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Original Article: Clinical

Whole blood Epstein-Barr virus DNA load as a diagnostic and prognostic surrogate: extranodal natural killer/T-cell lymphoma

, , , , , , , , , , MD, PhD, , & , MD, PhD show all
Pages 757-763 | Received 16 Dec 2008, Accepted 05 Feb 2009, Published online: 21 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Xiao-Xiao Wang, Peng-Fei Li, Bing Bai, Yan Gao, Qi-Xiang Rong, Qing-Qing Cai, Su-Xia Lin, Yu-Jing Zhang, Zhi-Ming Li, Wen-Qi Jiang & Hui-Qiang Huang. (2019) Differential clinical significance of pre-, interim-, and post-treatment plasma Epstein–Barr virus DNA load in NK/T-cell lymphoma treated with P-GEMOX protocol. Leukemia & Lymphoma 60:8, pages 1917-1925.
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Sung Won Lim, Kyung Ju Ryu, Hansang Lee, Young Hyeh Ko, Won Seog Kim & Seok Jin Kim. (2019) Serum IL18 is associated with hemophagocytosis and poor survival in extranodal natural killer/T-cell lymphoma. Leukemia & Lymphoma 60:2, pages 317-325.
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Ruiwan Chen, Chengtao Wang, Yu Zhou & Bixiu Wen. (2018) Prognostic implications of circulating Epstein–Barr virus DNA for extranodal natural killer/T-cell lymphoma, nasal type: a meta-analysis. Cancer Management and Research 10, pages 2183-2192.
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Qian Fei, Xiao-Kang Tian, Jing Wu, Hong-Ming Zhu, Yan Wang, Fan-Yu Peng, Wen-Jun Zhang, Li Yin & Xia He. (2018) Prognostic significance of Epstein–Barr virus DNA in NK/T-cell lymphoma: a meta-analysis. OncoTargets and Therapy 11, pages 997-1004.
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Stephanie Ruf & Hans-Joachim Wagner. (2013) Determining EBV load: current best practice and future requirements. Expert Review of Clinical Immunology 9:2, pages 139-151.
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Holbrook Kohrt, Mark Lee & Ranjana Advani. (2010) Risk stratification in extranodal natural killer/T-cell lymphoma. Expert Review of Anticancer Therapy 10:9, pages 1395-1405.
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Alex S. C. Machado, Marcela C. Da Silva Robaina, Lidia M. Magalhães De Rezende, Alexandre G. Apa, Nívea D. Amoêdo, Carlos E. Bacchi & Claudete E. Klumb. (2010) Circulating cell-free and Epstein–Barr virus DNA in pediatric B-non-Hodgkin lymphomas. Leukemia & Lymphoma 51:6, pages 1020-1027.
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Holbrook Kohrt & Ranjana Advani. (2009) Extranodal natural killer/T-cell lymphoma: current concepts in biology and treatment. Leukemia & Lymphoma 50:11, pages 1773-1784.
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Articles from other publishers (46)

Mateusz Rzepka, Dagmara Depka, Eugenia Gospodarek-Komkowska & Tomasz Bogiel. (2023) Diagnostic Value of Whole-Blood and Plasma Samples in Epstein–Barr Virus Infections. Diagnostics 13:3, pages 476.
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Zheng Yan, Zhihua Yao, Haiying Wang, Shuna Yao, Xiaoxiao Wang, Yan Gao, Bing Bai, Junfeng Chu, Shuang Zhao, Xufeng Luo, Wenping Zhou, Jiuyang Zhang, Peipei Zhang, Huiqiang Huang & Yanyan Liu. (2022) Plasma EBV-DNA and peripheral blood mononuclear cell EBV-DNA have disparate clinical relevance in patients with extranodal NK/T-cell lymphoma. Journal of Clinical Virology 157, pages 105320.
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Na Li, Ming Jiang, Wan-chun Wu & Li-qun Zou. (2022) Nomograms to predict progression of disease within 24 months in patients with localized natural killer/T-cell lymphoma. Future Oncology 18:32, pages 3573-3583.
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Lihua Qiu, Junqi Si, Junnan Kang, Zehui Chen, Rexidan Nuermaimaiti, Zhengzi Qian, Lanfang Li, Shiyong Zhou, Mingjian James You, Huilai Zhang & Chen Tian. (2022) A retrospective analysis of EBV‐DNA status with the prognosis of lymphoma . Journal of Cellular and Molecular Medicine 26:20, pages 5195-5201.
