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Leukemia & Lymphoma Volume 49, 2008 - Issue 6
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Original Article: Research

Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma

Elisabetta Capriotti Department of Dermatology, University of Rome, “Tor Vergata”, Italy
,
Eric C. Vonderheid Department of Dermatology, Johns Hopkins Medical Institutes, Baltimore, MD, USA; Department of Oncology, Johns Hopkins Medical Institutes, Baltimore, MD, USACorrespondence[email protected]
,
Christopher J. Thoburn Department of Oncology, Johns Hopkins Medical Institutes, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA
,
Mariusz A. Wasik Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
,
David W. Bahler Department of Pathology, University of Utah, Salt Lake City, UT, USA
&
Allan D. Hess Department of Oncology, Johns Hopkins Medical Institutes, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA
Pages 1190-1201 | Received 04 Dec 2008, Accepted 18 Mar 2008, Published online: 01 Jul 2009

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Edda Blümel, Shamaila Munir Ahmad, Claudia Nastasi, Andreas Willerslev-Olsen, Maria Gluud, Simon Fredholm, Tengpeng Hu, Bas G. J. Surewaard, Lise M. Lindahl, Hanne Fogh, Sergei B. Koralov, Lise Mette Rahbek Gjerdrum, Rachael A. Clark, Lars Iversen, Thorbjørn Krejsgaard, Charlotte Menné Bonefeld, Carsten Geisler, Jürgen C. Becker, Anders Woetmann, Mads Hald Andersen, Terkild Brink Buus & Niels Ødum. (2020) Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. OncoImmunology 9:1.
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Paola A Bignone & Alison H Banham. (2008) FOXP3+ regulatory T cells as biomarkers in human malignancies. Expert Opinion on Biological Therapy 8:12, pages 1897-1920.
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Tomomitsu MIYAGAKI. (2022) Immune Checkpoint Molecules and Co-stimulatory Molecules in Cutaneous T-cell Lymphoma皮膚 T 細胞リンパ腫における免疫チェックポイント分子・共刺激分子. Nishi Nihon Hifuka 84:3, pages 187-193.
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Alessandro Pileri, Alba Guglielmo, Vieri Grandi, Silvia Alberti Violetti, Daniele Fanoni, Paolo Fava, Claudio Agostinelli, Emilio Berti, Pietro Quaglino & Nicola Pimpinelli. (2021) The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications. Cells 10:10, pages 2780.
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Andrea Moerman-Herzog, Syed J. Mehdi & Henry K. Wong. (2020) Gene Expression Comparison between Sézary Syndrome and Lymphocytic-Variant Hypereosinophilic Syndrome Refines Biomarkers for Sézary Syndrome. Cells 9:9, pages 1992.
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Larisa J. Geskin, Oleg E. Akilov, Soonyou Kwon, Michael Schowalter, Simon Watkins, Theresa L. Whiteside, Lisa H. Butterfield & Louis D. Falo. (2017) Therapeutic reduction of cell-mediated immunosuppression in mycosis fungoides and Sézary syndrome. Cancer Immunology, Immunotherapy 67:3, pages 423-434.
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Kelly C.G. Manfrere, Marina P. Torrealba, Denis R. Miyashiro, Nátalli Z. Pereira, Fabio S.Y. Yoshikawa, Luana de M. Oliveira, Jade Cury-Martins, Alberto J.S. Duarte, José A. Sanches & Maria N. Sato. (2017) Profile of differentially expressed Toll-like receptor signaling genes in the natural killer cells of patients with Sézary syndrome. Oncotarget 8:54, pages 92183-92194.
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Benjamin Demoulin, W. James Cook, Joana Murad, David J Graber, Marie-Louise Sentman, Caroline Lonez, David E Gilham, Charles L Sentman & Sophie Agaugue. (2017) Exploiting natural killer group 2D receptors for CAR T-cell therapy. Future Oncology 13:18, pages 1593-1605.
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Rebecca Kohnken, Stephanie Fabbro, Justin Hastings, Pierluigi Porcu & Anjali Mishra. (2016) Sézary Syndrome: Clinical and Biological Aspects. Current Hematologic Malignancy Reports 11:6, pages 468-479.
