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Original Article

Interleukin-7 in T-cell acute lymphoblastic leukemia: An extrinsic factor supporting leukemogenesis?

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Pages 483-495 | Received 29 Oct 2004, Published online: 03 Aug 2009

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Leonor M Sarmento & João T Barata. (2011) Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises. Expert Review of Anticancer Therapy 11:9, pages 1403-1415.
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Articles from other publishers (53)

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C Delgado-Martin, L K Meyer, B J Huang, K A Shimano, M S Zinter, J V Nguyen, G A Smith, J Taunton, S S Winter, J R Roderick, M A Kelliher, T M Horton, B L Wood, D T Teachey & M L Hermiston. (2017) JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia 31:12, pages 2568-2576.
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Priya K. Gopal, Mausumi Paul & Santanu Paul. (2014) Role of different aberrant cell signalling pathways prevalent in acute lymphoblastic leukemia. Biologia 69:9, pages 1097-1107.
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Olga Ksionda, Andre Limnander & Jeroen P. Roose. (2013) RasGRP Ras guanine nucleotide exchange factors in cancer. Frontiers in Biology 8:5, pages 508-532.
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A J Yost, O O Shevchuk, R Gooch, S Gusscott, M J You, T A Ince, J C Aster & A P Weng. (2012) Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts. Leukemia 27:6, pages 1437-1440.
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Daniel Ribeiro, Alice Melão & João T. Barata. (2013) IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia. Advances in Biological Regulation 53:2, pages 211-222.
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Pravin KesarwaniAnuradha K. MuraliAmir A. Al-KhamiShikhar Mehrotra. (2013) Redox Regulation of T-Cell Function: From Molecular Mechanisms to Significance in Human Health and Disease. Antioxidants & Redox Signaling 18:12, pages 1497-1534.
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Catherine HartzellOlga KsiondaEd LemmensKristen CoakleyMing YangMonique DailRichard C. HarveyChristopher GovernJeroen BakkerTineke L. LenstraKristin AmmonAnne BoeterStuart S. WinterMignon LohKevin ShannonArup K. ChakrabortyMatthias WablJeroen P. Roose. (2013) Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis. Science Signaling 6:268.
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Ekta S. Patel & Lung-Ji Chang. (2012) Synergistic Effects of Interleukin-7 and Pre-T Cell Receptor Signaling in Human T Cell Development. Journal of Biological Chemistry 287:40, pages 33826-33835.
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Sara González-García, Marina García-Peydró, Juan Alcain & María L. Toribio. 2012. Notch Regulation of the Immune System. Notch Regulation of the Immune System 47 73 .
Armel Hervé Nwabo Kamdje & Mauro Krampera. (2011) Notch signaling in acute lymphoblastic leukemia: any role for stromal microenvironment?. Blood 118:25, pages 6506-6514.
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Ute Koch & Freddy Radtke. (2011) Mechanisms of T Cell Development and Transformation. Annual Review of Cell and Developmental Biology 27:1, pages 539-562.
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Shoshana D. Katzman, Katrina K. Hoyer, Hans Dooms, Iris K. Gratz, Michael D. Rosenblum, Jonathan S. Paw, Sara H. Isakson & Abul K. Abbas. (2011) Opposing functions of IL-2 and IL-7 in the regulation of immune responses. Cytokine 56:1, pages 116-121.
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Hind Medyouf, Samuel Gusscott, Hongfang Wang, Jen-Chieh Tseng, Carol Wai, Oksana Nemirovsky, Andreas Trumpp, Francoise Pflumio, Joan Carboni, Marco Gottardis, Michael Pollak, Andrew L. Kung, Jon C. Aster, Martin Holzenberger & Andrew P. Weng. (2011) High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. Journal of Experimental Medicine 208:9, pages 1809-1822.
Crossref
Ana Silva, Angelo B.A. Laranjeira, Leila R. Martins, Bruno A. Cardoso, Jocelyne Demengeot, J. Andrés Yunes, Benedict Seddon & João T. Barata. (2011) IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias. Cancer Research 71:14, pages 4780-4789.
