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Leukemia & Lymphoma Volume 49, 2008 - Issue 6
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Original Article: Clinical

Serum immunoglobulin free light chain correlates with tumor burden markers in Waldenstrom macroglobulinemia

Xavier Leleu Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA; Service des Maladies du Sang, CHRU, Lille, France
,
Anne-Sophie Moreau Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA; Service des Maladies du Sang, CHRU, Lille, France
,
Edie Weller Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health Boston, MA, USA
,
Aldo M. Roccaro Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
ValéRie Coiteux Service des Maladies du Sang, CHRU, Lille, France
,
Robert Manning Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Marybeth Nelson Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Renee Leduc Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Daniela Robu Service des Maladies du Sang, CHRU, Lille, France
,
Sophie Dupire Service des Maladies du Sang, CHRU, Lille, France
,
Evdoxia Hatjiharissi Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Nicholas Burwick Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Stéphane Darre Service des Maladies du Sang, CHRU, Lille, France
,
Bernadette Hennache Laboratoire de Biochimie, CHRU, Lille, France
,
Steven P. Treon Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Thierry Facon Service des Maladies du Sang, CHRU, Lille, France
,
Morie A. Gertz Mayo Clinic College of Medicine, Division of Hematology, Mayo Clinic, RochesterUSA
&
Irene M. Ghobrial Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USACorrespondence[email protected]
, MD show all
Pages 1104-1107 | Received 05 Feb 2008, Accepted 21 Mar 2008, Published online: 01 Jul 2009

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Elham Askari, Sara Rodriguez & Ramon Garcia-Sanz. (2021) Waldenström’s Macroglobulinemia: An Exploration into the Pathology and Diagnosis of a Complex B-Cell Malignancy. Journal of Blood Medicine 12, pages 795-807.
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Ilyas Sahin, Houry Leblebjian, Steven P Treon & Irene M Ghobrial. (2014) Waldenström macroglobulinemia: from biology to treatment. Expert Review of Hematology 7:1, pages 157-168.
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Pierre Morel & Giampaolo Merlini. (2012) Risk stratification in Waldenström macroglobulinemia. Expert Review of Hematology 5:2, pages 187-199.
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Guner Hayri Ozsan & Angela Dispenzieri. (2011) Serum free light chain analysis in multiple myeloma and plasma cell dyscrasias. Expert Review of Clinical Immunology 7:1, pages 65-73.
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Meghan Rourke, Kenneth C. Anderson & Irene M. Ghobrial. (2010) Review of clinical trials conducted in Waldenstrom macroglobulinemia and recommendations for reporting clinical trial responses in these patients. Leukemia & Lymphoma 51:10, pages 1779-1792.
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Articles from other publishers (34)

Daniel S Pearson, Dustin S McEvoy, Mandakolathur R Murali & Anand S Dighe. (2023) Use of Clinical Decision Support to Improve the Laboratory Evaluation of Monoclonal Gammopathies. American Journal of Clinical Pathology 159:2, pages 192-204.
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Morie A. Gertz. (2023) Waldenström macroglobulinemia: 2023 update on diagnosis, risk stratification, and management. American Journal of Hematology 98:2, pages 348-358.
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Zdeněk Adam, David Zeman, Luděk Pour, Marta Krejčí, Martin Krejčí, Zdeněk Řehák, Renata Koukalová, Viera Sandecká, Martin Štork, Gabriela Romanová, Zuzana Adamová & Zdeněk Král. (2022) Waldenström´s macroglobulinemia, overview of clinical symptoms, and therapy and our experience with ibrutinib therapy. Onkologie 16:Suppl. B, pages 83-102.
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Guy Pratt, Dima El‐Sharkawi, Jaimal Kothari, Shirley D’Sa, Rebecca Auer, Helen McCarthy, Rajesh Krishna, Oliver Miles, Charalampia Kyriakou & Roger Owen. (2022) Diagnosis and management of Waldenström macroglobulinaemia—A British Society for Haematology guideline . British Journal of Haematology 197:2, pages 171-187.
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Jin Seok Kim, Sung-Soo Yoon, Chang-Ki Min, Je-Jung Lee, Dok Hyun Yoon & Kihyun Kim. (2021) Screening Tests for Early Diagnosis of Multiple Myeloma and Related Plasma Cell Disorders. The Korean Journal of Medicine 96:5, pages 371-381.
