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Leukemia & Lymphoma Volume 59, 2018 - Issue 3
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Overcoming multiple myeloma drug resistance in the era of cancer ‘omics’

Matthew Ho Zhi GuangDepartment of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; ;UCD School of Medicine, College of Health and Agricultural Science and UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland;
,
Amanda McCannUCD School of Medicine, College of Health and Agricultural Science and UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland;
,
Giada BianchiDepartment of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA;
,
Li ZhangDepartment of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; ;Department of Hematology, West China Hospital, Sichuan University, Chengdu, China;
,
Paul DowlingDepartment of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
,
Despina BazouDepartment of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
,
Peter O’GormanDepartment of Haematology, Mater Misericordiae University Hospital, Dublin, IrelandCorrespondence[email protected]
&
Kenneth C. AndersonDepartment of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Correspondence[email protected]
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Pages 542-561 | Received 10 Apr 2017, Accepted 26 May 2017, Published online: 13 Jun 2017

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Qiqi Zhang, Zhan Wang, Zhenghua Zhang, Lifei Zhu & Xijing Yang. (2022) Analysis of microarray-identified genes and MicroRNAs associated with Trifluridine resistance in colorectal cancer. All Life 15:1, pages 636-648.
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Karolinny Cristiny de Oliveira Vieira, Hevelin Regiane Augusto da Silva, Isabela Poletto Masselli Rocha, Emmanuel Barboza & Lizziane Kretli Winkelstroter Eller. (2022) Foodborne pathogens in the omics era. Critical Reviews in Food Science and Nutrition 62:24, pages 6726-6741.
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Matthew Ho, Giada Bianchi & Kenneth C. Anderson. (2020) Proteomics-inspired precision medicine for treating and understanding multiple myeloma. Expert Review of Precision Medicine and Drug Development 5:2, pages 67-85.
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Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou & Evangelos Terpos. (2020) Antibody therapies for multiple myeloma. Expert Opinion on Biological Therapy 20:3, pages 295-303.
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Thomas A. Guerrero-Garcia, Sara Gandolfi, Jacob P. Laubach, Teru Hideshima, Dharminder Chauhan, Constantine Mitsiades, Kenneth C. Anderson & Paul G. Richardson. (2018) The power of proteasome inhibition in multiple myeloma. Expert Review of Proteomics 15:12, pages 1033-1052.
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Larissa Haertle, Natalia Buenache, Hipólito Nicolás Cuesta Hernández, Michal Simicek, Renata Snaurova, Inmaculada Rapado, Nerea Martinez, Nieves López-Muñoz, José María Sánchez-Pina, Umair Munawar, Seungbin Han, Yanira Ruiz-Heredia, Rafael Colmenares, Miguel Gallardo, Margarita Sanchez-Beato, Miguel Angel Piris, Mehmet Kemal Samur, Nikhil C. Munshi, Rosa Ayala, Klaus Martin Kortüm, Santiago Barrio & Joaquín Martínez-López. (2023) Genetic Alterations in Members of the Proteasome 26S Subunit, AAA-ATPase (PSMC) Gene Family in the Light of Proteasome Inhibitor Resistance in Multiple Myeloma. Cancers 15:2, pages 532.
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Diana Lourenço, Raquel Lopes, Carolina Pestana, Ana C. Queirós, Cristina João & Emilie Arnault Carneiro. (2022) Patient-Derived Multiple Myeloma 3D Models for Personalized Medicine—Are We There Yet?. International Journal of Molecular Sciences 23:21, pages 12888.
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Linqing Shi, Bo Chen, Tianyu Liu, Liqiang Li, Biao Hu, Chenzhen Li, Bing Jia & Fan Wang. (2022) 99m Tc-CD3813: A Nanobody-Based Single Photon Emission Computed Tomography Radiotracer with Clinical Potential for Myeloma Imaging and Evaluation of CD38 Expression . Molecular Pharmaceutics 19:7, pages 2583-2594.
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Tianzeng Chen, Matthew Ho, Jenna BriereMaria MoscvinPeter G. Czarnecki, Kenneth C. AndersonT. Keith Blackwell & Giada Bianchi. (2022) Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival. Blood Advances 6:2, pages 429-440.
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Lin Wang, Xueting Wang, Tong Wang, Yingping Zhuang & Guan Wang. (2021) Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model. Bioresources and Bioprocessing 8:1.
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Micaela F. Freitas Misakyan, E. M. Kithsiri Wijeratne, Mark E. Issa, Ya-ming Xu, Aymeric Monteillier, A. A. Leslie Gunatilaka & Muriel Cuendet. (2021) Structure–Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model. Journal of Natural Products 84:8, pages 2321-2335.
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Ciara Tierney, Despina Bazou, Muntasir M. Majumder, Pekka Anttila, Raija Silvennoinen, Caroline A. Heckman, Paul Dowling & Peter O’Gorman. (2021) Next generation proteomics with drug sensitivity screening identifies sub-clones informing therapeutic and drug development strategies for multiple myeloma patients. Scientific Reports 11:1.
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Sanyog Dwivedi, Erika P. Rendón-Huerta, Vianney Ortiz-Navarrete & Luis F. Montaño. (2021) CD38 and Regulation of the Immune Response Cells in Cancer. Journal of Oncology 2021, pages 1-11.
