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Leukemia & Lymphoma Volume 50, 2009 - Issue 5
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Original Article: Research

Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia

Margot Jak Department of Hematology; Department of Experimental Immunology, Academic Medical Center, Amsterdam, The NetherlandsCorrespondence[email protected]
,
Margot Jak Department of Hematology; Department of Experimental Immunology, Academic Medical Center, Amsterdam, The NetherlandsCorrespondence[email protected]
,
Rogier Mous Department of Hematology; Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
,
Ester B. M. Remmerswaal Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
,
René Spijker Department of Hematology; Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
,
Annelieke Jaspers Department of Hematology; Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
,
Adriana Yagüe Department of Hematology
,
Eric Eldering Department of Hematology; Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
,
René A. W. Van Lier Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
&
Marinus H. J. Van Oers Department of Hematology
 show all
Pages 788-801 | Received 22 Dec 2008, Accepted 05 Feb 2009, Published online: 21 Jul 2009

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Xiaoyan Li, Ning Kang, Xuan Zhang, Xiaoying Dong, Wei Wei, Lianxian Cui, Denian Ba & Wei He. (2011) Generation of Human Regulatory γδ T Cells by TCRγδ Stimulation in the Presence of TGF-β and Their Involvement in the Pathogenesis of Systemic Lupus Erythematosus. The Journal of Immunology 186:12, pages 6693-6700.
Crossref
Giovanni D’Arena, Luca Laurenti, Maria Marta Minervini, Silvia Deaglio, Lisa Bonello, Laura De Martino, Laura De Padua, Lucia Savino, Michela Tarnani, Vincenzo De Feo & Nicola Cascavilla. (2011) Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease. Leukemia Research 35:3, pages 363-368.
Crossref
M Le Garff-Tavernier, J Decocq, C de Romeuf, C Parizot, C A Dutertre, E Chapiro, F Davi, P Debré, J F Prost, J L Teillaud, H Merle-Beral & V Vieillard. (2010) Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies. Leukemia 25:1, pages 101-109.
Crossref
Mark C. Lanasa. (2010) Novel Insights into the Biology of CLL. Hematology 2010:1, pages 70-76.
Crossref
John C. Riches, Alan G. Ramsay & John G. Gribben. (2010) T-cell function in chronic lymphocytic leukaemia. Seminars in Cancer Biology 20:6, pages 431-438.
Crossref
Rajendra N. Damle, Carlo Calissano & Nicholas Chiorazzi. (2010) Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells. Best Practice & Research Clinical Haematology 23:1, pages 33-45.
Crossref
Dimitrios Mougiakakos, Aniruddha Choudhury, Alvaro Lladser, Rolf Kiessling & C. Christian Johansson. 2010. 57 117 .
Martijn A. Nolte, Ronald W. van Olffen, Klaas P. J. M. van Gisbergen & René A. W. van Lier. (2009) Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunological Reviews 229:1, pages 216-231.
Crossref

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