Advanced search
Publication Cover
Leukemia & Lymphoma Volume 46, 2005 - Issue 12
Submit an article Journal homepage
716
Views
60
CrossRef citations to date
0
Altmetric
Original

Significance of macrophage inflammatory protein-1 alpha (MIP-1α) in multiple myeloma

Evangelos Terpos Department of Hematology, 251 General Airforce Hospital, Athens, Greece; Department of Hematology, Faculty of Medicine Imperial College London, Hammersmith Hospital, London, UKCorrespondence[email protected],[email protected]
,
Marianna Politou Department of Hematology, Faculty of Medicine Imperial College London, Hammersmith Hospital, London, UK
,
Nora Viniou First Department of Internal Medicine, University of Athens School of Medicine, Athens, Greece
&
Amin Rahemtulla Department of Hematology, Faculty of Medicine Imperial College London, Hammersmith Hospital, London, UK
Pages 1699-1707 | Received 10 May 2005, Published online: 01 Jul 2009

Citations (60)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Yong Won Choi, Joon Seong Park, Jae Ho Han, Jang-Hee Kim, Mi Sun Ahn, Hyun Woo Lee, Seok Yun Kang, Jin-Hyuk Choi & Seong Hyun Jeong. (2018) Strong immunoexpression of dickkopf-1 is associated with response to bortezomib in multiple myeloma. Leukemia & Lymphoma 59:11, pages 2670-2678.
Read now
Maria Gavriatopoulou, Meletios A. Dimopoulos, Efstathios Kastritis & Evangelos Terpos. (2017) Emerging treatment approaches for myeloma-related bone disease. Expert Review of Hematology 10:3, pages 217-228.
Read now
Marcin Kubeczko, Elżbieta Nowara, Dobromiła Karwasiecka, Grażyna Siewior, Paulina Czajka-Francuz, Jerzy Chudek & Jerzy Wojnar. (2016) C–C motif ligand 11 reduction in CLL patients serum after vitamin D supplementation. Hematology 21:6, pages 343-350.
Read now
Niklas Feldhahn, Anna Arutyunyan, Sonia Stoddart, Bin Zhang, Sabine Schmidhuber, Sun-Ju Yi, Yong-mi Kim, John Groffen & Nora Heisterkamp. (2012) Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia. OncoImmunology 1:5, pages 618-629.
Read now
Sherry T. Shu, Wessel P. Dirksen, Lisa G. Lanigan, Chelsea K. Martin, Nanda K. Thudi, Jillian L. Werbeck, Soledad A. Fernandez, Blake E. Hildreth & Thomas J. Rosol. (2012) Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro. Leukemia & Lymphoma 53:4, pages 688-698.
Read now
Konstantinos Anargyrou, Meletios-Athanassios Dimopoulos, Orhan Sezer & Evangelos Terpos. (2008) Novel anti-myeloma agents and angiogenesis. Leukemia & Lymphoma 49:4, pages 677-689.
Read now

Articles from other publishers (54)

Tünde Tóth, Hussain Alizadeh, Beáta Polgár, Renáta Csalódi, Dóra Reglődi & Andrea Tamás. (2023) Diagnostic and Prognostic Value of PACAP in Multiple Myeloma. International Journal of Molecular Sciences 24:13, pages 10801.
Crossref
Yuh-Ching Gau, Tsung-Jang Yeh, Chin-Mu Hsu, Samuel Yien Hsiao & Hui-Hua Hsiao. (2022) Pathogenesis and Treatment of Myeloma-Related Bone Disease. International Journal of Molecular Sciences 23:6, pages 3112.
Crossref
Zhili Rao, Jiuseng Zeng, Xiangyu Li, Lixia Peng, Baojun Wang, Fei Luan & Nan Zeng. (2022) JFNE-A isolated from Jing-Fang n-butanol extract attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and the NF-κB signaling pathway via promotion of autophagy. Phytomedicine 96, pages 153891.
Crossref
Alexandra Tavares Dias, Claudia Callegaro de Menezes, Sergio Kahn, Ricardo Guimarães Fischer, Carlos Marcelo da Silva Figueredo & Gustavo Vicentis de Oliveira Fernandes. (2021) Gingival recession treatment with enamel matrix derivative associated with coronally advanced flap and subepithelial connective tissue graft: a split-mouth randomized controlled clinical trial with molecular evaluation. Clinical Oral Investigations 26:2, pages 1453-1463.
