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Leukemia & Lymphoma Volume 45, 2004 - Issue 4
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Original Article

The PML-RARα Fusion Protein and Targeted Therapy for Acute Promyelocytic Leukemia

Yongkui Jing Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, 10029, USACorrespondence[email protected]
Pages 639-648 | Received 17 Jul 2003, Published online: 03 Aug 2009

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Paul Hasty & Cristina Montagna. (2014) Chromosomal rearrangements in cancer. Molecular & Cellular Oncology 1:1.
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Natasa Tosic, Irena Marjanovic & Jelena Lazic. (2023) Pediatric acute myeloid leukemia: Insight into genetic landscape and novel targeted approaches. Biochemical Pharmacology 215, pages 115705.
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Archana Chaudhary, Ghulam Mohammad Ashraf, Md. Margoob Ahmad, Manish Kumar & Rizwanul Haque. 2023. Arsenic Toxicity Remediation: Biotechnological Approaches. Arsenic Toxicity Remediation: Biotechnological Approaches 61 84 .
Victoria Korsos & Wilson H Miller Jr. (2022) How retinoic acid and arsenic transformed acute promyelocytic leukemia therapy. Journal of Molecular Endocrinology 69:4, pages T69-T83.
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Elena Cerutti, Morgana D’Amico, Isotta Cainero, Pier Giuseppe Pelicci, Mario Faretta, Gaetano Ivan Dellino, Alberto Diaspro & Luca Lanzanò. (2022) Alterations induced by the PML-RARα oncogene revealed by image cross correlation spectroscopy. Biophysical Journal 121:22, pages 4358-4367.
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Michael Maher, Jeannine Diesch, Marguerite-Marie Le Pannérer, Marta Cabezón, Mar Mallo, Sara Vergara, Aleix Méndez López, Alba Mesa Tudel, Francesc Solé, Marc Sorigue, Lurdes Zamora, Isabel Granada & Marcus Buschbeck. (2021) Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18. Scientific Reports 11:1.
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B.M. Geetha, K.N. Brinda, Gautam Achar, Jan Grzegorz Małecki, Madhavarani Alwarsamy, Virupaxappa S. Betageri & Srinivasa Budagumpi. (2020) Coumarin incorporated 1,2,4–triazole derived silver(I) N–heterocyclic carbene complexes as efficient antioxidant and antihaemolytic agents. Journal of Molecular Liquids 301, pages 112352.
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Lara Costantini, Romina Molinari, Barbara Farinon & Nicolò Merendino. (2020) Retinoic Acids in the Treatment of Most Lethal Solid Cancers. Journal of Clinical Medicine 9:2, pages 360.
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Huifang Wu, Jian Liu, Xiaofeng Huang, Lili Pian, Qianqian Cheng, Qingyang Wang, Min Zhao, Zhou Lin, Beifen Shen, Jiyan Zhang, Shulian Li & Jing Wang. (2018) RACK1 deficiency synergizes with all-trans retinoic acid to induce apoptosis in human acute promyelocytic leukemia cells. Molecular and Cellular Biochemistry 451:1-2, pages 155-163.
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Yoshitaka Sunami, Marito Araki, Shin Kan, Akihiro Ito, Yumi Hironaka, Misa Imai, Soji Morishita, Akimichi Ohsaka & Norio Komatsu. (2017) Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. Journal of Biological Chemistry 292:7, pages 2815-2829.
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Ting Liu, Qiuxu Men, Guixian Wu, Chunrong Yu, Zan Huang, Xin Liu & Wenhua Li. (2015) Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells. Oncotarget 6:10, pages 7992-8006.
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Soya S. Sam & Gregory J. Tsongalis. 2014. Molecular Testing in Cancer. Molecular Testing in Cancer 405 421 .
Yohei Amano, Masayuki Noguchi, Madoka Nakagomi, Hideaki Muratake, Hiroshi Fukasawa & Koichi Shudo. (2013) Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures. Bioorganic & Medicinal Chemistry 21:14, pages 4342-4350.
