Advanced search
Publication Cover
Leukemia & Lymphoma Volume 50, 2009 - Issue 6
Submit an article Journal homepage
353
Views
33
CrossRef citations to date
0
Altmetric
Original Article: Research

Human T-leukemia and T-lymphoma express glutamate receptor AMPA GluR3, and the neurotransmitter glutamate elevates the cancer-related matrix-metalloproteinases inducer CD147/EMMPRIN, MMP-9 secretion and engraftment of T-leukemia in vivo

Yonatan Ganor Department of Neurobiology, the Weizmann Institute of Science, Rehovot, Israel
,
Igor Grinberg The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
,
Yonatan Ganor Department of Neurobiology, the Weizmann Institute of Science, Rehovot, Israel
,
Igor Grinberg The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
,
Arbel Reis The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
,
Itzik Cooper Department of Neurobiology, the Weizmann Institute of Science, Rehovot, Israel
,
Ronald S. Goldstein The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
&
Dr. Mia Levite Department of Neurobiology, the Weizmann Institute of Science, Rehovot, Israel; The School of Behavioral Sciences, the Academic College of Tel-Aviv-Yaffo, IsraelCorrespondence[email protected]
 show all
Pages 985-997 | Received 06 Dec 2008, Accepted 08 Mar 2009, Published online: 21 Jul 2009

Citations (33)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Jennifer Vandooren, Philippe E. Van den Steen & Ghislain Opdenakker. (2013) Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade. Critical Reviews in Biochemistry and Molecular Biology 48:3, pages 222-272.
Read now

Articles from other publishers (32)

