491
Views
75
CrossRef citations to date
0
Altmetric
Original Article

Current understanding of the role of Epstein–Barr virus in lymphomagenesis and therapeutic approaches to EBV-associated lymphomas

, , &
Pages 27-34 | Received 16 Jun 2008, Accepted 29 Jun 2008, Published online: 01 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Johanna Kampers, Manuela Orjuela-Grimm, Tilmann Schober, Thomas F. Schulz, Martina Stiefel, Christoph Klein, Dieter Körholz, Christine Mauz-Körholz, Hans Kreipe, Rita Beier & Britta Maecker-Kolhoff. (2017) Classical Hodgkin lymphoma-type PTLD after solid organ transplantation in children: a report on 17 patients treated according to subsequent GPOH-HD treatment schedules. Leukemia & Lymphoma 58:3, pages 633-638.
Read now
Amber N. Shatzer, Michael Graham Espey, Mayra Chavez, Hongbin Tu, Mark Levine & Jeffrey I. Cohen. (2013) Ascorbic acid kills Epstein–Barr virus positive Burkitt lymphoma cells and Epstein–Barr virus transformed B-cells in vitro, but not in vivo. Leukemia & Lymphoma 54:5, pages 1069-1078.
Read now
Anjali Bheda, Wei Yue, Anuradha Gullapalli, Julia Shackelford & Joseph S. Pagano. (2011) PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells. Leukemia & Lymphoma 52:7, pages 1336-1347.
Read now
Alana A. Kennedy-Nasser, Patrick Hanley & Catherine M. Bollard. (2011) Hodgkin Disease and the Role of the Immune System. Pediatric Hematology and Oncology 28:3, pages 176-186.
Read now
Anne H Blaes & Vicki A Morrison. (2010) Post-transplant lymphoproliferative disorders following solid-organ transplantation. Expert Review of Hematology 3:1, pages 35-44.
Read now

Articles from other publishers (70)

Chong Wang & Bo Zhao. (2023) Epstein‐Barr virus and host cell 3D genome organization. Journal of Medical Virology 95:11.
Crossref
Chenglong Pan, Xiaoling Ma, Yanfei Yao & Chunyan Wang. (2023) EBV-Positive Intravascular Large B-Cell Lymphoma of the Small Intestine: A Case Report and Literature Review. International Journal of Surgical Pathology.
Crossref
Junhun Cho, Eojin Kim, Sang Eun Yoon, Seok Jin Kim & Won Seog Kim. (2023) TET2 and LILRB1 mutations are frequent in Epstein–Barr virus‐positive diffuse large B‐cell lymphoma especially in elderly patients . Cancer 129:10, pages 1502-1512.
Crossref
Evelyn Stelzl, Harald H. Kessler, Amit D. Parulekar, Carolin Bier, Dominik Nörz, Tanja Schneider, Suchitra Kumar, Christian O. Simon & Marc Lütgehetmann. (2023) Comparison of four commercial EBV DNA quantitative tests to a new test at an early stage of development. Journal of Clinical Virology 161, pages 105400.
Crossref
JewWin Kuan & Noraidah Masir. (2023) A case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review. Journal of Applied Hematology 14:1, pages 62.
Crossref
Azza Ghannem, Amina Aounallah, Mossab Ghannouchi, Nacef Karim, Mohamed Ben Khalifa, Moez Boudokhan, Abdelsayyed Nihed, Sriha Badreddine, Colandane Belajouza & Mohamed Denguezli. (2021) Primary cutaneous natural killer/T‐cell lymphoma presenting as sacrococcygeal and perianal ulcers. Journal of Cutaneous Pathology 49:11, pages 925-928.
Crossref
Abhishek Tippabhatla, Rediet T Atalay, Alex Gyftopoulos, Girma M Ayele & Miriam B Michael. (2022) Epstein-Barr Virus-Positive Not Otherwise Specified (EBV+ NOS) Lymphoma Presentation of Primary Bone Tumor Underlying a Pathological Fracture. Cureus.
Crossref
Rabea Asleh, Hilmi Alnsasra, Thomas M. Habermann, Alexandros Briasoulis & Sudhir S. Kushwaha. (2022) Post-transplant Lymphoproliferative Disorder Following Cardiac Transplantation. Frontiers in Cardiovascular Medicine 9.
Crossref
Keri Toner & Catherine M. Bollard. (2022) EBV+ lymphoproliferative diseases: opportunities for leveraging EBV as a therapeutic target. Blood 139:7, pages 983-994.
