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Leukemia & Lymphoma Volume 43, 2002 - Issue 5
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Research Article

Serum Tryptase Measurements in Patients with Myelodysplastic Syndromes

W. R. Sperr Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
B. Stehberger Institute of Pathology, University of Tübingen, Tübingen, Germany
,
F. Wimazal Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
M. Baghestanian Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
L. B. Schwartz Division of Rheumatology, Allergy & Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
,
M. Kundi Institute of Environmental Hygiene, University of Vienna, Vienna, Austria
,
H. Semper Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
J-H. Jordan Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
A. Chott Department of Clinical Pathology, University of Vienna, Vienna, Austria
,
J. Drach Division of Oncology, Department of Internal Medicine I, University of Vienna, Vienna, Austria
,
U. Jäger Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
K. Geissler Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
A. Greschniok Institute of Pathology, University of Tübingen, Tübingen, Germany
,
H-P. Horny Institute of Pathology, University of Tübingen, Tübingen, Germany
,
K. Lechner Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
&
P. Valent Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
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Pages 1097-1105 | Published online: 25 May 2011

Citations (50)

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Read on this site (4)

Peter Valent, Wolfgang R Sperr, Karl Sotlar, Andreas Reiter, Cem Akin, Jason Gotlib, Hans-Peter Horny & Michel Arock. (2014) The serum tryptase test: an emerging robust biomarker in clinical hematology. Expert Review of Hematology 7:5, pages 683-690.
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Wolfgang R Sperr & Peter Valent. (2012) Diagnosis, progression patterns and prognostication in mastocytosis. Expert Review of Hematology 5:3, pages 261-274.
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Animesh Pardanani & Ayalew Tefferi. (2006) A role for tryptase in myeloid disorders?. Leukemia & Lymphoma 47:5, pages 789-790.
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Peter Valent, Cem Akin, Wolfgang Sperr, Matthias Mayerhofer, Manuela Födinger, Robert Fritsche-Polanz, Karl Sotlar, Luis Escribano, Michel Arock, Hans-Peter Horny & Dean Metcalfe. (2005) Mastocytosis: Pathology, genetics, and current options for therapy. Leukemia & Lymphoma 46:1, pages 35-48.
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Articles from other publishers (46)

Peter Valent, Gregor Hoermann, Patrizia Bonadonna, Karin Hartmann, Wolfgang R. Sperr, Sigurd Broesby-Olsen, Knut Brockow, Marek Niedoszytko, Olivier Hermine, Yannick Chantran, Joseph H. Butterfield, Georg Greiner, Melody C. Carter, Vito Sabato, Deepti H. Radia, Frank Siebenhaar, Massimo Triggiani, Theo Gülen, Ivan Alvarez-Twose, Thomas Staudinger, Ludwig Traby, Karl Sotlar, Andreas Reiter, Hans-Peter Horny, Alberto Orfao, Stephen J. Galli, Lawrence B. Schwartz, Jonathan J. Lyons, Jason Gotlib, Dean D. Metcalfe, Michel Arock & Cem Akin. (2023) The Normal Range of Baseline Tryptase Should Be 1 to 15 ng/mL and Covers Healthy Individuals With HαT. The Journal of Allergy and Clinical Immunology: In Practice 11:10, pages 3010-3020.
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Roberta Parente, Valentina Giudice, Chiara Cardamone, Bianca Serio, Carmine Selleri & Massimo Triggiani. (2023) Secretory and Membrane-Associated Biomarkers of Mast Cell Activation and Proliferation. International Journal of Molecular Sciences 24:8, pages 7071.
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Shana De Vos, Kristel Demeyere, Hilde De Cock, Nausikaa Devriendt, Ilona Schwarzkopf, Ruth Fortrie, Tom Roggeman, Evelyne Meyer, Ward De Spiegelaere & Hilde de Rooster. (2022) Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms. Research in Veterinary Science 151, pages 90-95.
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S. François, E. Collet, P. Nicaise Roland & H. Chabane. (2022) Tryptase : un dosage, une formule, plusieurs indications. Revue Française d'Allergologie 62:7, pages 604-608.
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Aubri M. Waters, Hyun J. Park, Andrew L. Weskamp, Allyson Mateja, Megan E. Kachur, Jonathan J. Lyons, Benjamin J. Rosen & Nathan A. Boggs. (2022) Elevated Basal Serum Tryptase: Disease Distribution and Variability in a Regional Health System. The Journal of Allergy and Clinical Immunology: In Practice 10:9, pages 2424-2435.e5.
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Michael P. O’Connell & Jonathan J. Lyons. (2022) Resolving the genetics of human tryptases: implications for health, disease, and clinical use as a biomarker. Current Opinion in Allergy & Clinical Immunology 22:2, pages 143-152.
