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Case Report

TLS/FUS-ERG fusion gene in acute lymphoblastic leukemia with t(16;21)(p11;q22) and monitoring of minimal residual disease

Pages 1833-1835 | Received 29 Apr 2005, Published online: 01 Jul 2009

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Xingqin Huang, Ting Li, Yun Zhang, Xiaopeng Gao & Fang Long. (2023) Hemophagocytosis by multinucleated leukemic blasts, basophilia, and micromegakaryocytes in AML with TLS::ERG. Annals of Hematology.
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Gord Guo Zhu, Zaina Inam, Amanda Calleroz, Vinodh Pillai, Reuven J Schore & Jinjun Cheng. (2023) Pediatric acute erythroid leukemias with monocytic antigen expression and novel chromosomal translocations. Pediatric Blood & Cancer 70:8.
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Heyang Zhang, Qianru Zhan, Xiaoxue Wang, Feng Gao, Jinxiang Yu, Jing Wang, Wei Fu, Pingping Wang, Xin Wei & Lijun Zhang. (2022) TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review. Annals of Hematology 101:12, pages 2583-2600.
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Feiling Jiang, Xingping Lang, Nan Chen, Liqin Jin, Lingfeng Liu, Xiaobin Wei, Jianhua Pan, Feng Yu, Angella Blake & Sheng Xiao. (2022) A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia . Genes, Chromosomes and Cancer 61:8, pages 503-508.
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Sisi Li, Wei Huang, Yuanyuan Wu, Xiaojun Xu, Chan Liao & Yongmin Tang. (2021) Rare and favorable prognosis of pediatric acute lymphoblastic leukemia with TLS-ERG fusion gene: Case report with long-term follow-up and review of literature. Cancer Genetics 256-257, pages 51-56.
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Elena Zerkalenkova, Agnesa Panfyorova, Anna Kazakova, Pavel Baryshev, Larisa Shelihova, Irina Kalinina, Galina Novichkova, Michael Maschan, Aleksey Maschan & Yulia Olshanskaya. (2018) Molecular characteristic of acute leukemias with t(16;21)/FUS-ERG. Annals of Hematology 97:6, pages 977-988.
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Ya-Zhen Qin, Yao Chen, Lan-Ping Xu, Yu Wang, Xiao-Hui Zhang, Huan Chen, Xiao-Su Zhao, Kai-Yan Liu & Xiao-Jun Huang. (2018) Outcome and Minimal Residual Disease Monitoring in Patients with t(16;21) Acute Myelogenous Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 24:1, pages 163-168.
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Akifumi Endo, Daisuke Tomizawa, Yuki Aoki, Tomohiro Morio, Shuki Mizutani & Masatoshi Takagi. (2016) EWSR 1/ ELF 5 induces acute myeloid leukemia by inhibiting p53/p21 pathway . Cancer Science 107:12, pages 1745-1754.
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B. Kim, Y.-U. Cho, M.-H. Bae, S. Jang, E.-J. Seo, H.-S. Chi & C.-J. Park. (2016) The added values of multiplex reverse transcriptase-PCR followed by mutation screening in the initial evaluation of acute leukemia. International Journal of Laboratory Hematology 38:4, pages 444-453.
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Hatem Abou-Ouf, Liena Zhao & Tarek A. Bismar. (2015) ERG expression in prostate cancer: biological relevance and clinical implication. Journal of Cancer Research and Clinical Oncology 142:8, pages 1781-1793.
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Tsion Zewdu Minas, Jenny Han, Tahereh Javaheri, Sung-Hyeok Hong, Michaela Schlederer, Yasemin Saygideğer-Kont, Haydar Çelik, Kristina M. Mueller, Idil Temel, Metin Özdemirli, Heinrich Kovar, Hayriye Verda Erkizan, Jeffrey Toretsky, Lukas Kenner, Richard Moriggl & Aykut Üren. (2015) YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. Oncotarget 6:35, pages 37678-37694.
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Bertil Johansson & Christine J. Harrison. 2015. Cancer Cytogenetics. Cancer Cytogenetics 62 125 .
Mariela C. CoccéCristina N. AlonsoJorge RossiMaria S. FeliceMyriam R. GitterMarta S. Gallego. (2015) A case of pediatric ALL with t(16;21)(p11.2;q22) and FUS-ERG rearrangement . Blood Research 50:1, pages 55.
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IOANNIS PANAGOPOULOS, LUDMILA GORUNOVA, BERNWARD ZELLER, ANNE TIERENS & SVERRE HEIM. (2013) Cryptic FUS-ERG fusion identified by RNA-sequencing in childhood acute myeloid leukemia. Oncology Reports 30:6, pages 2587-2592.
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E Tijchon, J Havinga, F N van Leeuwen & B Scheijen. (2012) B-lineage transcription factors and cooperating gene lesions required for leukemia development. Leukemia 27:3, pages 541-552.
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Ashley P. Ng, Stephen J. Loughran, Donald Metcalf, Craig D. HylandCarolyn A. de Graaf, Yifang Hu, Gordon K. Smyth, Douglas J. Hilton, Benjamin T. Kile & Warren S. Alexander. (2011) Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood 118:9, pages 2454-2461.
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Hui Jiang, Huiying Qiu, Yongquan Xue, Jinlan Pan, Yafang Wu, Jun Zhang, Jifu Zheng, Qian Wang, Jianying Liang & Suning Chen. (2011) Establishment and characterization of a novel acute myeloid leukemia cell line, JIH-4, carrying a t(16;21)(p11.2;q22) and expressing the FUS-ERG fusion. Cancer Genetics 204:4, pages 219-223.
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Seung Hwan Oh, Tae Sung Park, Jong Rak Choi, Sanggyu Lee, Sun Young Cho, So Young Kim, Juwon Kim, Ji Kyoung Park, Sae Am Song, Ja Young Lee, Jeong Hwan Shin, Hye Ran Kim & Jeong Nyeo Lee. (2010) Two childhood cases of acute leukemia with t(16;21)(p11.2;q22): second case report of infantile acute lymphoblastic leukemia with unusual type of FUS-ERG chimeric transcript. Cancer Genetics and Cytogenetics 200:2, pages 180-183.
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Woong Rin Chang, Il Joong Park, Hyun Woo Lee, Joon Seong Park, Hugh Chul Kim, Hyon Joo Kim, Jae Ho Han & Sung Ran Cho. (2009) Two Cases of Acute Myeloid Leukemia with t(16;21)(p11;q22) and TLS/FUS-ERG Fusion Transcripts . Annals of Laboratory Medicine 29:5, pages 390-395.
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Juwon Kim, Tae Sung Park, Jaewoo Song, Kyung-A. Lee, Duk Jin Hong, Yoo Hong Min, June-Won Cheong & Jong Rak Choi. (2009) Detection of FUS–ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics. Cancer Genetics and Cytogenetics 194:2, pages 111-118.
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Elisabeth J. Walsby, Amanda F. Gilkes, Alex Tonks, Richard L. Darley & Kenneth I. Mills. (2007) FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells. British Journal of Haematology 139:1, pages 94-97.
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