Crossref
Divaya Bhutani, Rajshekhar Chakraborty & Suzanne Lentzsch. 2022. Hypercalcemia. Hypercalcemia 157 169 .
Khanyisile Mngomezulu, Gugulethu F. Mzobe, Andile Mtshali, Farzana Osman, Lenine J. P. Liebenberg, Nigel Garrett, Ravesh Singh, Anne Rompalo, Adrian Mindel, Salim S. Abdool Karim, Quarraisha Abdool Karim, Cheryl Baxter & Sinaye Ngcapu. (2021) Recent Semen Exposure Impacts the Cytokine Response and Bacterial Vaginosis in Women. Frontiers in Immunology 12.
Crossref
Nikolaos Giannakoulas, Ioannis Ntanasis-Stathopoulos & Evangelos Terpos. (2021) The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma. International Journal of Molecular Sciences 22:9, pages 4462.
Crossref
Dominika Bębnowska, Rafał Hrynkiewicz, Ewelina Grywalska, Marcin Pasiarski, Barbara Sosnowska-Pasiarska, Iwona Smarz-Widelska, Stanisław Góźdź, Jacek Roliński & Paulina Niedźwiedzka-Rystwej. (2021) Immunological Prognostic Factors in Multiple Myeloma. International Journal of Molecular Sciences 22:7, pages 3587.
Crossref
Aristea-Maria Papanota, Paraskevi Karousi, Christos K. Kontos, Ioannis Ntanasis-Stathopoulos, Andreas Scorilas & Evangelos Terpos. (2021) Multiple Myeloma Bone Disease: Implication of MicroRNAs in Its Molecular Background. International Journal of Molecular Sciences 22:5, pages 2375.
Crossref
Emmanuel Varlet, Sara Ovejero, Anne-Marie Martinez, Giacomo Cavalli & Jerome Moreaux. (2020) Role of Polycomb Complexes in Normal and Malignant Plasma Cells. International Journal of Molecular Sciences 21:21, pages 8047.
Crossref
Francisco Rafael de la Peña, Carlos Cruz-Fuentes, Lino Palacios, Manuel Iván Girón-Pérez, Emilio Medina-Rivero, Maria Dolores Ponce-Regalado, Samantha Alvarez-Herrera, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, José Luis Maldonado-García, María C Jiménez-Martínez & Lenin Pavón. (2020) Serum levels of chemokines in adolescents with major depression treated with fluoxetine. World Journal of Psychiatry 10:8, pages 175-186.
Crossref
Yitian Xu, Lu Huang, Jonathan L. Kirschman, Daryll A. Vanover, Pooja M. Tiwari, Philip J. Santangelo, Xiling Shen & David G. Russell. (2019) Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo. The Journal of Immunology 202:2, pages 608-617.
Crossref
Kok-Lun Pang & Kok-Yong Chin. (2018) The Biological Activities of Oleocanthal from a Molecular Perspective. Nutrients 10:5, pages 570.
Crossref
Masanobu Tsubaki, Tomoya Takeda, Yoshika Tomonari, Kenji Mashimo, Yu‐ichi Koumoto, Sachi Hoshida, Tatsuki Itoh, Motohiro Imano, Takao Satou, Katsuhiko Sakaguchi & Shozo Nishida. (2017) The MIP‐1α autocrine loop contributes to decreased sensitivity to anticancer drugs. Journal of Cellular Physiology 233:5, pages 4258-4271.
Crossref
Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou & Meletios A. Dimopoulos. (2018) Pathogenesis of bone disease in multiple myeloma: from bench to bedside. Blood Cancer Journal 8:1.
Crossref
Jiri Ruzicka, LuciaMachova Urdzikova, Barbora Svobodova, AnubhavG Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal & Pavla Jendelova. (2018) Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?. Neural Regeneration Research 13:1, pages 119.
Crossref
Hae Su Kim, Kyung Ju Ryu, Young Hyeh Ko, Hee-Jin Kim, Sun-Hee Kim, Won Seog Kim & Seok Jin Kim. (2017) Macrophage inflammatory protein 1 alpha (MIP-1α) may be associated with poor outcome in patients with extranodal NK/T-cell lymphoma. Hematological Oncology 35:3, pages 310-316.