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Francesca Gobbo, Giuseppe Sarli, Margherita De Silva, Giorgia Galiazzo, Roberto Chiocchetti & Maria Morini. (2021) A Double Histochemical/Immunohistochemical Staining for the Identification of Canine Mast Cells in Light Microscopy. Veterinary Sciences 8:10, pages 229.
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Anca Angela Simionescu, Ana Maria Alexandra Stanescu & Florin-Dan Popescu. (2021) State-of-the-Art on Biomarkers for Anaphylaxis in Obstetrics. Life 11:9, pages 870.
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Bettina Sprinzl, Georg Greiner, Goekhan Uyanik, Michel Arock, Torsten Haferlach, Wolfgang R. Sperr, Peter Valent & Gregor Hoermann. (2021) Genetic Regulation of Tryptase Production and Clinical Impact: Hereditary Alpha Tryptasemia, Mastocytosis and Beyond. International Journal of Molecular Sciences 22:5, pages 2458.
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H. Lobbes, Q. Reynaud, S. Mainbourg, J.C. Lega, I. Durieu & S. Durupt. (2020) Dosage de la tryptase : un guide d'utilisation pour le clinicien. La Revue de Médecine Interne 41:11, pages 748-755.
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Adrian Y.S. Lee. (2020) Elevated Serum Tryptase in Non-Anaphylaxis Cases: A Concise Review. International Archives of Allergy and Immunology 181:5, pages 357-364.
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Giovanni Paolino, Paola Corsetti, Elisa Moliterni, Serena Corsetti, Dario Didona, Marcello Albanesi, Carlo Mattozzi, Paolo Lido & Stefano Calvieri. (2019) Mast cells and cancer. Giornale Italiano di Dermatologia e Venereologia 154:6.
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Stefan Platzgummer, Laura Caponi, Vittorio Sargentini, Daniela Visentini, Ignazio Brusca, Nicola Bizzaro, Giampaola Pesce, Marcello Bagnasco, Gaia Deleonardi, Beatrice Caruso, Antonio Antico, Chiara Bonaguri, Maria Pompilia Visconti, Bruno Milanesi, Pierfrancesco Agostini, Maura Musso & Danilo Villalta. (2019) Raccomandazioni sull'uso della triptasi nella diagnosi dell'anafilassi e della mastocitosi. La Rivista Italiana della Medicina di Laboratorio 15:3.
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Peter Valent, Cem Akin, Patrizia Bonadonna, Karin Hartmann, Knut Brockow, Marek Niedoszytko, Boguslaw Nedoszytko, Frank Siebenhaar, Wolfgang R. Sperr, Joanna N.G. Oude Elberink, Joseph H. Butterfield, Ivan Alvarez-Twose, Karl Sotlar, Andreas Reiter, Hanneke C. Kluin-Nelemans, Olivier Hermine, Jason Gotlib, Sigurd Broesby-Olsen, Alberto Orfao, Hans-Peter Horny, Massimo Triggiani, Michel Arock, Lawrence B. Schwartz & Dean D. Metcalfe. (2019) Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome. The Journal of Allergy and Clinical Immunology: In Practice 7:4, pages 1125-1133.e1.
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Peter Valent, Patrizia Bonadonna, Karin Hartmann, Sigurd Broesby-Olsen, Knut Brockow, Joseph H. Butterfield, Massimo Triggiani, Jonathan J. Lyons, Joanna N.G. Oude Elberink, Michel Arock, Dean D. Metcalfe & Cem Akin. (2019) Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome. International Archives of Allergy and Immunology 180:1, pages 44-51.
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Michaela KopkaMichael J. MonumentA. Dean BefusMei ZhangDavid A. HartPaul T. SaloPrism S. SchneiderCun-Yi Fan, Xiangdang LiangAlexandra GarvenKevin A. Hildebrand. (2017) Serum Mast Cell Tryptase as a Marker of Posttraumatic Joint Contracture in a Rabbit Model. Journal of Orthopaedic Trauma 31:3, pages e86-e89.
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Feryal Abbas Ibrahim Hilmi, Ahmad Al-Sabbagh, Dina Sameh Soliman, Hesham Al SabahOmar Mohammad IsmailMohamed YassinHalima El-Omri. (2017) Acute Myeloid Leukemia With Inv(16)(p13q22) Associated With Hidden Systemic Mastocytosis: Case Report and Review of Literature. Clinical Medicine Insights: Blood Disorders 10, pages 1179545X1770085.
