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Leukemia & Lymphoma Volume 45, 2004 - Issue 4
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Original Article

Mechanisms of Resistance to STI571 (Imatinib) in Philadelphia-chromosome Positive Acute Lymphoblastic Leukemia

Wolf-K Hofmann Department of Hematology and Oncology, University Hospital, Frankfurt/Main, GermanyCorrespondence[email protected]
,
Martina Komor Department of Hematology and Oncology, University Hospital, Frankfurt/Main, Germany
,
Dieter Hoelzer Department of Hematology and Oncology, University Hospital, Frankfurt/Main, Germany
&
Oliver G Ottmann Department of Hematology and Oncology, University Hospital, Frankfurt/Main, Germany
Pages 655-660 | Received 20 Sep 2003, Published online: 03 Aug 2009

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Amber Fullmer, Hagop Kantarjian, Jorge Cortes & Elias Jabbour. (2011) New developments in the treatment of chronic myeloid leukemia and Philadelphia-positive acute lymphoblastic leukemia. Leukemia & Lymphoma 52:sup1, pages 81-91.
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Wendy Stock. (2010) Current treatment options for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia & Lymphoma 51:2, pages 188-198.
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Jorge H. Milone & Alicia Enrico. (2009) Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia & Lymphoma 50:sup2, pages 9-15.
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Bhushan Nagar. (2008) Structural biology in the battle against BCR-Abl. Expert Opinion on Therapeutic Patents 18:9, pages 975-988.
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Xavier Thomas & Hervé Dombret. (2008) Treatment of Philadelphia chromosome-positive adult acute lymphoblastic leukemia. Leukemia & Lymphoma 49:7, pages 1246-1254.
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Pier Paolo Piccaluga, Michela Rondoni, Stefania Paolini, Gianantonio Rosti, Giovanni Martinelli & Michele Baccarani. (2007) Imatinib mesylate in the treatment of hematologic malignancies. Expert Opinion on Biological Therapy 7:10, pages 1597-1611.
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Giovanni Reddiconto, Patrizia Chiusolo, Alessia Fiorini, Giuliana Farina, Federica Sorà, Giuseppe Leone & Simona Sica. (2007) Dasatinib restores full donor chimerism in a patient with imatinib-resistant Ph+ ALL relapsing after unrelated cord blood transplantation. Leukemia & Lymphoma 48:10, pages 2054-2057.
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Pier Paolo Piccaluga, Giovanni Martinelli, Michela Rondoni, Giuseppe Visani & Michele Baccarani. (2006) Advances and potential treatment for Philadelphia chromosome-positive adult acute lymphoid leukaemia. Expert Opinion on Biological Therapy 6:10, pages 1011-1022.
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Keren Paz & Zhenping Zhu. (2005) Recent advances in targeted therapy of human myelogenous leukaemia. Expert Opinion on Therapeutic Targets 9:6, pages 1147-1163.
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Articles from other publishers (35)