Crossref
Michelle M. McDonald, Heather Fairfield, Carolyne Falank & Michaela R. Reagan. (2016) Adipose, Bone, and Myeloma: Contributions from the Microenvironment. Calcified Tissue International 100:5, pages 433-448.
Crossref
Erika Elgström, Tomas G Ohlsson & Sophie E Eriksson. (2017) Cytokine evaluation in untreated and radioimmunotherapy-treated tumors in an immunocompetent rat model. Tumor Biology 39:4, pages 101042831769755.
Crossref
Rachel Piddock, Kristian Bowles & Stuart Rushworth. (2017) The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma. Cancers 9:12, pages 29.
Crossref
Samantha E. Heron & Shokrollah Elahi. (2017) HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation. Frontiers in Immunology 8.
Crossref
Eun-Jung Park, Young-Shick Hong, Byoung-Seok Lee, Cheolho Yoon, Uiseok Jeong & Younghun Kim. (2016) Single-walled carbon nanotubes disturbed the immune and metabolic regulation function 13-weeks after a single intratracheal instillation. Environmental Research 148, pages 184-195.
Crossref
Radhakrishnan Nagarajan, Craig S. Miller, Dolph Dawson, Mohanad Al-Sabbagh & Jeffrey L. Ebersole. (2015) Patient-Specific Variations in Biomarkers across Gingivitis and Periodontitis. PLOS ONE 10:9, pages e0136792.
Crossref
Yi Li, Yuhuan Zheng, Tianshu Li, Qiang Wang, Jianfei Qian, Yong Lu, Mingjun Zhang, Enguang Bi, Maojie Yang, Frederic Reu, Qing Yi & Zhen Cai. (2015) Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma. Oncotarget 6:27, pages 24218-24229.
Crossref
Jeffrey L. Ebersole, Radhakrishnan Nagarajan, David Akers & Craig S. Miller. (2015) Targeted salivary biomarkers for discrimination of periodontal health and disease(s). Frontiers in Cellular and Infection Microbiology 5.
Crossref
Sabino CiavarellaAnna CaselliAntonella Valentina TammaAnnalisa SavonarolaGiuseppe LoverroRoberto PaganelliMarco TucciFranco Silvestris. (2015) A Peculiar Molecular Profile of Umbilical Cord-Mesenchymal Stromal Cells Drives Their Inhibitory Effects on Multiple Myeloma Cell Growth and Tumor Progression. Stem Cells and Development 24:12, pages 1457-1470.
Crossref
Adel Ersek, Ke Xu, Aristotelis Antonopoulos, Terry D. Butters, Ana Espirito Santo, Youridies Vattakuzhi, Lynn M. Williams, Katerina Goudevenou, Lynett Danks, Andrew Freidin, Emmanouil Spanoudakis, Simon Parry, Maria Papaioannou, Evdoxia Hatjiharissi, Aristeidis Chaidos, Dominic S. Alonzi, Gabriele Twigg, Ming Hu, Raymond A. Dwek, Stuart M. Haslam, Irene Roberts, Anne Dell, Amin Rahemtulla, Nicole J. Horwood & Anastasios Karadimitris. (2015) Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease. Journal of Clinical Investigation 125:6, pages 2279-2292.
Crossref
Seunggon JUNG, Hee-Young YANG & Tae-Hoon LEE. (2015) Differential expression of immunologic proteins in gingiva after socket preservation in mini pigs. Journal of Applied Oral Science 23:2, pages 187-195.
Crossref
Neeharika Nemani, Loredana Santo, Homare Eda, Diana Cirstea, Yuko Mishima, Chirayu Patel, Elizabeth O'Donnell, Andrew Yee & Noopur Raje. (2015) Role of Decorin in Multiple Myeloma (MM) Bone Marrow Microenvironment. Journal of Bone and Mineral Research 30:3, pages 465-470.
Crossref
Peter V. Aka, Troy J. Kemp, Charles S. Rabkin, Meredith S. Shiels, Mark N. Polizzotto, Carmela Lauria, Francesco Vitale, Ligia A. Pinto & James J. Goedert. (2015) A Multiplex Panel of Plasma Markers of Immunity and Inflammation in Classical Kaposi Sarcoma. Journal of Infectious Diseases 211:2, pages 226-229.
Crossref
Ishita Bhavsar, Craig S. Miller & Mohanad Al-Sabbagh. 2015. General Methods in Biomarker Research and their Applications. General Methods in Biomarker Research and their Applications 223 249 .