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Jie Shen Fok, Pravin Hissaria, Pratyush Giri, Robert Heddle & William Smith. (2013) Acquired angioedema with raised serum tryptase. Annals of Allergy, Asthma & Immunology 110:1, pages 59-60.
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I. ALVAREZ-TWOSE, J. M. MORGADO, L. SÁNCHEZ-MUÑOZ, A. GARCÍA-MONTERO, M. MOLLEJO, A. ORFAO & L. ESCRIBANO. (2012) Current state of biology and diagnosis of clonal mast cell diseases in adults. International Journal of Laboratory Hematology 34:5, pages 445-460.
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Animesh Pardanani. (2012) Systemic Mastocytosis. Hematology/Oncology Clinics of North America 26:5, pages 1117-1128.
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Alberto Álvarez-Larrán, Jordi Rimola, Francisco Lomeña & María Rozman. (2012) Varón de 67 años con dolor abdominal, esplenomegalia, adenopatías y alteraciones de la densidad ósea. Medicina Clínica 139:7, pages 300-306.
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Luis Escribano, Andrés Garcia‐Montero, Laura Sanchez‐Muñoz, Cristina Teodosio, Ivan Alvarez‐Twose, Maria Jara‐Acevedo, José Mario Morgado, Julia Almeida & Alberto Orfao. 2012. Laboratory Hematology Practice. Laboratory Hematology Practice 388 398 .
Didem Ozdemir, Selcuk Dagdelen & Tomris Erbas. (2011) Systemic Mastocytosis. The American Journal of the Medical Sciences 342:5, pages 409-415.
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Laura Sánchez-Muñoz, Ivan Alvarez-Twose, Andrés C García-Montero, Cristina Teodosio, María Jara-Acevedo, Carlos E Pedreira, Almudena Matito, Jose Mario T Morgado, Maria Luz Sánchez, Manuela Mollejo, David Gonzalez-de-Olano, Alberto Orfao & Luis Escribano. (2011) Evaluation of the WHO criteria for the classification of patients with mastocytosis. Modern Pathology 24:9, pages 1157-1168.
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Dale R. Shepard. 2011. Supportive Oncology. Supportive Oncology 10 15 .
Laura Sánchez-Muñoz, Cristina Teodósio, José M. Morgado & Luis Escribano. 2011. Recent Advances in Cytometry, Part B - Advances in Applications. Recent Advances in Cytometry, Part B - Advances in Applications 333 359 .
Peter Valent, Attilio Orazi, Guntram Büsche, Annette Schmitt-Gräff, Tracy I. George, Karl Sotlar, Berthold Streubel, Christine Beham-Schmid, Sabine Cerny-Reiterer, Otto Krieger, Arjan van de Loosdrecht, Wolfgang Kern, Kiyoyuki Ogata, Friedrich Wimazal, Judit Csomor, Judit Várkonyi, Wolfgang R. Sperr, Martin Werner, Hans Kreipe & Hans-Peter Horny. (2010) Standards and Impact of Hematopathology in Myelodysplastic Syndromes (MDS). Oncotarget 1:7, pages 483-496.
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Karl Sotlar, Sema Colak, Anja Bache, Sabina Berezowska, Manuela Krokowski, Burkhard Bültmann, Peter Valent & Hans‐Peter Horny. (2010) Variable presence of KIT D816V in clonal haematological non‐mast cell lineage diseases associated with systemic mastocytosis (SM–AHNMD) . The Journal of Pathology 220:5, pages 586-595.
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Franziska Ruëff, Bernhard Przybilla, Maria Beatrice Biló, Ulrich Müller, Fabian Scheipl, Werner Aberer, Joëlle Birnbaum, Anna Bodzenta-Lukaszyk, Floriano Bonifazi, Christoph Bucher, Paolo Campi, Ulf Darsow, Cornelia Egger, Gabrielle Haeberli, Thomas Hawranek, Michael Körner, Iwona Kucharewicz, Helmut Küchenhoff, Roland Lang, Oliviero Quercia, Norbert Reider, Maurizio Severino, Michael Sticherling, Gunter Johannes Sturm & Brunello Wüthrich. (2009) Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: Importance of baseline serum tryptase—a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity. Journal of Allergy and Clinical Immunology 124:5, pages 1047-1054.
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W. R. Sperr, A. El-Samahi, M. Kundi, M. Girschikofsky, S. Winkler, D. Lutz, G. Endler, H. Rumpold, H. Agis, C. Sillaber, U. Jäger & P. Valent. (2009) Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology. European Journal of Clinical Investigation 39:10, pages 914-923.