Crossref
Masami Kawaharada, Satoshi Maruyama, Tatsuya Abé, Manabu Yamazaki, Akira Kurokawa, Wataru Katagiri, Ritsuo Takagi, Takafumi Hayashi, Tadaharu Kobayashi & Jun-ichi Tanuma. (2021) Other iatrogenic immunodeficiency-associated lymphoproliferative disorders in the oral cavity: a clinicopathologic study of 4 cases and literature review. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 132:6, pages 687-697.
Crossref
Johanna Stachelscheid, Qu Jiang & Marco Herling. (2021) The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A. Cancers 13:21, pages 5455.
Crossref
Jisun Hwang, Chong Hyun Suh, Kyung Won Kim, Ho Sung Kim, Philippe Armand, Raymond Y. Huang & Jeffrey P. Guenette. (2021) The Incidence of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis. Cancers 13:8, pages 1785.
Crossref
Sumaiya Cassim, Katherine Antel, Dharshnee Rama Chetty, Jenna Oosthuizen, Jessica Opie, Zainab Mohamed & Estelle Verburgh. (2020) Diffuse large B-cell lymphoma in a South African cohort with a high HIV prevalence: an analysis by cell-of-origin, Epstein–Barr virus infection and survival. Pathology 52:4, pages 453-459.
Crossref
Nadine S. Aguilera & Aaron Auerbach. (2020) T-cell lymphoproliferative processes in the spleen. Seminars in Diagnostic Pathology 37:1, pages 47-56.
Crossref
Maria Maślińska. (2019) The role of Epstein–Barr virus infection in primary Sjögren's syndrome. Current Opinion in Rheumatology 31:5, pages 475-483.
Crossref
Keri Toner, Catherine M. Bollard & Hema Dave. (2019) T-cell therapies for T-cell lymphoma. Cytotherapy 21:9, pages 935-942.
Crossref
Jennifer L. Crombie & Ann S. LaCasce. (2019) Epstein Barr Virus Associated B-Cell Lymphomas and Iatrogenic Lymphoproliferative Disorders. Frontiers in Oncology 9.
Crossref
Osman Cen, Karuppiah Kannan, Jessica Huck Sappal, Jie Yu, Mengkun Zhang, Muzaffer Arikan, Ali Ucur, Duran Ustek, Yeter Cen, Leo Gordon & Richard Longnecker. (2018) Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma. mSphere 3:4.
Crossref
Vikas R. Dharnidharka. (2018) Comprehensive review of post-organ transplant hematologic cancers. American Journal of Transplantation 18:3, pages 537-549.
Crossref
Hongying Wu, Liyan Wei, Lumei Hao, Xuemei Li, Lei Wang & Chenglu Yuan. (2018) Synchronous Hodgkin lymphoma and gastric adenocarcinoma. Medicine 97:3, pages e9484.
Crossref
Nadine Aguilera & Aaron Auerbach. (2018) Epstein-Barr Virus (EBV) associated reactive and indeterminate lymphoid proliferations in the lymph node. Seminars in Diagnostic Pathology 35:1, pages 54-60.
Crossref
Awais Masood, Anna Tumyan, Daniel R. Nussenzveig, Dara N. Wakefield, Diana Barb, Hans K. Ghayee & Naim M. Maalouf. (2017) THE DIVERSE CLINICAL PRESENTATIONS OF ADRENAL LYMPHOMA. AACE Clinical Case Reports 3:4, pages e307-e312.
Crossref
Bradley S. Podd, Dennis W. Simon, Santiago Lopez, Andrew Nowalk, Rajesh Aneja & Joseph A. Carcillo. (2017) Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure. Pediatric Clinics of North America 64:5, pages 1071-1088.
Crossref
Amy S. Duffield, Maria Libera AsciertoRobert A. Anders, Janis M. TaubeAlan K. Meeker, Shuming Chen, Tracee L. McMiller, Neil A. Phillips, Haiying XuAleksandra OgurtsovaAlan E. Berger, Drew M. PardollSuzanne L. Topalian & Richard F. Ambinder. (2017) Th17 immune microenvironment in Epstein-Barr virus–negative Hodgkin lymphoma: implications for immunotherapy. Blood Advances 1:17, pages 1324-1334.
Crossref
L. Cavicchioli, S. Ferraresso, S. Westmoreland, S. Kaliyaperumal, H. Knight, C. Crossan, L. Scobie, A. Danesi, M. Vadori, D. Trez, R. Aron Badin, P. Hantraye & E. Cozzi. (2016) Posttransplant Lymphoproliferative Disorders in Neuronal Xenotransplanted Macaques. Veterinary Pathology 54:2, pages 336-344.
