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Original Article

Problems Related to Resistance to Cytarabine in Acute Myeloid Leukemia

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Pages 1123-1132 | Received 03 Oct 2003, Published online: 03 Aug 2009

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Adrian C Jaramillo, Andries M Bergman, Elizabeth M Comijn, Gerrit Jansen, Gertjan J L Kaspers, Jacqueline Cloos & Godefridus J Peters. (2020) Effect of dexamethasone on the antileukemic effect of cytarabine: role of deoxycytidine kinase. Nucleosides, Nucleotides & Nucleic Acids 39:10-12, pages 1346-1346.
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Niamh Keane, Ciara Freeman, Ronan Swords & Francis J Giles. (2013) Elacytarabine: lipid vector technology under investigation in acute myeloid leukemia. Expert Review of Hematology 6:1, pages 9-24.
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David J. Adams, Marit L. Sandvold, Finn Myhren, Tove F. Jacobsen, Frank Giles & David A. Rizzieri. (2008) Anti proliferative activity of ELACYT™ (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. Leukemia & Lymphoma 49:4, pages 786-797.
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Nina Anensen, Anne M Øyan, Sjur Huseby, Karl-Henning Kalland, Øystein Bruserud & Bjørn T Gjertsen. (2007) Early gene expression of acute myeloid leukemia in response to chemotherapy. Expert Review of Anticancer Therapy 7:5, pages 741-751.
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C Müller-Tidow, P Tschanter, C Röllig, C Thiede, A Koschmieder, M Stelljes, S Koschmieder, M Dugas, J Gerss, T Butterfaß-Bahloul, R Wagner, M Eveslage, U Thiem, S W Krause, U Kaiser, V Kunzmann, B Steffen, R Noppeney, W Herr, C D Baldus, N Schmitz, K Götze, A Reichle, M Kaufmann, A Neubauer, K Schäfer-Eckart, M Hänel, R Peceny, N Frickhofen, M Kiehl, A Giagounidis, M Görner, R Repp, H Link, A Kiani, R Naumann, T H Brümmendorf, H Serve, G Ehninger, W E Berdel & U Krug. (2015) Azacitidine in combination with intensive induction chemotherapy in older patients with acute myeloid leukemia: The AML-AZA trial of the study alliance leukemia. Leukemia 30:3, pages 555-561.
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Mihajlo Bosnjak, Biljana Ristic, Katarina Arsikin, Aleksandar Mircic, Violeta Suzin-Zivkovic, Vladimir Perovic, Andrija Bogdanovic, Verica Paunovic, Ivanka Markovic, Vladimir Bumbasirevic, Vladimir Trajkovic & Ljubica Harhaji-Trajkovic. (2014) Inhibition of mTOR-Dependent Autophagy Sensitizes Leukemic Cells to Cytarabine-Induced Apoptotic Death. PLoS ONE 9:4, pages e94374.
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Dong-Oh Moon, Yukihiro Asami, Mun-Ock Kim, Jae-Hyuk Jang, Bo Yeon Kim, Jong Seog Ahn, Gi-Young Kim & Sung Gyu Yun. (2013) Xestospongin C induces monocytic differentiation of HL60 cells through activation of the ERK pathway. Food and Chemical Toxicology 55, pages 505-512.
Crossref
Utz Krug, Anja Koschmieder, Daniela Schwammbach, Joachim Gerss, Nicola Tidow, Bj?rn Steffen, Gesine Bug, Christian H. Brandts, Markus Schaich, Christoph R?llig, Christian Thiede, Richard Noppeney, Matthias Stelljes, Thomas B?chner, Steffen Koschmieder, Ulrich D?hrsen, Hubert Serve, Gerhard Ehninger, Wolfgang E. Berdel & Carsten M?ller-Tidow. (2012) Feasibility of Azacitidine Added to Standard Chemotherapy in Older Patients with Acute Myeloid Leukemia ? A Randomised SAL Pilot Study. PLoS ONE 7:12, pages e52695.
Crossref
Mikkel Krogh-Madsen, Brendan Bender, Morten Krogh Jensen, Ove Juul Nielsen, Lena E. Friberg & Per Hartvig Honoré. (2012) Population pharmacokinetics of cytarabine, etoposide, and daunorubicin in the treatment for acute myeloid leukemia. Cancer Chemotherapy and Pharmacology 69:5, pages 1155-1163.
Crossref
William R. Waud, Karen S. Gilbert & John A. SecristIIIIII. (2010) Lack of in vivo cross-resistance with 4′-thio-ara-C against drug-resistant murine P388 and L1210 leukemias. Cancer Chemotherapy and Pharmacology 68:2, pages 399-403.