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Leona Yamamoto, Nicola Amodio, Annamaria Gulla & Kenneth Carl Anderson. (2021) Harnessing the Immune System Against Multiple Myeloma: Challenges and Opportunities. Frontiers in Oncology 10.
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Miao Li, Lin Qi, Jing-Bo Xu, Li-Ye Zhong, Szehoi Chan, Shu-Na Chen, Xin-Rong Shao, Li-Yuan Zheng, Zhao-Xia Dong, Tian-Liang Fang, Zhi-Ying Mai, Juan Li, Yongjiang Zheng & Xing-Ding Zhang. (2020) Methylation of the Promoter Region of the Tight Junction Protein-1 by DNMT1 Induces EMT-like Features in Multiple Myeloma. Molecular Therapy - Oncolytics 19, pages 197-207.
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Matthew Ho, Chia Yin Goh, Ashish Patel, Susannah Staunton, Ronan O’Connor, Marc Godeau & Giada Bianchi. (2020) Role of the Bone Marrow Milieu in Multiple Myeloma Progression and Therapeutic Resistance. Clinical Lymphoma Myeloma and Leukemia 20:10, pages e752-e768.
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Clément Bailly, Benjamin Chalopin, Sébastien Gouard, Thomas Carlier, Patricia Remaud-Le Saëc, Séverine Marionneau-Lambot, Philippe Moreau, Cyrille Touzeau, Françoise Kraeber-Bodere, Caroline Bodet-Milin & Michel Chérel. (2020) ImmunoPET in Multiple Myeloma—What? So What? Now What?. Cancers 12:6, pages 1467.
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Ilaria Saltarella, Vanessa Desantis, Assunta Melaccio, Antonio Giovanni Solimando, Aurelia Lamanuzzi, Roberto Ria, Clelia Tiziana Storlazzi, Maria Addolorata Mariggiò, Angelo Vacca & Maria Antonia Frassanito. (2020) Mechanisms of Resistance to Anti-CD38 Daratumumab in Multiple Myeloma. Cells 9:1, pages 167.
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Ahmed Mohamed, Joel Collins, Hui Jiang, Jeffrey Molendijk, Thomas Stoll, Federico Torta, Markus R. Wenk, Robert J. Bird, Paula Marlton, Peter Mollee, Kate A. Markey & Michelle M. Hill. (2020) Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome. PLOS ONE 15:1, pages e0227455.
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Matthew Ho, Tianzeng Chen, Jiye Liu, Paul Dowling, Teru Hideshima, Li Zhang, Eugenio Morelli, Gulden Camci-Unal, Xinchen Wu, Yu-Tzu Tai, Kenneth Wen, Mehmet Samur, Robert L. Schlossman, Ralph Mazitschek, Emma L. Kavanagh, Sinéad Lindsay, Takeshi Harada, Amanda McCann, Kenneth C. Anderson, Peter O’Gorman & Giada Bianchi. (2019) Targeting histone deacetylase 3 (HDAC3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling. Leukemia 34:1, pages 196-209.
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Érica Aparecida de Oliveira, Colin R. Goding & Silvya Stuchi Maria-Engler. 2021. Organotypic Models in Drug Development. Organotypic Models in Drug Development 269 301 .
Jahangir Abdi, Nasrin Rastgoo, Yan Chen, Guo An Chen & Hong Chang. (2019) Ectopic expression of BIRC5-targeting miR-101-3p overcomes bone marrow stroma-mediated drug resistance in multiple myeloma cells. BMC Cancer 19:1.
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Venkatesh Chanukuppa, Tushar H. More, Khushman Taunk, Ravindra Taware, Tathagata Chatterjee, Sanjeevan Sharma & Srikanth Rapole. (2019) Serum metabolomic alterations in multiple myeloma revealed by targeted and untargeted metabolomics approaches: a pilot study. RSC Advances 9:51, pages 29522-29532.
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Anna K. Scherger, Mona Al-Maarri, Hans C. Maurer, Markus Schick, Sabine Maurer, Rupert Öllinger, Irene Gonzalez-Menendez, Manuela Martella, Markus Thaler, Konstanze Pechloff, Katja Steiger, Sandrine Sander, Jürgen Ruland, Roland Rad, Leticia Quintanilla-Martinez, Frank T. Wunderlich, Stefan Rose-John & Ulrich Keller. (2019) Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma. JCI Insight 4:15.
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Taylor Harding, Linda Baughn, Shaji Kumar & Brian Van Ness. (2019) The future of myeloma precision medicine: integrating the compendium of known drug resistance mechanisms with emerging tumor profiling technologies. Leukemia 33:4, pages 863-883.
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Jonathan J. Morgan, Roisin M. McAvera & Lisa J. Crawford. (2019) TRAF6 Silencing Attenuates Multiple Myeloma Cell Adhesion to Bone Marrow Stromal Cells. International Journal of Molecular Sciences 20:3, pages 702.
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Pawel Robak, Izabela Drozdz, Janusz Szemraj & Tadeusz Robak. (2018) Drug resistance in multiple myeloma. Cancer Treatment Reviews 70, pages 199-208.
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Han-Byul Kim & Seung-Jae Myung. (2018) Clinical implications of the Hippo-YAP pathway in multiple cancer contexts. BMB Reports 51:3, pages 119-125.
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