119
Views
49
CrossRef citations to date
0
Altmetric
Original Article

Adhesion to Bone Marrow Stroma Inhibits Apoptosis of Chronic Lymphocytic Leukemia Cells

, , , &
Pages 445-453 | Received 08 Jan 1999, Published online: 30 Mar 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Ashima Shukla, Vipul Shukla & Shantaram S. Joshi. (2018) Regulation of MAPK signaling and implications in chronic lymphocytic leukemia. Leukemia & Lymphoma 59:7, pages 1565-1573.
Read now
Kyle Crassini, Yandong Shen, Stephen Mulligan & O. Giles Best. (2017) Modeling the chronic lymphocytic leukemia microenvironment in vitro. Leukemia & Lymphoma 58:2, pages 266-279.
Read now
Wan Zhang & Peng Huang. (2011) Cancer-stromal interactions. Cancer Biology & Therapy 11:2, pages 150-156.
Read now
Falk Dillmann, Marlon R. Veldwijk, Stephanie Laufs, Markus Sperandio, Gary Calandra, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf, Falk Dillmann, Marlon R. Veldwijk, Stephanie Laufs, Markus Sperandio, Gary Calandra, Frederik Wenz, W. Jens Zeller & Stefan Fruehauf. (2009) Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib. Leukemia & Lymphoma 50:10, pages 1676-1686.
Read now

Articles from other publishers (45)

Marina Cerreto, Robin Foà & Alessandro Natoni. (2023) The Role of the Microenvironment and Cell Adhesion Molecules in Chronic Lymphocytic Leukemia. Cancers 15:21, pages 5160.
Crossref
Erwan Dumontet, Stéphane J. C. Mancini & Karin Tarte. (2021) Bone Marrow Lymphoid Niche Adaptation to Mature B Cell Neoplasms. Frontiers in Immunology 12.
Crossref
Pablo Oppezzo, Marcelo Navarrete & Nicholas Chiorazzi. (2021) AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression. Frontiers in Oncology 11.
Crossref
Nathan Dubois, Emerence Crompot, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux & Basile Stamatopoulos. (2020) Importance of Crosstalk Between Chronic Lymphocytic Leukemia Cells and the Stromal Microenvironment: Direct Contact, Soluble Factors, and Extracellular Vesicles. Frontiers in Oncology 10.
Crossref
Hanbo Cao, Wenjun Li, Yizhou Zhou, Renxiang Tan, Yue Yang, You Zhou, Qinglong Guo & Li Zhao. (2019) Oroxylin a Inhibits the Protection of Bone Marrow Microenvironment on CML Cells Through CXCL12/CXCR4/P-gp Signaling Pathway. Frontiers in Oncology 9.
Crossref
Javier Redondo-Muñoz, Angeles García-Pardo & Joaquin Teixidó. (2019) Molecular Players in Hematologic Tumor Cell Trafficking. Frontiers in Immunology 10.
Crossref
Dilini C. Gunasekara, Mary M. Zheng, Tara Mojtahed, James R. Woods, Tamer E. Fandy, Mark V. Riofski, Carlotta A. Glackin, Hazem E. Hassan, Julia Kirshner & David A. Colby. (2016) 15-Methylene-Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia. ChemMedChem 11:21, pages 2392-2397.
Crossref
Miguel A. Flores, Paula Fortea, Eva M. Trinidad, Dolores García, Gloria Soler, Francisco J. Ortuño, Agustín G. Zapata & Luis M. Alonso-Colmenar. (2016) EphrinA4 plays a critical role in α4 and αL mediated survival of human CLL cells during extravasation. Oncotarget 7:30, pages 48481-48500.
Crossref
Sarah E.M. Herman & Adrian Wiestner. (2016) Preclinical modeling of novel therapeutics in chronic lymphocytic leukemia: the tools of the trade. Seminars in Oncology 43:2, pages 222-232.
Crossref
Clare Sun & Adrian Wiestner. 2015. Non-Hodgkin Lymphoma. Non-Hodgkin Lymphoma 147 175 .
Alexandre JanelFrédérique Dubois-GalopinCéline BourgneJuliette BergerKarin TarteNathalie Boiret-DupréStéphane BoisgardPierre VerrellePierre DéchelotteOlivier TournilhacMarc G. Berger. (2014) The Chronic Lymphocytic Leukemia Clone Disrupts the Bone Marrow Microenvironment. Stem Cells and Development 23:24, pages 2972-2982.
Crossref
Gabriele Brachtl, Josefina Piñón Hofbauer, Richard Greil & Tanja Nicole Hartmann. (2013) The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia. Annals of Hematology 93:3, pages 361-374.
Crossref
Yair Herishanu, Ben-Zion Katz, Andrew Lipsky & Adrian Wiestner. (2013) Biology of Chronic Lymphocytic Leukemia in Different Microenvironments. Hematology/Oncology Clinics of North America 27:2, pages 173-206.
