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Original Articles: Clinical

Low rather than high Ki-67 protein expression is an adverse prognostic factor in diffuse large B-cell lymphoma

, MD, , , , &
Pages 1501-1509 | Received 05 Feb 2008, Accepted 18 Apr 2008, Published online: 01 Jul 2009

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Shahroo Etemad-Moghadam, Ali Ghaseminejad-Bandpey, Habibollah Mahmoodzadeh & Mojgan Alaeddini. (2022) Clinicopathologic significance of DNA replication licensing factors in head and neck diffuse large B-cell lymphoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 133:4, pages 462-469.
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Fabian Huber, Elisabeth Zwickl-Traxler, Martin Pecherstorfer & Josef Singer. (2021) Evaluation of Ki-67 as a Prognostic Marker in Diffuse Large B-Cell Lymphoma—A Single-Center Retrospective Cohort Study. Current Oncology 28:6, pages 4521-4529.
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Atif A Hashmi, Syeda N Iftikhar, Gul Nargus, Omer Ahmed, Ishaq Azeem Asghar, Umme Aiman Shirazi, Anoshia Afzal, Muhammad Irfan & Javaria Ali. (2021) Ki67 Proliferation Index in Germinal and Non-Germinal Subtypes of Diffuse Large B-Cell Lymphoma. Cureus.
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Feras Zaiem, Rada Jerbi, Omar Albanyan, Jordyn Puccio, Zyad Kafri, Jay Yang & Ali M Gabali. (2021) High Ki67 proliferation index but not cell-of-origin subtypes is associated with shorter overall survival in diffuse large B-cell lymphoma. Avicenna Journal of Medicine 10:04, pages 241-248.
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Antonio Giovanni Solimando, Tiziana Annese, Roberto Tamma, Giuseppe Ingravallo, Eugenio Maiorano, Angelo Vacca, Giorgina Specchia & Domenico Ribatti. (2020) New Insights into Diffuse Large B-Cell Lymphoma Pathobiology. Cancers 12:7, pages 1869.
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Osman Kupik, Serkan Akin, Murat Tuncel, Gülnihan Eren, Alev Türker, Ayşe Kars & Belkis Erbaş. (2020) Comparison of clinical and PET-derived prognostic factors in patients with non-Hodgkin lymphoma. Nuclear Medicine Communications 41:6, pages 540-549.
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Xin-Yu Zhang, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Wei Wu, Lei Cao, Lei Fan, Jian-Yong Li & Wei Xu. (2018) DA-EPOCH-R improves the outcome over that of R-CHOP regimen for DLBCL patients below 60 years, GCB phenotype, and those with high-risk IPI, but not for double expressor lymphoma. Journal of Cancer Research and Clinical Oncology 145:1, pages 117-127.
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Dan-ming Wei, Wen-jie Chen, Rong-mei Meng, Na Zhao, Xiang-yu Zhang, Dan-yu Liao & Gang Chen. (2018) Augmented expression of Ki-67 is correlated with clinicopathological characteristics and prognosis for lung cancer patients: an up-dated systematic review and meta-analysis with 108 studies and 14,732 patients. Respiratory Research 19:1.
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Yun-Long Tang, Yan Zhou, Ling-Ling Cheng, Yong-Zhong Su & Chun-Bin Wang. (2017) BCL2/Ki-67 index predict survival in germinal center B-cell-like diffuse large B-cell lymphoma. Oncology Letters 14:3, pages 3767-3773.
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Xin He, Zhigang Chen, Tao Fu, Xueli Jin, Teng Yu, Yun Liang, Xiaoying Zhao & Liansheng Huang. (2014) Ki-67 is a valuable prognostic predictor of lymphoma but its utility varies in lymphoma subtypes: evidence from a systematic meta-analysis. BMC Cancer 14:1.
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Brian Thabile FlepisiPatrick BouicGerhard SissolakBernd Rosenkranz. (2014) Biomarkers of HIV-associated Cancer. Biomarkers in Cancer 6, pages BIC.S15056.
