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Original Article

P15INK4b Gene Methylation and Myelodysplastic Syndromes

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Pages 437-443 | Published online: 30 Mar 2010

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Read on this site (5)

Massimo Breccia, Matteo Molica, Irene Zacheo & Giuliana Alimena. (2014) Azacitidine for myelodysplastic patients aged > 65 years: a review of clinical efficacy. Expert Opinion on Pharmacotherapy 15:11, pages 1621-1630.
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Hussain I Saba. (2007) Decitabine in the treatment of myelodysplastic syndromes. Therapeutics and Clinical Risk Management 3:5, pages 807-817.
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Sophie Kusy, Christian-Jacques Larsen & Joëlle Roche. (2004) p14ARF, p15INK4b and p16INK4a Methylation Status in Chronic Myelogenous Leukemia. Leukemia & Lymphoma 45:10, pages 1989-1994.
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Bryan T Hennessy, Guillermo Garcia-Manero, Hagop M Kantarjian & Francis J Giles. (2003) DNA methylation in haematological malignancies: the role of decitabine. Expert Opinion on Investigational Drugs 12:12, pages 1985-1993.
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Articles from other publishers (36)

Mohammad Sadeghi, Mehrdad Fathi, Jamshid Gholizadeh Navashenaq, Hamed Mohammadi, Mehdi Yousefi, Mohammad Hojjat-Farsangi, Afshin Namdar, Ali Akbar Movasaghpour Akbari & Farhad Jadidi-Niaragh. (2023) The prognostic and therapeutic potential of HO-1 in leukemia and MDS. Cell Communication and Signaling 21:1.
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Alexandra Besser & Joyce Slingerland. 2023. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 243 253 .
Fang Ye & Ningning Li. (2019) Role of p15(INK4B) Methylation in Patients With Myelodysplastic Syndromes: A Systematic Meta-Analysis. Clinical Lymphoma Myeloma and Leukemia 19:6, pages e259-e265.
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Hong Wang, Yan Li, Na Lv, Yonghui Li, Lili Wang & Li Yu. (2018) Predictors of clinical responses to hypomethylating agents in acute myeloid leukemia or myelodysplastic syndromes. Annals of Hematology 97:11, pages 2025-2038.
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Domenico Mattiucci, Giulia Maurizi, Pietro Leoni & Antonella Poloni. (2018) Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes. Cell Transplantation 27:5, pages 754-764.
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Christopher J. Gibson, Benjamin L. Ebert & David P. Steensma. 2018. Hematology. Hematology 944 969.e13 .
A. Besser & J. Slingerland. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 437 446 .
Jixue Zou, Zhigang Zhou, Liping Wan, Yin Tong, Youwen Qin, Chun Wang & Kun Zhou. (2015) Targeting the Sonic Hedgehog-Gli1 Pathway as a Potential New Therapeutic Strategy for Myelodysplastic Syndromes. PLOS ONE 10:8, pages e0136843.
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Gabriela Bernadeta Iwanski, Nils Heinrich Thoennissen, Dorothy J. Park & H. Phillip Koeffler. 2013. Neoplastic Diseases of the Blood. Neoplastic Diseases of the Blood 455 486 .
Yue Wei, Irene Gañán-Gómez, Sophie Salazar-Dimicoli, Sara L McCay & Guillermo Garcia-Manero. (2011) Histone methylation in myelodysplastic syndromes. Epigenomics 3:2, pages 193-205.
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Hsing-Chen Tsai & Stephen B Baylin. (2011) Cancer epigenetics: linking basic biology to clinical medicine. Cell Research 21:3, pages 502-517.
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Patrick Brown, Gregory H. Reaman, Nita L. Seibel & Pamela Kearns. 2011. Childhood Leukemia. Childhood Leukemia 193 214 .
Pamela Kearns. 2011. New Agents for the Treatment of Acute Lymphoblastic Leukemia. New Agents for the Treatment of Acute Lymphoblastic Leukemia 299 310 .
Lisa Pleyer, Daniel Neureiter, Victoria Faber & Richard Greil. 2010. Chronic Myeloid Neoplasias and Clonal Overlap Syndromes. Chronic Myeloid Neoplasias and Clonal Overlap Syndromes 153 222 .
A. YALCIN, M. S. SERIN, G. EMEKDAS, N. TIFTIK, G. ASLAN, G. ESKANDARI & S. TEZCAN. (2009) Promoter methylation of P15 INK4B gene is possibly associated with parvovirus B19 infection in adult acute leukemias . International Journal of Laboratory Hematology 31:4, pages 407-419.
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Rebecca B. Klisovic, Wendy Stock, Spero Cataland, Marko I. Klisovic, Shujun Liu, William Blum, Margaret Green, Olatoyosi Odenike, Lucy Godley, Jennifer Vanden Burgt, Emily Van Laar, Michael Cullen, A. Robert Macleod, Jeffrey M. Besterman, Gregory K. Reid, John C. Byrd & Guido Marcucci. (2008) A Phase I Biological Study of MG98, an Oligodeoxynucleotide Antisense to DNA Methyltransferase 1, in Patients with High-Risk Myelodysplasia and Acute Myeloid Leukemia. Clinical Cancer Research 14:8, pages 2444-2449.
