Advanced search
Publication Cover
Leukemia & Lymphoma Volume 48, 2007 - Issue 11
Submit an article Journal homepage
325
Views
42
CrossRef citations to date
0
Altmetric
Original Article: Research

Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: Higher expression of ZAP70 and PKC-β II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN

Marie Fridberg Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden
,
Anna Servin Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden
,
Lola Anagnostaki Department of Pathology, Lund University, Malmö University Hospital, Malmö, Sweden
,
Johan Linderoth Department of Oncology, Lund University, Lund, Sweden
,
Mattias Berglund Department of Oncology, Radiology and Clinical Immunology, Section of Oncology, Uppsala University, Uppsala, Sweden
,
Ola Söderberg Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
,
Gunilla Enblad Department of Oncology, Radiology and Clinical Immunology, Section of Oncology, Uppsala University, Uppsala, Sweden
,
Anders Rosén Department of Biomedicine and Surgery, Division of Cell Biology, Linköping University, Linköping, Sweden
,
Tomas Mustelin Laboratory of Signal Transduction, The Burnham Institute, La Jolla, CA, USA
,
Mats Jerkeman Department of Oncology, Lund University, Lund, Sweden
,
Jenny L. Persson Department of Pathology, Lund University, Malmö University Hospital, Malmö, Sweden
&
Anette Gjörloff Wingren Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, SwedenCorrespondence[email protected]
 show all
Pages 2221-2232 | Received 15 May 2007, Accepted 15 Aug 2007, Published online: 01 Jul 2009

Citations (42)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Tobias Herold, Medhanie A. Mulaw, Vindi Jurinovic, Till Seiler, Klaus H. Metzeler, Annika Dufour, Stephanie Schneider, Purvi M. Kakadia, Karsten Spiekermann, Ulrich Mansmann, Wolfgang Hiddemann, Christian Buske, Martin Dreyling & Stefan K. Bohlander. (2013) High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature. Leukemia & Lymphoma 54:8, pages 1652-1657.
Read now
Yan-Yan Liu, Shu-Na Yao, Yan Zhao, Zhi-Hua Yao, Jie MA, Qing-Xin Xia, Kai Fu & Shu-Jun Yang. (2010) tumor suppressor plays less prognostic role than P53 tumor suppressor in diffuse large B-cell lymphoma. Leukemia & Lymphoma 51:9, pages 1692-1698.
Read now
Rosalia Rabinovsky, Panisa Pochanard, Chontelle McNear, Saskia M. Brachmann, Jonathan S. Duke-Cohan, Levi A. Garraway & William R. Sellers. (2009) p85 Associates with Unphosphorylated PTEN and the PTEN-Associated Complex. Molecular and Cellular Biology 29:19, pages 5377-5388.
Read now
Kritika Chaiwatanatorn, Georgia Stamaratis, Ken Opeskin, Frank Firkin & Harshal Nandurkar. (2009) Protein kinase C-beta II expression in diffuse large B-cell lymphoma predicts for inferior outcome of anthracycline-based chemotherapy with and without rituximab. Leukemia & Lymphoma 50:10, pages 1666-1675.
Read now
Fredrika Gauffin, Eva Diffner, Bertil Gustafsson, Ann Nordgren, Anette Gjörloff Wingren, Birgitta Sander, Jenny Liao Persson & Britt Gustafsson. (2009) EXPRESSION OF PTEN AND SHP1, INVESTIGATED FROM TISSUE MICROARRAYS IN PEDIATRIC ACUTE LYMPHOBLASTIC, LEUKEMIA. Pediatric Hematology and Oncology 26:1, pages 48-56.
Read now

Articles from other publishers (37)