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Junhyup Song, Jun Yong Kim, Sinyoung Kim & Younhee Park. (2022) Utility of Epstein-Barr Viral Load in Blood for Diagnosing and Predicting Prognosis of Lymphoma. The Journal of Molecular Diagnostics 24:9, pages 977-991.
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Na Li, Ming Jiang, Wan-chun Wu & Li-qun Zou. (2022) The value of prognostic nutritional index in nasal-type, extranodal natural killer/T-cell lymphoma. Annals of Hematology 101:7, pages 1545-1556.
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Jason Yongsheng Chan, Jing Quan Lim & Choon Kiat Ong. (2021) Towards Next Generation Biomarkers in Natural Killer/T-Cell Lymphoma. Life 11:8, pages 838.
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Joo Hyun Kim, Won Seog Kim & Chaehwa Park. (2021) Sildenafil prevents HDACi-induced Epstein-Barr virus reactivation through the PKG pathway in NK/T cell lymphoma; potential implications for HDACi-mediated fatal complications. Antiviral Research 189, pages 105063.
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Young Hyeh Ko. (2021) EBV-Associated Lymphoproliferative Disorders. Clinical Pediatric Hematology-Oncology 28:1, pages 14-27.
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Zegeng Chen, Xiaojie Fang, He Huang, Zhao Wang, Huangming Hong, Meiting Chen, Quanguang Ren, Yuyi Yao, Limei Zhang, Ying Tian, Suxia Lin & Tongyu Lin. (2020) A proposal for a prognostic index for non-nasal type natural killer/T cell lymphoma after asparaginase-based treatment. Annals of Hematology 99:12, pages 2811-2819.
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Khee Ming Tan, Burton Chia, Jing Quan Lim, Lay Poh Khoo, Chee Leong Cheng, Leonard Tan, Eileen Poon, Nagavalli Somasundaram, Mohamad Farid, Tiffany Pooi Ling Tang, Miriam Tao, Daryl Ming Zhe Cheah, Yurike Laurensia, Jane Wan Lu Pang, Tammy Song, Jing Tan, Dachuan Huang, Seok Jin Kim, Won Seog Kim, Choon Kiat Ong, Soon Thye Lim & Jason Yongsheng Chan. (2019) A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study. Scientific Reports 9:1.
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Ibraheem Motabi, Musa Alzahrani, Reyad Dada, Mubarak Al-Mansour, Hani Alhashmi, Magdy Kandil, Ahmed Sagheir & Ayman Alhejazi. (2019) Natural Killer/T-Cell lymphoma: Saudi Lymphoma Group's clinical practice guidelines for diagnosis, management and follow-up. Saudi Journal of Medicine and Medical Sciences 7:3, pages 222.
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Seok Jin Kim, Sang Eun Yoon & Won Seog Kim. (2018) Treatment of localized extranodal NK/T cell lymphoma, nasal type: a systematic review. Journal of Hematology & Oncology 11:1.
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Peng-fei Li, Yi-ze Mao, Bing Bai, Yan Gao, Yu-jing Zhang, Zhi-ming Li, Wen-qi Jiang & Hui-qiang Huang. (2018) Persistent peripheral blood EBV-DNA positive with high expression of PD-L1 and upregulation of CD4 + CD25 + T cell ratio in early stage NK/T cell lymphoma patients may predict worse outcome. Annals of Hematology 97:12, pages 2381-2389.
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Ze-Long Liu, Xi-Wen Bi, Pan-Pan Liu, De-Xin Lei, Wen-Qi Jiang & Yi Xia. (2018) The Clinical Utility of Circulating Epstein-Barr Virus DNA Concentrations in NK/T-Cell Lymphoma: A Meta-Analysis. Disease Markers 2018, pages 1-8.
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Jinhyun Cho, Seok Jin Kim, Silvia Park, Kwai Han Yoo, Chang-Seok Ki, Younghyeh Ko & Won Seog Kim. (2018) Significance of circulating Epstein-Barr virus DNA monitoring after remission in patients with extranodal natural killer T cell lymphoma. Annals of Hematology 97:8, pages 1427-1436.
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J-H Liang, L Wang, R Peter Gale, W Wu, Y Xia, L Fan, J-Y Li & W Xu. (2017) Efficacy of pegaspargase, etoposide, methotrexate and dexamethasone in newly diagnosed advanced-stage extra-nodal natural killer/T-cell lymphoma with the analysis of the prognosis of whole blood EBV-DNA. Blood Cancer Journal 7:9, pages e608-e608.
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S H Lim, S H Hyun, H S Kim, J Y Lee, K H Yoo, K S Jung, H-N Song, J Cho, S Park, Y H Ko, S J Kim, J Y Choi & W S Kim. (2016) Prognostic relevance of pretransplant Deauville score on PET-CT and presence of EBV DNA in patients who underwent autologous stem cell transplantation for ENKTL. Bone Marrow Transplantation 51:6, pages 807-812.