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Luis Escribano, Iván Álvarez-Twose, Laura Sánchez-Muñoz, Andres Garcia-Montero, Rosa Núñez, Julia Almeida, Maria Jara-Acevedo, Cristina Teodósio, Mónica García-Cosío, Carmen Bellas & Alberto Orfao. (2009) Prognosis in adult indolent systemic mastocytosis: A long-term study of the Spanish Network on Mastocytosis in a series of 145 patients. Journal of Allergy and Clinical Immunology 124:3, pages 514-521.
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Malisha R Johnson, Srdan Verstovsek, Jeffrey L Jorgensen, T Manshouri, Raja Luthra, Dan M Jones, Carlos E Bueso-Ramos, L Jeffrey Medeiros & Yang O Huh. (2008) Utility of the World Heath Organization classification criteria for the diagnosis of systemic mastocytosis in bone marrow. Modern Pathology 22:1, pages 50-57.
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Helen M. Shields, Kitt Shaffer, Richard P. O’Farrell, Robin Travers, Jane N. Hayward, Laren S. Becker & Gregory Y. Lauwers. (2007) Gastrointestinal Manifestations of Dermatologic Disorders. Clinical Gastroenterology and Hepatology 5:9, pages 1010-1017.
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Peter Valent, Hans-Peter Horny, John M. Bennett, Christa Fonatsch, Ulrich Germing, Peter Greenberg, Torsten Haferlach, Detlef Haase, Hans-Jochen Kolb, Otto Krieger, Michael Loken, Arjan van de Loosdrecht, Kiyoyuki Ogata, Alberto Orfao, Michael Pfeilstöcker, Björn Rüter, Wolfgang R. Sperr, Reinhard Stauder & Denise A. Wells. (2007) Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference. Leukemia Research 31:6, pages 727-736.
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Mrinal M. PatnaikMichelle RindosPeter A. KouidesAyalew TefferiAnimesh Pardanani. (2007) Systemic Mastocytosis: A Concise Clinical and Laboratory Review. Archives of Pathology & Laboratory Medicine 131:5, pages 784-791.
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Franziska Ruëff, Marianne Placzek & Bernhard Przybilla. (2006) Mastocytosis and Hymenoptera venom allergy. Current Opinion in Allergy & Clinical Immunology 6:4, pages 284-288.
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Lawrence B. Schwartz. (2006) Diagnostic Value of Tryptase in Anaphylaxis and Mastocytosis. Immunology and Allergy Clinics of North America 26:3, pages 451-463.
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Peter Valent. (2006) Diagnostic Evaluation and Classification of Mastocytosis. Immunology and Allergy Clinics of North America 26:3, pages 515-534.
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Jamie Robyn & Dean D. Metcalfe. 2006. 169 243 .
Hermine Agis, Karl Sotlar, Peter Valent & Hans-Peter Horny. (2005) Ph-Chromosome-positive chronic myeloid leukemia with associated bone marrow mastocytosis. Leukemia Research 29:10, pages 1227-1232.
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Hae-Ki Min, George Moxley, Michael C Neale & Lawrence B Schwartz. (2004) Effect of sex and haplotype on plasma tryptase levels in healthy adults. Journal of Allergy and Clinical Immunology 114:1, pages 48-51.
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Peter Valent, Wolfgang R Sperr, Lawrence B Schwartz & Hans-Peter Horny. (2004) Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non–mast cell hematopoietic neoplasms. Journal of Allergy and Clinical Immunology 114:1, pages 3-11.
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Luis Escribano, Andrés Garcı́a-Montero, Rosa Núñez-López, Javier López-Jiménez, Julia Almeida, Aranzazu Prados & Alberto Orfao. (2004) Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis. Journal of Allergy and Clinical Immunology 114:1, pages 28-33.
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Joseph H. Butterfield & Chin-Yang Li. (2004) Bone Marrow Biopsies for the Diagnosis of Systemic Mastocytosis: Is One Biopsy Sufficient?. American Journal of Clinical Pathology 121:2, pages 264-267.
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Peter Valent, Cem Akin, Wolfgang R. Sperr, Hans-P. Horny, Michel Arock, Klaus Lechner, John M. Bennett & Dean D. Metcalfe. (2003) Diagnosis and treatment of systemic mastocytosis: state of the art. British Journal of Haematology 122:5, pages 695-717.
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Lawrence B. Schwartz, Hae-Ki Min, Shunlin Ren, Han-Zhang Xia, Jiang Hu, Wei Zhao, George Moxley & Yoshihiro Fukuoka. (2003) Tryptase Precursors Are Preferentially and Spontaneously Released, Whereas Mature Tryptase Is Retained by HMC-1 Cells, Mono-Mac-6 Cells, and Human Skin-Derived Mast Cells. The Journal of Immunology 170:11, pages 5667-5673.
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