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Original Article

The Role of NUP98 Gene Fusions in Hematologic Malignancy

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Pages 1341-1350 | Received 12 Dec 2003, Published online: 03 Aug 2009

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Wei Xie, Philipp W. Raess, Jennifer Dunlap, Cristina Magallanes Hoyos, Hongmei Li, Peng Li, Ronan Swords, Susan B. Olson, Fei Yang, Tauangtham Anekpuritanang, Shimin Hu, Joanna Wiszniewska, Guang Fan, Richard D. Press & Stephen R. Moore. (2022) Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome. Leukemia & Lymphoma 63:8, pages 1907-1916.
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Valentina Salsi, Sebastian Fantini & Vincenzo Zappavigna. (2016) NUP98 fusion oncoproteins interact with the APC/CCdc20 as a pseudosubstrate and prevent mitotic checkpoint complex binding. Cell Cycle 15:17, pages 2275-2287.
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Fredrik Mertens, Bertil Johansson, Thoas Fioretos & Felix Mitelman. (2015) The emerging complexity of gene fusions in cancer. Nature Reviews Cancer 15:6, pages 371-381.
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Valentina Salsi, Silvia Ferrari, Paolo Gorello, Sebastian Fantini, Francesca Chiavolelli, Cristina Mecucci & Vincenzo Zappavigna. (2014) NUP98 Fusion Oncoproteins Promote Aneuploidy by Attenuating the Mitotic Spindle Checkpoint. Cancer Research 74:4, pages 1079-1090.
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Junfeng Ji, Ruth M. Risueño, Seokho Hong, David Allan, Patty Rosten, Keith Humphries & Mickie Bhatia. (2011) Brief Report: Ectopic Expression of Nup98-HoxA10 Augments Erythroid Differentiation of Human Embryonic Stem Cells . Stem Cells 29:4, pages 736-741.
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SM Buckley & C Verfaillie. 2011. Blood and Bone Marrow Pathology. Blood and Bone Marrow Pathology 63 76 .
Jocelyn C. Reader, Qixin Leng, Feyruz V. Rassool & Yi Ning. (2010) Regulation of differentiation by a PHD domain in the NUP98-PHF23 fusion protein. Leukemia Research 34:8, pages 1094-1097.
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Songli Xu & Maureen A. Powers. (2010) Nup98-Homeodomain Fusions Interact with Endogenous Nup98 during Interphase and Localize to Kinetochores and Chromosome Arms during Mitosis. Molecular Biology of the Cell 21:9, pages 1585-1596.
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Akiko Takeda, Nayan J. Sarma, Anmaar M. Abdul-Nabi & Nabeel R. Yaseen. (2010) Inhibition of CRM1-mediated Nuclear Export of Transcription Factors by Leukemogenic NUP98 Fusion Proteins. Journal of Biological Chemistry 285:21, pages 16248-16257.
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E R Yassin, A M Abdul-Nabi, A Takeda & N R Yaseen. (2010) Effects of the NUP98–DDX10 oncogene on primary human CD34+ cells: role of a conserved helicase motif. Leukemia 24:5, pages 1001-1011.
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C. Slape, Y. W. Lin, H. Hartung, Z. Zhang, L. Wolff & P. D. Aplan. (2008) NUP98-HOX Translocations Lead to Myelodysplastic Syndrome in Mice and Men. JNCI Monographs 2008:39, pages 64-68.
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Crossref
Q Pan, Y-J Zhu, B-W Gu, X Cai, X-T Bai, H-Y Yun, J Zhu, B Chen, L Weng, Z Chen, Y-Q Xue & S-J Chen. (2007) A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation. Oncogene 27:24, pages 3414-3423.
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Yixin Sun & Hwai-Chen Guo. (2008) Structural constraints on autoprocessing of the human nucleoporin Nup98. Protein Science 17:3, pages 494-505.
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Jana Paderova, Marija Orlic-Milacic, Maisa Yoshimoto, Gilda da Cunha Santos, Brenda Gallie & Jeremy A. Squire. (2007) Novel 6p rearrangements and recurrent translocation breakpoints in retinoblastoma cell lines identified by spectral karyotyping and mBAND analyses. Cancer Genetics and Cytogenetics 179:2, pages 102-111.
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B Argiropoulos & R K Humphries. (2007) Hox genes in hematopoiesis and leukemogenesis. Oncogene 26:47, pages 6766-6776.
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David Caudell, Zhenhua Zhang, Yang Jo Chung & Peter D. Aplan. (2007) Expression of a CALM-AF10 Fusion Gene Leads to Hoxa Cluster Overexpression and Acute Leukemia in Transgenic Mice . Cancer Research 67:17, pages 8022-8031.
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Lars Palmqvist, Nicolas Pineault, Carina Wasslavik & R. Keith Humphries. (2007) Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion Genes. PLoS ONE 2:8, pages e768.
Crossref