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Mohamed Moustafa Shareef, Lamia Hamouda Elgarhy & Rania El-Said Wasfy. (2015) Expression of Granulysin and FOXP3 in Cutaneous T Cell Lymphoma and Sézary Syndrome. Asian Pacific Journal of Cancer Prevention 16:13, pages 5359-5364.
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Aurélia Henn, Laurence Michel, Charlotte Fite, Lydia Deschamps, Nicolas Ortonne, Saskia Ingen-Housz-Oro, Eduardo Marinho, Marie Beylot-Barry, Martine Bagot, Liliane Laroche, Béatrice Crickx & Eve Maubec. (2015) Sézary syndrome without erythroderma. Journal of the American Academy of Dermatology 72:6, pages 1003-1009.e1.
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DARIUSZ GRZANKA, MACIEJ GAGAT, MAGDALENA IZDEBSKA & ANDRZEJ MARSZAŁEK. (2015) Expression of special AT-rich sequence-binding protein 1 is an independent prognostic factor in cutaneous T-cell lymphoma. Oncology Reports 33:1, pages 250-266.
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Rekha Bhat, Bhavna Khandpur, Eric C. Vonderheid & J. Steve Hou. (2014) FoxP3-Positive T-Regulatory Cells in Lymph Nodes with Mycosis Fungoides and Sézary Syndrome. Lymphoma 2014, pages 1-9.
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V.E. Johnson, E.C. Vonderheid, A.D. Hess, C.M. Eischen & L.Y. McGirt. (2013) Genetic markers associated with progression in early mycosis fungoides. Journal of the European Academy of Dermatology and Venereology 28:11, pages 1431-1435.
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J.J. Scarisbrick, Y.H. Kim, S.J. Whittaker, G.S. Wood, M.H. Vermeer, H.M. Prince & P. Quaglino. (2014) Prognostic factors, prognostic indices and staging in mycosis fungoides and Sézary syndrome: where are we now?. British Journal of Dermatology 170:6, pages 1226-1236.
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. 2014. Skin Lymphoma. Skin Lymphoma 74 84 .
Francisco Llamas-Gutierrez, Gerardo Espinoza-Macias, Yvette Neme-Yunes, Ricardo Aguilar-Guadarrama, Gladys Agreda-Vásquez & Carmen Lome-Maldonado. (2014) Peripheral T cell lymphoma with a regulatory T cell phenotype: a Mexican case not associated with HTLV-1 virus infection. Journal of Hematopathology 7:1, pages 39-45.
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S K Larsen, S Munir, A Woetmann, T M Frøsig, N Odum, I M Svane, J C Becker & M H Andersen. (2013) Functional characterization of Foxp3-specific spontaneous immune responses. Leukemia 27:12, pages 2332-2340.
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Hajnalka Jókai, Márta Marschalkó, Judit Csomor, József Szakonyi, Orsolya Kontár, Gábor Barna, Sarolta Kárpáti & Péter Holló. (2012) Tissue-Specific Homing of Immune Cells in Malignant Skin Tumors. Pathology & Oncology Research 18:4, pages 749-759.
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Christine L. Jones, Silvia Ferreira, Robert C.T. McKenzie, Isabella Tosi, Jacqueline A. Caesar, Martine Bagot, Sean J. Whittaker & Tracey J. Mitchell. (2012) Regulation of T-Plastin Expression by Promoter Hypomethylation in Primary Cutaneous T-Cell Lymphoma. Journal of Investigative Dermatology 132:8, pages 2042-2049.
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E. Begue, F. Jean-Louis, M. Bagot, S. Jauliac, J.-M. Cayuela, L. Laroche, N. Parquet, H. Bachelez, A. Bensussan, G. Courtois & L. Michel. (2012) Inducible expression and pathophysiologic functions of T-plastin in cutaneous T-cell lymphoma. Blood 120:1, pages 143-154.
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T Krejsgaard, N Odum, C Geisler, M A Wasik & A Woetmann. (2011) Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome. Leukemia 26:3, pages 424-432.
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Hiroto Shinomiya. (2012) Plastin Family of Actin-Bundling Proteins: Its Functions in Leukocytes, Neurons, Intestines, and Cancer. International Journal of Cell Biology 2012, pages 1-8.