Kunhwa Kim, Elias Jabbour, Nicholas J. Short, Partow Kebriaei, Hagop Kantarjian & Farhad Ravandi. (2021) Current Approaches to Philadelphia Chromosome–Positive B-Cell Lineage Acute Lymphoblastic Leukemia: Role of Tyrosine Kinase Inhibitor and Stem Cell Transplant. Current Oncology Reports 23:8.
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Xin Wang, Yanqing Li, Wei Chen, Yawen Wang, Lingyun Hui, Juan Liu, Na Li, Lin Zhang, Yuanwu Zou & Fang Wang. (2017) Nrf-2/Gst-α mediated imatinib resistance through rapid 4-HNE clearance. Experimental Cell Research 353:2, pages 72-78.
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Aaron Ronson, Ariella Tvito & Jacob M. Rowe. (2017) Treatment of Philadelphia Chromosome-Positive Acute Lymphocytic Leukemia. Current Treatment Options in Oncology 18:3.
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Xavier Thomas & Maël Heiblig. (2016) Diagnostic and treatment of adult Philadelphia chromosome-positive acute lymphoblastic leukemia. International Journal of Hematologic Oncology 5:2, pages 77-90.
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Dae-Young Kim, Young-Don JooSung-Nam LimSung-Doo KimJung-Hee LeeJe-Hwan LeeDong Hwan (Dennis) KimKihyun KimChul Won JungInho KimSung-Soo YoonSeonyang ParkJae-Sook AhnDeok-Hwan YangJe-Jung LeeHo-Sup LeeYang Soo KimYeung-Chul MunHawk KimJae Hoo ParkJoon Ho MoonSang Kyun SohnSang Min LeeWon Sik LeeKyoung Ha KimJong-Ho WonMyung Soo HyunJinny ParkJae Hoon LeeHo-Jin ShinJoo-Seop ChungHyewon LeeHyeon-Seok EomGyeong Won Lee, Young-Uk Cho, Seongsoo Jang, Chan-Jeoung Park, Hyun-Sook Chi & Kyoo-Hyung Lee. (2015) Nilotinib combined with multiagent chemotherapy for newly diagnosed Philadelphia-positive acute lymphoblastic leukemia. Blood 126:6, pages 746-756.
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Susanne Badura, Tamara Tesanovic, Heike Pfeifer, Sylvia Wystub, Bart A. Nijmeijer, Marcus Liebermann, J. H. Frederik Falkenburg, Martin Ruthardt & Oliver G. Ottmann. (2013) Differential Effects of Selective Inhibitors Targeting the PI3K/AKT/mTOR Pathway in Acute Lymphoblastic Leukemia. PLoS ONE 8:11, pages e80070.
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Annette S. Kim, Stephen R. Master & Cherie H. Dunphy. 2012. Laboratory Hematology Practice. Laboratory Hematology Practice 244 266 .
Xavier Thomas. (2012) Philadelphia chromosome-positive leukemia stem cells in acute lymphoblastic leukemia and tyrosine kinase inhibitor therapy. World Journal of Stem Cells 4:6, pages 44.
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Stefania Paolini, Anna Gazzola, Elena Sabattini, Francesco Bacci, Stefano Pileri & Pier Paolo Piccaluga. (2011) Pathobiology of acute lymphoblastic leukemia. Seminars in Diagnostic Pathology 28:2, pages 124-134.
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Farhad Ravandi. (2011) Managing Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Role of Tyrosine Kinase Inhibitors. Clinical Lymphoma Myeloma and Leukemia 11:2, pages 198-203.
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Ryan Mattison, Sarah Larson & Wendy Stock. 2011. Management of Hematologic Malignancies. Management of Hematologic Malignancies 43 67 .
Hyun Pyo Kim, Arthur E. Frankel & Donna E. Hogge. (2010) A diphtheria toxin interleukin-3 fusion protein synergizes with tyrosine kinase inhibitors in killing leukemic progenitors from BCR/ABL positive acute leukemia. Leukemia Research 34:8, pages 1035-1042.
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Syed A. Abutalib, Meir Wetzler & Wendy Stock. (2009) Looking Toward the Future: Novel Strategies Based on Molecular Pathogenesis of Acute Lymphoblastic Leukemia. Hematology/Oncology Clinics of North America 23:5, pages 1099-1119.
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Franz Gruber, Satu Mustjoki & Kimmo Porkka. (2009) Impact of tyrosine kinase inhibitors on patient outcomes in Philadelphia chromosome-positive acute lymphoblastic leukaemia. British Journal of Haematology 145:5, pages 581-597.
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Dan Jones, Deborah Thomas, C. Cameron Yin, Susan O'Brien, Jorge E. Cortes, Elias Jabbour, Megan Breeden, Francis J. Giles, Weiqiang Zhao & Hagop M. Kantarjian. (2008) Kinase domain point mutations in Philadelphia chromosome‐positive acute lymphoblastic leukemia emerge after therapy with BCR‐ABL kinase inhibitors. Cancer 113:5, pages 985-994.
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Sarah Larson & Wendy Stock. (2008) Progress in the treatment of adults with acute lymphoblastic leukemia. Current Opinion in Hematology 15:4, pages 400-407.
