Citations (42)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Tingyun Xu, Yiwei Zhu, Shuaishuai Ge & Song-Bai Liu. (2023) The roles of TPL in hematological malignancies. Hematology 28:1.
Read now
Read now
Yan Huang, Sun Wu, Yuan Zhang, Lihua Wang & Yan Guo. (2018) Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial–mesenchymal transition via regulating the PI3K/AKT/mTOR pathway. OncoTargets and Therapy 11, pages 769-779.
Read now
Read now
Xin Huang, Min Yang & Jie Jin. (2012) Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs. Leukemia & Lymphoma 53:6, pages 1188-1195.
Read now
Read now
Articles from other publishers (39)
Tariq Khan, Muhammad Ali, Ajmal Khan, Parveen Nisar, Sohail Ahmad Jan, Shakeeb Afridi & Zabta Khan Shinwari. (2019) Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects. Biomolecules 10:1, pages 47.
Crossref
Crossref
Wei Hou, Bo Liu & Hongtao Xu. (2019) Triptolide: Medicinal chemistry, chemical biology and clinical progress. European Journal of Medicinal Chemistry 176, pages 378-392.
Crossref
Crossref
Bowen Dong, Zirui Liang, Zhirong Chen, Bin Li, Lingling Zheng, Jianhua Yang, Hui Zhou & Lianghu Qu. (2018) Cryptotanshinone suppresses key onco-proliferative and drug-resistant pathways of chronic myeloid leukemia by targeting STAT5 and STAT3 phosphorylation. Science China Life Sciences 61:9, pages 999-1009.
Crossref
Crossref
Xu Jun. 2016. Cancer Inhibitors from Chinese Natural Medicines. Cancer Inhibitors from Chinese Natural Medicines
193
276
.
Claudia Villicaña, Grisel Cruz & Mario Zurita. (2014) The basal transcription machinery as a target for cancer therapy. Cancer Cell International 14:1.
Crossref
Crossref
Yisheng LiuErhui XiaoLin YuanGuofeng Li. (2014)
Triptolide Synergistically Enhances Antitumor Activity of Oxaliplatin in Colon Carcinoma
In Vitro
and
In Vivo
. DNA and Cell Biology 33:7, pages 418-425.
Crossref
Crossref
Jianyuan Wu, Qingdi Quentin Li, Huiping Zhou, Yinying Lu, Jueli M. Li, Yao Ma, Li Wang, Tingting Fu, Xingjiang Gong, Michael Weintraub, Shuangchan Wu & Hong Ding. (2014) Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas. Medical Oncology 31:7.
Crossref
Crossref
TOMONORI NAKAZATO, MORIHIKO SAGAWA & MASAHIRO KIZAKI. (2014) Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1. International Journal of Oncology 44:4, pages 1131-1138.
Crossref
Crossref
L Liu, G Li, Q Li, Z Jin, L Zhang, J Zhou, X Hu, T Zhou, J Chen & N Gao. (2013) Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation. Cell Death & Disease 4:12, pages e941-e941.
Crossref
Crossref
FU-SHIN CHUEH, YUNG-LIANG CHEN, SHU-CHUN HSU, JAI-SING YANG, SHU-CHING HSUEH, BIN-CHUAN JI, HSU-FENG LU & JING-GUNG CHUNG. (2013) Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes. Oncology Reports 29:2, pages 613-618.
Crossref
Crossref
Mei Huang, Hailong Zhang, Tao Liu, Dan Tian, Lubing Gu & Muxiang Zhou. (2013) Triptolide Inhibits MDM2 and Induces Apoptosis in Acute Lymphoblastic Leukemia Cells through a p53-Independent Pathway. Molecular Cancer Therapeutics 12:2, pages 184-194.
Crossref
Crossref
Tareq Al Baghdadi, Rafat Abonour & H. Scott Boswell. (2012) Novel Combination Treatments Targeting Chronic Myeloid Leukemia Stem Cells. Clinical Lymphoma Myeloma and Leukemia 12:2, pages 94-105.
