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Leukemia & Lymphoma Volume 58, 2017 - Issue 12
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Original Articles: Research

Tariquidar sensitizes multiple myeloma cells to proteasome inhibitors via reduction of hypoxia-induced P-gp-mediated drug resistance

Barbara MuzDepartment of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA; View further author information
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Hubert D. KusdonoDepartment of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA; ;Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA; View further author information
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Feda AzabDepartment of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA; View further author information
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Pilar de la PuenteDepartment of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA; View further author information
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Cinzia FedericoDepartment of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA; View further author information
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Mark FialaSection of Stem Cell Transplant and Leukemia, Division of Medical Oncology, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA; View further author information
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Ravi VijSection of Stem Cell Transplant and Leukemia, Division of Medical Oncology, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA; View further author information
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Noha N. SalamaDepartment of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA; ;Department of Pharmaceutics and Industrial Pharmacy, Cairo University Faculty of Pharmacy, Cairo, EgyptView further author information
&
Abdel Kareem AzabDepartment of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA; Correspondence[email protected]
View further author information
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Pages 2916-2925 | Received 28 Oct 2016, Accepted 06 Apr 2017, Published online: 16 May 2017

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Shanshan Wang, Ming-Yue Li, Yi Liu, Alexander C Vlantis, Jason YK Chan, Lingbin Xue, Bao-Guang Hu, Shucai Yang, Mo-Xian Chen, Shaoming Zhou, Wei Guo, Xianhai Zeng, Shuqi Qiu, C Andrew van Hasselt, Michael CF Tong & George G Chen. (2020) The role of microRNA in cisplatin resistance or sensitivity. Expert Opinion on Therapeutic Targets 24:9, pages 885-897.
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Ming-Yu Wang, Ming Yang, Pi-Yong Hou, Xiu-Bo Chen, Hong-Gang Li, Jiu-Xing Yan, Jun Zhang, Yan-Wen Zhang & Xiao-Hui Wu. (2018) Intestinal absorption of pallidifloside D are limited by P-glycoprotein in mice. Xenobiotica 48:7, pages 739-744.
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Articles from other publishers (21)

