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Leukemia & Lymphoma Volume 49, 2008 - Issue 12
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Original Articles: Research

Rapamycin shows anticancer activity in primary chronic lymphocytic leukemia cells in vitro, as single agent and in drug combination

Anna Åleskog Department of Medical Sciences (Hematology)Correspondence[email protected]
,
Maria Norberg Department of Genetics and Pathology
,
Peter Nygren Department of Oncology, Radiology and Clinical Immunology
,
Linda Rickardson Department of Medical Sciences (Clinical Pharmacology)
,
Meena Kanduri Department of Genetics and Pathology
,
Gerard Tobin Department of Genetics and Pathology
,
Magnus Åberg Department of Engineering Sciences, Uppsala University, Uppsala, Sweden
,
Mats G. Gustafsson Department of Medical Sciences (Clinical Pharmacology); Department of Engineering Sciences, Uppsala University, Uppsala, Sweden
,
Richard Rosenquist Department of Genetics and Pathology
&
Elin Lindhagen Department of Medical Sciences (Clinical Pharmacology)
 show all
Pages 2333-2343 | Received 20 Jan 2008, Accepted 12 Sep 2008, Published online: 01 Jul 2009

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Hany Khalil, Amira Abd ElHady, Khaled A. Elawdan, Dalia Mohamed, Doaa D. Mohamed, Ahmed I Abd El Maksoud, Farha A. El-Chennawi, Bhgat El-Fikiy & Ibrahim H. El-Sayed. (2022) The Mechanical Autophagy as a Part of Cellular Immunity; Facts and Features in Treating the Medical Disorders. Immunological Investigations 51:2, pages 266-289.
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Cecilia M. Rodriguez, Claudio Bussi, Daniela S. Arroyo, Dario Sastre, Viviana Heller, Carmen Stanganelli, Irma Slavutsky & Pablo Iribarren. (2019) Effects of rapamycin in combination with fludarabine on primary chronic lymphocytic leukemia cells. Leukemia & Lymphoma 60:5, pages 1299-1303.
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Ali Bazargan & Constantine S. Tam. (2010) New angles of attack in the fight against chronic lymphocytic leukemia: the advent of novel non-chemotherapeutic agents. Leukemia & Lymphoma 51:9, pages 1596-1611.
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Anne H Blaes & Vicki A Morrison. (2010) Post-transplant lymphoproliferative disorders following solid-organ transplantation. Expert Review of Hematology 3:1, pages 35-44.
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Bertrand Coiffier & Vincent Ribrag. (2009) Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies. Leukemia & Lymphoma 50:12, pages 1916-1930.
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Thomas Decker. (2008) Is mTOR inhibition a therapeutic option in chronic lymphocytic leukemia?. Leukemia & Lymphoma 49:12, pages 2235-2236.
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Articles from other publishers (10)

Matthew D. BluntMatthew J. CarterMarta LarrayozLindsay D. SmithMaria Aguilar-HernandezKerry L. CoxThomas TiptonMark ReynoldsSarah MurphyElizabeth LemmSamantha DiasAndrew Duncombe, Jonathan C. StreffordPeter W. M. JohnsonFrancesco Forconi, Freda K. StevensonGraham PackhamMark S. CraggAndrew J. Steele. (2015) The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model. Blood 125:26, pages 4032-4041.
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Toby A. Eyre, Graham P. Collins, Anthony H. Goldstone & Kate Cwynarski. (2014) Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies. British Journal of Haematology 166:3, pages 336-351.
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Roel Polak & Miranda Buitenhuis. (2012) The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia. Blood 119:4, pages 911-923.
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Lia Ginaldi & Massimo De Martinis. 2012. Biotargets of Cancer in Current Clinical Practice. Biotargets of Cancer in Current Clinical Practice 159 194 .
John C. Riches, Alan G. Ramsay & John G. Gribben. (2011) Chronic Lymphocytic Leukemia: An Update on Biology and Treatment. Current Oncology Reports 13:5.
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Jonathan H. Schatz. (2011) Targeting the PI3K/AKT/mTOR Pathway in Non-Hodgkin’s Lymphoma: Results, Biology, and Development Strategies. Current Oncology Reports 13:5, pages 398-406.
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R. Gitendra Wickremasinghe, Archibald G. Prentice & Andrew J. Steele. (2011) Aberrantly activated anti-apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: clues to the identification of novel therapeutic targets. British Journal of Haematology 153:5, pages 545-556.
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N Chapuis, J Tamburini, A S Green, L Willems, V Bardet, S Park, C Lacombe, P Mayeux & D Bouscary. (2010) Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies. Leukemia 24:10, pages 1686-1699.
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Clive S. Zent, Betsy R. LaPlant, Patrick B. Johnston, Timothy G. Call, Thomas M. Habermann, Ivana N. Micallef & Thomas E. Witzig. (2010) The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation. Cancer, pages NA-NA.
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Tadeusz Robak, Krzysztof Jamroziak & Pawel Robak. (2009) Current and Emerging Treatments for Chronic Lymphocytic Leukaemia. Drugs 69:17, pages 2415-2449.
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