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Leukemia & Lymphoma Volume 48, 2007 - Issue 5
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Original

Homoharringtonine-induced apoptosis of MDS cell line MUTZ-1 cells is mediated by the endoplasmic reticulum stress pathway

Hu Jie Department of Hematology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, People's Republic of China
,
He Donghua Department of Hematology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, People's Republic of China
,
Xue Xingkui Department of Hematology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, People's Republic of China
,
Gao Liang Department of Hematology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, People's Republic of China
,
Wu Wenjun Department of Hematology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, People's Republic of China
,
Han Xiaoyan Department of Hematology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, People's Republic of China
&
Dr Cai Zhen Department of Hematology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, People's Republic of ChinaCorrespondence[email protected]
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Pages 964-977 | Received 25 Sep 2006, Accepted 13 Jan 2007, Published online: 01 Jul 2009

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Xuan Zhou, Na Xu, Rong Li, Yajuan Xiao, Guanlun Gao, Qisi Lu, Li Ding, Ling Li, Yuling Li, Qingfeng Du & Xiaoli Liu. (2015) A comparative proteomic study of Homoharringtonine-induced apoptosis in leukemia K562 cells. Leukemia & Lymphoma 56:7, pages 2162-2169.
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Kumudha Balakrishnan & Varsha Gandhi. (2013) Uncoupling endoplasmic reticulum stress and autophagy: a potential implication for chronic lymphocytic leukemia therapy. Leukemia & Lymphoma 54:12, pages 2581-2583.
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Lingyun Wu, Xiao Li, Jiying Su, Chunkang Chang, Qi He, Xi Zhang, Li Xu, Luxi Song & Quan Pu. (2009) Effect of low-dose cytarabine, homoharringtonine and granulocyte colony-stimulating factor priming regimen on patients with advanced myelodysplastic syndrome or acute myeloid leukemia transformed from myelodysplastic syndrome. Leukemia & Lymphoma 50:9, pages 1461-1467.
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Haitao Meng, Chunmei Yang, Jie Jin, Yuhong Zhou & Wenbin Qian. (2008) Homoharringtonine inhibits the AKT pathway and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Leukemia & Lymphoma 49:10, pages 1954-1962.
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Articles from other publishers (13)

DP Franco, BI de Biazi, TA Zanetti, LA Marques, LVA de Lima, SR Lepri & MS Mantovani. (2020) Apoptotic and cell cycle response to homoharringtonine and harringtonine in wild and mutant p53 hepatocarcinoma cells. Human & Experimental Toxicology 39:10, pages 1405-1416.
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Cai Xiu, Xiao Li, Lingyun Wu, Feng Xu, Qi He, Zheng Zhang, Dong Wu, Luxi Song, Jiying Su, Liyu Zhou, Youshan Zhao, Ying Tao & Chunkang Chang. (2019) The efficacy and toxicity of the CHG priming regimen (low-dose cytarabine, homoharringtonine, and G-CSF) in higher risk MDS patients relapsed or refractory to decitabine. Journal of Cancer Research and Clinical Oncology 145:12, pages 3089-3097.
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Xia Li, Xiufeng Yin, Huafeng Wang, Jiansong Huang, Mengxia Yu, Zhixin Ma, Chenying Li, Yile Zhou, Xiao Yan, ShuJuan Huang & Jie Jin. (2017) The combination effect of homoharringtonine and ibrutinib on FLT3-ITD mutant acute myeloid leukemia. Oncotarget 8:8, pages 12764-12774.
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Joëlle Pérard-Viret, Laith Quteishat, Rana Alsalim, Jacques Royer & Françoise Dumas. 2017. 205 352 .
Suxia Geng, Han Yao, Jianyu Weng, Jiaqi Tong, Xin Huang, Ping Wu, Chengxin Deng, Minming Li, Zesheng Lu & Xin Du. (2016) Effects of the combination of decitabine and homoharringtonine in SKM-1 and Kg-1a cells. Leukemia Research 44, pages 17-24.
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FENG XIAO, YING LI, WEILAI XU, LIANGSHUN YOU, CHUNMEI YANG, HUI LIU & WENBIN QIAN. (2016) Efficacy and safety of homoharringtonine plus cytarabine and aclarubicin for patients with myelodysplastic syndrome-RAEB. Oncology Letters 11:1, pages 355-359.
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Akihiro Watari, Maki Hashegawa, Kiyohito Yagi & Masuo Kondoh. (2015) Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers. European Journal of Pharmaceutics and Biopharmaceutics 89, pages 232-238.
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Shuqing Lü & Jianmin Wang. (2014) Homoharringtonine and omacetaxine for myeloid hematological malignancies. Journal of Hematology & Oncology 7:1.
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N. Daver, A. Vega-Ruiz, H.M. Kantarjian, Z. Estrov, A. Ferrajoli, S. Kornblau, S. Verstovsek, G. Garcia-Manero & J.E. Cortes. (2013) A phase II open-label study of the intravenous administration of homoharringtonine in the treatment of myelodysplastic syndrome. European Journal of Cancer Care 22:5, pages 605-611.
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Jing Chen, Hulai Wei, Bei Xie, Bei Wang, Juan Cheng & Jie Cheng. (2012) Endoplasmic reticulum stress contributes to arsenic trioxide-induced apoptosis in drug-sensitive and -resistant leukemia cells. Leukemia Research 36:12, pages 1526-1535.
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S. Yin, R. Wang, F. Zhou, H. Zhang & Y. Jing. (2011) Bcl-xL Is a Dominant Antiapoptotic Protein that Inhibits Homoharringtonine-Induced Apoptosis in Leukemia Cells. Molecular Pharmacology 79:6, pages 1072-1083.
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Ross T. Weston & Hamsa Puthalakath. 2010. BCL-2 Protein Family. BCL-2 Protein Family 65 77 .
E Gyan, E Frisan, O Beyne-Rauzy, J-C Deschemin, C Pierre-Eugene, C Randriamampita, A Dubart-Kupperschmitt, C Garrido, F Dreyfus, P Mayeux, C Lacombe, E Solary & M Fontenay. (2008) Spontaneous and Fas-induced apoptosis of low-grade MDS erythroid precursors involves the endoplasmic reticulum. Leukemia 22:10, pages 1864-1873.
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