Jiayu Zhang, Chenguang Li, Luanbiao Sun, Denghua Sun & Tiancheng Zhao. (2023) P53‑microRNA interactions regulate the response of colorectal tumor cells to oxaliplatin under normoxic and hypoxic conditions. Oncology Reports 50:6.
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Diana Lourenço, Raquel Lopes, Carolina Pestana, Ana C. Queirós, Cristina João & Emilie Arnault Carneiro. (2022) Patient-Derived Multiple Myeloma 3D Models for Personalized Medicine—Are We There Yet?. International Journal of Molecular Sciences 23:21, pages 12888.
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Luca Filippi, Alessandro Pini, Maurizio Cammalleri, Paola Bagnoli & Massimo Dal Monte. (2021) β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo. Medicinal Research Reviews 42:3, pages 1179-1201.
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Jitu Halder, Deepak Pradhan, Biswakanth Kar, Goutam Ghosh & Goutam Rath. (2022) Nanotherapeutics approaches to overcome P-glycoprotein-mediated multi-drug resistance in cancer. Nanomedicine: Nanotechnology, Biology and Medicine 40, pages 102494.
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Xuechun Ren, Ying Wang, Liangliang Jia, Xiaoqing Guo, Xinyu He, Zhipeng Zhao, Di Gao & Zhe Yang. (2022) Intelligent Nanomedicine Approaches Using Medical Gas-Mediated Multi-Therapeutic Modalities Against Cancer. Journal of Biomedical Nanotechnology 18:1, pages 24-49.
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Rachel L. Mynott & Craig T. Wallington-Beddoe. (2021) Drug and Solute Transporters in Mediating Resistance to Novel Therapeutics in Multiple Myeloma. ACS Pharmacology & Translational Science 4:3, pages 1050-1065.
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Amrutha Mohan, Reshma Raj R.Gayathri Mohan, Padmaja K. P.Tessy Thomas Maliekal. (2021) Reporters of Cancer Stem Cells as a Tool for Drug Discovery. Frontiers in Oncology 11.
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Rachel L. Mynott & Craig T. Wallington-Beddoe. (2021) Inhibition of P-Glycoprotein Does Not Increase the Efficacy of Proteasome Inhibitors in Multiple Myeloma Cells. ACS Pharmacology & Translational Science 4:2, pages 713-729.
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Asieh Emami Nejad, Simin Najafgholian, Alireza Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard, Marjan Taherian, Mojtaba Ahmadlou, Rasoul Salehi, Bahman Sadeghi & Mostafa Manian. (2021) The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment. Cancer Cell International 21:1.
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Melissa K. Bennett, Stuart M. Pitson & Craig T. Wallington-Beddoe. 2021. Resistance to Targeted Therapies in Multiple Myeloma. Resistance to Targeted Therapies in Multiple Myeloma 39 59 .
Nuray Erin, Jelena Grahovac, Anamaria Brozovic & Thomas Efferth. (2020) Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance. Drug Resistance Updates 53, pages 100715.
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Yue Zhang, Zhongjie Han & Chunhua Li. (2020) Molecular insight into human P-glycoprotein allosteric transition from outward- to inward-facing state. Chemical Physics 538, pages 110823.
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Maura Calvani, Annalisa Dabraio, Gennaro Bruno, Veronica De Gregorio, Marcella Coronnello, Costanza Bogani, Sara Ciullini, Giancarlo la Marca, Marina Vignoli, Paola Chiarugi, Margherita Nardi, Alessandro Maria Vannucchi, Luca Filippi & Claudio Favre. (2020) β3-Adrenoreceptor Blockade Reduces Hypoxic Myeloid Leukemic Cells Survival and Chemoresistance. International Journal of Molecular Sciences 21:12, pages 4210.
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Vadim Tsvankin, Rintaro Hashizume, Hiroaki Katagi, James E Herndon, Christopher Lascola, Talaignair N Venkatraman, Daniel Picard, Brainard Burrus, Oren J Becher & Eric M Thompson. (2020) ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma. Neurosurgery 86:5, pages 742-751.
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L. A. Laletina, N. I. Moiseeva & A. F. Karamysheva. (2020) The importance of preexisting drug resistance due to overexpression of P-glycoprotein for the formation of resistance to bortezomib. Advances in Molecular Oncology 7:1, pages 23-31.
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Silpa Narayanan, Chao-Yun Cai, Yehuda G. Assaraf, Hui-Qin Guo, Qingbin Cui, Liuya Wei, Juan-Juan Huang, Charles R. AshbyJrJr & Zhe-Sheng Chen. (2020) Targeting the ubiquitin-proteasome pathway to overcome anti-cancer drug resistance. Drug Resistance Updates 48, pages 100663.
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Alberto Lazarowski. 2020. Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy. Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy 149 195 .
Fang‑Xiao Zhu, Xiao‑Tao Wang, Hui‑Qiong Zeng, Zhi‑Hua Yin & Zhi‑Zhong Ye. (2019) A predicted risk score based on the expression of 16 autophagy‑related genes for multiple myeloma survival. Oncology Letters.
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Yue Pan, Yunqiu Zhang, Qing Chen, Xufeng Tao, Jianzhou Liu & Gary Guishan Xiao. (2019) CTAB Enhances Chemo-Sensitivity Through Activation of AMPK Signaling Cascades in Breast Cancer. Frontiers in Pharmacology 10.
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Yingying Wang, Linlin Wu, Haiyan Cai, Hu Lei, Chun-Min Ma, Li Yang, Hanzhang Xu, Qi Zhu, Zhujun Yao & Yingli Wu. (2018) YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells. Cell Death Discovery 4:1.
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Sara Gandolfi, Jacob P. Laubach, Teru Hideshima, Dharminder Chauhan, Kenneth C. Anderson & Paul G. Richardson. (2017) The proteasome and proteasome inhibitors in multiple myeloma. Cancer and Metastasis Reviews 36:4, pages 561-584.
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