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Leukemia & Lymphoma Volume 44, 2003 - Issue 11
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Research Article

Conventional Dose Fludarabine-based Regimens are Effective but have Excessive Toxicity in Elderly Patients with Refractory Chronic Lymphocytic Leukemia

Lev Shvidel On behalf of the Israeli Study Group on CLL, Hematology Institute Kaplan Medical Center 76100 Rehovot Israel
,
Mordechai Shtalrid On behalf of the Israeli Study Group on CLL, Hematology Institute Kaplan Medical Center 76100 Rehovot Israel
,
Osnat Bairey Hematology Institute Rabin Medical Center Beilinson Campus Petah Tikva Israel
,
Naomi Rahimi-Levene Hematology Institute Assaf Harofeh Medical Center Zerifin Israel
,
Gilles Lugassy Hematology Institute Barzilai Medical Center Ashkelon Israel
,
Ofer Shpilberg Hematology Institute Soroka University Medical Center Beer-Sheva Israel
,
Aaron Polliack Hematology Department Hadassah University Hospital Jerusalem Israel
&
Alain Berrebi On behalf of the Israeli Study Group on CLL, Hematology Institute Kaplan Medical Center 76100 Rehovot Israel
 show all
Pages 1947-1950 | Published online: 01 Jul 2009

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Caroline Dartigeas, Eric Van Den Neste, Christian Berthou, Hervé Maisonneuve, Stéphane Leprêtre, Marie-Sarah Dilhuydy, Marie-Christine Béné, Florence Nguyen-Khac, Rémi Letestu, Florence Cymbalista, Sophie De Guibert, Thérèse Aurran, Kamel Laribi, Jean-Pierre Vilque, Olivier Tournilhac, Alain Delmer, Pierre Feugier, Bruno Cazin, Anne-Sophie Michallet, Vincent Lévy, Xavier Troussard, Roselyne Delepine, Elsa Tavernier, Philippe Colombat & Véronique Leblond. (2016) Evaluating abbreviated induction with fludarabine, cyclophosphamide, and dose-dense rituximab in elderly patients with chronic lymphocytic leukemia. Leukemia & Lymphoma 57:2, pages 328-334.
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Zahra Mozaheb. (2014) Treating the elderly patient with chronic lymphocytic leukemia: current and emerging options. Blood and Lymphatic Cancer: Targets and Therapy 4, pages 9-14.
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Alberto Fabbri, Emanuele Cencini, Luigi Rigacci, Giulia Bartalucci, Benedetta Puccini, Roberto Dottori, Alessandro Gozzetti, Alberto Bosi & Monica Bocchia. (2014) Efficacy and safety of rituximab plus low-dose oral fludarabine and cyclophosphamide as first-line treatment of elderly patients with indolent non-Hodgkin lymphomas. Leukemia & Lymphoma 55:4, pages 781-785.
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Ilaria Del Giudice, Francesca Romana Mauro & Robin Foà. (2011) Chronic lymphocytic leukemia in less fit patients: “slow-go”. Leukemia & Lymphoma 52:12, pages 2207-2216.
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Barbara Eichhorst, Valentin Goede & Michael Hallek. (2009) Treatment of elderly patients with chronic lymphocytic leukemia. Leukemia & Lymphoma 50:2, pages 171-178.
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Valentin Goede & Michael Hallek. (2011) Optimal Pharmacotherapeutic Management of Chronic Lymphocytic Leukaemia. Drugs & Aging 28:3, pages 163-176.
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Melhem Solh & Punit Wadhwa. 2011. Pulmonary Involvement in Patients with Hematological Malignancies. Pulmonary Involvement in Patients with Hematological Malignancies 715 723 .
Wei‐Gang Tong & Alessandra Ferrajoli. 2010. Leukemias: Principles and Practice of Therapy. Leukemias: Principles and Practice of Therapy 327 337 .
Vicki A. Morrison. (2010) Infectious complications of chronic lymphocytic leukaemia: pathogenesis, spectrum of infection, preventive approaches. Best Practice & Research Clinical Haematology 23:1, pages 145-153.
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Lukáš Smolej. (2010) How I Treat Elderly or Comorbid Patients with Chronic Lymphocytic Leukemia. Acta Medica (Hradec Kralove, Czech Republic) 53:4, pages 213-220.
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Lev ShvidelMirel CohnErica Sigler. (2009) Pharmacotherapy Update: Fludarabine in the Treatment of Non-Hodgkin's Lymphoma. Clinical Medicine. Therapeutics 1, pages CMT.S2553.
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Sean A. Grimm & Lisa M. Deangelis. 2008. Neurology and General Medicine. Neurology and General Medicine 523 545 .
Alberto Fabbri, Mariapia Lenoci, Alessandro Gozzetti, Ida Chitarrelli, Francesca Olcese, Donatella Raspadori, Marco Gobbi & Francesco Lauria. (2007) Low-dose oral fludarabine plus cyclophosphamide as first-line treatment in elderly patients with indolent non-Hodgkin lymphoma. British Journal of Haematology 139:1, pages 90-93.
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Tait D. Shanafelt, Thomas Lin, Susan M. Geyer, Clive S. Zent, Nelson Leung, Brian Kabat, Deborah Bowen, Michael R. Grever, John C. Byrd & Neil E. Kay. (2007) Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia. Cancer 109:11, pages 2291-2298.
Crossref
Vicki A. Morrison. (2007) Management of Infectious Complications in Patients with Chronic Lymphocytic Leukemia. Hematology 2007:1, pages 332-338.
Crossref
Margaret K. Yu. (2006) Epigenetics and chronic lymphocytic leukemia. American Journal of Hematology 81:11, pages 864-869.
Crossref
Tadeusz Robak. (2005) Therapy of Chronic Lymphocytic Leukaemia with Purine Nucleoside Analogues. Drugs & Aging 22:12, pages 983-1012.
Crossref
. (2004) Current Awareness in Hematological Oncology. Hematological Oncology 22:2, pages 73-84.
Crossref
. (2004) Current awareness: Pharmacoepidemiology and drug safety. Pharmacoepidemiology and Drug Safety 13:2, pages 117-132.
Crossref

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