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Leukemia & Lymphoma Volume 49, 2008 - Issue 11
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Original Articles: Research

Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins

Alexandra Giatromanolaki Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece; Department of Radiotherapy/Oncology, Democritus University of Thrace, Alexandroupolis, GreeceCorrespondence[email protected]
,
Michael I. Koukourakis Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece; Department of Radiotherapy/Oncology, Democritus University of Thrace, Alexandroupolis, Greece
,
Francesco Pezzella Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
,
Efthimios Sivridis Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece; Department of Radiotherapy/Oncology, Democritus University of Thrace, Alexandroupolis, Greece
,
Helen Turley Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
,
Adrian L. Harris Cancer Research UK, Molecular Oncology Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
&
Kevin C. Gatter Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
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Pages 2181-2186 | Received 06 Jul 2008, Accepted 01 Sep 2008, Published online: 01 Jul 2009

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Kevin Rouault-Pierre, Ashley Hamilton & Dominique Bonnet. (2016) Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact. Expert Opinion on Biological Therapy 16:4, pages 463-476.
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Articles from other publishers (15)

Qianlei Wang, James Asenso, Ning Xiao, Jinzhang Gao, Feng Xiao, Jiajie Kuai, Wei Wei & Chun Wang. (2022) Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis. Journal of Immunology Research 2022, pages 1-11.
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Jinyan Zheng, Yongdong Dai, Xiang Lin, Qianmeng Huang, Libing Shi, Xiaoying Jin, Na Liu, Feng Zhou & Songying Zhang. (2021) Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis. Molecular Medicine Reports 24:3.
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Qiangqiang Zhao, Jian Li, Bin Wu, Yinghui Shang, Xueyuan Huang, Hang Dong, Haiting Liu, Wansong Chen, Rong Gui & Xinmin Nie. (2020) Smart Biomimetic Nanocomposites Mediate Mitochondrial Outcome through Aerobic Glycolysis Reprogramming: A Promising Treatment for Lymphoma. ACS Applied Materials & Interfaces 12:20, pages 22687-22701.
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Tajindra Singh Saluja, Anita Spadigam, Anita Dhupar & Shaheen Syed. (2015) Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype. Tumor Biology 37:4, pages 5609-5620.
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YanHong Yao, HaiTao Wang & BaoGuo Li. (2014) LDH5 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis. Tumor Biology 35:7, pages 6973-6981.
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Carlotta Granchi, Ilaria Paterni, Reshma Rani & Filippo Minutolo. (2013) Small-molecule inhibitors of human LDH5. Future Medicinal Chemistry 5:16, pages 1967-1991.
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Renquan Lu, Minglei Jiang, Zhujun Chen, Xiaofeng Xu, Hongfeng Hu, Xinmin Zhao, Xiang Gao & Lin Guo. (2013) Lactate Dehydrogenase 5 Expression in Non-Hodgkin Lymphoma Is Associated with the Induced Hypoxia Regulated Protein and Poor Prognosis. PLoS ONE 8:9, pages e74853.
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Martin Grimm, Dorothea Alexander, Adelheid Munz, Juergen Hoffmann & Siegmar Reinert. (2012) Increased LDH5 expression is associated with lymph node metastasis and outcome in oral squamous cell carcinoma. Clinical & Experimental Metastasis 30:4, pages 529-540.
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Ewa Lech-Maranda, Jacques Bienvenu, Florence Broussais-Guillaumot, Anne-Sophie Michallet, Krzysztof Warzocha, Przemysław Biliński, Peter Boyle, Bertrand Coiffier & Gilles Salles. (2013) Pretreatment Levels of Vascular Endothelial Growth Factor in Plasma Predict a Complete Remission Rate and Time to Relapse or Progression in Patients with Diffuse Large B-Cell Lymphoma. Archivum Immunologiae et Therapiae Experimentalis 61:2, pages 165-174.
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Robert Matthew Kottmann, Ajit A. Kulkarni, Katie A. Smolnycki, Elizabeth Lyda, Thinesh Dahanayake, Rami Salibi, Sylvie Honnons, Carolyn Jones, Nancy G. Isern, Jian Z. Hu, Steven D. Nathan, Geraldine Grant, Richard P. Phipps & Patricia J. Sime. (2012) Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-β. American Journal of Respiratory and Critical Care Medicine 186:8, pages 740-751.
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Stefan Langhammer, Maher Najjar, Holger Hess-Stumpp & Karl-Heinz Thierauch. (2011) LDH-A influences hypoxia-inducible factor 1? (HIF1 ?) and is critical for growth of HT29 colon carcinoma cells in vivo. Targeted Oncology 6:3, pages 155-162.
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Jinsong HuDamian R. Handisides, Els Van ValckenborghHendrik De Raeve, Eline MenuIsabelle Vande BroekQian Liu, Jessica D. Sun, Ben Van CampCharles P. Hart & Karin Vanderkerken. (2010) Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug. Blood 116:9, pages 1524-1527.
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Manal M. El Behery, Mansour H. Huda, Ebtesam M. Kamal & Amaal E. Shehatta. (2009) Diagnostic accuracy of uterine fluid lactate dehydrogenase isoenzyme activity profile and vaginal ultrasound in detecting endometrial cancer in women with postmenopausal bleeding. Archives of Gynecology and Obstetrics 281:4, pages 717-721.
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Anne LeCharles R. CooperArvin M. GouwRamani DinavahiAnirban MaitraLorraine M. Deck, Robert E. Royer, David L. Vander Jagt, Gregg L. SemenzaChi V. Dang. (2010) Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proceedings of the National Academy of Sciences 107:5, pages 2037-2042.
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Lei Yang, Xiaohong Xu, Chunlei Peng, Jinzhi Wei, Zhuchen Song & Zhirong Cong. (2009) Prognostic values of serum LDH and β2-MG in patients with non-Hodgkin’s lymphoma. The Chinese-German Journal of Clinical Oncology 8:6, pages 353-355.
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