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Original Article

Treatment of Multiple Myeloma with All-Trans Retinoic Acid Alone and in Combination with Chemotherapy: a Phase I/II Trial

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Pages 749-754 | Received 27 Sep 2003, Published online: 03 Aug 2009

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Gabriel Silva Marques Borges, Flávia Alves Lima, Guilherme Carneiro, Gisele Assis Castro Goulart & Lucas Antônio Miranda Ferreira. (2021) All-trans retinoic acid in anticancer therapy: how nanotechnology can enhance its efficacy and resolve its drawbacks. Expert Opinion on Drug Delivery 18:10, pages 1335-1354.
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Takaomi Sanda. (2007) Transcription Factors as Therapeutic Targets in Lymphoid Malignancies. International Reviews of Immunology 26:5-6, pages 305-332.
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Articles from other publishers (16)

Estefanía García-Guerrero, Luis G. Rodríguez-Lobato, Belén Sierro-Martínez, Sophia Danhof, Stephan Bates, Silke Frenz, Larissa Härtle, Ralph Götz, Markus Sauer, Leo Rasche, K. Martin Kortüm, Jose A. Pérez-Simón, Hermann Einsele, Michael Hudecek & Sabrina R. Prommersberger. (2022) All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells. Haematologica 108:2, pages 568-580.
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Qiang Wang, Zhijuan Lin, Zhuo WangLingqun Ye, Miao XianLiuling XiaoPan SuEnguang BiYung-hsing Huang, Jianfei QianLintao LiuXingzhe MaMaojie YangWei Xiong, Youli Zu, Sai Ravi Pingali, Bing XuQing Yi. (2022) RARγ activation sensitizes human myeloma cells to carfilzomib treatment through the OAS-RNase L innate immune pathway. Blood 139:1, pages 59-72.
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Mohamed R. Abdelaal, Sameh H. Soror, Mohamed R. Elnagar & Hesham Haffez. (2021) Revealing the Potential Application of EC-Synthetic Retinoid Analogues in Anticancer Therapy. Molecules 26:2, pages 506.
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Gabriel Silva Marques Borges, Micael de Oliveira Ferencs, Cristina de Mello Gomide Loures, Mostafa AL Abdel-Salam, Fernanda Cristina Gontijo Evangelista, Camila Campos Sales, Pedro Henrique Reis da Silva, Renata Barbosa de Oliveira, Ângelo Malachias, Maria Irene Yoshida, Elaine Maria de Souza-Fagundes, Adriano de Paula Sabino, Christian Fernandes & Lucas Antônio Miranda Ferreira. (2020) Novel self-nanoemulsifying drug-delivery system enhances antileukemic properties of all- trans retinoic acid . Nanomedicine 15:15, pages 1471-1486.
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N. N. Kalitin, Yu. B. Chernykh & I. V. Buravtsova. (2017) Comparative Analysis of Quantitative Parameters of Expression of the Retinoic Acid Nuclear Receptor RARα Gene and APE1/YB-1/MDR1 Pattern Genes in Patients with Newly Detected Multiple Myeloma. Bulletin of Experimental Biology and Medicine 164:1, pages 90-94.
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Alessandra di Masi, Loris Leboffe, Elisabetta De Marinis, Francesca Pagano, Laura Cicconi, Cécile Rochette-Egly, Francesco Lo-Coco, Paolo Ascenzi & Clara Nervi. (2015) Retinoic acid receptors: From molecular mechanisms to cancer therapy. Molecular Aspects of Medicine 41, pages 1-115.
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K. Martin Kortuem, Kaitlyn Zidich, Steven R. Schuster, Meaghan L. Khan, Victor H. Jimenez-Zepeda, Joseph R. Mikhael, Rafael Fonseca & A. Keith Stewart. (2014) Activity of 129 Single-Agent Drugs in 228 Phase I and II Clinical Trials in Multiple Myeloma. Clinical Lymphoma Myeloma and Leukemia 14:4, pages 284-290.e5.
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C C Bjorklund, V Baladandayuthapani, H Y Lin, R J Jones, I Kuiatse, H Wang, J Yang, J J Shah, S K Thomas, M Wang, D M Weber & R Z Orlowski. (2013) Evidence of a role for CD44 and cell adhesion in mediating resistance to lenalidomide in multiple myeloma: therapeutic implications. Leukemia 28:2, pages 373-383.
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Zhiqiang Liu, Tao Li, Kesheng Jiang, Qiaoli Huang, Yicheng Chen & Feng Qian. (2014) Induction of Chemoresistance by All-Trans Retinoic Acid via a Noncanonical Signaling in Multiple Myeloma Cells. PLoS ONE 9:1, pages e85571.
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Mohsen Malehmir, Vahid Haghpanah, Bagher Larijani, Shahin Ahmadian, Kamran Alimoghaddam, Ramin Heshmat, Ardeshir Ghavamzadeh, Khadijeh Adabi & Seyed H. Ghaffari. (2011) Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Molecular and Cellular Endocrinology.
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Siqing Wang, Guido Tricot, Lei Shi, Wei Xiong, Zhaoyang Zeng, Hongwei Xu, Maurizio Zangari, Bart Barlogie, John D. ShaughnessyJrJr & Fenghuang Zhan. (2009) RARα2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma. Blood 114:3, pages 600-607.
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Tomoya Fukui, Yasuo Kodera, Kazuto Nishio, Noriyuki Masuda, Tomohide Tamura & Fumiaki Koizumi. (2009) Synergistic interactions between the synthetic retinoid tamibarotene and glucocorticoids in human myeloma cells. Cancer Science 100:6, pages 1137-1143.
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Åse Ertesvåg, Soheil Naderi & Heidi Kiil Blomhoff. (2009) Regulation of B cell proliferation and differentiation by retinoic acid. Seminars in Immunology 21:1, pages 36-41.
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Enrico Garattini, Maurizio Gianni'Mineko Terao. 2007. Vitamin A. Vitamin A 301 354 .
T Sanda, T Kuwano, S Nakao, S Iida, T Ishida, H Komatsu, K Shudo, M Kuwano, M Ono & R Ueda. (2005) Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis. Leukemia 19:6, pages 901-909.
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