Zoe N. Loh, Mu-En Wang, Changxin Wan, John M. Asara, Zhicheng Ji & Ming Chen. (2023) Nuclear PTEN Regulates Thymidylate Biosynthesis in Human Prostate Cancer Cell Lines. Metabolites 13:8, pages 939.
Crossref
Casey G. Langdon. (2023) Nuclear PTEN’s Functions in Suppressing Tumorigenesis: Implications for Rare Cancers. Biomolecules 13:2, pages 259.
Crossref
Dimitar G. Efremov, Sven Turkalj & Luca Laurenti. (2020) Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies. Cancers 12:6, pages 1396.
Crossref
Binu K. Sasi, Claudio Martines, Elena Xerxa, Fabiola Porro, Hilal Kalkan, Rosa Fazio, Sven Turkalj, Engin Bojnik, Beata Pyrzynska, Joanna Stachura, Abdessamad Zerrouqi, Małgorzata Bobrowicz, Magdalena Winiarska, Valdemar Priebe, Francesco Bertoni, Larry Mansouri, Richard Rosenquist & Dimitar G. Efremov. (2019) Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma. Leukemia 33:10, pages 2416-2428.
Crossref
Wenzhe Si, Xujun Liu, Rui Wei, Yuan Zhang, Yang Zhao, Liyan Cui & Tianpei Hong. (2019) MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity. Cell Death & Disease 10:3.
Crossref
Xiaoxiao Wang, Xin Cao, Ruifang Sun, Charlene Tang, Alexandar Tzankov, Jun Zhang, Ganiraju C. Manyam, Min Xiao, Yi Miao, Kausar Jabbar, Xiaohong Tan, Yuyang Pang, Carlo Visco, Yan Xie, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Ben M. Parsons, Jane N. Winter, Miguel A. Piris, Shaoying Li, Roberto N. Miranda, L. Jeffrey Medeiros, Yong Li, Zijun Y. Xu-Monette & Ken H. Young. (2018) Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma. Neoplasia 20:6, pages 574-593.
Crossref
Larissa Kotelevets, Mark G. H. Scott & Eric Chastre. 2018. Targeted Therapy of Colorectal Cancer Subtypes. Targeted Therapy of Colorectal Cancer Subtypes 55 73 .
Wenli Cui, Mingfu Ma, Shutao Zheng, Zhiping Ma, Liping Su & Wei Zhang. (2017) PIK3CA amplification and PTEN loss in diffused large B-cell lymphoma. Oncotarget 8:39, pages 66237-66247.
Crossref
Hilmar Quentmeier, Hans G. Drexler, Vivien Hauer, Roderick A. F. MacLeod, Claudia Pommerenke, Cord C. Uphoff, Margarete Zaborski, Mattias Berglund, Gunilla Enblad & Rose-Marie Amini. (2016) Diffuse Large B Cell Lymphoma Cell Line U-2946: Model for MCL1 Inhibitor Testing. PLOS ONE 11:12, pages e0167599.
Crossref
Jinxue He, Zhong Zhang, Meng Ouyang, Fan Yang, Hongbo Hao, Kristy L. Lamb, Jingyi Yang, Yuxin Yin & Wen H. Shen. (2016) PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis. Nature Communications 7:1.
Crossref
Olena Gorbenko & Vuk Stambolic. 2016. PTEN. PTEN 13 19 .
Xi Kang, Chang Song, Xiao Du, Cong Zhang, Yu Liu, Ling Liang, Jinxue He, Kristy Lamb, Wen H. Shen & Yuxin Yin. (2015) PTEN stabilizes TOP2A and regulates the DNA decatenation. Scientific Reports 5:1.
Crossref
Rosalba Camicia, Hans C. Winkler & Paul O. Hassa. (2015) Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review. Molecular Cancer 14:1.
Crossref
Carolyn A. WorbyJack E. Dixon. (2014) PTEN. Annual Review of Biochemistry 83:1, pages 641-669.
Crossref
Izak Tait, Yan Li & Jun Lu. (2013) PTEN, Longevity and Age-Related Diseases. Biomedicines 1:1, pages 17-48.
Crossref
Xiaosheng Fang, Xiangxiang Zhou & Xin Wang. (2013) Clinical development of phosphatidylinositol 3-kinase inhibitors for non-Hodgkin lymphoma. Biomarker Research 1:1.
Crossref
Chuanbing Zang, Jan Eucker, Hongyu Liu, Anja Müller, Kurt Possinger & Christian Wilfried Scholz. (2013) Concurrent inhibition of PI3-Kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1. Cancer Letters 339:2, pages 288-297.
Crossref
Steve A Maxwell & Seyed Mousavi-Fard. (2013) Non-Hodgkin’s B-cell lymphoma: Advances in molecular strategies targeting drug resistance. Experimental Biology and Medicine 238:9, pages 971-990.
Crossref
F. Darío Cuello-Carrión, Niubys Cayado-Gutiérrez, Anthony L. Natoli, Christina Restall, Robin L. Anderson, Silvina Nadin, Daiana Alvarez-Olmedo, Gisela N. Castro, Francisco E. Gago, Mariel A. Fanelli & Daniel R. Ciocca. (2013) In MMTV-Her-2/neu transgenic mammary tumors the absence of caveolin-1−/− alters PTEN and NHERF1 but not β-catenin expression. Cell Stress and Chaperones 18:5, pages 559-567.