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Henry K. Wong, Anjali Mishra, Timothy Hake & Pierluigi Porcu. (2011) Evolving Insights in the Pathogenesis and Therapy of Cutaneous T-cell lymphoma (Mycosis Fungoides and Sezary Syndrome). British Journal of Haematology 155:2, pages 150-166.
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Christopher G. Kanakry, Allan D. Hess, Christopher D. Gocke, Christopher Thoburn, Ferdynand Kos, Christian Meyer, Janet Briel, Leo Luznik, B. Douglas Smith, Hyam Levitsky & Judith E. Karp. (2011) Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells. Blood 117:2, pages 608-617.
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Mansooreh Jaberipour, Mojtaba Habibagahi, Ahmad Hosseini, Saadat Rezai Habibabad, Abdolrasoul Talei & Abbas Ghaderi. (2010) Increased CTLA-4 and FOXP3 Transcripts in Peripheral Blood Mononuclear Cells of Patients with Breast Cancer. Pathology & Oncology Research 16:4, pages 547-551.
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Laura Y. McGirt, Christopher Thoburn, Allan Hess & Eric C. Vonderheid. (2010) Predictors of response to extracorporeal photopheresis in advanced mycosis fungoides and Sézary syndrome. Photodermatology, Photoimmunology & Photomedicine 26:4, pages 182-191.
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Anne Chantal Knol, Gaëlle Quéreux, Anabelle Brocard, Fabienne Ballanger, Amir Khammari, Jean-Michel Nguyen & Brigitte Dréno. (2009) Absence of modulation of CD4+CD25high regulatory T cells in CTCL patients treated with bexarotene. Experimental Dermatology 19:8, pages e95-e102.
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David A. Wada, Ryan A. Wilcox, Roger H. Weenig & Lawrence E. Gibson. (2010) Paucity of intraepidermal FoxP3‐positive T cells in cutaneous T‐cell lymphoma in contrast with spongiotic and lichenoid dermatitis. Journal of Cutaneous Pathology 37:5, pages 535-541.
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Julie M Wu, Christopher J Thoburn, Joshua Wisell, Evan R Farmer & Allan D Hess. (2010) CD20, AIF-1, and TGF-β in graft-versus-host disease: a study of mRNA expression in histologically matched skin biopsies. Modern Pathology 23:5, pages 720-728.
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Laura Ardighieri, Silvia Lonardi, William Vermi, Daniela Medicina, Lorenzo Cerroni & Fabio Facchetti. (2010) Intralymphatic atypical T‐cell proliferation in a cutaneous hemangioma. Journal of Cutaneous Pathology 37:4, pages 497-503.
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N. Tang, H. Gibson, T. Germeroth, P. Porcu, H.W. Lim & H.K. Wong. (2010) T-plastin ( PLS3 ) gene expression differentiates Sézary syndrome from mycosis fungoides and inflammatory skin diseases and can serve as a biomarker to monitor disease progression . British Journal of Dermatology 162:2, pages 463-466.
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Julia B. Heid, Angelika Schmidt, Nina Oberle, Sergij Goerdt, Peter H. Krammer, Elisabeth Suri-Payer & Claus-Detlev Klemke. (2009) FOXP3+CD25− Tumor Cells with Regulatory Function in Sézary Syndrome. Journal of Investigative Dermatology 129:12, pages 2875-2885.
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Zhu Shen, Ling Chen, Fei Hao & Jinjin Wu. (2009) Transcriptional regulation of Foxp3 gene: Multiple signal pathways on the road . Medicinal Research Reviews 29:5, pages 742-766.
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Lorenzo Cerroni, Kevin Gatter & Helmut Kerl. 2009. Skin Lymphoma: The Illustrated Guide. Skin Lymphoma: The Illustrated Guide 57 65 .
P. Quaglino, A. Comessatti, R. Ponti, A. Peroni, F. Mola, M.T. Fierro, P. Savoia, M. Novelli & M.G. Bernengo. (2009) Reciprocal Modulation of Circulating CD4+CD25+ bright T Cells Induced by Extracorporeal Photochemotherapy in Cutaneous T-Cell Lymphoma and Chronic GRAFT- Versus -Host-Disease Patients . International Journal of Immunopathology and Pharmacology 22:2, pages 353-362.
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