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Original Articles: Research

Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels

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Pages 965-973 | Received 20 Aug 2007, Accepted 15 Feb 2008, Published online: 01 Jul 2009

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Charles Mullighan & James Downing. (2008) Ikaros and acute leukemia. Leukemia & Lymphoma 49:5, pages 847-849.
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Articles from other publishers (20)

Adele Mucci, Gabriele Antonarelli, Carolina Caserta, Francesco Maria Vittoria, Giacomo Desantis, Riccardo Pagani, Beatrice Greco, Monica Casucci, Giulia Escobar, Laura Passerini, Nico Lachmann, Francesca Sanvito, Matteo Barcella, Ivan Merelli, Luigi Naldini & Bernhard Gentner. (2021) Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses. EMBO Molecular Medicine 13:10.
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Jason H. Rogers, Rohit Gupta, Jaime M. Reyes, Michael Gundry, Geraldo Medrano, Anna Guzman, Rogelio Aguilar, Shannon E. Conneely, Tidie Song, Cade Anthony Johnson, Sean Barnes, Carlo D.D. Cristobal, Kristen Kurtz, Lorenzo Brunetti, Margaret A Goodell & Rachel E. Rau. (2021) Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities . Blood Advances.
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Sana Mahjoub, Vera Chayeb, Hedia Zitouni, Rabeb M. Ghali, Haifa Regaieg, Wassim Y. Almawi & Touhami Mahjoub. (2019) IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study. BMC Medical Genetics 20:1.
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Changfeng Shao, Jie Yang, Yirong Kong, Cong Cheng, Wei Lu, Hongzai Guan & Haiyan Wang. (2017) Overexpression of dominant-negative Ikaros 6 isoform is associated with resistance to TKIs in patients with Philadelphia chromosome positive acute lymphoblastic leukemia. Experimental and Therapeutic Medicine 14:4, pages 3874-3879.
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Juan Han, Runming Jin, Meiling Zhang, Qing Guo & Fen Zhou. (2017) Ikaros 6 protects acute lymphoblastic leukemia cells against daunorubicin-induced apoptosis by activating the Akt-FoxO1 pathway. Journal of Leukocyte Biology 101:3, pages 675-681.
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Xiaojing Lin, Xingli Zou, Ziming Wang, Qin Fang, Shuya Chen, Jun Huang, Nana Zhe, Meisheng Yu, Yaming Zhang & Jishi Wang. (2016) Targeting of heme oxygenase-1 attenuates the negative impact of Ikaros isoform 6 in adult BCR-ABL1-positive B-ALL. Oncotarget 7:33, pages 53679-53701.
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Sofia von Palffy, Elizabeth Bulaeva, Sonja Babovic, Nagarajan Kannan, David J.H.F. Knapp, Lisa Wei, Connie J. Eaves & Philip A. Beer. (2015) Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1+ mouse BA/F3 cells. Experimental Hematology 43:7, pages 514-523.e2.
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Linda Olsson & Bertil Johansson. (2015) Ikaros and leukaemia. British Journal of Haematology 169:4, pages 479-491.
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Nicole C. C. Them & Robert Kralovics. (2013) Genetic Basis of MPN: Beyond JAK2-V617F. Current Hematologic Malignancy Reports 8:4, pages 299-306.
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Satomi Asanuma, Makoto Yamagishi, Katsuaki Kawanami, Kazumi Nakano, Aiko Sato-Otsubo, Satsuki Muto, Masashi Sanada, Tadanori Yamochi, Seiichiro Kobayashi, Atae Utsunomiya, Masako Iwanaga, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa & Toshiki Watanabe. (2013) Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T cell growth . Cancer Science 104:8, pages 1097-1106.
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Daria Capece, Francesca Zazzeroni, Maria Michela Mancarelli, Daniela Verzella, Mariafausta Fischietti, Ambra Di Tommaso, Rita Maccarone, Sara Plebani, Mauro Di Ianni, Alberto Gulino & Edoardo Alesse. (2013) A Novel, Non-canonical Splice Variant of the Ikaros Gene Is Aberrantly Expressed in B-cell Lymphoproliferative Disorders. PLoS ONE 8:7, pages e68080.
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Jelena D. Milosevic & Robert Kralovics. (2012) Genetic and epigenetic alterations of myeloproliferative disorders. International Journal of Hematology 97:2, pages 183-197.
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Ilaria Iacobucci, Nunzio Iraci, Monica Messina, Annalisa Lonetti, Sabina Chiaretti, Emanuele Valli, Anna Ferrari, Cristina Papayannidis, Francesca Paoloni, Antonella Vitale, Clelia Tiziana Storlazzi, Emanuela Ottaviani, Viviana Guadagnuolo, Sandra Durante, Marco Vignetti, Simona Soverini, Fabrizio Pane, Robin Foà, Michele Baccarani, Markus Müschen, Giovanni Perini & Giovanni Martinelli. (2012) IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic Leukemia. PLoS ONE 7:7, pages e40934.
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Kara L. Davis. (2011) Ikaros: master of hematopoiesis, agent of leukemia. Therapeutic Advances in Hematology 2:6, pages 359-368.
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Fen Zhou, Heng Mei, Runming Jin, Xiaoqing Li & Xiangjun Chen. (2011) Expression of Ikaros Isoform 6 in Chinese Children With Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology/Oncology 33:6, pages 429-432.
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Sudhir Pai Kasturi, Ioanna Skountzou, Randy A. Albrecht, Dimitrios Koutsonanos, Tang Hua, Helder I. Nakaya, Rajesh Ravindran, Shelley Stewart, Munir Alam, Marcin Kwissa, Francois Villinger, Niren Murthy, John Steel, Joshy Jacob, Robert J. Hogan, Adolfo García-Sastre, Richard Compans & Bali Pulendran. (2011) Programming the magnitude and persistence of antibody responses with innate immunity. Nature 470:7335, pages 543-547.
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Olivia L Francis. (2011) Regulator of myeloid differentiation and function: The secret life of Ikaros. World Journal of Biological Chemistry 2:6, pages 119.
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Jerald P. Radich & Olga Sala. 2011. Adult Acute Lymphocytic Leukemia. Adult Acute Lymphocytic Leukemia 25 44 .
Matthias Merkenschlager. (2010) Ikaros in immune receptor signaling, lymphocyte differentiation, and function. FEBS Letters 584:24, pages 4910-4914.
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R Jäger, H Gisslinger, F Passamonti, E Rumi, T Berg, B Gisslinger, D Pietra, A Harutyunyan, T Klampfl, D Olcaydu, M Cazzola & R Kralovics. (2010) Deletions of the transcription factor Ikaros in myeloproliferative neoplasms. Leukemia 24:7, pages 1290-1298.
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