Crossref
M T S Bertilaccio, C Scielzo, G Simonetti, E Ten Hacken, B Apollonio, P Ghia & F Caligaris-Cappio. (2012) Xenograft models of chronic lymphocytic leukemia: problems, pitfalls and future directions. Leukemia 27:3, pages 534-540.
Crossref
Rajesh R. Nair, Anthony W. Gebhard & Lori A. Hazlehurst. 2013. Cell Death Signaling in Cancer Biology and Treatment. Cell Death Signaling in Cancer Biology and Treatment 53 86 .
E Weisberg, Q Liu, Erik Nelson, A L Kung, A L Christie, R Bronson, M Sattler, T Sanda, Z Zhao, W Hur, C Mitsiades, R Smith, J F Daley, R Stone, I Galinsky, J D Griffin & N Gray. (2012) Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors. Leukemia 26:10, pages 2233-2244.
Crossref
E Weisberg, A K Azab, P W Manley, A L Kung, A L Christie, R Bronson, I M Ghobrial & J D Griffin. (2011) Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib. Leukemia 26:5, pages 985-990.
Crossref
Márk Plander, Peter Ugocsai, Silvia Seegers, Evelyn Orsó, Albrecht Reichle, Gerd Schmitz, Ferdinand Hofstädter & Gero Brockhoff. (2011) Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma. Annals of Hematology 90:12, pages 1381-1390.
Crossref
Davide BagnaraMatthew S. KaufmanCarlo CalissanoSonia MarsilioPiers E. M. PattenRita SimonePhilip ChumXiao-Jie YanSteven L. AllenJonathan E. KolitzSivasubramanian BaskarChristoph RaderHakan MellstedtHodjattallah RabbaniAnnette Lee, Peter K. Gregersen, Kanti R. RaiNicholas Chiorazzi. (2011) A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood 117:20, pages 5463-5472.
Crossref
Axel Schulenburg, Kira Brämswig, Harald Herrmann, Heidrun Karlic, Irina Mirkina, Rainer Hubmann, Sylvia Laffer, Brigitte Marian, Medhat Shehata, Clemens Krepler, Hubert Pehamberger, Thomas Grunt, Ulrich Jäger, Christoph C. Zielinski & Peter Valent. (2010) Neoplastic stem cells: Current concepts and clinical perspectives. Critical Reviews in Oncology/Hematology 76:2, pages 79-98.
Crossref
Medhat Shehata, Susanne SchnablDita DemirtasMartin HilgarthRainer Hubmann, Elena PonathSigrun BadrnyaClaudia LehnerAndrea HoelblMarkus DuechlerAlexander GaigerChristoph Zielinski, Josef D. SchwarzmeierUlrich Jaeger. (2010) Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia. Blood 116:14, pages 2513-2521.
Crossref
E Weisberg, M Sattler, A Ray & J D Griffin. (2010) Drug resistance in mutant FLT3-positive AML. Oncogene 29:37, pages 5120-5134.
Crossref
Sebastian W. Hofbauer, Josefina D. Piñón, Gabriele Brachtl, Lucia Haginger, Wei Wang, Karin Jöhrer, Ingeborg Tinhofer, Tanja Nicole Hartmann & Richard Greil. (2010) Modifying Akt Signaling in B-Cell Chronic Lymphocytic Leukemia Cells. Cancer Research 70:18, pages 7336-7344.
Crossref
Maike BuchnerConstance BaerGabriele PrinzChristine DierksMeike BurgerThorsten Zenz, Stephan Stilgenbauer, Hassan Jumaa, Hendrik VeelkenKatja Zirlik. (2010) Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia. Blood 115:22, pages 4497-4506.
Crossref
Wei Ding, Grzegorz S. Nowakowski, Traci R. Knox, Justin C. Boysen, Mary L. Maas, Susan M. Schwager, Wenting Wu, Linda E. Wellik, Allan B. Dietz, Asish K. Ghosh, Charla R. Secreto, Kay L. Medina, Tait D. Shanafelt, Clive S. Zent, Timothy G. Call & Neil E. Kay. (2009) Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression. British Journal of Haematology 147:4, pages 471-483.
Crossref
Andrew J. Mhyre, A. Mario Marcondes, Emily Y. Spaulding & H. Joachim Deeg. (2009) Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD. Blood 113:3, pages 649-658.
Crossref
Nicholas Chiorazzi & Manlio Ferrarini. 2008. Chronic Lymphocytic Leukemia. Chronic Lymphocytic Leukemia 1 18 .
Ellen Weisberg, Renee D. Wright, Douglas W. McMillin, Constantine Mitsiades, Arghya Ray, Rosemary Barrett, Sophia Adamia, Richard Stone, Ilene Galinsky, Andrew L. Kung & James D. Griffin. (2008) Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells. Molecular Cancer Therapeutics 7:5, pages 1121-1129.