Crossref
N I Noguera, M S Song, M Divona, G Catalano, K L Calvo, F García, T Ottone, F Florenzano, I Faraoni, L Battistini, E Colombo, S Amadori, P P Pandolfi & F Lo-Coco. (2012) Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia. Leukemia 27:5, pages 1037-1043.
Crossref
Haitao Bai, Ju Wei, Chong Deng, Xiaoyu Yang, Chun Wang & Rang Xu. (2012) MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen. International Journal of Hematology 97:2, pages 223-231.
Crossref
Fabrice Jardin & Hervé Tilly. 2013. Lymphoma. Lymphoma 177 202 .
Cristina Robledo, Juan Luis García & Jesús M. Hernández. 2013. Array Comparative Genomic Hybridization. Array Comparative Genomic Hybridization 121 145 .
Alejandro Conde-Perez & Lionel Larue. (2012) PTEN and melanomagenesis. Future Oncology 8:9, pages 1109-1120.
Crossref
Amparo Andrés-Pons, Anabel Gil, María D. Oliver, Natalia-Soledad Sotelo & Rafael Pulido. (2012) Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus. Cellular Signalling 24:2, pages 577-587.
Crossref
Elizabeth M. Davies, David A. Sheffield, Priyanka Tibarewal, Clare G. Fedele, Christina A. Mitchell & Nicholas R. Leslie. 2012. Phosphoinositides I: Enzymes of Synthesis and Degradation. Phosphoinositides I: Enzymes of Synthesis and Degradation 281 336 .
Vera L. Moncalero, Roxana V. Costanzo, Claudia Perandones & Martin Radrizzani. (2011) Different Conformations of Phosphatase and Tensin Homolog, Deleted on Chromosome 10 (PTEN) Protein within the Nucleus and Cytoplasm of Neurons. PLoS ONE 6:4, pages e18857.
Crossref
J.-L. Liu, Z. Mao, G. E. Gallick & W. K. A. Yung. (2010) AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor. Neuro-Oncology 13:2, pages 184-194.
Crossref
Min Sup Song, Arkaitz Carracedo, Leonardo Salmena, Su Jung Song, Ainara Egia, Marcos Malumbres & Pier Paolo Pandolfi. (2011) Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner. Cell 144:2, pages 187-199.
Crossref
Yesim Gökmen-Polar, Rutika Mehta, Sukru Tuzmen, Spyro Mousses, Mangesh A. Thorat, Kerry L. Sanders, Dmitry Turbin, Samuel Leung, David G. Huntsman, George W. SledgeJr.Jr. & Sunil Badve. (2010) Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes. Breast Cancer Research and Treatment 124:2, pages 327-335.
Crossref
John P. Voris, Leonid A. Sitailo, Heidi R. Rahn, Ann Defnet, Aaron T. Gerds, Robert Sprague, Vipin Yadav, I. Caroline Le Poole & Mitchell F. Denning. (2010) Functional alterations in protein kinase C beta II expression in melanoma. Pigment Cell & Melanoma Research 23:2, pages 216-224.
Crossref
Joseph J. Sacco, Judy M. Coulson, Michael J. Clague & Sylvie Urbé. (2010) Emerging roles of deubiquitinases in cancer‐associated pathways. IUBMB Life 62:2, pages 140-157.
Crossref
Mitchell F. Denning. 2010. Protein Kinase C in Cancer Signaling and Therapy. Protein Kinase C in Cancer Signaling and Therapy 323 345 .
Cristina Robledo, Juan L. García, Dolores Caballero, Eulogio Conde, Reyes Arranz, Teresa Flores, Carlos Grande, José Rodríguez, Eva García, Ana I. Sáez, Marcos González, Norma C. Gutiérrez, Miguel A. Piris & Jesús M. Hernández. (2009) Array comparative genomic hybridization identifies genetic regions associated with outcome in aggressive diffuse large B‐cell lymphomas. Cancer 115:16, pages 3728-3737.
Crossref
Glenn P. Lobo, Kristin A. Waite, Sarah M. Planchon, Todd Romigh, Najah T. Nassif & Charis Eng. (2009) Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function. Human Molecular Genetics 18:15, pages 2851-2862.
Crossref
Min Sup Song, Leonardo Salmena, Arkaitz Carracedo, Ainara Egia, Francesco Lo-Coco, Julie Teruya-Feldstein & Pier Paolo Pandolfi. (2008) The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network. Nature 455:7214, pages 813-817.
Crossref
Leonardo Salmena, Arkaitz Carracedo & Pier Paolo Pandolfi. (2008) Tenets of PTEN Tumor Suppression. Cell 133:3, pages 403-414.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.