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Leukemia & Lymphoma Volume 50, 2009 - Issue 5
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Clinical challenges associated with bortezomib therapy in multiple myeloma and Waldenströms Macroglobulinemia

Dr Jacob P. Laubach Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USACorrespondence[email protected]
,
Constantine S. Mitsiades Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
,
Aldo M. Roccaro Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
,
Irene M. Ghobrial Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
,
Kenneth C. Anderson Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
&
Paul G. Richardson Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Pages 694-702 | Received 20 Feb 2009, Accepted 04 Mar 2009, Published online: 21 Jul 2009

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Giorgia Gazzaroli, Andrea Angeli, Arianna Giacomini & Roberto Ronca. (2023) Proteasome inhibitors as anticancer agents. Expert Opinion on Therapeutic Patents 0:0, pages 1-22.
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Steffan T Nawrocki, Patrick Griffin, Kevin R Kelly & Jennifer S Carew. (2012) MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy. Expert Opinion on Investigational Drugs 21:10, pages 1563-1573.
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Laia Sadeghi & Anthony P. H. Wright. (2023) GSK-J4 Inhibition of KDM6B Histone Demethylase Blocks Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells by Modulating NF-κB Signaling. Cells 12:15, pages 2010.
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Jia Wen Yeap & Mei Lan Tan. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 54 .
E. Oksuzoglu & B. Dursun. (2023) Patterns of the Expression of Cyclin Genes in Bortezomib-Sensitive and Resistant Cells of Multiple Myeloma. Biology Bulletin 49:S2, pages S37-S45.
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Christopher N. Grimont, Natalia E. Castillo Almeida & Morie A. Gertz. (2021) Current and Emerging Treatments for Waldenström Macroglobulinemia. Acta Haematologica 144:2, pages 146-157.
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Mei Lan Tan, Shahrul Bariyah Sahul Hamid, Muhammad Asyraf Abduraman & Heng Kean Tan. 2020. Cancer Immunology. Cancer Immunology 307 353 .
Tiffany A. Thibaudeau & David M. Smith. (2019) A Practical Review of Proteasome Pharmacology. Pharmacological Reviews 71:2, pages 170-197.
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Ming Gao, Quan Liu & Liping Chen. (2019) Cardiac amyloidosis as a rare cause of heart failure. Medicine 98:14, pages e15036.
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Kush Patel, Zainab SO Ahmed, Xuemei Huang, Qianqian Yang, Elmira Ekinci, Christine M Neslund-Dudas, Bharati Mitra, Fawzy AEM Elnady, Young-Hoon Ahn, Huanjie Yang, Jinbao Liu & Qing Ping Dou. (2018) Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition. Future Medicinal Chemistry 10:17, pages 2087-2108.
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Bingzong Li, Jinxiang Fu, Ping Chen, Xueping Ge, Yali Li, Isere Kuiatse, Hua Wang, Huihan Wang, Xingding Zhang & Robert Z. Orlowski. (2015) The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediate Bortezomib Resistance in Multiple Myeloma. Journal of Biological Chemistry 290:50, pages 29854-29868.
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Yunhua He, Yuchan Wang, Hong Liu, Xiaohong Xu, Song He, Jie Tang, Yuejiao Huang, Xiaobing Miao, Yaxun Wu, Qiru Wang & Chun Cheng. (2015) Pyruvate kinase isoform M2 (PKM2) participates in multiple myeloma cell proliferation, adhesion and chemoresistance. Leukemia Research 39:12, pages 1428-1436.
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Subrahmanya D. Vallabhapurapu, Sunil K. Noothi, Derek A. Pullum, Charles H. Lawrie, Rachel Pallapati, Veena Potluri, Christian Kuntzen, Sohaib Khan, David R. Plas, Robert Z. Orlowski, Marta Chesi, W. Michael Kuehl, P. Leif Bergsagel, Michael Karin & Sivakumar Vallabhapurapu. (2015) Transcriptional repression by the HDAC4–RelB–p52 complex regulates multiple myeloma survival and growth. Nature Communications 6:1.
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Jie Tang, Lili Ji, Yuchan Wang, Yuejiao Huang, Haibing Yin, Yunhua He, Jing Liu, Xiaobing Miao, Yaxun Wu, Xiaohong Xu, Song He & Chun Cheng. (2015) Cell adhesion down-regulates the expression of vacuolar protein sorting 4B (VPS4B) and contributes to drug resistance in multiple myeloma cells. International Journal of Hematology 102:1, pages 25-34.