Crossref
Seok Jin Kim, Dok Hyun Yoon, Arnaud Jaccard, Wee Joo Chng, Soon Thye Lim, Huangming Hong, Yong Park, Kian Meng Chang, Yoshinobu Maeda, Fumihiro Ishida, Dong-Yeop Shin, Jin Seok Kim, Seong Hyun Jeong, Deok-Hwan Yang, Jae-Cheol Jo, Gyeong-Won Lee, Chul Won Choi, Won-Sik Lee, Tsai-Yun Chen, Kiyeun Kim, Sin-Ho Jung, Tohru Murayama, Yasuhiro Oki, Ranjana Advani, Francesco d'Amore, Norbert Schmitz, Cheolwon Suh, Ritsuro Suzuki, Yok Lam Kwong, Tong-Yu Lin & Won Seog Kim. (2016) A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis. The Lancet Oncology 17:3, pages 389-400.
Crossref
Rong Liang, Zhe Wang, Qing-Xian Bai, Guang-Xun Gao, Lan Yang, Tao Zhang, Hong-Tao Gu, Bao-Xia Dong, Mi-Mi Shu, Cai-Xia Hao, Na Zhang & Xie-Qun Chen. (2016) Natural Killer/T Cell Lymphoma, Nasal Type: A Retrospective Clinical Analysis in North-Western China. Oncology Research and Treatment 39:1-2, pages 45-52.
Crossref
Yiting Li & Ivan Damjanov. (2016) Extranodal NK/T Cell Lymphoma Causing Cardiorespiratory Failure. Case Reports in Hematology 2016, pages 1-6.
Crossref
Lielian Zuo, Haibo Yu, Lingzhi Liu, Yunlian Tang, Hongzhuan Wu, Jing Yang, Meijuan Zhu, Shujuan Du, Lian Zhao, Li Cao, Guiyuan Li & Jianhong Lu. (2015) The copy number of Epstein-Barr virus latent genome correlates with the oncogenicity by the activation level of LMP1 and NF-κB. Oncotarget 6:38, pages 41033-41044.
Crossref
Seok Jin Kim, Kyung Ju Ryu, Mineui Hong, Young Hyeh Ko & Won Seog Kim. (2015) The serum CXCL13 level is associated with the Glasgow Prognostic Score in extranodal NK/T-cell lymphoma patients. Journal of Hematology & Oncology 8:1.
Crossref
LIANG WANG, ZHI-HUI WANG, XIAO-QIN CHEN, KE-FENG WANG, HUI-QIANG HUANG & ZHONG-JUN XIA. (2015) First-line combination of GELOX followed by radiation therapy for patients with stage IE/IIE ENKTL: An updated analysis with long-term follow-up. Oncology Letters 10:2, pages 1036-1040.
Crossref
Seok Jin Kim, Joon Young Choi, Seung Hyup Hyun, Chang-Seok Ki, Dongryul Oh, Yong Chan Ahn, Young Hyeh Ko, Sunkyu Choi, Sin-Ho Jung, Pek-Lan Khong, Tiffany Tang, Xuexian Yan, Soon Thye Lim, Yok-Lam Kwong & Won Seog Kim. (2015) Risk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphoma, nasal type: a multicentre, retrospective analysis. The Lancet Haematology 2:2, pages e66-e74.
Crossref
Liang Wang, Zhong-jun Xia, Yue Lu & Yu-jing Zhang. (2014) Prophylactic cervical lymph node irradiation provides no benefit for patients of stage IE extranodal natural killer/T cell lymphoma, nasal type. Medical Oncology 32:1.
Crossref
Seok Jin Kim, Silvia Park, Eun Suk Kang, Joon Young Choi, Do Hoon Lim, Young Hyeh Ko & Won Seog Kim. (2014) Induction treatment with SMILE and consolidation with autologous stem cell transplantation for newly diagnosed stage IV extranodal natural killer/T-cell lymphoma patients. Annals of Hematology 94:1, pages 71-78.
Crossref
Seok Jin Kim, Deok-Hwan Yang, Jin Seok Kim, Jae-Yong Kwak, Hyeon-Seok Eom, Dae Sik Hong, Jong Ho Won, Jae Hoon Lee, Dok Hyun Yoon, Jaeho Cho, Taek-Keun Nam, Sang-wook Lee, Yong Chan Ahn, Cheolwon Suh & Won Seog Kim. (2014) Concurrent chemoradiotherapy followed by l-asparaginase-containing chemotherapy, VIDL, for localized nasal extranodal NK/T cell lymphoma: CISL08-01 phase II study. Annals of Hematology 93:11, pages 1895-1901.