Crossref
Hans-Helmut Niller & Georg Bauer. 2017. Epstein Barr Virus. Epstein Barr Virus 33 55 .
Mateusz Ziarkiewicz, Dominika Wołosz, Tomasz Dzieciątkowski, Ewa Wilczek, Jadwiga Dwilewicz-Trojaczek, Wiesław Wiktor Jędrzejczak, Beata Gierej & Bogna Ziarkiewicz-Wróblewska. (2015) Epstein–Barr Virus-Positive Diffuse Large B cell Lymphoma in the Experience of a Tertiary Medical Center in Poland. Archivum Immunologiae et Therapiae Experimentalis 64:2, pages 159-169.
Crossref
Hyeoncheol ParkJae Seok KimJee Hyun KongSung Hoon KimSang Wook ParkShin Han SongJae Won YangByoung Geun HanSeung Ok Choi. (2016) Post-transplant Lymphoproliferative Disorder in Transplanted Kidney Causing Urinary Tract Obstruction. The Journal of the Korean Society for Transplantation 30:1, pages 44.
Crossref
Lu Sun, Yu Zhao, Huaiyin Shi, Chao Ma & Lixin Wei. (2015) LMP1 promotes nasal NK/T-cell lymphoma cell function by eIF4E via NF-κB pathway. Oncology Reports.
Crossref
Jung-Woo Choi, Younghye Kim, Ju-Han Lee & Young-Sik Kim. (2015) Human Herpesvirus 8-Negative and Epstein-Barr Virus-Positive Effusion-Based Lymphoma in a Patient with Human Immunodeficiency Virus. Journal of Pathology and Translational Medicine 49:5, pages 409-412.
Crossref
Phillip K Darcy & Paul J Neeson. (2015) Adoptive immunotherapy: a new era for the treatment of cancer. Immunotherapy 7:5, pages 469-471.
Crossref
Margit Hübner, Michael Bozic, Petra M. Konrad, Katharina Grohs, Brigitte I. Santner & Harald H. Kessler. (2015) Analytical and clinical performance of a new molecular assay for Epstein-Barr virus DNA quantitation. Journal of Virological Methods 212, pages 39-43.
Crossref
Juri Ota-Kuroki, John M. Ragsdale, Bhupinder Bawa, Nobuko Wakamatsu & Keiichi Kuroki. (2014) Intraocular and periocular lymphoma in dogs and cats: a retrospective review of 21 cases (2001-2012). Veterinary Ophthalmology 17:6, pages 389-396.
Crossref
Rachel Ochs & Kristen M. Stashek. (2014) Post-immunosuppressive and immunomodulatory therapy lymphoproliferative disorders of the gastrointestinal tract. Diagnostic Histopathology 20:4, pages 156-161.
Crossref
Armin Rashidi & Stephen I. Fisher. (2013) Primary adrenal lymphoma: a systematic review. Annals of Hematology 92:12, pages 1583-1593.
Crossref
A. Conrad, A.-S. Brunet, V. Hervieu, C. Chauvet, F. Buron, S. Collardeau-Frachon, C. Rivet, P. Cassier, S. Testelin, A. Lachaux, E. Morelon & O. Thaunat. (2013) Epstein-Barr virus-associated smooth muscle tumors in a composite tissue allograft and a pediatric liver transplant recipient. Transplant Infectious Disease, pages n/a-n/a.
Crossref
Nazan Ozsan, Seckin Cagirgan, Guray Saydam, Ajda Gunes & Mine Hekimgil. (2013) Epstein-Barr virus (EBV) positive diffuse large B cell lymphoma of the elderly—Experience of a single center from Turkey. Pathology - Research and Practice 209:8, pages 471-478.
Crossref
Laura Seynaeve, Jo Caekebeke & Gert Cypers. (2012) A fatal case of Epstein Barr encephalitis presenting as fever of unknown origin. Acta Neurologica Belgica 113:1, pages 91-94.
Crossref
Nadine Wilsdorf, Britta Eiz-Vesper, Cornelia Henke-Gendo, Jana Diestelhorst, Ilske Oschlies, Kais Hussein, Lars Pape, Ulrich Baumann, Burkhard Tönshoff, Martin Pohl, Britta Höcker, Anne-Margret Wingen, Wolfram Klapper, Hans Kreipe, Thomas F. Schulz, Christoph Klein & Britta Maecker-Kolhoff. (2013) EBV-Specific T-Cell Immunity in Pediatric Solid Organ Graft Recipients With Posttransplantation Lymphoproliferative Disease. Transplantation 95:1, pages 247-255.
Crossref
Huilan Rao & Roberto N. Miranda. 2013. Non-Hodgkin Lymphoma. Non-Hodgkin Lymphoma 47 61 .