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E Frei, C Visco, Z Y Xu-Monette, S Dirnhofer, K Dybkær, A Orazi, G Bhagat, E D Hsi, J H van Krieken, M Ponzoni, R S Go, M A Piris, M B Møller, K H Young & A Tzankov. (2013) Addition of rituximab to chemotherapy overcomes the negative prognostic impact of cyclin E expression in diffuse large B-cell lymphoma. Journal of Clinical Pathology 66:11, pages 956-961.
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Mark A. Samols, Nathan E. Smith, Jonathan M. Gerber, Milena Vuica-Ross, Christopher D. Gocke, Kathleen H. Burns, Michael J. Borowitz, Toby C. Cornish & Amy S. Duffield. (2013) Software-Automated Counting of Ki-67 Proliferation Index Correlates With Pathologic Grade and Disease Progression of Follicular Lymphomas. American Journal of Clinical Pathology 140:4, pages 579-587.
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Judy Yan & Damu Tang. 2013. Proteins of the Nucleolus. Proteins of the Nucleolus 275 304 .
Chin-Chuan Chang, Shih-Feng Cho, Yu-Wen Chen, Hung-Pin Tu, Chia-Yang Lin & Chao-Sung Chang. (2012) SUV on Dual-Phase FDG PET/CT Correlates With the Ki-67 Proliferation Index in Patients With Newly Diagnosed Non-Hodgkin Lymphoma. Clinical Nuclear Medicine 37:8, pages e189-e195.
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Zhi‐Ming Li, Jia‐Jia Huang, Yi Xia, Ying‐Jie Zhu, Wei Zhao, Wen‐Xiao Wei, Wen‐Qi Jiang, Tong‐Yu Lin, Hui‐Qiang Huang & Zhong‐Zhen Guan. (2012) High Ki‐67 expression in diffuse large B‐cell lymphoma patients with non‐germinal center subtype indicates limited survival benefit from R‐CHOP therapy. European Journal of Haematology 88:6, pages 510-517.
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Francesco Gaudio, Annamaria Giordano, Tommasina Perrone, Domenico Pastore, Paola Curci, Mario Delia, Anna Napoli, Clara de’ Risi, Alessandro Spina, Rosalia Ricco, Vincenzo Liso & Giorgina Specchia. (2011) High Ki67 Index and Bulky Disease Remain Significant Adverse Prognostic Factors in Patients with Diffuse Large B Cell Lymphoma before and after the Introduction of Rituximab. Acta Haematologica 126:1, pages 44-51.
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Devon S Chabot-Richards, David R Martin, Orrin B Myers, David R Czuchlewski & Kristin E Hunt. (2011) Quantitative image analysis in the assessment of diffuse large B-cell lymphoma. Modern Pathology 24:12, pages 1598-1605.
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Dok Hyun Yoon, Dae Ro Choi, Heui June Ahn, Shin Kim, Dae Ho Lee, Sang‐We Kim, Bong‐Hee Park, Sun Och Yoon, Jooryung Huh, Sang‐Wook Lee & Cheolwon Suh. (2010) Ki‐67 expression as a prognostic factor in diffuse large B‐cell lymphoma patients treated with rituximab plus CHOP. European Journal of Haematology 85:2, pages 149-157.
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Sverker Hasselblom, Ulrika Hansson, Markus Olsson, Leif Torén, Anders Bergström, Herman Nilsson-Ehle & Per-Ola Andersson. (2010) High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. British Journal of Haematology 149:4, pages 560-568.
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E C Obermann, M Csato, S Dirnhofer & A Tzankov. (2009) BCL2 gene aberration as an IPI-independent marker for poor outcome in non-germinal-centre diffuse large B cell lymphoma. Journal of Clinical Pathology 62:10, pages 903-907.
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J. Han van Krieken. (2009) New developments in the pathology of malignant lymphoma: a review of the literature published from August to December 2008. Journal of Hematopathology 2:1, pages 50-61.
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Vera Uzurov-Dinic, Aleksandar Savic, Tanja Lazarevic, Vesna Cemerikic-Martinovic, Danijela Agic & Stevan Popovic. (2009) Prognostic factors in patients with diffuse large B-cell lymphoma. Medicinski pregled Medical review 62:3-4, pages 171-176.
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