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Sotirios G. Papageorgiou, Stefanos Lambropoulos, Vassiliki Pappa, Christina Economopoulou, Frinta Kontsioti, Efstathios Papageorgiou, Panagiotis Tsirigotis, John Dervenoulas & Theofanis Economopoulos. (2007) Hypermethylation of the p15 INK4B gene promoter in B‐chronic lymphocytic leukemia . American Journal of Hematology 82:9, pages 824-825.
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Margaret K. Yu. (2006) Epigenetics and chronic lymphocytic leukemia. American Journal of Hematology 81:11, pages 864-869.
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Paresh Vyas & Alexander Sternberg. (2006) Characterization of the hemopoietic defect in early stages of the myelodysplastic syndromes. Advances in Enzyme Regulation 46:1, pages 98-112.
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Ha Thanh Nishino & Chung-Che Chang. (2005) Myelodysplastic Syndromes: Clinicopathologic Features, Pathobiology, and Molecular Pathogenesis. Archives of Pathology & Laboratory Medicine 129:10, pages 1299-1310.
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Sotirios G. Papageorgiou, Vassiliki Pappa, Efstathios Papageorgiou, Panagiotis Tsirigotis, Frida Kontsioti, Anna Panani, John Dervenoulas & Theofanis Economopoulos. (2005) Absence of p16 and p27 gene rearrangements and mutations in de novo myelodysplastic syndromes. European Journal of Haematology 75:3, pages 193-198.
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Peter A. Jones. (2005) Overview of Cancer Epigenetics. Seminars in Hematology 42, pages S3-S8.
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Takashi Shimamoto, Junko H. Ohyashiki & Kazuma Ohyashiki. (2005) Methylation of p15INK4b and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia. Leukemia Research 29:6, pages 653-659.
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David P. Steensma & Alan F. List. (2005) Genetic Testing in the Myelodysplastic Syndromes: Molecular Insights Into Hematologic Diversity. Mayo Clinic Proceedings 80:5, pages 681-698.
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Gregory K. Reid & A. Robert MacLeod. 2005. DNA Methylation and Cancer Therapy. DNA Methylation and Cancer Therapy 187 204 .
Lewis R. Silverman. (2004) DNA methyltransferase inhibitors in myelodysplastic syndrome. Best Practice & Research Clinical Haematology 17:4, pages 585-594.
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Ghulam J. Mufti. (2004) Pathobiology, classification, and diagnosis of myelodysplastic syndrome. Best Practice & Research Clinical Haematology 17:4, pages 543-557.
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Alison M John, N.Shaun B Thomas, Ghulam J Mufti & Rose Ann Padua. (2004) Targeted therapies in myeloid leukemia. Seminars in Cancer Biology 14:1, pages 41-62.
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M Tessema, F Länger, J Dingemann, A Ganser, H Kreipe & U Lehmann. (2003) Aberrant methylation and impaired expression of the p15INK4b cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML). Leukemia 17:5, pages 910-918.
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PETER A. JONES. (2003) Epigenetics in Carcinogenesis and Cancer Prevention. Annals of the New York Academy of Sciences 983:1, pages 213-219.
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Long Wong, Joan Zhou, Daniel Anderson & Robert A Kratzke. (2002) Inactivation of p16INK4a expression in malignant mesothelioma by methylation. Lung Cancer 38:2, pages 131-136.
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Jeffrey Gryn, Zella R. Zeigler, Richard K. Shadduck, John Lister, Jane M. Raymond, Ibrahim Sbeitan, Charles Srodes, Dennis Meisner & Cynthia Evans. (2002) Treatment of myelodysplastic syndromes with 5-azacytidine. Leukemia Research 26:10, pages 893-897.
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Karim Roder, Maria-Jesus Latasa & Hei Sook Sul. (2002) Silencing of the Mouse H-rev107 Gene Encoding a Class II Tumor Suppressor by CpG Methylation. Journal of Biological Chemistry 277:34, pages 30543-30550.
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Lewis R. Silverman. (2001) Targeting Hypomethylation of DNA to Achieve Cellular Differentiation in Myelodysplastic Syndromes (MDS). The Oncologist 6:S5, pages 8-14.
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Lenka Krsková-Honzátková, Jaroslav Čermák, Jana Sajdová, Jan Starý, Petr Sedláček & Zuzana Sieglová. (2001) Loss of heterozygosity and heterogeneity of its appearance and persisting in the course of acute myeloid leukemia and myelodysplastic syndromes. Leukemia Research 25:1, pages 45-53.
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Rose Ann Padua, Angela McGlynn & Hugh McGlynn. 2001. Myelodysplastic Syndromes & Secondary Acute Myelogenous Leukemia. Myelodysplastic Syndromes & Secondary Acute Myelogenous Leukemia 111 157 .

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