C Slape, Y J Chung, P D Soloway, L Tessarollo & P D Aplan. (2007) Mouse embryonic stem cells that express a NUP98–HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL. Leukemia 21:6, pages 1239-1248.
Crossref
J C Reader, J S Meekins, I Gojo & Y Ning. (2007) A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia. Leukemia 21:4, pages 842-844.
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Mary E. EdgertonDouglas H. Fisher, Lianhong Tang, Lewis J. Frey & Zhihua Chen. (2017) Data Mining for Gene Networks Relevant to Poor Prognosis in Lung Cancer via Backward-Chaining Rule Induction. Cancer Informatics 3, pages 117693510700300.
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Ioannis Panagopoulos, Gitte Kerndrup, Niels Carlsen, Bodil Strömbeck, Margareth Isaksson & Bertil Johansson. (2007) Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12). British Journal of Haematology 136:2, pages 294-296.
Crossref
Ki Y. Chung, Giovanni Morrone, Jan Jacob Schuringa, Magdalena Plasilova, Jae-Hung Shieh, Yue Zhang, Pengbo Zhou & Malcolm A.S. Moore. (2006) Enforced Expression of NUP98-HOXA9 in Human CD34+ Cells Enhances Stem Cell Proliferation . Cancer Research 66:24, pages 11781-11791.
Crossref
Lars PalmqvistBob ArgiropoulosNicolas PineaultCarolina AbramovichLaura M. SlyGerald KrystalAdrian WanR. Keith Humphries. (2006) The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia. Blood 108:3, pages 1030-1036.
Crossref
A R Mariano, E Colombo, L Luzi, P Martinelli, S Volorio, L Bernard, N Meani, R Bergomas, M Alcalay & P G Pelicci. (2006) Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal. Oncogene 25:31, pages 4376-4380.
Crossref
Akiko Takeda, Charles Goolsby & Nabeel R. Yaseen. (2006) NUP98-HOXA9 Induces Long-term Proliferation and Blocks Differentiation of Primary Human CD34+ Hematopoietic Cells. Cancer Research 66:13, pages 6628-6637.
Crossref
Xue-Tao Bai, Bai-Wei Gu, Tong Yin, Chao Niu, Xiao-Dong Xi, Ji Zhang, Zhu Chen & Sai-Juan Chen. (2006) Trans-Repressive Effect of NUP98-PMX1 on PMX1-Regulated c- FOS Gene through Recruitment of Histone Deacetylase 1 by FG Repeats . Cancer Research 66:9, pages 4584-4590.
Crossref
S P Romana, I Radford-Weiss, R Ben Abdelali, C Schluth, A Petit, N Dastugue, P Talmant, C Bilhou-Nabera, F Mugneret, M Lafage-Pochitaloff, M-J Mozziconacci, J Andrieu, J-L Lai, C Terre, K Rack, P Cornillet-Lefebvre, I Luquet, N Nadal, F Nguyen-Khac, C Perot, J Van den Akker, S Fert-Ferrer, C Cabrol, C Charrin, I Tigaud, H Poirel, M Vekemans, O A Bernard & R Berger. (2006) NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique. Leukemia 20:4, pages 696-706.
Crossref
H. J. Deeg, D. T. Bowen, S. D. Gore, T. Haferlach, M. M. Le Beau & C. NiemeyerPhilip Nivatpumin & Steven Gore. 2006. Hematologic Malignancies: Myelodysplastic Syndromes. Hematologic Malignancies: Myelodysplastic Syndromes 23 38 .
Francis H. Grand, Prasad Koduru, Nicholas C.P. Cross & Steven L. Allen. (2005) NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia. Leukemia Research 29:12, pages 1469-1472.
Crossref
Hong-li LIU, Yan CHEN, Guo-hui CUI, Qiu-ling WU, Jing HE, Wei-hua CHEN & Jian-feng ZHOU. (2005) Deguelin regulates nuclear pore complex proteins Nup98 and Nup88 in U937 cells in vitro1. Acta Pharmacologica Sinica 26:10, pages 1265-1273.
Crossref
Karin Nebral, Helmut H. Schmidt, Oskar A. Haas & Sabine Strehl. (2005) NUP98 Is Fused to Topoisomerase (DNA) IIβ 180 kDa ( TOP2B ) in a Patient with Acute Myeloid Leukemia with a New t(3;11)(p24;p15) . Clinical Cancer Research 11:18, pages 6489-6494.
Crossref
Martin S. TallmanD. Gary GillilandJacob M. Rowe. (2005) Drug therapy for acute myeloid leukemia. Blood 106:4, pages 1154-1163.
Crossref
Mariko Eguchi, Minenori Eguchi-Ishimae & Mel Greaves. (2005) Molecular Pathogenesis of MLL-Associated Leukemias. International Journal of Hematology 82:1, pages 9-20.
Crossref
Oskar A. Haas. (2005) Genetische Diagnostik in der pädiatrischen Onkologie Genetic diagnosis in pediatric oncology. LaboratoriumsMedizin 29:3, pages 162-175.
Crossref
Ying-Wei LinChristopher SlapeZhenhua ZhangPeter D. Aplan. (2005) NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood 106:1, pages 287-295.
Crossref
Malcolm A.S. Moore. (2005) Converging pathways in leukemogenesis and stem cell self-renewal. Experimental Hematology 33:7, pages 719-737.
Crossref
Nazneen Rahman. (2005) Mechanisms predisposing to childhood overgrowth and cancer. Current Opinion in Genetics & Development 15:3, pages 227-233.
Crossref
Carolina Abramovich & R Keith Humphries. (2005) Hox regulation of normal and leukemic hematopoietic stem cells. Current Opinion in Hematology 12:3, pages 210-216.
Crossref

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