Brian E. CrucianSara R. ZwartSatish MehtaPeter UchakinHeather D. QuiriarteDuane PiersonClarence F. SamsScott M. Smith. (2014) Plasma Cytokine Concentrations Indicate That In Vivo Hormonal Regulation of Immunity Is Altered During Long-Duration Spaceflight . Journal of Interferon & Cytokine Research 34:10, pages 778-786.
Crossref
Giovanna Ribeiro Souto, Celso Martins Queiroz-Junior, Fernando Oliveira Costa & Ricardo Alves Mesquita. (2014) Smoking effect on chemokines of the human chronic periodontitis. Immunobiology 219:8, pages 633-636.
Crossref
Sakshi Sikka, Muthu K. Shanmugam, Radhamani Kannaiyan, Rohit Surana, Eun Myoung Shin, Alan Prem Kumar, Gautam Sethi & Kwang Seok Ahn. (2013) Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of Multiple Myeloma. Phytochemistry Reviews 13:1, pages 79-106.
Crossref
Nikolaos A. Stavropoulos, Argyro Papadoyiannis, Dimitris Maltezas, Petros Stavrou, George C. Babis, Panayiotis J. Papagelopoulos, Gerasimos A. Pangalis & Marie-Christine Kyrtsonis. (2014) Biology and Treatment of Skeletal Manifestations in Multiple Myeloma. Journal of Cancer Therapy 05:04, pages 387-402.
Crossref
Ishita Bhavsar, Craig S. Miller & Mohanad Al-Sabbagh. 2014. General Methods in Biomarker Research and their Applications. General Methods in Biomarker Research and their Applications 1 22 .
Knut Anders Mosevoll, Çiğdem Akalin Akkök, Tor Hervig, Guro K. Melve, Øystein Bruserud & Håkon Reikvam. (2013) Stem cell mobilization and harvesting by leukapheresis alters systemic cytokine levels in patients with multiple myeloma. Cytotherapy 15:7, pages 850-860.
Crossref
Patrizia Tosi. (2013) Diagnosis and Treatment of Bone Disease in Multiple Myeloma: Spotlight on Spinal Involvement. Scientifica 2013, pages 1-12.
Crossref
Daniel J. Dairaghi, Babatunde O. Oyajobi, Anjana Gupta, Brandon McCluskey, Shichang Miao, Jay P. Powers, Lisa C. Seitz, Yu Wang, Yibin Zeng, Penglie Zhang, Thomas J. Schall & Juan C. Jaen. (2012) CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease. Blood 120:7, pages 1449-1457.
Crossref
M. Al‐Sabbagh, A. Alladah, Y. Lin, R. J. Kryscio, M. V. Thomas, J. L. Ebersole & C. S. Miller. (2011) Bone remodeling‐associated salivary biomarker MIP‐1α distinguishes periodontal disease from health. Journal of Periodontal Research 47:3, pages 389-395.
Crossref
Eléonore Otjacques, Marilène Binsfeld, Agnes Noel, Yves Beguin, Didier Cataldo & Jo Caers. (2011) Biological aspects of angiogenesis in multiple myeloma. International Journal of Hematology 94:6, pages 505-518.
Crossref
Yujin Kobayashi, Yoshihiro Hatta, Yukio Hirabayashi, Atsuko Hojo, Toshitake Tanaka, Kazuhiro Takei, Hikari Ishizuka, Masahiko Sugitani, Shin Aizawa & Jin Takeuchi. (2011) Positive Expression of Macrophage Inflammatory Protein-1.ALPHA. and-1.BETA. in a Patient with Diffuse Large B-cell Lymphoma Accompanied by Hypercalcemia and Multiple Osteolysis. Journal of Nihon University Medical Association 70:2, pages 112-115.
Crossref
Jiegou Xu, Mitsuru Futakuchi, Masaaki Iigo, Katsumi Fukamachi, David B. Alexander, Hideo Shimizu, Yuto Sakai, Seiko Tamano, Fumio Furukawa, Tadashi Uchino, Hiroshi Tokunaga, Tetsuji Nishimura, Akihiko Hirose, Jun Kanno & Hiroyuki Tsuda. (2010) Involvement of macrophage inflammatory protein 1α (MIP1α) in promotion of rat lung and mammary carcinogenic activity of nanoscale titanium dioxide particles administered by intra-pulmonary spraying. Carcinogenesis 31:5, pages 927-935.
