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Leukemia & Lymphoma Volume 45, 2004 - Issue 8
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Original Article

Thromboembolism in Adults with Acute Lymphoblastic Leukemia During Induction with L-Asparaginase-containing Multi-agent Regimens: Incidence, Risk Factors, and Possible Role of Antithrombin

Michelle A Elliott Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USACorrespondence[email protected]
,
Robert C Wolf Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
,
Christopher C Hook Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
,
Rajiv K Pruthi Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
,
John A Heit Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
,
Louis L Letendre Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
,
Ayalew Tefferi Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
,
Scott H Kaufmann Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
,
Ruben A Mesa Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
&
Mark R Litzow Department of Internal Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
 show all
Pages 1545-1551 | Received 04 Mar 2004, Accepted 07 Mar 2004, Published online: 26 Aug 2009

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Craig W. Freyer, Alison Carulli, Alex Ganetsky, Mitchell E. Hughes, Tracy M. Krause, Colleen Timlin, Noelle V. Frey, Saar I. Gill, Elizabeth O. Hexner, Alison W. Loren, James K. Mangan, Mary Ellen Martin, Shannon R. McCurdy, Alexander E. Perl, Keith Pratz, David L. Porter & Selina M. Luger. (2020) Venous thromboembolism following pegaspargase in adults receiving antithrombin supplementation. Leukemia & Lymphoma 61:9, pages 2200-2207.
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Thomas Sau-Yan Chan, Yu Yan Hwang & Eric Tse. (2020) Risk assessment of venous thromboembolism in hematological cancer patients: a review. Expert Review of Hematology 13:5, pages 471-480.
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Jason Chen, Dat Ngo, Ibrahim Aldoss, Sepideh Shayani, Ni-Chun Tsai & Vinod Pullarkat. (2019) Antithrombin supplementation did not impact the incidence of pegylated asparaginase-induced venous thromboembolism in adults with acute lymphoblastic leukemia. Leukemia & Lymphoma 60:5, pages 1187-1192.
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Jamie Koprivnikar, James McCloskey & Stefan Faderl. (2017) Safety, efficacy, and clinical utility of asparaginase in the treatment of adult patients with acute lymphoblastic leukemia. OncoTargets and Therapy 10, pages 1413-1422.
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Jason N. Barreto, Kristen B. McCullough, Candy S. Peskey, Ross A. Dierkhising, Kristin C. Mara, Michelle A. Elliott, Dennis A. Gastineau, Aref Al-Kali, Naseema Gangat, Louis Letendre, William J. Hogan, Mark R. Litzow & Mrinal M. Patnaik. (2017) Safety and feasibility of lower antithrombin replacement targets in adult patients with hematological malignancies receiving asparaginase therapy. Leukemia & Lymphoma 58:11, pages 2588-2597.
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Katrina Farrell, Andrew Fyfe, Jonathan Allan, R. Campbell Tait & Mike Leach. (2016) An antithrombin replacement strategy during asparaginase therapy for acute lymphoblastic leukemia is associated with a reduction in thrombotic events. Leukemia & Lymphoma 57:11, pages 2568-2574.
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Wendy Stock, Dan Douer, Daniel J. DeAngelo, Martha Arellano, Anjali Advani, Lloyd Damon, Tibor Kovacsovics, Mark Litzow, Michael Rytting, Gautam Borthakur & Archie Bleyer. (2011) Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel. Leukemia & Lymphoma 52:12, pages 2237-2253.
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Ted Wun & Richard H. White. (2009) Venous Thromboembolism (VTE) in Patients with Cancer: Epidemiology and Risk Factors. Cancer Investigation 27:sup1, pages 63-74.
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