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Morie A. Gertz. (2021) Waldenström macroglobulinemia: 2021 update on diagnosis, risk stratification, and management. American Journal of Hematology 96:2, pages 258-269.
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J.-P. Martellosio, X. Leleu, P. Roblot, M. Martin & M. Puyade. (2019) Dosage des chaînes légères libres : indications et méthodes. La Revue de Médecine Interne 40:5, pages 297-305.
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Morie A. Gertz. (2019) Waldenström macroglobulinemia: 2019 update on diagnosis, risk stratification, and management. American Journal of Hematology 94:2, pages 266-276.
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Morie A. Gertz. (2017) Waldenström macroglobulinemia: 2017 update on diagnosis, risk stratification, and management. American Journal of Hematology 92:2, pages 209-217.
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Marcio Andrade-Campos, Ilda Murillo-Flórez, Ramón García-Sanz & Pilar Giraldo. (2017) Immunoparesis in IgM gammopathies as a useful biomarker to predict disease progression. Clinical Chemistry and Laboratory Medicine (CCLM) 55:10.
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D. Kazmierski, M. L. Palomba & C. Barsigian. (2017) Utility of MYD88 in the Differential Diagnosis and Choice of Second-Line Therapy in a Case of Nonsecretory Lymphoplasmacytic Lymphoma versus Free Light Chain Waldenstrom’s Macroglobulinemia. Case Reports in Hematology 2017, pages 1-4.
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Eva Kimby, Roger G. Owen & Enrica Morra. 2017. Waldenström’s Macroglobulinemia. Waldenström’s Macroglobulinemia 265 275 .
Guillemette Fouquet, Stéphanie Poulain, Suzanna Schraen, Efstathios Koulieris, Elisabeth Bertrand, Stéphanie Guidez, Cécile Tomowiak, Marie-Christine Kyrtsonis, Efstathios Kastritis, Irene Ghobrial, Véronique Leblond & Xavier Leleu. 2017. Waldenström’s Macroglobulinemia. Waldenström’s Macroglobulinemia 239 261 .
Josephine M. Vos, Joshua Gustine, Helmut G. Rennke, Zachary Hunter, Robert J. Manning, Toni E. Dubeau, Kirsten Meid, Monique C. Minnema, Marie-Jose Kersten, Steven P. Treon & Jorge J. Castillo. (2016) Renal disease related to Waldenström macroglobulinaemia: incidence, pathology and clinical outcomes. British Journal of Haematology 175:4, pages 623-630.
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Jorge J. Castillo, M. Lia Palomba, Ranjana Advani & Steven P. Treon. (2016) Ibrutinib in Waldenström macroglobulinemia: latest evidence and clinical experience. Therapeutic Advances in Hematology 7:4, pages 179-186.
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Kamal Kant Singh Abbi, Margarida Silverman, Umar Farooq, Annick Tricot, Lindsey Dozeman, Kalyan Nadiminti, Matthew D. Krasowski & Guido J. Tricot. (2016) Potential pitfalls of serum free light chain analysis to assess treatment response for multiple myeloma. British Journal of Haematology 174:4, pages 536-540.
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Morie A. Gertz. (2015) Waldenström macroglobulinemia: 2015 update on diagnosis, risk stratification, and management. American Journal of Hematology 90:4, pages 346-354.
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Thomas E. Witzig, Matthew J. Maurer, Thomas M. Habermann, Brian K. Link, Ivana N.M. Micallef, Grzegorz S. Nowakowski, Stephen M. Ansell, Joseph P. Colgan, David J. Inwards, Luis F. Porrata, Svetomir N. Markovic, Patrick B. Johnston, Yi Lin, Carrie Thompson, Mamta Gupta, Jerry A. Katzmann & James R. Cerhan. (2014) Elevated monoclonal and polyclonal serum immunoglobulin free light chain as prognostic factors in B- and T-cell non-Hodgkin lymphoma. American Journal of Hematology 89:12, pages 1116-1120.
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Roger G. Owen, Guy Pratt, Rebecca L. Auer, Rita Flatley, Charalampia Kyriakou, Michael P. Lunn, Francis Matthey, Helen McCarthy, Feargal P. McNicholl, Saad M. Rassam, Simon D. Wagner, Matthew Streetly & Shirley D'Sa. (2014) Guidelines on the diagnosis and management of Waldenström macroglobulinaemia. British Journal of Haematology 165:3, pages 316-333.