Crossref
Crossref
Kwong‐Fai Wong, Yi Yuan & John M Luk. (2012)
Tripterygium wilfordii
bioactive compounds as anticancer and anti‐inflammatory agents
. Clinical and Experimental Pharmacology and Physiology 39:3, pages 311-320.
Crossref
Crossref
B Z Carter, D H Mak, Y Shi, J M Fidler, R Chen, X Ling, W Plunkett & M Andreeff. (2011) MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML. Leukemia 26:3, pages 443-450.
Crossref
Crossref
Lu Wen, Yan Chen, Ling-lan Zeng, Fei Zhao, Rui Li, Yuan Liu & Chun Zhang. (2011) Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B. Acta Pharmacologica Sinica 33:1, pages 109-119.
Crossref
Crossref
Mei-qiang Cai, Xiao-hong Chen, Shi-wei He, Xiao-kun OuYang & Mi-cong Jin. (2011) Determination of four pyridine alkaloids from Tripterygium wilfordii Hook. f. in human plasma by high-performance liquid chromatography coupled with mass spectrometry. Journal of Chromatography B 879:30, pages 3516-3522.
Crossref
Crossref
Hai-tao Meng, Li Zhu, Wan-mao Ni, Liang-shun You, Jie Jin & Wen-bin Qian. (2011) Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*. Acta Pharmacologica Sinica 32:4, pages 503-511.
Crossref
Crossref
Ming Chen, Zhiqiang Lv & Shanping Jiang. (2011) The effects of triptolide on airway remodelling and transforming growth factor-β1/Smad signalling pathway in ovalbumin-sensitized mice. Immunology 132:3, pages 376-384.
Crossref
Crossref
Qiuyan Liu. (2011) Triptolide and its expanding multiple pharmacological functions. International Immunopharmacology 11:3, pages 377-383.
Crossref
Crossref
Bing Zhou, Huanyu Tang, Huijin Feng & Yuanchao Li. (2011) First total synthesis of tripdiolide. Tetrahedron 67:5, pages 904-909.
Crossref
Crossref
Gui-Sheng Zhou, Zheng Hu, Hai-Tong Fang, Feng-Xiang Zhang, Xiao-Fen Pan, Xiao-Qin Chen, An-Mei Hu, Ling Xu & Guang-Biao Zhou. (2011) Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells. Leukemia Research 35:2, pages 214-218.
Crossref
Crossref
Su-Wen Yang, Wei Wang, Xin-You Xie, Wan-Ping Zhu & Fang-Qiong Li. (2012)
In Vitro
Synergistic Cytotoxic Effect of Triptolide Combined with Hydroxycamptothecin on Pancreatic Cancer Cells
. The American Journal of Chinese Medicine 39:01, pages 121-134.
Crossref
Crossref
Zhao-Li Zhou, Zhi-Guo Luo, Bing Yu, Yi Jiang, Yi Chen, Jian-Ming Feng, Mei Dai, Lin-Jiang Tong, Zheng Li, Yuan-Chao Li, Jian Ding & Ze-Hong Miao. (2010) Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide. Molecular Cancer 9:1.
Crossref
Crossref
Fei Zhao, Yan Chen, Linglan Zeng, Rui Li, Rong Zeng, Lu Wen, Yuan Liu & Chun Zhang. (2010) Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells. European Journal of Pharmacology 646:1-3, pages 1-11.
Crossref
Crossref
Yuan Liu, Ling-lan Zeng, Yan Chen, Fei Zhao, Rui Li, Chun Zhang & Lu Wen. (2010) Triptolide inhibits cell growth and induces G0- G1 arrest by regulating P21wap1/cip1 and P27 kip1 in human multiple myeloma RPMI-8226 cells. Chinese Journal of Cancer Research 22:2, pages 141-147.
Crossref
Crossref
Ming‐Fang He, Yi‐Hsien Huang, Li‐Wha Wu, Wei Ge, Pang‐Chui Shaw & Paul Pui‐Hay But. (2009) Triptolide functions as a potent angiogenesis inhibitor. International Journal of Cancer 126:1, pages 266-278.
