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Leukemia & Lymphoma Volume 45, 2004 - Issue 8
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Original Article

Toxicology and Pharmacokinetics of DT388IL3, a Fusion Toxin Consisting of a Truncated Diphtheria Toxin (DT388) Linked to Human Interleukin 3 (IL3), in Cynomolgus Monkeys

Kimberley A Cohen Department of Comparative Medicine and Cancer Biology, Wake Forest Health Sciences, Winston-Salem, NC, 27157, USACorrespondence[email protected]
,
Tie Fu LIU College of Pharmacy, Medical University of South Carolina, Charleston, SC, 29425, USA
,
J Mark Cline Department of Comparative Medicine and Cancer Biology, Wake Forest Health Sciences, Winston-Salem, NC, 27157, USA
,
Janice D Wagner College of Pharmacy, Medical University of South Carolina, Charleston, SC, 29425, USA
,
Philip D Hall Department of Comparative Medicine and Cancer Biology, Wake Forest Health Sciences, Winston-Salem, NC, 27157, USA
&
Arthur E Frankel College of Pharmacy, Medical University of South Carolina, Charleston, SC, 29425, USA
Pages 1647-1656 | Received 19 Dec 2003, Published online: 26 Aug 2009

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Ryne J. DeBo, Thomas C. Register, David L. Caudell, Gregory D. Sempowski, Gregory Dugan, Shauna Gray, Kouros Owzar, Chen Jiang, J. Daniel Bourland, Nelson J. Chao & J. Mark Cline. (2015) Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. International Journal of Radiation Biology 91:6, pages 510-518.
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Brynn T Kvinlaug$suffix/text()$suffix/text() & Brian JP Huntly$suffix/text()$suffix/text(). (2007) Targeting cancer stem cells. Expert Opinion on Therapeutic Targets 11:7, pages 915-927.
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Shu-Ru Kuo, Randall W. Alfano, Arthur E. Frankel & Jen-Sing Liu. (2009) Antibody Internalization after Cell Surface Antigen Binding is Critical for Immunotoxin Development. Bioconjugate Chemistry 20:10, pages 1975-1982.
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Xing Du, Mitchell Ho & Ira Pastan. (2007) New Immunotoxins Targeting CD123, a Stem Cell Antigen on Acute Myeloid Leukemia Cells. Journal of Immunotherapy 30:6, pages 607-613.
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Ugo TestaRoberta RiccioniMauro BiffoniDaniela DiverioFrancesco Lo-CocoRobin FoàCesare PeschleArthur E. Frankel. (2005) Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression. Blood 106:7, pages 2527-2529.
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Kimberley A. Cohen, Tie Fu Liu, J. Mark. Cline, Janice D. Wagner, Philip D. Hall & Arthur E. Frankel. (2004) Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey. Cancer Immunology, Immunotherapy 54:8, pages 799-806.
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Marlena M. Westcott, Ralph J. Abi-Habib, Kimberley A. Cohen, Mark C. Willingham, Shihui Liu, Thomas H. Bugge, Stephen H. Leppla & Arthur E. Frankel. (2004) Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells. Molecular Cancer Therapeutics 3:12, pages 1681-1689.
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