Crossref
Tait D. Shanafelt, Susan M. Geyer, Nancy D. Bone, Renee C. Tschumper, Tom E. Witzig, Greg S. Nowakowski, Clive S. Zent, Tim G. Call, Betsy LaPlant, Gordon W. Dewald, Diane F. Jelinek & Neil E. Kay. (2008) CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potential. British Journal of Haematology 140:5, pages 537-546.
Crossref
Tetsuya Fukuda, Liguang Chen, Tomoyuki Endo, Li Tang, Desheng Lu, Januario E. Castro, George F. WidhopfIIII, Laura Z. Rassenti, Mark J. Cantwell, Charles E. Prussak, Dennis A. Carson & Thomas J. Kipps. (2008) Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proceedings of the National Academy of Sciences 105:8, pages 3047-3052.
Crossref
Neil E. Kay, Tait D. Shanafelt, Ann K. Strege, Yean K. Lee, Nancy D. Bone & Azra Raza. (2007) Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an “angiogenic switch”. Leukemia Research 31:7, pages 899-906.
Crossref
Beerelli Seshi. (2006) An integrated approach to mapping the proteome of the human bone marrow stromal cell. PROTEOMICS 6:19, pages 5169-5182.
Crossref
Sarah J. RichardsonChristine MatthewsMark A. CatherwoodH. Denis AlexanderB. Sean CareyJoanna FarrugiaAnne GardinerSarah MouldDavid OscierJ. Adrian CopplestoneArchibald G. Prentice. (2006) ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL). Blood 107:9, pages 3584-3592.
Crossref
Mitsufumi NishioTomoyuki EndoNobuhiro TsukadaJunko OhataShinichi KitadaJohn C. ReedNathan J. ZvaiflerThomas J. Kipps. (2005) Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α. Blood 106:3, pages 1012-1020.
Crossref
Ciro Romano, Umberto De Fanis, Ausilia Sellitto, Federico Chiurazzi, Salvatore Guastafierro, Riccardo Giunta, Angelo Tirelli, Bruno Rotoli & Giacomo Lucivero. (2005) Induction of CD95 upregulation does not render chronic lymphocytic leukemia B-cells susceptible to CD95-mediated apoptosis. Immunology Letters 97:1, pages 131-139.
Crossref
P. Oppezzo & G. Dighiero. 2005. Chronic Lymphocytic Leukemia. Chronic Lymphocytic Leukemia 71 89 .
Guillaume Dighiero. (2004) Perspectives in chronic lymphocytic leukemia biology and management. Hematology/Oncology Clinics of North America 18:4, pages 927-943.
Crossref
Andy Rawstron, Peter Hillmen & Richard Houlston. (2004) Clonal lymphocytes in persons without known chronic lymphocytic leukemia (CLL): implications of recent findings in family members of CLL patients. Seminars in Hematology 41:3, pages 192-200.
Crossref
G Dighiero. (2003) Unsolved issues in CLL biology and management. Leukemia 17:12, pages 2385-2391.
Crossref
F H Paraguassú-Braga, R Borojevic, L F Bouzas, M A Barcinski & A Bonomo. (2003) Bone marrow stroma inhibits proliferation and apoptosis in leukemic cells through gap junction-mediated cell communication. Cell Death & Differentiation 10:9, pages 1101-1108.
Crossref
Z Zheng, S Venkatapathy, G Rao & CA Harrington. (2002) Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells. Leukemia 16:12, pages 2429-2437.
Crossref
Carmela Gurrieri, Peter McGuire, Hong Zan, Xiao-Jie Yan, Andrea Cerutti, Emilia Albesiano, Steven L. Allen, Vincent Vinciguerra, Kanti R. Rai, Manlio Ferrarini, Paolo Casali & Nicholas Chiorazzi. (2002) Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin VHDJH Gene Diversification. The Journal of Experimental Medicine 196:5, pages 629-639.
Crossref
Neil E. Kay, Terry J. Hamblin, Diane F. Jelinek, Gordon W. Dewald, John C. Byrd, Sherif Farag, Margaret Lucas & Thomas Lin. (2002) Chronic Lymphocytic Leukemia. Hematology 2002:1, pages 193-213.
Crossref
Luisa GranzieroPaolo GhiaPaola CircostaDaniela GottardiGiuliana StrolaMassimo GeunaLicia MontagnaPaola PiccoliMarco ChilosiFederico Caligaris-Cappio. (2001) Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood 97:9, pages 2777-2783.
Crossref
L. Lagneaux, A. Delforge, S. Carlier, M. Massy, M. Bernier & D. Bron. (2001) Early induction of apoptosis in B‐chronic lymphocytic leukaemia cells by hydroxychloroquine: activation of caspase‐3 and no protection by survival factors. British Journal of Haematology 112:2, pages 344-352.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.