Yuan Mao, Da-Wei Zhang, Huijun Zhu, Hong Lin, Lin Xiong, Qing Cao, Ying Liu, Qing-Dong Li, Jia-Ren Xu, Lin-Feng Xu & Ren-Jie Chen. (2012) LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL). Diagnostic Pathology 7:1.
Crossref
Andrea CrowleyJeff ConnellKirsten SchafferWilliam HallJaythoon Hassan. (2012) Is There Diagnostic Value in Detection of Immunoglobulin G Antibodies to the Epstein–Barr Virus Early Antigen?. BioResearch Open Access 1:6, pages 291-296.
Crossref
Kejie Zhang. (2012) Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma. Molecular Medicine Reports.
Crossref
Karin Schreiber, Ainhoa Arina, Boris Engels, Michael T. Spiotto, John Sidney, Alessandro Sette, Theodore G. Karrison, Ralph R. Weichselbaum, Donald A. Rowley & Hans Schreiber. (2012) Spleen Cells from Young but Not Old Immunized Mice Eradicate Large Established Cancers. Clinical Cancer Research 18:9, pages 2526-2533.
Crossref
Tawatchai Pongpruttipan, Sanya Sukpanichnant, Thamathorn Assanasen, Pongsak Wannakrairot, Paisarn Boonsakan, Wasana Kanoksil, Kanita Kayasut, Winyou Mitarnun, Archrob Khuhapinant, Udomsak Bunworasate, Teeraya Puavilai, Anan Bedavanija, Adriana Garcia-Herrera, Elias Campo, James R. Cook, John Choi & Steven H. Swerdlow. (2012) Extranodal NK/T-cell Lymphoma, Nasal Type, Includes Cases of Natural Killer Cell and αβ, γδ, and αβ/γδ T-cell Origin. American Journal of Surgical Pathology 36:4, pages 481-499.
Crossref
Brandon E. Kremer, Ran Reshef, Jamal G. Misleh, Jason D. Christie, Vivek N. Ahya, Nancy P. Blumenthal, Robert M. Kotloff, Denis Hadjiliadis, Edward A. Stadtmauer, Stephen J. Schuster & Donald E. Tsai. (2012) Post-transplant lymphoproliferative disorder after lung transplantation: A review of 35 cases. The Journal of Heart and Lung Transplantation 31:3, pages 296-304.
Crossref
Naoki Yanagawa, Shin-ya Ogata, Norimasa Fukushima, Kunihiko Maeda & Gen Tamura. (2012) Synchronous Double Malignant Tumors Consisting of Stomach and Hodgkins Lymphoma with Collision between Gastric Adenocarcinoma and Hodgkins Lymphoma in the Stomach. Case Reports in Gastroenterology 6:3, pages 797-802.
Crossref
Nicky Leeborg, Thomas Russell & Guang Fan. (2012) Systemic Epstein-Barr Virus–Positive T-Cell Lymphoproliferative Disease of Childhood. Pathology Case Reviews 17:3, pages 120-124.
Crossref
Mari Takashima, Tsunayuki Kakimoto, Hideaki Saito, Sayaka Misaki, Yoshiki Onishi, Tsutomu Kasugai, Keigo Akuta, Hidenori Kasahara, Kazutaka Yamamoto, Yukiko Doi, Hidetoshi Ujiie, Hiroyuki Sugahara, Yoshihiko Hoshida & Hiroto Sakoda. (2011) Synchronous Tumor With Diffuse Large B-Cell Lymphoma and Ameboma. Journal of Clinical Oncology 29:31, pages e769-e771.
Crossref
Annegret Hofscheier, Ana Ponciano, Irina Bonzheim, Patrick Adam, Carmen Lome-Maldonado, Teresa Vela, Evelyn Cortes, Carlos Ortiz-Hidalgo, Falko Fend & Leticia Quintanilla-Martinez. (2011) Geographic variation in the prevalence of Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly: a comparative analysis of a Mexican and a German population. Modern Pathology 24:8, pages 1046-1054.
Crossref
Maurício G. Saueressig, Veronique Boussaud, Catherine Amrein, Romain Guillemain, Jihane Souilamas & Redha Souilamas. (2011) Risk factors for post-transplant lymphoproliferative disease in patients with cystic fibrosis. Clinical Transplantation 25:4, pages E430-E436.
Crossref
Courtney M. Shirley, Jianmeng Chen, Meir Shamay, Huili Li, Cynthia A. Zahnow, S. Diane Hayward & Richard F. Ambinder. (2011) Bortezomib induction of C/EBPβ mediates Epstein-Barr virus lytic activation in Burkitt lymphoma. Blood 117:23, pages 6297-6303.