Crossref
Craig S MillerJoseph D Foley, Alison L Bailey, Charles L Campell, Roger L Humphries, Nicolaos Christodoulides, Pierre N Floriano, Glennon Simmons, Bryon Bhagwandin, James W Jacobson, Spencer W Redding, Jeffrey L EbersoleJohn T McDevitt. (2010) Current developments in salivary diagnostics. Biomarkers in Medicine 4:1, pages 171-189.
Crossref
. 2010. Robbins and Cotran Pathologic Basis of Disease. Robbins and Cotran Pathologic Basis of Disease 589 638 .
Giuliana Cassinelli, Domenica Ronchetti, Diletta Laccabue, Michela Mattioli, Giuditta Cuccuru, Enrica Favini, Valentina Nicolini, Angela Greco, Antonino Neri, Franco Zunino & Cinzia Lanzi. (2009) Concomitant downregulation of proliferation/survival pathways dependent on FGF-R3, JAK2 and BCMA in human multiple myeloma cells by multi-kinase targeting. Biochemical Pharmacology 78:9, pages 1139-1147.
Crossref
Gali Soria & Adit Ben-Baruch. 2009. Chemokine Receptors in Cancer. Chemokine Receptors in Cancer 109 130 .
Li Zhong, Jonathon Roybal, Raghothama Chaerkady, Wan Zhang, Kuicheon Choi, Cristina A. Alvarez, Hai Tran, Chad J. Creighton, Shaoyu Yan, Robert M. Strieter, Akhilesh Pandey & Jonathan M. Kurie. (2008) Identification of Secreted Proteins that Mediate Cell-Cell Interactions in an In vitro Model of the Lung Cancer Microenvironment . Cancer Research 68:17, pages 7237-7245.
Crossref
Chi-Hsun Hsieh, Michael Frink, Ya-Ching Hsieh, Wen-Hong Kan, Jun-Te Hsu, Martin G. Schwacha, Mashkoor A. Choudhry & Irshad H. Chaudry. (2008) The Role of MIP-1α in the Development of Systemic Inflammatory Response and Organ Injury following Trauma Hemorrhage. The Journal of Immunology 181:4, pages 2806-2812.
Crossref
Nicola Giuliani, Gina Lisignoli, Simona Colla, Mirca Lazzaretti, Paola Storti, Cristina Mancini, Sabrina Bonomini, Cristina Manferdini, Katia Codeluppi, Andrea Facchini & Vittorio Rizzoli. (2008) CC-Chemokine Ligand 20/Macrophage Inflammatory Protein-3α and CC-Chemokine Receptor 6 Are Overexpressed in Myeloma Microenvironment Related to Osteolytic Bone Lesions. Cancer Research 68:16, pages 6840-6850.
Crossref
Jacob Haaber, Niels Abildgaard, Lene Meldgaard Knudsen, Inger Marie Dahl, Marianne Lodahl, Mads Thomassen, Gitte Birk Kerndrup & Thomas Rasmussen. (2007) Myeloma cell expression of 10 candidate genes for osteolytic bone disease. Only overexpression of DKK1 correlates with clinical bone involvement at diagnosis. British Journal of Haematology 0:0, pages 071116225528003-???.
Crossref
Iris Breitkreutz, Marc S. Raab, Sonia Vallet, Teru Hideshima, Noopur Raje, Dharminder Chauhan, Nikhil C. Munshi, Paul G. Richardson & Kenneth C. Anderson. (2007) Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma. British Journal of Haematology 139:1, pages 55-63.
Crossref
Mariëlle J. van Breemen, Maaike de Fost, Jane S.A. Voerman, Jon D. Laman, Rolf G. Boot, Mario Maas, Carla E.M. Hollak, Johannes M. Aerts & Farhad Rezaee. (2007) Increased plasma macrophage inflammatory protein (MIP)-1α and MIP-1β levels in type 1 Gaucher disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1772:7, pages 788-796.
Crossref
Franco Silvestris, Lucia Lombardi, Monica De Matteo, Arianna Bruno & Franco Dammacco. (2007) Myeloma bone disease: Pathogenetic mechanisms and clinical assessment. Leukemia Research 31:2, pages 129-138.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.