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Ding Wang, Scott A. Boerner, James D. Winkler & Patricia M. LoRusso. (2007) Clinical experience of MEK inhibitors in cancer therapy. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:8, pages 1248-1255.
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Alan V. Boddy, Julieann Sludden, Melanie J. Griffin, Colin Garner, John Kendrick, Pritesh Mistry, Catherine Dutreix, David R. Newell & Stephen G. O'Brien. (2007) Pharmacokinetic Investigation of Imatinib Using Accelerator Mass Spectrometry in Patients with Chronic Myeloid Leukemia. Clinical Cancer Research 13:14, pages 4164-4169.
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Sarah A Cross & Katherine A Lyseng-Williamson. (2007) Imatinib. Drugs 67:17, pages 2645-2654.
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S Mishra, V Pertz, B Zhang, P Kaur, H Shimada, J Groffen, Z Kazimierczuk, L A Pinna & N Heisterkamp. (2006) Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2. Leukemia 21:1, pages 178-180.
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Yiwen Li. (2006) FLT3 Antibody-based therapy for leukemia. Drug Development Research 67:6, pages 495-500.
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Cherie H. Dunphy. (2006) Gene Expression Profiling Data in Lymphoma and Leukemia: Review of the Literature and Extrapolation of Pertinent Clinical Applications. Archives of Pathology & Laboratory Medicine 130:4, pages 483-520.
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Marc Marull & Bertrand Rochat. (2006) Fragmentation study of imatinib and characterization of new imatinib metabolites by liquid chromatography–triple-quadrupole and linear ion trap mass spectrometers. Journal of Mass Spectrometry 41:3, pages 390-404.
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Helene Stridh, Vladimir J. N. Bykov, Galina Selivanova & Klas G. Wiman. 2006. Apoptosis and Cancer Therapy. Apoptosis and Cancer Therapy 891 912 .
Yiwen Li & Zhenping Zhu. (2005) FLT3 Antibody-Based Therapeutics for Leukemia Therapy. International Journal of Hematology 82:2, pages 108-114.
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Louise K. Jones & Vaskar Saha. (2005) Philadelphia positive acute lymphoblastic leukaemia of childhood. British Journal of Haematology 130:4, pages 489-500.
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Jan Cools, Chantal Maertens & Peter Marynen. (2005) Resistance to tyrosine kinase inhibitors: Calling on extra forces. Drug Resistance Updates 8:3, pages 119-129.
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László G. Boros. (2005) Metabolic targeted therapy of cancer: current tracer technologies and future drug design strategies in the old metabolic network. Metabolomics 1:1, pages 11-15.
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Wei Wang. (2005) Effects of STI571 and p27 gene clone on proliferation and apoptosis of K562 cells. World Journal of Gastroenterology 11:14, pages 2130.
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Zhuo Zhang, Mao Li, Elizabeth R Rayburn, Donald L Hill, Ruiwen Zhang & Hui Wang. (2005) Oncogenes as Novel Targets for Cancer Therapy (Part I). American Journal of PharmacoGenomics 5:3, pages 173-190.
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Oliver G. Ottmann & Barbara Wassmann. (2005) Treatment of Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia. Hematology 2005:1, pages 118-122.
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László G. Boros & Wai-Nang Paul Lee. 2005. Metabolome Analyses: Strategies for Systems Biology. Metabolome Analyses: Strategies for Systems Biology 323 335 .
Shane Atwell, Jason M. Adams, John Badger, Michelle D. Buchanan, Ingeborg K. Feil, Karen J. Froning, Xia Gao, Jörg Hendle, Kevin Keegan, Barbara C. Leon, Hans J. Müller-Dieckmann, Vicki L. Nienaber, Brian W. Noland, Kai Post, K.R. Rajashankar, Aurora Ramos, Marijane Russell, Stephen K. Burley & Sean G. Buchanan. (2004) A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase. Journal of Biological Chemistry 279:53, pages 55827-55832.
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László G. Boros, Natalie J. Serkova, Marta S. Cascante & Wai-Nang Paul Lee. (2004) Use of metabolic pathway flux information in targeted cancer drug design. Drug Discovery Today: Therapeutic Strategies 1:4, pages 435-443.
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Torsten Haferlach, Alexander Kohlmann, Susanne Schnittger, Claudia Schoch & Wolfgang Kern. 2009. Gene Expression Profiling by Microarrays. Gene Expression Profiling by Microarrays 106 131 .

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