Mia Levite. (2023) Neuro faces of beneficial T cells: essential in brain, impaired in aging and neurological diseases, and activated functionally by neurotransmitters and neuropeptides. Neural Regeneration Research 18:6, pages 1165.
Crossref
Kathleen Holton. 2023. Translational Neuroimmunology, Volume 7. Translational Neuroimmunology, Volume 7 239 266 .
Ana Cristina García-Gaytán, Andy Hernández-Abrego, Mauricio Díaz-Muñoz & Isabel Méndez. (2022) Glutamatergic system components as potential biomarkers and therapeutic targets in cancer in non-neural organs. Frontiers in Endocrinology 13.
Crossref
Nai-Shan Zheng, Xiang-Yu Zhao, Ding Wei, Jin-Lin Miao, Ze-Kun Liu, Yu-Le Yong, Ren-Yu Zhang, Yi-Xiao Guo, Lin He, Bin Wang, Xiu-Xuan Sun, Hai-Jiao Yang, Tian-Jiao Zhang, Qian He, Xiao-Min Li, Hai Zhang, Rong Hou, Peng Lin, Ying-Ming Xu, Xiao-Jun Huang, Zhi-Nan Chen & Huijie Bian. (2022) CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia. Cancer Letters 542, pages 215762.
Crossref
Yan Zhang, John-Man-Tak Chu & Gordon-Tin-Chun Wong. (2022) Cerebral Glutamate Regulation and Receptor Changes in Perioperative Neuroinflammation and Cognitive Dysfunction. Biomolecules 12:4, pages 597.
Crossref
Alessandro Allegra, Emanuela Sant’Antonio, Caterina Musolino & Roberta Ettari. (2022) New Insights into Neuropeptides Regulation of the Immune System and Hemopoiesis: Effects on Hematologic Malignancies. Current Medicinal Chemistry 29:14, pages 2412-2437.
Crossref
Rohan Rao, Sanjit Shah, Debanjan Bhattacharya, Donatien Kamdem Toukam, Román Cáceres, Daniel A. Pomeranz Krummel & Soma Sengupta. (2022) Ligand-Gated Ion Channels as Targets for Treatment and Management of Cancers. Frontiers in Physiology 13.
Crossref
Mia Levite & Hadassa Goldberg. (2022) Autoimmune Epilepsy - Novel Multidisciplinary Analysis, Discoveries and Insights. Frontiers in Immunology 12.
Crossref
Yurii V. Stepanov, Iuliia Golovynska, Nataliia V. Dziubenko, Halyna M. Kuznietsova, Nataliia Petriv, Inessa Skrypkina, Sergii Golovynskyi, Liudmyla I. Stepanova, Yevhenii Stohnii, Liudmyla V. Garmanchuk, Liudmyla I. Ostapchenko, Tetyana Yevsa, Junle Qu & Tymish Y. Ohulchanskyy. (2022) NMDA receptor expression during cell transformation process at early stages of liver cancer in rodent models. American Journal of Physiology-Gastrointestinal and Liver Physiology 322:1, pages G142-G153.
Crossref
Mia Levite, Rifaat Safadi, Yael Milgrom, Muhammad Massarwa & Eithan Galun. (2021) Neurotransmitters and Neuropeptides decrease PD-1 in T cells of healthy subjects and patients with hepatocellular carcinoma (HCC), and increase their proliferation and eradication of HCC cells. Neuropeptides 89, pages 102159.
Crossref
Manh Tien Tran. (2021) Effects of Tumor Microenvironment Acidification on Progression of Pancreatic Ductal Adenocarcinoma: A Review. Asia-Pacific Journal of Oncology, pages 17-26.
Crossref
Mia Levite. (2021) T Cells Plead for Rejuvenation and Amplification; With the Brain’s Neurotransmitters and Neuropeptides We Can Make It Happen. Frontiers in Immunology 12.
Crossref
Shree Goyal, Pallab Chakraborty & Balasubramaniam Shankar. (2021) Ionotropic glutamate receptors and their implications in cancer and cancer therapeutics. Biomedical and Biotechnology Research Journal (BBRJ) 5:4, pages 349.
Crossref
Thomas Wesley Hodo, Maria Teresa Prudente de Aquino, Akiko Shimamoto & Anil Shanker. (2020) Critical Neurotransmitters in the Neuroimmune Network. Frontiers in Immunology 11.
Crossref
Mohammad Ayoub Rigi-Ladiz, Tayebeh Baranzehi, Behnaz Hassanpour, Mohammad Javad Ashraf & Dor Mohammad Kordi-Tamandani. (2019) DNA methylation and expression status of glutamate receptor genes in patients with oral squamous cell carcinoma. Meta Gene 20, pages 100545.
Crossref
Mohammad Ayoub Rigi-Ladiz, Tayebeh Baranzehi, Behnaz Hassanpour, Mohammad Javad Ashraf, Leila Farhad-Mollashahi & Dor Mohammad Kordi-Tamandani. (2019) DNA methylation and expression status of glutamate receptor genes in patients with oral squamous cell carcinoma. Meta Gene, pages 100555.
Crossref
Mia Levite. (2017) Glutamate, T cells and multiple sclerosis. Journal of Neural Transmission 124:7, pages 775-798.
Crossref
S. Parenti, G. Casagrande, M. Montanari, M. Espahbodinia, R. Ettari, A. Grande & L. Corsi. (2016) A novel 2,3-benzodiazepine-4-one derivative AMPA antagonist inhibits G2/M transition and induces apoptosis in human leukemia Jurkat T cell line. Life Sciences 152, pages 117-125.
Crossref
S?bastien J. Dumas, Marc Humbert & Sylvia Cohen-Kaminsky. (2017) Le paradigme du cancer dans l?hypertension art?rielle pulmonaire?: vers une th?rapie anti-remodelage ciblant la dysfonction m?tabolique??. Biologie Aujourd'hui 210:4, pages 171-189.
Crossref
. 2016. Translational Neuroimmunology in Multiple Sclerosis. Translational Neuroimmunology in Multiple Sclerosis e1 .
Ming-Xiang FengJing-Pei LiHao WangYa-Xing ShenLi-Jie TanQun WangYu-Qi Wang. (2015) Clinical Significance of Cyclophilin A Expression in Esophageal Squamous Cell Carcinoma. Genetic Testing and Molecular Biomarkers 19:4, pages 182-186.
Crossref
Marcel Klingenberg, Jürgen Becker, Sonja Eberth, Dieter Kube & Jörg Wilting. (2014) The chick chorioallantoic membrane as an in vivo xenograft model for Burkitt lymphoma. BMC Cancer 14:1.
Crossref
Sven Saussez, Barbara Laumbacher, Gilbert Chantrain, Alexandra Rodriguez, Songhai Gu, Rudolf Wank & Mia Levite. (2014) Towards Neuroimmunotherapy for Cancer: the Neurotransmitters Glutamate, Dopamine and GnRH-II augment substantially the ability of T cells of few Head and Neck cancer patients to perform spontaneous migration, chemotactic migration and migration towards the autologous tumor, and also elevate markedly the expression of CD3zeta and CD3epsilon TCR-associated chains. Journal of Neural Transmission 121:8, pages 1007-1027.
Crossref
Mia Levite. (2014) GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren’s syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. Journal of Neural Transmission 121:8, pages 1029-1075.
Crossref
Andrzej Stepulak, Radoslaw Rola, Krzysztof Polberg & Chrysanthy Ikonomidou. (2014) Glutamate and its receptors in cancer. Journal of Neural Transmission 121:8, pages 933-944.
Crossref
Yonatan Ganor & Mia Levite. (2014) The neurotransmitter glutamate and human T cells: glutamate receptors and glutamate-induced direct and potent effects on normal human T cells, cancerous human leukemia and lymphoma T cells, and autoimmune human T cells. Journal of Neural Transmission 121:8, pages 983-1006.
Crossref
Craig N. MorrellAngela A. AggreyLesley M. Chapman & Kristina L. Modjeski. (2014) Emerging roles for platelets as immune and inflammatory cells. Blood 123:18, pages 2759-2767.
Crossref
Susanne Krasemann, Melanie Neumann, Beata Szalay, Carol Stocking & Markus Glatzel. (2013) Protease-sensitive prion species in neoplastic spleens of prion-infected mice with uncoupling of PrPSc and prion infectivity. Journal of General Virology 94:2, pages 453-463.
Crossref
Yonatan Ganor & Mia Levite. 2012. Nerve-Driven Immunity. Nerve-Driven Immunity 121 161 .
Karin Edsparr, Per H. Basse, Ronald H. Goldfarb & Per Albertsson. (2010) Matrix Metalloproteinases in Cytotoxic Lymphocytes Impact on Tumour Infiltration and Immunomodulation. Cancer Microenvironment 4:3, pages 351-360.
Crossref
Stefanie Ripka, Jan Riedel, Albrecht Neesse, Heidi Griesmann, Malte Buchholz, Volker Ellenrieder, Franz Moeller, Peter Bartht, Thomas M. Gress & Patrick Michl. (2010) Glutamate Receptor GRIA3—Target of CUX1 and Mediator of Tumor Progression in Pancreatic Cancer. Neoplasia 12:8, pages 659-IN6.
Crossref
Shree Goyal & Pallab Chakraborty. (2020) Ionotropic Glutamate Receptors and Their Implications in Cancer and Therapeutics. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.