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Mei Lan Tan, Heng Kean Tan & Tengku Sifzizul Tengku Muhammad. 2015. Cancer Immunology. Cancer Immunology 209 242 .
Pádraig D'Arcy & Stig Linder. (2014) Molecular Pathways: Translational Potential of Deubiquitinases as Drug Targets. Clinical Cancer Research 20:15, pages 3908-3914.
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Thorsten Hoppe. (2014) Limited Proteolysis: DisRUPting Proteasomal Inhibition. Current Biology 24:15, pages R693-R695.
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Zhe Sha & Alfred L. Goldberg. (2014) Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97. Current Biology 24:14, pages 1573-1583.
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Li Yin, Turner Kufe, David Avigan & Donald Kufe. (2014) Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death. Blood 123:19, pages 2997-3006.
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Binhua Zhou, Yinglin Zuo, Baojian Li, Hao Wang, Hao Liu, Xianfeng Wang, Xu Qiu, Yun Hu, Shijun Wen, Jun Du & Xianzhang Bu. (2013) Deubiquitinase Inhibition of 19S Regulatory Particles by 4-Arylidene Curcumin Analog AC17 Causes NF-κB Inhibition and p53 Reactivation in Human Lung Cancer Cells. Molecular Cancer Therapeutics 12:8, pages 1381-1392.
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Veena Potluri, Sunil K. Noothi, Subrahmanya D. Vallabhapurapu, Sang-Oh Yoon, James J. Driscoll, Charles H. Lawrie & Sivakumar Vallabhapurapu. (2013) Transcriptional Repression of Bim by a Novel YY1-RelA Complex Is Essential for the Survival and Growth of Multiple Myeloma. PLoS ONE 8:7, pages e66121.
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Y Zheng, J Yang, J Qian, P Qiu, S Hanabuchi, Y Lu, Z Wang, Z Liu, H Li, J He, P Lin, D Weber, R E Davis, L Kwak, Z Cai & Q Yi. (2012) PSGL-1/selectin and ICAM-1/CD18 interactions are involved in macrophage-induced drug resistance in myeloma. Leukemia 27:3, pages 702-710.
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David I. LichterHadi DanaeeMichael D. PickardOlga TayberMichael SintchakHongliang ShiPaul G. RichardsonJamie CavenaghJoan BladéThierry FaçonRuben NiesvizkyMelissa AlsinaWilliam DaltonPieter SonneveldSagar LonialHelgi van de Velde, Deborah Ricci, Dixie-Lee EsseltineWilliam L. TrepicchioGeorge MulliganKenneth C. Anderson. (2012) Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone. Blood 120:23, pages 4513-4516.
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Pádraig D’Arcy & Stig Linder. (2012) Proteasome deubiquitinases as novel targets for cancer therapy. The International Journal of Biochemistry & Cell Biology 44:11, pages 1729-1738.
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Deborah J. KuhnZuzana BerkovaRichard J. JonesRichard Woessner, Chad C. BjorklundWencai MaR. Eric DavisPei LinHua WangTimothy L. Madden, Caimiao Wei, Veerabhadran Baladandayuthapani, Michael WangSheeba K. ThomasJatin J. ShahDonna M. WeberRobert Z. Orlowski. (2012) Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma. Blood 120:16, pages 3260-3270.
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Ashish Anshu, Simmy Thomas, Puneet Agarwal, Tannya R. Ibarra-Rivera, Michael C. Pirrung & Axel H. Schönthal. (2011) Novel proteasome-inhibitory syrbactin analogs inducing endoplasmic reticulum stress and apoptosis in hematological tumor cell lines. Biochemical Pharmacology 82:6, pages 600-609.
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Leonardo Mirandola, Yuefei Yu, Kitty Chui, Marjorie R. Jenkins, Everardo Cobos, Constance M. John & Maurizio Chiriva-Internati. (2011) Galectin-3C Inhibits Tumor Growth and Increases the Anticancer Activity of Bortezomib in a Murine Model of Human Multiple Myeloma. PLoS ONE 6:7, pages e21811.
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Xiang Ling, Diane Calinski, Asher A Chanan-Khan, Muxiang Zhou & Fengzhi Li. (2010) Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types. Journal of Experimental & Clinical Cancer Research 29:1.
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