Crossref
Owen A. O'Connor, Govind Bhagat, Karthik Ganapathi, Martin Bjerregaard Pedersen, Francesco D'Amore, Dejan Radeski & Susan E. Bates. (2014) Changing the Paradigms of Treatment in Peripheral T-cell Lymphoma: From Biology to Clinical Practice. Clinical Cancer Research 20:20, pages 5240-5254.
Crossref
Y-L Kwong, A W K Pang, A Y H Leung, C-S Chim & E Tse. (2013) Quantification of circulating Epstein–Barr virus DNA in NK/T-cell lymphoma treated with the SMILE protocol: diagnostic and prognostic significance. Leukemia 28:4, pages 865-870.
Crossref
Liang Wang, Pei-dong Chi, Hao Chen, Jin Xiang, Zhong-jun Xia & Yu-jing Zhang. (2013) Low level of high-density lipoprotein cholesterol correlates with poor prognosis in extranodal natural killer/T cell lymphoma. Tumor Biology 35:3, pages 2141-2149.
Crossref
Won Seog Kim, Seok Jin Kim & Young Hyeh Ko. 2014. Rare Lymphomas. Rare Lymphomas 121 131 .
Ya‐Jun Li, Wen‐Qi Jiang, Jia‐Jia Huang, Zhong‐Jun Xia, Hui‐Qiang Huang & Zhi‐Ming Li. (2013) The Glasgow Prognostic Score (GPS) as a novel and significant predictor of extranodal natural killer/T‐cell lymphoma, nasal type. American Journal of Hematology 88:5, pages 394-399.
Crossref
Liang Wang, Zhi‐hui Wang, Xiao‐qin Chen, Ya‐jun Li, Ke‐feng Wang, Yun‐fei Xia & Zhong‐jun Xia. (2012) First‐line combination of gemcitabine, oxaliplatin, and L‐asparaginase (GELOX) followed by involved‐field radiation therapy for patients with stage IE/IIE extranodal natural killer/T‐cell lymphoma. Cancer 119:2, pages 348-355.
Crossref
Liang Wang, Zhong-jun Xia, Hui-qiang Huang, Yue Lu & Yu-jing Zhang. (2012) Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type: 13-year follow-up in 135 patients. International Journal of Hematology 96:5, pages 617-623.
Crossref
Zhao-Yang Wang, Qing-Feng Liu, Hua Wang, Jing Jin, Wei-Hu Wang, Shu-Lian Wang, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Hua Ren, Run-Ye Wu, Bo Chen, Xi-Mei Zhang, Ning-Ning Lu, Li-Qiang Zhou & Ye-Xiong Li. (2012) Clinical implications of plasma Epstein-Barr virus DNA in early-stage extranodal nasal-type NK/T-cell lymphoma patients receiving primary radiotherapy. Blood 120:10, pages 2003-2010.
Crossref
Zhi-Ming Li, Ying-Jie Zhu, Jian Sun, Yi Xia, Jia-Jia Huang, Ben-Yan Zou, Tong-Yu Lin, Hui-Qiang Huang & Wen-Qi Jiang. (2012) Serum beta2-microglobin is a predictor of prognosis in patients with upper aerodigestive tract NK/T-cell lymphoma. Annals of Hematology 91:8, pages 1265-1270.
Crossref
Claire E. Dearden, Rod Johnson, Ruth Pettengell, Stephen Devereux, Kate Cwynarski, Sean Whittaker & Andrew McMillan. (2011) Guidelines for the management of mature T‐cell and NK‐cell neoplasms (excluding cutaneous T‐cell lymphoma). British Journal of Haematology 153:4, pages 451-485.
Crossref
Francine M. Foss. (2011) Molecular Predictors of Response in Aggressive T-cell Lymphomas. The Cancer Journal 17:2, pages 142-148.
Crossref
Seok Jin KimKihyun KimByung Soo KimChul Yong KimCheolwon SuhJooryung HuhSang-Wook LeeJin Seok KimJaeho ChoGyeong-Won LeeKi Mun KangHyeon Seok EomHong Ryull PyoYong Chan AhnYoung Hyeh KoWon Seog Kim. (2009) Phase II Trial of Concurrent Radiation and Weekly Cisplatin Followed by VIPD Chemotherapy in Newly Diagnosed, Stage IE to IIE, Nasal, Extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma Study. Journal of Clinical Oncology 27:35, pages 6027-6032.
Crossref

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