:1.
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Yong Park, Myoung Hee Kang, Hee Yeon Seo, Joong Min Park, Chul Won Choi, Yeul Hong Kim, In Sun Kim, Jun Suk Kim & Sang Cheul Oh. (2009) Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression. Medical Oncology 27:4, pages 1192-1199.
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Nikolai N. Nørgaard, Toril Holien, Sofia Jönsson, Hanne Hella, Terje Espevik, Anders Sundan & Therese Standal. (2010) CpG-Oligodeoxynucleotide Inhibits Smad-Dependent Bone Morphogenetic Protein Signaling: Effects on Myeloma Cell Apoptosis and In Vitro Osteoblastogenesis. The Journal of Immunology 185:6, pages 3131-3139.
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Danka Grčević, Rajko Kušec, Nataša Kovačić, Anita Lukić, Ivan Krešimir Lukić, Sanja Ivčević, Damir Nemet, Ranka Serventi Seiwerth, Slobodanka Kolonić Ostojić, Peter I. Croucher & Ana Marušić. (2010) Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leukemia Research 34:6, pages 742-751.
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Cecilia Wei Lin Lee, Kosei Ito & Yoshiaki Ito. (2010) Role of RUNX3 in Bone Morphogenetic Protein Signaling in Colorectal Cancer. Cancer Research 70:10, pages 4243-4252.
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Qiming Fan, Tingting Tang, Xiaoling Zhang & Kerong Dai. (2008) The role of CCAAT/enhancer binding protein (C/EBP)‐α in osteogenesis of C3H10T1/2 cells induced by BMP‐2. Journal of Cellular and Molecular Medicine 13:8b, pages 2489-2505.
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Brian Van Ness, Christine Ramos, Majda Haznadar, Antje Hoering, Jeff Haessler, John Crowley, Susanna Jacobus, Martin Oken, Vincent Rajkumar, Philip Greipp, Bart Barlogie, Brian Durie, Michael Katz, Gowtham Atluri, Gang Fang, Rohit Gupta, Michael Steinbach, Vipin Kumar, Richard Mushlin, David Johnson & Gareth Morgan. (2008) Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival. BMC Medicine 6:1.
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Xin Li, Angela Pennisi & Shmuel Yaccoby. (2008) Role of decorin in the antimyeloma effects of osteoblasts. Blood 112:1, pages 159-168.
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Yong ParkJee Won KimDae Sik KimEui Bae KimSe Jong ParkJin Yong ParkWoo Suk ChoiJong Gyu SongHee Yun SeoSang Cheul OhByung Soo KimJong Jae ParkYeul Hong KimJun Suk Kim. (2008) The Bone Morphogenesis Protein-2 (BMP-2) is Associated with Progression to Metastatic Disease in Gastric Cancer. Cancer Research and Treatment 40:3, pages 127.
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Wook Jin, Chohee Yun, Hae-Suk Kim & Seong-Jin Kim. (2007) TrkC Binds to the Bone Morphogenetic Protein Type II Receptor to Suppress Bone Morphogenetic Protein Signaling. Cancer Research 67:20, pages 9869-9877.
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Ambros Huber, Gernot Hudelist, Martin Knöfler, Leila Saleh, Johannes C. Huber & Christian F. Singer. (2007) Effect of highly purified human chorionic gonadotropin preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of human chorionic gonadotropin in vivo. Fertility and Sterility 88:4, pages 1232-1239.
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Brigitte L. Thériault, Trevor G. Shepherd, Michelle L. Mujoomdar & Mark W. Nachtigal. (2007) BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells. Carcinogenesis 28:6, pages 1153-1162.
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Isaac Yi Kim & Seong Jin Kim. (2006) Role of bone morphogenetic proteins in transitional cell carcinoma cells. Cancer Letters 241:1, pages 118-123.
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N Fukuda, M Saitoh, N Kobayashi & K Miyazono. (2006) Execution of BMP-4-induced apoptosis by p53-dependent ER dysfunction in myeloma and B-cell hybridoma cells. Oncogene 25:25, pages 3509-3517.
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Isaac Yi Kim, Dong-Hyeon Lee, Dug Keun Lee, Wun Jae Kim, Moses M. Kim, Ronald A. Morton, Seth P. Lerner & Seong Jin Kim. (2004) Restoration of Bone Morphogenetic Protein Receptor Type II Expression Leads to a Decreased Rate of Tumor Growth in Bladder Transitional Cell Carcinoma Cell Line TSU-Pr1. Cancer Research 64:20, pages 7355-7360.
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Isaac Yi Kim, Dong-Hyeon Lee, Dug Keun Lee, Han-Jong Ahn, Moses M Kim, Seong Jin Kim & Ronald A Morton. (2004) Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells. Oncogene 23:46, pages 7651-7659.
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Shunichi Shimasaki, R. Kelly Moore, Fumio Otsuka & Gregory F. Erickson. (2004) The Bone Morphogenetic Protein System In Mammalian Reproduction. Endocrine Reviews 25:1, pages 72-101.
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Joachim H. Clement & Stefan Wölfl. 2004. Bone Morphogenetic Proteins: Regeneration of Bone and Beyond. Bone Morphogenetic Proteins: Regeneration of Bone and Beyond 267 292 .
K.D. Brubaker, E. Corey, L.G. Brown & R.L. Vessella. (2003) Bone morphogenetic protein signaling in prostate cancer cell lines. Journal of Cellular Biochemistry 91:1, pages 151-160.
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Jong G. Kim, Jian H. Song, Jeffrey L. Vallet, Gary A. Rohrer, Greg A. Johnson, Margaret M. Joyce & Ronald K. Christenson. (2003) Molecular Characterization and Expression of Porcine Bone Morphogenetic Protein Receptor-IB in the Uterus of Cyclic and Pregnant Gilts1. Biology of Reproduction 68:3, pages 735-743.
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Masahiro Kizaki, Tomonori Nakazato, Keisuke Ito, Chiharu Kawamura, Yoshitaka Miyakawa & Yasuo Ikeda. (2002) A novel therapeutic approach for hematological malignancies based on cellular differentiation and apoptosis. International Journal of Hematology 76:S1, pages 250-252.
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