Crossref
Jatinder K LambaKristine R Crews, Stanley B Pounds, Xueyuan Cao, Varsha Gandhi, William Plunkett, Bassem I Razzouk, Vishal Lamba, Sharyn D Baker, Susana C Raimondi, Dario Campana, Ching-Hon Pui, James R Downing, Jeffrey E Rubnitz & Raul C Ribeiro. (2011) Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes. Pharmacogenomics 12:3, pages 327-339.
Crossref
Ping Chen, Josephine Aimiuwu, Zhiliang Xie, Xiaohui Wei, Shujun Liu, Rebecca Klisovic, Guido Marcucci & Kenneth K. Chan. (2010) Biochemical Modulation of Aracytidine (Ara-C) Effects by GTI-2040, a Ribonucleotide Reductase Inhibitor, in K562 Human Leukemia Cells. The AAPS Journal 13:1, pages 131-140.
Crossref
June-Won Cheong, Haeng-Im Jung, Ju In Eom, Soo Jung Kim, Hoi-Kyung Jeung & Yoo Hong Min. (2010) Aurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe. Cancer Letters 297:2, pages 171-181.
Crossref
Heiko Singer, Christian Kellner, Harald Lanig, Michael Aigner, Bernhard Stockmeyer, Fuat Oduncu, Michael Schwemmlein, Christoph Stein, Kristin Mentz, Andreas Mackensen & Georg H. Fey. (2010) Effective Elimination of Acute Myeloid Leukemic Cells by Recombinant Bispecific Antibody Derivatives Directed Against CD33 and CD16. Journal of Immunotherapy 33:6, pages 599-608.
Crossref
Pallavi Lagisetty, Prachi Vilekar & Vibhudutta Awasthi. (2009) Synthesis of radiolabeled cytarabine conjugates. Bioorganic & Medicinal Chemistry Letters 19:16, pages 4764-4767.
Crossref
Christine M. Hartford, Shiwei Duan, Shannon M. Delaney, Shuangli Mi, Emily O. Kistner, Jatinder K. Lamba, R. Stephanie Huang & M. Eileen Dolan. (2009) Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. Blood 113:10, pages 2145-2153.
Crossref
Sarah A. Holstein & Raymond J. Hohl. 2009. Pharmacology and Therapeutics. Pharmacology and Therapeutics 83 90 .
Henrick Horita, Arthur E. Frankel & Andrew Thorburn. (2008) Acute Myeloid Leukemia-Targeted Toxin Activates Both Apoptotic and Necroptotic Death Mechanisms. PLoS ONE 3:12, pages e3909.
Crossref
Maria M. Ho, Donna E. Hogge & Victor Ling. (2008) MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia. Experimental Hematology 36:4, pages 433-442.
Crossref
Jatinder K. Lamba, Kristine Crews, Stanley Pounds, Erin G. Schuetz, Jessica Gresham, Varsha Gandhi, William Plunkett, Jeffrey Rubnitz & Raul Ribeiro. (2007) Pharmacogenetics of Deoxycytidine Kinase: Identification and Characterization of Novel Genetic Variants. Journal of Pharmacology and Experimental Therapeutics 323:3, pages 935-945.
Crossref
Bin Yin, Scott C. Kogan, Ross A. Dickins, Scott W. Lowe & David A. Largaespada. (2006) Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia. Experimental Hematology 34:5, pages 631-641.
Crossref
Je-Hwan Lee, Seong-Jun Choi, Jung-Hee Lee, Young-Shin Lee, Miee Seol, Seong-Gil Ryu, Seongsoo Jang, Chan-Jeoung Park, Hyun-Sook Chi, Jung-Shin Lee, Woo-Kun Kim & Kyoo-Hyung Lee. (2006) Continuous infusion intermediate-dose cytarabine, mitoxantrone, plus etoposide for refractory or early relapsed acute myelogenous leukemia. Leukemia Research 30:2, pages 204-210.
Crossref
B Yin, K Morgan, D E Hasz, Z Mao & D A Largaespada. (2005) Nf1 gene inactivation in acute myeloid leukemia cells confers cytarabine resistance through MAPK and mTOR pathways. Leukemia 20:1, pages 151-154.
Crossref
Ismael Samudio, Marina Konopleva, Stephen Safe, Teresa McQueen & Michael Andreeff. (2005) Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. Molecular Cancer Therapeutics 4:12, pages 1982-1992.
Crossref
Dzung H. Nguyen, Pam Tangvoranuntakul & Ajit Varki. (2005) Effects of Natural Human Antibodies against a Nonhuman Sialic Acid That Metabolically Incorporates into Activated and Malignant Immune Cells. The Journal of Immunology 175:1, pages 228-236.
Crossref

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