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Original Article: Research

Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells

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Pages 1199-1206 | Received 05 Mar 2005, Published online: 03 Aug 2009

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Gerald F Davies, Bernhard HJ Juurlink & Troy AA Harkness. (2009) Troglitazone reverses the multiple drug resistance phenotype in cancer cells. Drug Design, Development and Therapy 3, pages 79-88.
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Articles from other publishers (20)

Xia Wu, Shangqing Chen, Kechu Huang & Gongping Lin. (2022) Triptolide promotes ferroptosis by suppressing Nrf2 to overcome leukemia cell resistance to doxorubicin. Molecular Medicine Reports 27:1.
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Terra G. Arnason, Valerie MacDonald-Dickinson, Matthew Casey Gaunt, Gerald F. Davies, Liubov Lobanova, Brett Trost, Zoe E. Gillespie, Matthew Waldner, Paige Baldwin, Devon Borrowman, Hailey Marwood, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Christopher H. Eskiw, Anthony Kusalik & Troy A. A. Harkness. (2022) Activation of the Anaphase Promoting Complex Reverses Multiple Drug Resistant Cancer in a Canine Model of Multiple Drug Resistant Lymphoma. Cancers 14:17, pages 4215.
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Jingyuan Wang, Xiao Yang, Zhiqi Wang & Jianliu Wang. (2022) Role of the Glyoxalase System in Breast Cancer and Gynecological Cancer-Implications for Therapeutic Intervention: a Review. Frontiers in Oncology 12.
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Alessia Leone, Cecilia Nigro, Antonella Nicolò, Immacolata Prevenzano, Pietro Formisano, Francesco Beguinot & Claudia Miele. (2021) The Dual-Role of Methylglyoxal in Tumor Progression – Novel Therapeutic Approaches. Frontiers in Oncology 11.
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Akeila Bellahcène, Marie-Julie Nokin, Vincent Castronovo & Casper Schalkwijk. (2018) Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer. Seminars in Cancer Biology 49, pages 64-74.
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Gerald Davies, Liubov Lobanova, Wojciech Dawicki, Gary Groot, John R. Gordon, Matthew Bowen, Troy Harkness & Terra Arnason. (2017) Metformin inhibits the development, and promotes the resensitization, of treatment-resistant breast cancer. PLOS ONE 12:12, pages e0187191.
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Antje Hutschenreuther, Marina Bigl, Nasr Hemdan, Tewodros Debebe, Frank Gaunitz & Gerd Birkenmeier. (2016) Modulation of GLO1 Expression Affects Malignant Properties of Cells. International Journal of Molecular Sciences 17:12, pages 2133.
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Terra Arnason & Troy Harkness. (2015) Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1. Cancers 7:4, pages 2063-2082.
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Cláudia M. Deus, Cheryl Zehowski, Kendra Nordgren, Kendall B. Wallace, Andrew Skildum & Paulo J. Oliveira. (2015) Stimulating basal mitochondrial respiration decreases doxorubicin apoptotic signaling in H9c2 cardiomyoblasts. Toxicology 334, pages 1-11.
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Gerald F. Davies, Arnie Berg, Spike D. L. Postnikoff, Heather L. Wilson, Terra G. Arnason, Anthony Kusalik & Troy A. A. Harkness. (2014) TFPI1 Mediates Resistance to Doxorubicin in Breast Cancer Cells by Inducing a Hypoxic-Like Response. PLoS ONE 9:1, pages e84611.
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Lingling Dong, Qian Zhou, Zhenbo Zhang, Yaping Zhu, Tao Duan & Youji Feng. (2012) Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression. Journal of Obstetrics and Gynaecology Research 38:8, pages 1077-1085.
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Shawn A Ritchie, Dushmanthi Jayasinghe, Gerald F Davies, Pearson Ahiahonu, Hong Ma & Dayan B Goodenowe. (2011) Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity. Journal of Experimental & Clinical Cancer Research 30:1.
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Alexander A. Goldberg, Adam Beach, Gerald F. Davies, Troy A. A. Harkness, Andréa LeBlanc & Vladimir I. Titorenko. (2011) Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget 2:10, pages 761-782.
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Zhenbo Zhang, Lingling Dong, Long Sui, Yixia Yang, Xuelian Liu, Yinhua Yu, Yaping Zhu & Youji Feng. (2011) Metformin Reverses Progestin Resistance in Endometrial Cancer Cells by Downregulating GloI Expression. International Journal of Gynecologic Cancer 21:2, pages 213-221.
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Thomas Santarius, Graham R. Bignell, Chris D. Greenman, Sara Widaa, Lina Chen, Claire L. Mahoney, Adam Butler, Sarah Edkins, Sahar Waris, Paul J. Thornalley, P. Andrew Futreal & Michael R. Stratton. (2010) GLO1 —A novel amplified gene in human cancer . Genes, Chromosomes and Cancer 49:8, pages 711-725.
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G.F. Davies, A.R. Ross, T.G. Arnason, B.H.J. Juurlink & T.A.A. Harkness. (2010) Troglitazone inhibits histone deacetylase activity in breast cancer cells. Cancer Letters 288:2, pages 236-250.
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Jeffrey Helgager, Jie Li, Irina A. Lubensky, Russell Lonser & Zhengping Zhuang. (2010) Troglitazone Reduces Glyoxalase I Protein Expression in Glioma and Potentiates the Effects of Chemotherapeutic Agents. Journal of Oncology 2010, pages 1-7.
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Alessandro Antonelli, Silvia Martina Ferrari, Poupak Fallahi, Piero Berti, Gabriele Materazzi, Michele Minuto, Riccardo Giannini, Ivo Marchetti, Lucio Barani, Fulvio Basolo, Ele Ferrannini & Paolo Miccoli. (2009) Thiazolidinediones and antiblastics in primary human anaplastic thyroid cancer cells. Clinical Endocrinology 70:6, pages 946-953.
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Paolo Miccoli, Gabriele Materazzi, Alessandro Antonelli, Erica Panicucci, Gianluca Frustaci & Piero Berti. (2006) New trends in the treatment of undifferentiated carcinomas of the thyroid. Langenbeck's Archives of Surgery 392:4, pages 397-404.
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. (2005) Current Awareness in Hematological Oncology. Hematological Oncology 23:3-4, pages 136-143.
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