Crossref
Crossref
Duncan H. Mak, Wendy D. Schober, Wenjing Chen, Marina Konopleva, Jorge Cortes, Hagop M. Kantarjian, Michael Andreeff & Bing Z. Carter. (2009) Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells. Molecular Cancer Therapeutics 8:9, pages 2509-2516.
Crossref
Crossref
Wenbo Zhu, Yanqiu Ou, Yan Li, Ru Xiao, Minfeng Shu, Yuehan Zhou, Jun Xie, Songmin He, Pengxin Qiu & Guangmei Yan. (2009) A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma Cells via Down-Regulation of the Nuclear Factor-κB Pathway. Molecular Pharmacology 75:4, pages 812-819.
Crossref
Crossref
Xianping Shi, Yanli Jin, Chao Cheng, Hui Zhang, Waiyi Zou, Qin Zheng, Zhongzheng Lu, Qi Chen, Yingrong Lai & Jingxuan Pan. (2009) Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation. Clinical Cancer Research 15:5, pages 1686-1697.
Crossref
Crossref
Mi-cong Jin, Xiao-hong Chen & Xiao-kun OuYang. (2009) Simultaneous determination of triptolide, tripdiolide and tripterine in human urine by high-performance liquid chromatography coupled with ion trap atmospheric-pressure chemical ionization mass spectrometry. Biomedical Chromatography 23:3, pages 289-294.
Crossref
Crossref
Ming-Fang He, Lin Liu, Wei Ge, Pang-Chui Shaw, Renwang Jiang, Li-Wha Wu & Paul Pui-Hay But. (2009) Antiangiogenic activity of Tripterygium wilfordii and its terpenoids. Journal of Ethnopharmacology 121:1, pages 61-68.
Crossref
Crossref
Kun-bai Chen, Mei-qiang Cai, Xiao-hong Chen & Mi-cong Jin. (2008) Quantitative Analysis of Triptolide in Human Whole Blood by LC–APCI-IT-MS-MS. Chromatographia 67:3-4, pages 225-230.
Crossref
Crossref
Wei Wang, Shanmin Yang, Ying Su, Zhenyu Xiao, Chunyou Wang, Xinfeng Li, Ling Lin, Bruce M. Fenton, Scott F. Paoni, Ivan Ding, Peter Keng, Paul Okunieff & Lurong Zhang. (2007) Enhanced Antitumor Effect of Combined Triptolide and Ionizing Radiation. Clinical Cancer Research 13:16, pages 4891-4899.
Crossref
Crossref
Xiao-yan Tang, You-qing Zhu, Wen-hui Tao, Bai Wei & Xiao-ling Lin. (2007) Synergistic effect of triptolide combined with 5-fluorouracil on colon carcinoma. Postgraduate Medical Journal 83:979, pages 338-343.
Crossref
Crossref
Xiangmin TONG, Shui'er ZHENG, Jie JIN, Lifen ZHU, Yinjun LOU & Hangping YAO. (2007) Triptolide Inhibits Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in Human Colon Cancer and Leukemia Cells. Acta Biochimica et Biophysica Sinica 39:2, pages 89-95.
Crossref
Crossref
Chun ZHANG, Guo-hui CUI, Fang LIU, Qiu-ling WU & Yan CHEN. (2006) Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin lymphoma by regulating SDF-1/CXCR4 axis in vitro. Acta Pharmacologica Sinica 27:11, pages 1438-1446.
Crossref
Crossref
Bing Z. CarterDuncan H. MakWendy D. SchoberTeresa McQueenDavid HarrisZeev EstrovRandall L. EvansMichael Andreeff. (2006) Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood 108:2, pages 630-637.
Crossref
Crossref
Feng Shao, Guangji Wang, Jianguo Sun, Haitang Xie, Hao Li, Yan Liang, Rong Zhang & Xiaoyan Zhu. (2006) Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis 41:2, pages 341-346.
Crossref
Crossref
Lou YinJun, Jin Jie & Wang YunGui. (2005) Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells. Leukemia Research 29:1, pages 99-105.
Crossref
Crossref