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Original Article

PI3-Kinase Regulates Survival of Chronic Lymphocytic Leukemia B-Cells by Preventing Caspase 8 Activation

Pages 1519-1529 | Received 26 Jan 2004, Published online: 26 Aug 2009

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Kumudha Balakrishnan & Varsha Gandhi. (2012) Protein kinases: emerging therapeutic targets in chronic lymphocytic leukemia. Expert Opinion on Investigational Drugs 21:4, pages 409-423.
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Ranadip Mandal, Joan Compte Barrón, Izabela Kostova, Sven Becker & Klaus Strebhardt. (2020) Caspase-8: The double-edged sword. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1873:2, pages 188357.
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Yair Herishanu, Ben-Zion Katz, Andrew Lipsky & Adrian Wiestner. (2013) Biology of Chronic Lymphocytic Leukemia in Different Microenvironments. Hematology/Oncology Clinics of North America 27:2, pages 173-206.
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E Tibaldi, A M Brunati, F Zonta, F Frezzato, C Gattazzo, R Zambello, E Gringeri, G Semenzato, M A Pagano & L Trentin. (2011) Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells. Leukemia 25:11, pages 1768-1781.
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Leila R. Martins, Paulo Lúcio, Milene C. Silva, Paula Gameiro, Maria G. Silva & João T. Barata. (2011) On CK2 regulation of chronic lymphocytic leukemia cell viability. Molecular and Cellular Biochemistry 356:1-2, pages 51-55.
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João T. Barata. (2011) The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival. Advances in Enzyme Regulation 51:1, pages 37-49.
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Leila R. MartinsPaulo Lúcio, Milene C. SilvaKenna L. Anderes, Paula Gameiro, Maria G. Silva & João T. Barata. (2010) Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia. Blood 116:15, pages 2724-2731.
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Zibo Song, Pin Lu, Richard R. Furman, John P. Leonard, Peter Martin, Lauren Tyrell, Francis Y. Lee, Daniel M. Knowles, Morton Coleman & Y. Lynn Wang. (2010) Activities of SYK and PLCγ2 Predict Apoptotic Response of CLL Cells to SRC Tyrosine Kinase Inhibitor Dasatinib. Clinical Cancer Research 16:2, pages 587-599.
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A D Baudot, P Y Jeandel, X Mouska, U Maurer, S Tartare-Deckert, S D Raynaud, J P Cassuto, M Ticchioni & M Deckert. (2009) The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCδ and proteasome-dependent regulation of Mcl-1 expression. Oncogene 28:37, pages 3261-3273.
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Matthias Niedermeier, Bryan T. HennessyZachary A. Knight, Marina Henneberg, Jianhua Hu, Antonina V. Kurtova, William G. Wierda, Michael J. Keating, Kevan M. Shokat & Jan A. Burger. (2009) Isoform-selective phosphoinositide 3′-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell–mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood 113:22, pages 5549-5557.
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Marta Muzio & Federico Caligaris-Cappio. 2008. Chronic Lymphocytic Leukemia. Chronic Lymphocytic Leukemia 45 67 .
Janet Plate. (2008) Signals that maintain leukemic cell viability. Blood 112:1, pages 1-2.
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Marta Muzio, Benedetta Apollonio, Cristina Scielzo, Michela Frenquelli, Irene Vandoni, Vassiliki Boussiotis, Federico Caligaris-Cappio & Paolo Ghia. (2008) Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood 112:1, pages 188-195.
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Robert T. WoodlandCasey J. FoxMadelyn R. SchmidtPeter S. HammermanJoseph T. Opferman, Stanley J. Korsmeyer, David M. Hilbert & Craig B. Thompson. (2008) Multiple signaling pathways promote B lymphocyte stimulator–dependent B-cell growth and survival. Blood 111:2, pages 750-760.
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Montserrat Barragán, Mercè de Frias, Daniel Iglesias-Serret, Clara Campàs, Esther Castaño, Antonio F Santidrián, Llorenç Coll-Mulet, Ana M Cosialls, Alicia Domingo, Gabriel Pons & Joan Gil. (2006) Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase Cβ. Journal of Leukocyte Biology 80:6, pages 1473-1479.
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I Oehme, S Bösser & M Zörnig. (2005) Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Cell Death & Differentiation 13:2, pages 189-201.
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Young-Lai Cho, Kwang-Soon Lee, Seon-Jin Lee, Seung Namkoong, Young-Mi Kim, Hansoo Lee, Kwon-Soo Ha, Jeong-A Han, Young-Guen Kwon & Young-Myeong Kim. (2005) Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation. Biochemical and Biophysical Research Communications 326:4, pages 752-758.
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