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Leukemia & Lymphoma Volume 48, 2007 - Issue 11
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Original Article: Research

(–)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells

Yang Meng Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Yan Li Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Jing Li Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Hongyan Li Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Jianjiang Fu Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Yue Liu Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
He Liu Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
&
Xiaoguang Chen Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, ChinaCorrespondence[email protected]
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Pages 2204-2212 | Received 20 May 2007, Accepted 17 Jul 2007, Published online: 01 Jul 2009

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Zhenhong Ni, Xufang Dai, Bin Wang, Wen Ding, Panke Cheng, Liang Xu, Jiqin Lian & Fengtian He. (2013) Natural Bcl-2 inhibitor (−)– gossypol induces protective autophagy via reactive oxygen species–high mobility group box 1 pathway in Burkitt lymphoma. Leukemia & Lymphoma 54:10, pages 2263-2268.
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Fahri Sahin, Cigir Biray Avci, Cumhur Gunduz, Canfeza Sezgin, Ilgin Yildirim Simsir & Guray Saydam. (2010) Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity. Hematology 15:3, pages 144-150.
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Articles from other publishers (15)

Yusuf Hussain, Abha Meena & Rohit Anthony Sinha. (2023) Gossypol synergises antiproliferative effect of sorafenib in metastatic lung cancer cells following Chou-Talalay algorithm. Toxicology in Vitro 93, pages 105666.
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Yanxia Liu, Lulu Wang, Lin Zhao & Yagang Zhang. (2022) Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design. Natural Product Reports 39:6, pages 1282-1304.
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Paul A. Townsend, Maria V. Kozhevnikova, Olivier N. F. Cexus, Andrey A. ZamyatninJrJr & Surinder M. Soond. (2021) BH3-mimetics: recent developments in cancer therapy. Journal of Experimental & Clinical Cancer Research 40:1.
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Natalie Yan Li Ngoi, Clarice Choong, Joanne Lee, Gregory Bellot, Andrea LA Wong, Boon Cher Goh & Shazib Pervaiz. (2020) Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer. Cancers 12:3, pages 574.
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Jayalakshmi Vallamkondu, Edwin Corgiat, Gollapelli Buchaiah, Ramesh Kandimalla & P. Reddy. (2018) Liquid Crystals: A Novel Approach for Cancer Detection and Treatment. Cancers 10:11, pages 462.
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Huanling Wu, L. Jeffrey Medeiros & Ken H. Young. (2018) Apoptosis signaling and BCL-2 pathways provide opportunities for novel targeted therapeutic strategies in hematologic malignances. Blood Reviews 32:1, pages 8-28.
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Ryan Chuang, Benjamin A. Hall, David Benque, Byron Cook, Samin Ishtiaq, Nir Piterman, Alex Taylor, Moshe Vardi, Steffen Koschmieder, Berthold Gottgens & Jasmin Fisher. (2015) Drug Target Optimization in Chronic Myeloid Leukemia Using Innovative Computational Platform. Scientific Reports 5:1.
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K Brinkmann & H Kashkar. (2014) Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?. Cell Death & Disease 5:3, pages e1098-e1098.
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Kumudha Balakrishnan & Varsha Gandhi. (2013) Bcl-2 antagonists: a proof of concept for CLL therapy. Investigational New Drugs 31:5, pages 1384-1394.
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Daniel J. Goff, Angela Court Recart, Anil Sadarangani, Hye-Jung Chun, Christian L. Barrett, Maryla Krajewska, Heather Leu, Janine Low-Marchelli, Wenxue Ma, Alice Y. Shih, Jun Wei, Dayong Zhai, Ifat Geron, Minya Pu, Lei Bao, Ryan Chuang, Larisa Balaian, Jason Gotlib, Mark Minden, Giovanni Martinelli, Jessica Rusert, Kim-Hien Dao, Kamran Shazand, Peggy Wentworth, Kristen M. Smith, Christina A.M. Jamieson, Sheldon R. Morris, Karen Messer, Lawrence S.B. Goldstein, Thomas J. Hudson, Marco Marra, Kelly A. Frazer, Maurizio Pellecchia, John C. Reed & Catriona H.M. Jamieson. (2013) A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition. Cell Stem Cell 12:3, pages 316-328.
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Yukako Fukushi, Masaharu Hazawa, Kenji Takahashi, Atsushi Yoshizawa & Ikuo Kashiwakura. (2010) Liquid crystal-related compound-induced cell growth suppression and apoptosis in the chronic myelogenous leukemia K562 cell line. Investigational New Drugs 29:5, pages 827-832.
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U Gupta. 2011. What's New About Crop Plants. What's New About Crop Plants 579 606 .
Feng Wang, Marcia A. Ogasawara & Peng Huang. (2010) Small mitochondria-targeting molecules as anti-cancer agents. Molecular Aspects of Medicine 31:1, pages 75-92.
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Shuraila F Zerp, Rianne Stoter, Gitta Kuipers, Dajun Yang, Marc E Lippman, Wim J van Blitterswijk, Harry Bartelink, Rogier Rooswinkel, Vincent Lafleur & Marcel Verheij. (2009) AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis. Radiation Oncology 4:1.
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Aitor Etxebarria, Olatz Landeta, Bruno Antonsson & Gorka Basañez. (2008) Regulation of antiapoptotic MCL-1 function by gossypol: Mechanistic insights from in vitro reconstituted systems. Biochemical Pharmacology 76:11, pages 1563-1576.
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