Crossref
Eleonora Aricò, Domenica M. Monque, Giuseppina D’Agostino, Federica Moschella, Massimo Venditti, Ulrich Kalinke, Deborah J. Allen, Anthony A. Nash, Filippo Belardelli & Maria Ferrantini. (2011) MHV-68 producing mIFNα1 is severely attenuated in vivo and effectively protects mice against challenge with wt MHV-68. Vaccine 29:23, pages 3935-3944.
Crossref
Jing OuyangPrzemyslaw JuszczynskiScott J. RodigMichael R. GreenEvan O'DonnellTreeve CurrieMyriam ArmantKunihiko TakeyamaStefano Monti, Gabriel A. Rabinovich, Jerome RitzJeffery L. KutokMargaret A. Shipp. (2011) Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders. Blood 117:16, pages 4315-4322.
Crossref
Elizabeth Ann Wey & Lauren B. Smith. (2010) Anaplastic large cell lymphoma (monomorphic post-transplant lymphoproliferative disorder) presenting in gallbladder. Journal of Hematopathology 4:1, pages 17-20.
Crossref
Ü. Yalçıntaş Arslan, B. Öksüzoğlu, F. O. Önder, Ç. Irkkan, Ü. Üyetürk, N. Gökbayrak & N. Alkış. (2010) Concomitant Hodgkin’s lymphoma and gastric adenocarcinoma: a rare coincidence. Medical Oncology 28:1, pages 251-254.
Crossref
Jorge J. CastilloBrady E. BeltranRoberto N. MirandaSemra PaydasEric S. Winer & James N. Butera. (2011) Epstein-Barr Virus–Positive Diffuse Large B-Cell Lymphoma of the Elderly: What We Know So Far. The Oncologist 16:1, pages 87-96.
Crossref
Nima Rezaei, Elham Mahmoudi, Asghar Aghamohammadi, Rupali Das & Kim E. Nichols. (2011) X-linked lymphoproliferative syndrome: a genetic condition typified by the triad of infection, immunodeficiency and lymphoma. British Journal of Haematology 152:1, pages 13-30.
Crossref
Elaine S. Jaffe, Nancy Lee Harris & Elias Campo. 2011. Hematopathology. Hematopathology 211 220 .
Ulrike Gerdemann & Malcolm K. Brenner. 2011. Experimental and Applied Immunotherapy. Experimental and Applied Immunotherapy 3 33 .
Valeria Bergonzini, Cristiano Salata, Arianna Calistri, Cristina Parolin & Giorgio Palù. (2010) View and review on viral oncology research. Infectious Agents and Cancer 5:1.
Crossref
Margaret L. Gulley & Weihua Tang. (2010) Using Epstein-Barr Viral Load Assays To Diagnose, Monitor, and Prevent Posttransplant Lymphoproliferative Disorder. Clinical Microbiology Reviews 23:2, pages 350-366.
Crossref
Sylvia Hoeller, Alexandar Tzankov, Stefano A. Pileri, Philip Went & Stephan Dirnhofer. (2010) Epstein-Barr virus–positive diffuse large B-cell lymphoma in elderly patients is rare in Western populations. Human Pathology 41:3, pages 352-357.
Crossref
Yolanda Nesbeth & Jose R. Conejo-Garcia. (2010) Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity. Clinical and Developmental Immunology 2010, pages 1-11.
Crossref
Deqin Ma & Dan Jones. 2010. Neoplastic Hematopathology. Neoplastic Hematopathology 521 527 .
Amy Chadburn & Ethel Cesarman. 2010. Molecular Pathology of Hematolymphoid Diseases. Molecular Pathology of Hematolymphoid Diseases 367 385 .
Lucie Kalinova, Jarmila Indrakova & Petr Bachleda. (2009) POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER. Biomedical Papers 153:4, pages 251-257.
Crossref
Amorette Barber, Agnieszka Rynda & Charles L. Sentman. (2009) Chimeric NKG2D Expressing T Cells Eliminate Immunosuppression and Activate Immunity within the Ovarian Tumor Microenvironment. The Journal of Immunology 183:11, pages 6939-6947.
Crossref
Bettina Gruhne, Siamak Akbari Kamranvar, Maria G. Masucci & Ramakrishna Sompallae. (2009) EBV and genomic instability—A new look at the role of the virus in the pathogenesis of Burkitt's lymphoma. Seminars in Cancer Biology 19:6, pages 394-400.
Crossref
Nicholas K. Conrad. 2009. 241 261 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.