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Morie A. Gertz. (2013) Waldenström macroglobulinemia: 2013 update on diagnosis, risk stratification, and management. American Journal of Hematology 88:8, pages 703-711.
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Roger G. Owen, Robert A. Kyle, Marvin J. Stone, Andy C. Rawstron, Veronique Leblond, Giampaolo Merlini, Ramon Garcia‐Sanz, Enrique M. Ocio, Enrica Morra, Pierre Morel, Kenneth C. Anderson, Christopher J. Patterson, Nikhil C. Munshi, Alessandra Tedeschi, Douglas E. Joshua, Efstathios Kastritis, Evangelos Terpos, Irene M. Ghobrial, Xavier Leleu, Morie A. Gertz, Stephen M. Ansell, William G. Morice, Eva Kimby & Steven P. Treon. (2012) Response assessment in W aldenström macroglobulinaemia: update from the VI th I nternational W orkshop . British Journal of Haematology 160:2, pages 171-176.
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Irene M. Ghobrial. (2012) Are you sure this is Waldenström macroglobulinemia?. Hematology 2012:1, pages 586-594.
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Morie A. Gertz. (2012) Waldenström Macroglobulinemia: 2012 update on diagnosis, risk stratification, and management. American Journal of Hematology 87:5, pages 503-510.
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Karen H. van Hoeven, Rosy E. Joseph, William J. Gaughan, Laura McBride, Elizabeth Bilotti, Ann McNeill, Linda Schmidt, Danielle Schillen & David S. Siegel. (2011) The Anion Gap and Routine Serum Protein Measurements in Monoclonal Gammopathies. Clinical Journal of the American Society of Nephrology 6:12, pages 2814-2821.
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Morie A. Gertz. (2011) Waldenström macroglobulinemia: 2011 update on diagnosis, risk stratification, and management. American Journal of Hematology 86:5, pages 411-416.
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Xavier Leleu, Efstathios Koulieris, Dimitrios Maltezas, Raphael Itzykson, Wanling Xie, Salomon Manier, Remy Dulery, Eilleen Boyle, Jordan Gauthier, Stéphanie Poulain, Tzenou Tatiana, Panayiotis Panayiotidis, Arthur R. Bradwell, Stephen Harding, Veronique Leblond, Marie-Christine Kyrtsonis & Irene M. Ghobrial. (2011) Novel M-Component Based Biomarkers in Waldenström's Macroglobulinemia. Clinical Lymphoma Myeloma and Leukemia 11:1, pages 164-167.
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David S. Viswanatha, Karen Dyer Montgomery & Kathryn Foucar. 2011. Hematopathology. Hematopathology 221 246 .
Matthew S. Davids, Mandakolathur R. Murali & David J. Kuter. (2010) Serum free light chain analysis. American Journal of Hematology 85:10, pages 787-790.
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Lucía López-Corral, Ramón García-Sanz & Jesús F. San Miguel. (2010) Aplicaciones del test sérico de cadenas ligeras libres en las gammapatías monoclonales. Medicina Clínica 135:8, pages 368-374.
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Trista Stankowski‐Drengler, Morie A. Gertz, Jerry A Katzmann, Martha Q. Lacy, Shaji Kumar, Nelson Leung, Suzanne R. Hayman, Francis Buadi, Robert A. Kyle, S. Vincent Rajkumar & Angela Dispenzieri. (2010) Serum immunoglobulin free light chain measurements and heavy chain isotype usage provide insight into disease biology in patients with POEMS syndrome. American Journal of Hematology 85:6, pages 431-434.
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Rebecca J Pattenden, Kerri L Davidson & Philip R Wenham. (2009) The value of serum free light chains in a case of Waldenstrom's macroglobulinaemia that produces a type I cryoglobulinaemia. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 46:6, pages 531-532.
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Abraham M. Varghese, Andy C. Rawstron, A. John Ashcroft, Paul Moreton & Roger G. Owen. (2009) Assessment of Bone Marrow Response in Waldenström's Macroglobulinemia. Clinical Lymphoma and Myeloma 9:1, pages 53-55.
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