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Gina Kirsammer & Mary J. C. Hendrix. 2013. Cell and Molecular Biology of Breast Cancer. Cell and Molecular Biology of Breast Cancer 175 189 .
S Saeed, C Logie, H G Stunnenberg & J H A Martens. (2011) Genome-wide functions of PML–RARα in acute promyelocytic leukaemia. British Journal of Cancer 104:4, pages 554-558.
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Antonello Mai. (2010) Small-molecule chromatin-modifying agents: therapeutic applications. Epigenomics 2:2, pages 307-324.
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Nuria Barbarroja, Emilio Siendones, Luis Arístides Torres, Mª Jose Luque, Julio Manuel Martinez, Gabriel Dorado, Francisco Velasco, Antonio Torres & Chary López-Pedrera. (2008) MEK inhibition induces caspases activation, differentiation blockade and PML/RARα degradation in acute promyelocytic leukaemia. British Journal of Haematology 142:1, pages 27-35.
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K. Mrozek & C. D. Bloomfield. (2008) Clinical Significance of the Most Common Chromosome Translocations in Adult Acute Myeloid Leukemia. JNCI Monographs 2008:39, pages 52-57.
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S Mainardi, A Pelosi, E Palescandolo, R Riccioni, G Fontemaggi, D Diverio, U Testa, A Sacchi, F Grignani, F Lo-Coco, M Levrero, G Blandino & M G Rizzo. (2007) ΔN-p73 is a transcriptional target of the PML/RARα oncogene in myeloid differentiation. Cell Death & Differentiation 14:11, pages 1968-1971.
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Mingzhang Gao, Songde Tan, Yiwen Chen & Ralph A. Zingaro. (2007) Synthesis of S-dialkylarsino-3-mercapto-1,2-propanediols and evaluation of their anticancer activity. Bioorganic & Medicinal Chemistry 15:7, pages 2660-2666.
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Duo Chen, Rosemarie Chan, Samuel Waxman & Yongkui Jing. (2006) Buthionine Sulfoximine Enhancement of Arsenic Trioxide-Induced Apoptosis in Leukemia and Lymphoma Cells Is Mediated via Activation of c-Jun NH2-Terminal Kinase and Up-regulation of Death Receptors. Cancer Research 66:23, pages 11416-11423.
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Federica Brugnoli, Matteo Bovolenta, Mascia Benedusi, Sebastianó Miscia, Silvano Capitani & Valeria Bertagnolo. (2006) PLC-β2 monitors the drug-induced release of differentiation blockade in tumoral myeloid precursors. Journal of Cellular Biochemistry 98:1, pages 160-173.
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Miguel A Sanz & Francesco Lo-Coco. (2006) Arsenic Trioxide. American Journal of Cancer 5:3, pages 183-191.
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Yongkui Jing, Nella Hellinger, Lijuan Xia, Anne Monks, Edward A. Sausville, Arthur Zelent & Samuel Waxman. (2005) Benzodithiophenes Induce Differentiation and Apoptosis in Human Leukemia Cells. Cancer Research 65:17, pages 7847-7855.
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Rosa Farràs, Guillaume Bossis, Elisabetta Andermarcher, Isabelle Jariel-Encontre & Marc Piechaczyk. (2005) Mechanisms of delivery of ubiquitylated proteins to the proteasome: new target for anti-cancer therapy?. Critical Reviews in Oncology/Hematology 54:1, pages 31-51.
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Elisabetta Andermarcher, Guillaume Bossis, Rosa Farras, Isabelle Jariel-Encontre & Marc Piechaczyk. (2005) La dégradation protéasomique : De l’adressage des protéins aux nouvelles perspectives thérapeutiques. médecine/sciences 21:2, pages 141-149.
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Guo-Qiang Chen, Qiong Wang, Hua Yan & Zhu Chen. 2005. Natural Products. Natural Products 251 272 .

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