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Megan J Palmer, Vinay S Mahajan, Jianzhu Chen, Darrell J Irvine & Douglas A Lauffenburger. (2011) Signaling thresholds govern heterogeneity in IL‐7‐receptor‐mediated responses of naïve CD8 + T cells . Immunology & Cell Biology 89:5, pages 581-594.
Crossref
A Silva, A Gírio, I Cebola, C I Santos, F Antunes & J T Barata. (2011) Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells. Leukemia 25:6, pages 960-967.
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Ana Batista, João T. Barata, Elke Raderschall, Stephen E. Sallan, Nadia Carlesso, Lee M. Nadler & Angelo A. Cardoso. (2011) Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors. Experimental Hematology 39:4, pages 457-472.e3.
Crossref
João T. Barata. (2011) The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival. Advances in Enzyme Regulation 51:1, pages 37-49.
Crossref
Jon C Aster, Stephen C Blacklow & Warren S Pear. (2011) Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. The Journal of Pathology 223:2, pages 263-274.
Crossref
Amanda L Cleaver, Alex H Beesley, Martin J Firth, Nina C Sturges, Rebecca A O'Leary, Stephen P Hunger, David L Baker & Ursula R Kees. (2010) Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study. Molecular Cancer 9:1.
Crossref
Amanda Leone, Mukta Rohankhedkar, Afam Okoye, Alfred Legasse, Michael K. Axthelm, Francois Villinger, Michael PiatakJr.Jr., Jeffrey D. Lifson, Brigitte Assouline, Michel Morre, Louis J. Picker & Donald L. Sodora. (2010) Increased CD4+ T Cell Levels during IL-7 Administration of Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Positive Macaques Are Not Dependent on Strong Proliferative Responses. The Journal of Immunology 185:3, pages 1650-1659.
Crossref
Mounir Chehtane & Annette R. Khaled. (2010) Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene. American Journal of Physiology-Cell Physiology 298:6, pages C1560-C1571.
Crossref
Catarina M. Henriques, José Rino, Robert J. Nibbs, Gerry J. Graham & João T. Barata. (2010) IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Rα in T cells. Blood 115:16, pages 3269-3277.
Crossref
Sara González-García & María L Toribio. (2009) Notch 1 signalling in human T-cell development and leukemia. Inmunología 28:4, pages 193-208.
Crossref
Q-L Zhang, L Wang, Y-W Zhang, X-X Jiang, F Yang, W-L Wu, A Janin, Z Chen, Z-X Shen, S-J Chen & W-L Zhao. (2009) The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis. Leukemia 23:8, pages 1507-1514.
Crossref
Dana S. Levy, Jason A. Kahana & Rakesh Kumar. (2009) AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood 113:8, pages 1723-1729.
Crossref
Steven J. Howe, Marc R. Mansour, Kerstin Schwarzwaelder, Cynthia Bartholomae, Michael Hubank, Helena Kempski, Martijn H. Brugman, Karin Pike-Overzet, Stephen J. Chatters, Dick de Ridder, Kimberly C. Gilmour, Stuart Adams, Susannah I. Thornhill, Kathryn L. Parsley, Frank J.T. Staal, Rosemary E. Gale, David C. Linch, Jinhua Bayford, Lucie Brown, Michelle Quaye, Christine Kinnon, Philip Ancliff, David K. Webb, Manfred Schmidt, Christof von Kalle, H. Bobby Gaspar & Adrian J. Thrasher. (2008) Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. Journal of Clinical Investigation 118:9, pages 3143-3150.
Crossref
Nuno R. dos Santos, Maryvonne Williame, Stéphanie Gachet, Françoise Cormier, Anne Janin, Debra Weih, Falk Weih & Jacques Ghysdael. (2008) RelB-Dependent Stromal Cells Promote T-Cell Leukemogenesis. PLoS ONE 3:7, pages e2555.
Crossref
B.A. Cardoso, A. Gírio, C. Henriques, L.R. Martins, C. Santos, A. Silva & J.T. Barata. (2008) Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications. Brazilian Journal of Medical and Biological Research 41:5, pages 344-350.
Crossref
Kia A. Duthie, Lisa C. Osborne, Leonard J. Foster & Ninan Abraham. (2007) Proteomics Analysis of Interleukin (IL)-7-induced Signaling Effectors Shows Selective Changes in IL-7Rα449F Knock-in T Cell Progenitors. Molecular & Cellular Proteomics 6:10, pages 1700-1710.
Crossref
Christina Kittipatarin & Annette R. Khaled. (2007) Interlinking interleukin-7. Cytokine 39:1, pages 75-83.
Crossref

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